LeishMANIAdb
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Putative U3 small nucleolar ribonucleoprotein protein MPP10

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative U3 small nucleolar ribonucleoprotein protein MPP10
Gene product:
U3 small nucleolar ribonucleoprotein protein MPP10 - putative
Species:
Leishmania infantum
UniProt:
A4I4C8_LEIIN
TriTrypDb:
LINF_290012600
Length:
675

Annotations

Annotations by Jardim et al.

RNA Processing, U3 small nucleolar ribonucleo MPP10

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005732 sno(s)RNA-containing ribonucleoprotein complex 3 9
GO:0032991 protein-containing complex 1 9
GO:0034457 Mpp10 complex 3 9
GO:0140513 nuclear protein-containing complex 2 9
GO:1990904 ribonucleoprotein complex 2 9
GO:0005730 nucleolus 5 1
GO:0030684 preribosome 3 1
GO:0032040 small-subunit processome 4 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote: 284, 369

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4C8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4C8

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 9
GO:0006364 rRNA processing 8 9
GO:0006396 RNA processing 6 9
GO:0006725 cellular aromatic compound metabolic process 3 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016070 RNA metabolic process 5 9
GO:0016072 rRNA metabolic process 7 9
GO:0034470 ncRNA processing 7 9
GO:0034641 cellular nitrogen compound metabolic process 3 9
GO:0034660 ncRNA metabolic process 6 9
GO:0043170 macromolecule metabolic process 3 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0046483 heterocycle metabolic process 3 9
GO:0071704 organic substance metabolic process 2 9
GO:0090304 nucleic acid metabolic process 4 9
GO:1901360 organic cyclic compound metabolic process 3 9
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 256 260 PF00656 0.367
CLV_NRD_NRD_1 112 114 PF00675 0.288
CLV_NRD_NRD_1 134 136 PF00675 0.353
CLV_NRD_NRD_1 190 192 PF00675 0.352
CLV_NRD_NRD_1 193 195 PF00675 0.329
CLV_NRD_NRD_1 241 243 PF00675 0.340
CLV_NRD_NRD_1 265 267 PF00675 0.228
CLV_NRD_NRD_1 415 417 PF00675 0.259
CLV_NRD_NRD_1 46 48 PF00675 0.582
CLV_NRD_NRD_1 487 489 PF00675 0.287
CLV_NRD_NRD_1 644 646 PF00675 0.337
CLV_NRD_NRD_1 660 662 PF00675 0.470
CLV_NRD_NRD_1 81 83 PF00675 0.557
CLV_PCSK_FUR_1 236 240 PF00082 0.349
CLV_PCSK_KEX2_1 112 114 PF00082 0.289
CLV_PCSK_KEX2_1 190 192 PF00082 0.353
CLV_PCSK_KEX2_1 238 240 PF00082 0.340
CLV_PCSK_KEX2_1 241 243 PF00082 0.340
CLV_PCSK_KEX2_1 265 267 PF00082 0.231
CLV_PCSK_KEX2_1 421 423 PF00082 0.290
CLV_PCSK_KEX2_1 438 440 PF00082 0.179
CLV_PCSK_KEX2_1 46 48 PF00082 0.582
CLV_PCSK_KEX2_1 487 489 PF00082 0.357
CLV_PCSK_KEX2_1 644 646 PF00082 0.300
CLV_PCSK_KEX2_1 662 664 PF00082 0.552
CLV_PCSK_PC1ET2_1 190 192 PF00082 0.342
CLV_PCSK_PC1ET2_1 421 423 PF00082 0.330
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.179
CLV_PCSK_PC1ET2_1 487 489 PF00082 0.397
CLV_PCSK_PC1ET2_1 662 664 PF00082 0.552
CLV_PCSK_PC7_1 236 242 PF00082 0.351
