LEM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4C6_LEIIN

TriTrypDb:

LINF_290012300

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.707
CLV_NRD_NRD_1	147	149	PF00675	0.485
CLV_NRD_NRD_1	16	18	PF00675	0.720
CLV_NRD_NRD_1	36	38	PF00675	0.461
CLV_NRD_NRD_1	48	50	PF00675	0.496
CLV_NRD_NRD_1	99	101	PF00675	0.622
CLV_PCSK_KEX2_1	147	149	PF00082	0.536
CLV_PCSK_KEX2_1	16	18	PF00082	0.720
CLV_PCSK_KEX2_1	36	38	PF00082	0.461
CLV_PCSK_KEX2_1	48	50	PF00082	0.496
CLV_PCSK_SKI1_1	100	104	PF00082	0.690
CLV_PCSK_SKI1_1	211	215	PF00082	0.524
CLV_PCSK_SKI1_1	41	45	PF00082	0.696
CLV_PCSK_SKI1_1	94	98	PF00082	0.674
DEG_COP1_1	165	176	PF00400	0.594
DEG_Nend_Nbox_1	1	3	PF02207	0.732
DOC_USP7_MATH_1	12	16	PF00917	0.686
DOC_USP7_MATH_1	124	128	PF00917	0.694
DOC_USP7_MATH_1	178	182	PF00917	0.574
DOC_USP7_MATH_1	191	195	PF00917	0.521
DOC_USP7_MATH_1	3	7	PF00917	0.804
DOC_USP7_UBL2_3	217	221	PF12436	0.564
DOC_WW_Pin1_4	100	105	PF00397	0.597
DOC_WW_Pin1_4	113	118	PF00397	0.613
DOC_WW_Pin1_4	159	164	PF00397	0.721
LIG_14-3-3_CanoR_1	137	146	PF00244	0.566
LIG_14-3-3_CanoR_1	177	183	PF00244	0.555
LIG_14-3-3_CanoR_1	4	8	PF00244	0.684
LIG_14-3-3_CanoR_1	67	71	PF00244	0.558
LIG_14-3-3_CterR_2	223	226	PF00244	0.674
LIG_APCC_ABBA_1	118	123	PF00400	0.723
LIG_FHA_1	168	174	PF00498	0.745
LIG_FHA_1	38	44	PF00498	0.542
LIG_FHA_2	104	110	PF00498	0.691
LIG_FHA_2	55	61	PF00498	0.601
LIG_LIR_Gen_1	133	143	PF02991	0.577
LIG_LIR_Gen_1	192	203	PF02991	0.555
LIG_LIR_Nem_3	133	138	PF02991	0.617
LIG_LIR_Nem_3	192	198	PF02991	0.554
LIG_LIR_Nem_3	201	207	PF02991	0.546
LIG_SH2_CRK	135	139	PF00017	0.609
LIG_SH2_CRK	68	72	PF00017	0.669
LIG_SH2_NCK_1	68	72	PF00017	0.698
LIG_SH2_STAP1	142	146	PF00017	0.546
LIG_SH2_STAP1	182	186	PF00017	0.552
LIG_SH2_STAT5	68	71	PF00017	0.617
LIG_SH3_3	111	117	PF00018	0.681
LIG_SH3_3	200	206	PF00018	0.606
LIG_SH3_3	22	28	PF00018	0.670
LIG_TRAF2_1	181	184	PF00917	0.538
MOD_CK1_1	112	118	PF00069	0.665
MOD_CK1_1	127	133	PF00069	0.676
MOD_CK1_1	159	165	PF00069	0.722
MOD_CK1_1	172	178	PF00069	0.613
MOD_CK2_1	127	133	PF00069	0.543
MOD_CK2_1	159	165	PF00069	0.802
MOD_CK2_1	178	184	PF00069	0.563
MOD_CK2_1	3	9	PF00069	0.556
MOD_GlcNHglycan	111	114	PF01048	0.649
MOD_GlcNHglycan	12	15	PF01048	0.675
MOD_GlcNHglycan	186	189	PF01048	0.668
MOD_GlcNHglycan	88	91	PF01048	0.807
MOD_GlcNHglycan	94	97	PF01048	0.693
MOD_GSK3_1	109	116	PF00069	0.628
MOD_GSK3_1	124	131	PF00069	0.637
MOD_GSK3_1	133	140	PF00069	0.691
MOD_GSK3_1	172	179	PF00069	0.625
MOD_GSK3_1	189	196	PF00069	0.527
MOD_GSK3_1	66	73	PF00069	0.667
MOD_GSK3_1	86	93	PF00069	0.721
MOD_LATS_1	92	98	PF00433	0.676
MOD_N-GLC_1	157	162	PF02516	0.696
MOD_N-GLC_1	18	23	PF02516	0.723
MOD_NEK2_1	157	162	PF00069	0.641
MOD_NEK2_1	2	7	PF00069	0.734
MOD_NEK2_1	43	48	PF00069	0.461
MOD_NEK2_1	54	59	PF00069	0.538
MOD_PIKK_1	137	143	PF00454	0.456
MOD_PIKK_1	43	49	PF00454	0.582
MOD_PK_1	169	175	PF00069	0.689
MOD_PKA_1	149	155	PF00069	0.616
MOD_PKA_2	131	137	PF00069	0.658
MOD_PKA_2	176	182	PF00069	0.498
MOD_PKA_2	3	9	PF00069	0.684
MOD_PKA_2	66	72	PF00069	0.616
MOD_Plk_4	20	26	PF00069	0.580
MOD_Plk_4	71	77	PF00069	0.767
MOD_ProDKin_1	100	106	PF00069	0.598
MOD_ProDKin_1	113	119	PF00069	0.614
MOD_ProDKin_1	159	165	PF00069	0.723
TRG_DiLeu_BaEn_1	210	215	PF01217	0.587
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.594
TRG_ENDOCYTIC_2	135	138	PF00928	0.611
TRG_ENDOCYTIC_2	204	207	PF00928	0.535
TRG_ER_diArg_1	146	148	PF00400	0.535
TRG_ER_diArg_1	36	38	PF00400	0.660
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I154	Leptomonas seymouri	40%	99%
A0A3Q8IF96	Leishmania donovani	98%	100%
A4HH80	Leishmania braziliensis	61%	100%
E9ADS5	Leishmania major	86%	100%
E9AM05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%