Putative RNA-binding protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triple RNA binding domain protein 3

Species:

Leishmania infantum

UniProt:

A4I4C1_LEIIN

TriTrypDb:

LINF_290011800

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I4C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4C1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.497
CLV_C14_Caspase3-7	682	686	PF00656	0.668
CLV_NRD_NRD_1	102	104	PF00675	0.634
CLV_NRD_NRD_1	156	158	PF00675	0.534
CLV_NRD_NRD_1	312	314	PF00675	0.436
CLV_NRD_NRD_1	389	391	PF00675	0.427
CLV_NRD_NRD_1	417	419	PF00675	0.448
CLV_NRD_NRD_1	490	492	PF00675	0.671
CLV_NRD_NRD_1	550	552	PF00675	0.291
CLV_NRD_NRD_1	634	636	PF00675	0.622
CLV_NRD_NRD_1	753	755	PF00675	0.668
CLV_NRD_NRD_1	83	85	PF00675	0.706
CLV_PCSK_FUR_1	40	44	PF00082	0.623
CLV_PCSK_KEX2_1	102	104	PF00082	0.634
CLV_PCSK_KEX2_1	156	158	PF00082	0.534
CLV_PCSK_KEX2_1	417	419	PF00082	0.448
CLV_PCSK_KEX2_1	42	44	PF00082	0.680
CLV_PCSK_KEX2_1	490	492	PF00082	0.671
CLV_PCSK_KEX2_1	634	636	PF00082	0.632
CLV_PCSK_KEX2_1	680	682	PF00082	0.690
CLV_PCSK_KEX2_1	698	700	PF00082	0.418
CLV_PCSK_KEX2_1	750	752	PF00082	0.618
CLV_PCSK_KEX2_1	76	78	PF00082	0.674
CLV_PCSK_KEX2_1	83	85	PF00082	0.693
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.680
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.632
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.690
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.418
CLV_PCSK_PC1ET2_1	750	752	PF00082	0.618
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.552
CLV_PCSK_SKI1_1	227	231	PF00082	0.530
CLV_PCSK_SKI1_1	283	287	PF00082	0.423
CLV_PCSK_SKI1_1	313	317	PF00082	0.439
CLV_PCSK_SKI1_1	349	353	PF00082	0.377
CLV_PCSK_SKI1_1	366	370	PF00082	0.422
CLV_PCSK_SKI1_1	390	394	PF00082	0.405
CLV_PCSK_SKI1_1	636	640	PF00082	0.588
CLV_PCSK_SKI1_1	710	714	PF00082	0.534
CLV_PCSK_SKI1_1	769	773	PF00082	0.681
CLV_Separin_Metazoa	367	371	PF03568	0.430
DEG_APCC_DBOX_1	365	373	PF00400	0.420
DEG_SCF_FBW7_1	402	407	PF00400	0.453
DOC_CKS1_1	61	66	PF01111	0.621
DOC_MAPK_gen_1	241	249	PF00069	0.495
DOC_MAPK_gen_1	390	396	PF00069	0.400
DOC_MAPK_gen_1	551	557	PF00069	0.510
DOC_MAPK_gen_1	589	597	PF00069	0.510
DOC_MAPK_RevD_3	404	418	PF00069	0.496
DOC_PP4_FxxP_1	116	119	PF00568	0.701
DOC_PP4_FxxP_1	572	575	PF00568	0.452
DOC_USP7_MATH_1	106	110	PF00917	0.507
DOC_USP7_MATH_1	173	177	PF00917	0.634
DOC_USP7_MATH_1	19	23	PF00917	0.687
DOC_USP7_MATH_1	33	37	PF00917	0.664
DOC_USP7_MATH_1	447	451	PF00917	0.664
DOC_USP7_MATH_1	456	460	PF00917	0.614
DOC_USP7_MATH_1	50	54	PF00917	0.623
DOC_USP7_MATH_1	718	722	PF00917	0.684
DOC_USP7_MATH_1	741	745	PF00917	0.657
DOC_USP7_UBL2_3	242	246	PF12436	0.527
DOC_USP7_UBL2_3	340	344	PF12436	0.549
DOC_USP7_UBL2_3	632	636	PF12436	0.533
DOC_USP7_UBL2_3	765	769	PF12436	0.650
DOC_WW_Pin1_4	183	188	PF00397	0.740
DOC_WW_Pin1_4	296	301	PF00397	0.423
DOC_WW_Pin1_4	400	405	PF00397	0.449
DOC_WW_Pin1_4	436	441	PF00397	0.643
DOC_WW_Pin1_4	452	457	PF00397	0.724
DOC_WW_Pin1_4	60	65	PF00397	0.623
LIG_14-3-3_CanoR_1	227	233	PF00244	0.525
LIG_14-3-3_CanoR_1	40	46	PF00244	0.666
LIG_14-3-3_CanoR_1	67	72	PF00244	0.651
LIG_AP2alpha_1	408	412	PF02296	0.441
LIG_APCC_ABBA_1	555	560	PF00400	0.510
LIG_BIR_III_2	93	97	PF00653	0.676
LIG_BRCT_BRCA1_1	112	116	PF00533	0.778
LIG_CaM_IQ_9	68	83	PF13499	0.511
LIG_DLG_GKlike_1	67	75	PF00625	0.554
LIG_FHA_1	224	230	PF00498	0.570
LIG_FHA_1	317	323	PF00498	0.517
LIG_FHA_1	331	337	PF00498	0.598
LIG_FHA_1	346	352	PF00498	0.452
LIG_FHA_1	401	407	PF00498	0.448
LIG_FHA_1	711	717	PF00498	0.537
LIG_FHA_1	733	739	PF00498	0.653
LIG_FHA_2	262	268	PF00498	0.547
LIG_FHA_2	358	364	PF00498	0.336
LIG_FHA_2	396	402	PF00498	0.461
LIG_FHA_2	405	411	PF00498	0.418
LIG_FHA_2	84	90	PF00498	0.679
LIG_Integrin_isoDGR_2	311	313	PF01839	0.425
LIG_LIR_Apic_2	113	119	PF02991	0.681
LIG_LIR_Apic_2	571	575	PF02991	0.479
LIG_LIR_Gen_1	410	419	PF02991	0.452
LIG_LIR_Gen_1	513	523	PF02991	0.552
LIG_LIR_Nem_3	410	415	PF02991	0.446
LIG_LIR_Nem_3	513	519	PF02991	0.575
LIG_NRP_CendR_1	772	774	PF00754	0.733
LIG_Pex14_2	272	276	PF04695	0.426
LIG_Pex14_2	408	412	PF04695	0.441
LIG_RPA_C_Fungi	413	425	PF08784	0.453
LIG_SH2_STAP1	254	258	PF00017	0.528
LIG_SH2_STAP1	577	581	PF00017	0.308
LIG_SH2_STAP1	620	624	PF00017	0.600
LIG_SH2_STAT5	254	257	PF00017	0.538
LIG_SH2_STAT5	527	530	PF00017	0.341
LIG_SH2_STAT5	637	640	PF00017	0.538
LIG_SH3_2	187	192	PF14604	0.581
LIG_SH3_3	184	190	PF00018	0.579
LIG_SH3_3	257	263	PF00018	0.601
LIG_SH3_3	275	281	PF00018	0.332
LIG_SH3_3	319	325	PF00018	0.437
LIG_SH3_3	356	362	PF00018	0.436
LIG_SH3_3	44	50	PF00018	0.676
LIG_SH3_3	450	456	PF00018	0.581
LIG_SH3_3	55	61	PF00018	0.702
LIG_SUMO_SIM_anti_2	467	476	PF11976	0.664
LIG_SUMO_SIM_par_1	95	100	PF11976	0.676
LIG_TRAF2_1	209	212	PF00917	0.760
LIG_TRAF2_1	264	267	PF00917	0.537
LIG_TRAF2_1	612	615	PF00917	0.638
LIG_UBA3_1	352	358	PF00899	0.391
LIG_WRC_WIRS_1	393	398	PF05994	0.435
MOD_CDC14_SPxK_1	189	192	PF00782	0.683
MOD_CDK_SPK_2	436	441	PF00069	0.525
MOD_CDK_SPxK_1	186	192	PF00069	0.679
MOD_CDK_SPxxK_3	60	67	PF00069	0.547
MOD_CK1_1	167	173	PF00069	0.733
MOD_CK1_1	186	192	PF00069	0.679
MOD_CK1_1	197	203	PF00069	0.715
MOD_CK1_1	299	305	PF00069	0.416
MOD_CK1_1	507	513	PF00069	0.572
MOD_CK1_1	745	751	PF00069	0.696
MOD_CK1_1	9	15	PF00069	0.751
MOD_CK2_1	106	112	PF00069	0.568
MOD_CK2_1	206	212	PF00069	0.715
MOD_CK2_1	261	267	PF00069	0.523
MOD_CK2_1	357	363	PF00069	0.416
MOD_CK2_1	395	401	PF00069	0.488
MOD_CK2_1	490	496	PF00069	0.504
MOD_CK2_1	657	663	PF00069	0.742
MOD_Cter_Amidation	311	314	PF01082	0.434
MOD_Cter_Amidation	415	418	PF01082	0.478
MOD_Cter_Amidation	678	681	PF01082	0.692
MOD_Cter_Amidation	81	84	PF01082	0.649
MOD_GlcNHglycan	112	115	PF01048	0.709
MOD_GlcNHglycan	142	145	PF01048	0.543