CLV_PCSK_PC7_1 640 646 PF00082 0.337
CLV_PCSK_SKI1_1 101 105 PF00082 0.255
CLV_PCSK_SKI1_1 161 165 PF00082 0.340
CLV_PCSK_SKI1_1 195 199 PF00082 0.293
CLV_PCSK_SKI1_1 209 213 PF00082 0.218
CLV_PCSK_SKI1_1 28 32 PF00082 0.488
CLV_PCSK_SKI1_1 421 425 PF00082 0.340
CLV_PCSK_SKI1_1 441 445 PF00082 0.103
CLV_PCSK_SKI1_1 522 526 PF00082 0.340
CLV_PCSK_SKI1_1 640 644 PF00082 0.231
CLV_PCSK_SKI1_1 85 89 PF00082 0.480
DEG_APCC_DBOX_1 100 108 PF00400 0.340
DEG_APCC_DBOX_1 440 448 PF00400 0.340
DEG_APCC_DBOX_1 53 61 PF00400 0.409
DEG_MDM2_SWIB_1 424 431 PF02201 0.351
DEG_SCF_TRCP1_1 231 237 PF00400 0.190
DOC_MAPK_gen_1 438 447 PF00069 0.340
DOC_MAPK_gen_1 511 519 PF00069 0.248
DOC_MAPK_MEF2A_6 66 74 PF00069 0.545
DOC_USP7_MATH_1 2 6 PF00917 0.585
DOC_USP7_MATH_1 366 370 PF00917 0.190
DOC_USP7_MATH_1 509 513 PF00917 0.317
DOC_USP7_UBL2_3 186 190 PF12436 0.288
DOC_USP7_UBL2_3 195 199 PF12436 0.226
DOC_USP7_UBL2_3 417 421 PF12436 0.351
DOC_USP7_UBL2_3 648 652 PF12436 0.308
DOC_WW_Pin1_4 258 263 PF00397 0.190
DOC_WW_Pin1_4 573 578 PF00397 0.248
DOC_WW_Pin1_4 633 638 PF00397 0.340
DOC_WW_Pin1_4 66 71 PF00397 0.527
DOC_WW_Pin1_4 7 12 PF00397 0.652
LIG_14-3-3_CanoR_1 33 43 PF00244 0.567
LIG_14-3-3_CanoR_1 422 431 PF00244 0.340
LIG_14-3-3_CanoR_1 488 493 PF00244 0.227
LIG_14-3-3_CanoR_1 621 630 PF00244 0.392
LIG_14-3-3_CanoR_1 85 93 PF00244 0.279
LIG_Actin_WH2_2 542 557 PF00022 0.226
LIG_Actin_WH2_2 60 75 PF00022 0.521
LIG_BIR_III_4 328 332 PF00653 0.263
LIG_BRCT_BRCA1_1 623 627 PF00533 0.340
LIG_Clathr_ClatBox_1 444 448 PF01394 0.340
LIG_deltaCOP1_diTrp_1 205 212 PF00928 0.252
LIG_FHA_1 166 172 PF00498 0.283
LIG_FHA_1 465 471 PF00498 0.253
LIG_FHA_1 630 636 PF00498 0.319
LIG_FHA_1 87 93 PF00498 0.300
LIG_FHA_2 259 265 PF00498 0.190
LIG_FHA_2 492 498 PF00498 0.249
LIG_FHA_2 545 551 PF00498 0.248
LIG_FHA_2 606 612 PF00498 0.283
LIG_FHA_2 634 640 PF00498 0.340
LIG_FHA_2 79 85 PF00498 0.534
LIG_LIR_Gen_1 426 436 PF02991 0.346
LIG_LIR_Gen_1 624 635 PF02991 0.283
LIG_LIR_Nem_3 426 431 PF02991 0.346
LIG_LIR_Nem_3 480 486 PF02991 0.248
LIG_LIR_Nem_3 624 630 PF02991 0.283
LIG_LIR_Nem_3 90 96 PF02991 0.283
LIG_Pex14_1 208 212 PF04695 0.248
LIG_Pex14_2 424 428 PF04695 0.283
LIG_PTB_Apo_2 446 453 PF02174 0.351
LIG_PTB_Apo_2 569 576 PF02174 0.248
LIG_PTB_Phospho_1 569 575 PF10480 0.340
LIG_SH2_NCK_1 61 65 PF00017 0.476
LIG_SH2_SRC 483 486 PF00017 0.340
LIG_SH2_STAP1 503 507 PF00017 0.340
LIG_SH2_STAP1 520 524 PF00017 0.103
LIG_SH2_STAT3 334 337 PF00017 0.292
LIG_SH2_STAT5 341 344 PF00017 0.283
LIG_SH2_STAT5 575 578 PF00017 0.340
LIG_SH3_3 12 18 PF00018 0.621
LIG_SH3_3 535 541 PF00018 0.319
LIG_SH3_4 578 585 PF00018 0.283
LIG_SUMO_SIM_par_1 442 448 PF11976 0.340
LIG_TRAF2_1 217 220 PF00917 0.342
LIG_TRAF2_1 245 248 PF00917 0.292
LIG_TRAF2_1 284 287 PF00917 0.245
LIG_UBA3_1 516 522 PF00899 0.248
MOD_CDC14_SPxK_1 10 13 PF00782 0.658
MOD_CDK_SPK_2 573 578 PF00069 0.248
MOD_CDK_SPK_2 633 638 PF00069 0.340
MOD_CDK_SPxK_1 7 13 PF00069 0.656
MOD_CDK_SPxxK_3 258 265 PF00069 0.190