MOD_GlcNHglycan	166	169	PF01048	0.680
MOD_GlcNHglycan	196	200	PF01048	0.703
MOD_GlcNHglycan	221	224	PF01048	0.651
MOD_GlcNHglycan	273	276	PF01048	0.563
MOD_GlcNHglycan	35	38	PF01048	0.700
MOD_GlcNHglycan	419	422	PF01048	0.395
MOD_GlcNHglycan	458	461	PF01048	0.680
MOD_GlcNHglycan	485	488	PF01048	0.670
MOD_GlcNHglycan	498	501	PF01048	0.653
MOD_GlcNHglycan	603	606	PF01048	0.581
MOD_GlcNHglycan	64	67	PF01048	0.710
MOD_GlcNHglycan	99	102	PF01048	0.765
MOD_GSK3_1	106	113	PF00069	0.668
MOD_GSK3_1	219	226	PF00069	0.588
MOD_GSK3_1	230	237	PF00069	0.519
MOD_GSK3_1	29	36	PF00069	0.626
MOD_GSK3_1	400	407	PF00069	0.491
MOD_GSK3_1	426	433	PF00069	0.537
MOD_GSK3_1	448	455	PF00069	0.644
MOD_GSK3_1	479	486	PF00069	0.586
MOD_GSK3_1	496	503	PF00069	0.719
MOD_GSK3_1	558	565	PF00069	0.323
MOD_GSK3_1	741	748	PF00069	0.724
MOD_N-GLC_1	140	145	PF02516	0.544
MOD_N-GLC_1	234	239	PF02516	0.553
MOD_N-GLC_1	496	501	PF02516	0.673
MOD_N-GLC_1	507	512	PF02516	0.546
MOD_N-GLC_1	671	676	PF02516	0.727
MOD_N-GLC_1	718	723	PF02516	0.684
MOD_NEK2_1	140	145	PF00069	0.544
MOD_NEK2_1	316	321	PF00069	0.479
MOD_NEK2_1	638	643	PF00069	0.531
MOD_NEK2_2	749	754	PF00069	0.588
MOD_PIKK_1	118	124	PF00454	0.571
MOD_PIKK_1	357	363	PF00454	0.416
MOD_PIKK_1	384	390	PF00454	0.524
MOD_PIKK_1	672	678	PF00454	0.518
MOD_PK_1	639	645	PF00069	0.535
MOD_PKA_1	417	423	PF00069	0.448
MOD_PKA_1	490	496	PF00069	0.504
MOD_PKA_1	83	89	PF00069	0.545
MOD_PKA_2	417	423	PF00069	0.448
MOD_PKA_2	490	496	PF00069	0.657
MOD_PKA_2	6	12	PF00069	0.748
MOD_PKA_2	82	88	PF00069	0.694
MOD_PKB_1	225	233	PF00069	0.567
MOD_Plk_1	470	476	PF00069	0.640
MOD_Plk_1	536	542	PF00069	0.229
MOD_Plk_2-3	657	663	PF00069	0.649
MOD_Plk_4	470	476	PF00069	0.640
MOD_ProDKin_1	183	189	PF00069	0.741
MOD_ProDKin_1	296	302	PF00069	0.416
MOD_ProDKin_1	400	406	PF00069	0.449
MOD_ProDKin_1	436	442	PF00069	0.643
MOD_ProDKin_1	452	458	PF00069	0.726
MOD_ProDKin_1	60	66	PF00069	0.622
MOD_SUMO_rev_2	323	327	PF00179	0.562
MOD_SUMO_rev_2	371	380	PF00179	0.468
MOD_SUMO_rev_2	682	689	PF00179	0.668
TRG_DiLeu_BaEn_1	514	519	PF01217	0.578
TRG_DiLeu_BaEn_2	111	117	PF01217	0.509
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.463
TRG_ENDOCYTIC_2	516	519	PF00928	0.570
TRG_ER_diArg_1	155	157	PF00400	0.659
TRG_ER_diArg_1	224	227	PF00400	0.591
TRG_ER_diArg_1	417	419	PF00400	0.448
TRG_ER_diLys_1	770	774	PF00400	0.697
TRG_NES_CRM1_1	238	250	PF08389	0.506
TRG_NLS_Bipartite_1	680	702	PF00514	0.747
TRG_NLS_Bipartite_1	754	773	PF00514	0.664
TRG_NLS_MonoExtC_3	697	703	PF00514	0.670
TRG_NLS_MonoExtC_3	768	773	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C3	Leptomonas seymouri	61%	100%
A0A0S4JB85	Bodo saltans	48%	100%
A0A3S7X2A3	Leishmania donovani	99%	100%
A4HH75	Leishmania braziliensis	74%	95%
C9ZL47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ADS0	Leishmania major	85%	100%
E9AM10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%