MOD_CDK_SPxxK_3 633 640 PF00069 0.340
MOD_CDK_SPxxK_3 66 73 PF00069 0.538
MOD_CK1_1 165 171 PF00069 0.301
MOD_CK1_1 3 9 PF00069 0.562
MOD_CK1_1 512 518 PF00069 0.290
MOD_CK1_1 53 59 PF00069 0.419
MOD_CK1_1 62 68 PF00069 0.441
MOD_CK2_1 281 287 PF00069 0.324
MOD_CK2_1 397 403 PF00069 0.301
MOD_CK2_1 544 550 PF00069 0.262
MOD_CK2_1 605 611 PF00069 0.283
MOD_CK2_1 633 639 PF00069 0.295
MOD_CK2_1 643 649 PF00069 0.308
MOD_CK2_1 78 84 PF00069 0.525
MOD_Cter_Amidation 650 653 PF01082 0.340
MOD_GlcNHglycan 120 123 PF01048 0.392
MOD_GlcNHglycan 125 128 PF01048 0.366
MOD_GlcNHglycan 140 143 PF01048 0.328
MOD_GlcNHglycan 149 152 PF01048 0.313
MOD_GlcNHglycan 2 5 PF01048 0.643
MOD_GlcNHglycan 230 234 PF01048 0.392
MOD_GlcNHglycan 368 371 PF01048 0.353
MOD_GlcNHglycan 6 9 PF01048 0.635
MOD_GSK3_1 118 125 PF00069 0.397
MOD_GSK3_1 162 169 PF00069 0.295
MOD_GSK3_1 2 9 PF00069 0.551
MOD_GSK3_1 460 467 PF00069 0.249
MOD_GSK3_1 487 494 PF00069 0.260
MOD_GSK3_1 62 69 PF00069 0.438
MOD_GSK3_1 629 636 PF00069 0.331
MOD_GSK3_1 665 672 PF00069 0.604
MOD_NEK2_1 24 29 PF00069 0.593
MOD_NEK2_1 34 39 PF00069 0.500
MOD_NEK2_1 42 47 PF00069 0.452
MOD_NEK2_1 643 648 PF00069 0.351
MOD_PKA_1 487 493 PF00069 0.324
MOD_PKA_2 166 172 PF00069 0.351
MOD_PKA_2 24 30 PF00069 0.539
MOD_PKA_2 32 38 PF00069 0.511
MOD_PKA_2 487 493 PF00069 0.231
MOD_PKA_2 53 59 PF00069 0.490
MOD_PKA_2 620 626 PF00069 0.265
MOD_PKA_2 643 649 PF00069 0.339
MOD_Plk_1 204 210 PF00069 0.340
MOD_Plk_1 426 432 PF00069 0.337
MOD_Plk_2-3 397 403 PF00069 0.351
MOD_Plk_2-3 544 550 PF00069 0.248
MOD_Plk_2-3 629 635 PF00069 0.319
MOD_Plk_4 337 343 PF00069 0.263
MOD_Plk_4 512 518 PF00069 0.248
MOD_ProDKin_1 258 264 PF00069 0.190
MOD_ProDKin_1 573 579 PF00069 0.248
MOD_ProDKin_1 633 639 PF00069 0.340
MOD_ProDKin_1 66 72 PF00069 0.531
MOD_ProDKin_1 7 13 PF00069 0.654
MOD_SUMO_for_1 468 471 PF00179 0.283
MOD_SUMO_for_1 541 544 PF00179 0.292
TRG_DiLeu_BaEn_1 179 184 PF01217 0.283
TRG_DiLeu_BaEn_3 419 425 PF01217 0.161
TRG_DiLeu_BaEn_4 286 292 PF01217 0.245
TRG_DiLeu_BaEn_4 317 323 PF01217 0.351
TRG_ENDOCYTIC_2 483 486 PF00928 0.340
TRG_ER_diArg_1 111 113 PF00400 0.369
TRG_ER_diArg_1 236 239 PF00400 0.349
TRG_ER_diArg_1 240 242 PF00400 0.331
TRG_ER_diArg_1 265 268 PF00400 0.233
TRG_ER_diArg_1 527 530 PF00400 0.319
TRG_ER_diArg_1 643 645 PF00400 0.279
TRG_ER_diArg_1 660 663 PF00400 0.477
TRG_NLS_Bipartite_1 644 666 PF00514 0.317
TRG_NLS_MonoCore_2 660 665 PF00514 0.573
TRG_NLS_MonoExtC_3 189 194 PF00514 0.288
TRG_NLS_MonoExtN_4 190 195 PF00514 0.234
TRG_NLS_MonoExtN_4 661 666 PF00514 0.584
TRG_Pf-PMV_PEXEL_1 191 196 PF00026 0.248
TRG_Pf-PMV_PEXEL_1 292 297 PF00026 0.351

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Q4 Leptomonas seymouri 71% 99%
A0A0S4JKJ8 Bodo saltans 45% 100%
A0A3S7X283 Leishmania donovani 100% 100%
A4HH82 Leishmania braziliensis 82% 100%
C9ZL36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9ADS7 Leishmania major 93% 100%
E9AM03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS