LeishMANIAdb
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Phosphate transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphate transporter
Gene product:
phosphate transporter - putative
Species:
Leishmania infantum
UniProt:
A4I4B8_LEIIN
TriTrypDb:
LINF_290011500
Length:
709

Annotations

Annotations by Jardim et al.

Transporters, Na/phosphate transporter (PHO89)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4I4B8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4B8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 8
GO:0006811 monoatomic ion transport 4 8
GO:0006817 phosphate ion transport 7 8
GO:0006820 monoatomic anion transport 5 8
GO:0015698 inorganic anion transport 6 8
GO:0051179 localization 1 8
GO:0051234 establishment of localization 2 8
GO:0009987 cellular process 1 1
GO:0034220 monoatomic ion transmembrane transport 3 1
GO:0035435 phosphate ion transmembrane transport 6 1
GO:0055085 transmembrane transport 2 1
GO:0098656 monoatomic anion transmembrane transport 4 1
GO:0098660 inorganic ion transmembrane transport 4 1
GO:0098661 inorganic anion transmembrane transport 5 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 8
GO:0005315 inorganic phosphate transmembrane transporter activity 4 8
GO:0015291 secondary active transmembrane transporter activity 4 8
GO:0015293 symporter activity 5 8
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 8
GO:0022804 active transmembrane transporter activity 3 8
GO:0022857 transmembrane transporter activity 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 340 344 PF00656 0.491
CLV_C14_Caspase3-7 401 405 PF00656 0.585
CLV_NRD_NRD_1 175 177 PF00675 0.297
CLV_NRD_NRD_1 358 360 PF00675 0.311
CLV_PCSK_KEX2_1 175 177 PF00082 0.297
CLV_PCSK_KEX2_1 358 360 PF00082 0.314
CLV_PCSK_SKI1_1 176 180 PF00082 0.296
CLV_PCSK_SKI1_1 680 684 PF00082 0.311
DEG_APCC_DBOX_1 269 277 PF00400 0.432
DOC_CYCLIN_yCln2_LP_2 157 163 PF00134 0.394
DOC_CYCLIN_yCln2_LP_2 533 539 PF00134 0.518
DOC_MAPK_DCC_7 79 88 PF00069 0.328
DOC_MAPK_gen_1 182 190 PF00069 0.538
DOC_MAPK_gen_1 492 500 PF00069 0.502
DOC_MAPK_MEF2A_6 145 154 PF00069 0.291
DOC_MAPK_MEF2A_6 184 192 PF00069 0.516
DOC_MAPK_MEF2A_6 92 99 PF00069 0.294
DOC_PIKK_1 277 285 PF02985 0.432
DOC_PP1_RVXF_1 284 291 PF00149 0.530
DOC_PP2B_LxvP_1 157 160 PF13499 0.394
DOC_PP2B_LxvP_1 336 339 PF13499 0.585
DOC_PP4_FxxP_1 116 119 PF00568 0.488
DOC_PP4_FxxP_1 290 293 PF00568 0.505
DOC_USP7_MATH_1 214 218 PF00917 0.334
DOC_USP7_MATH_1 255 259 PF00917 0.520
DOC_USP7_MATH_1 378 382 PF00917 0.585
DOC_USP7_MATH_1 402 406 PF00917 0.566
DOC_WW_Pin1_4 380 385 PF00397 0.523
DOC_WW_Pin1_4 422 427 PF00397 0.454
DOC_WW_Pin1_4 500 505 PF00397 0.509
DOC_WW_Pin1_4 622 627 PF00397 0.496
LIG_BRCT_BRCA1_1 112 116 PF00533 0.343
LIG_BRCT_BRCA1_1 37 41 PF00533 0.488
LIG_CaM_NSCaTE_8 630 637 PF13499 0.402
LIG_Clathr_ClatBox_1 273 277 PF01394 0.432
LIG_CtBP_PxDLS_1 649 653 PF00389 0.288
LIG_FHA_1 12 18 PF00498 0.288
LIG_FHA_1 121 127 PF00498 0.399
LIG_FHA_1 136 142 PF00498 0.343
LIG_FHA_1 165 171 PF00498 0.313
LIG_FHA_1 269 275 PF00498 0.561
LIG_FHA_1 298 304 PF00498 0.590
LIG_FHA_1 323 329 PF00498 0.542
LIG_FHA_1 4 10 PF00498 0.361
LIG_FHA_1 482 488 PF00498 0.432
LIG_FHA_1 638 644 PF00498 0.335
LIG_FHA_1 677 683 PF00498 0.463
LIG_FHA_1 686 692 PF00498 0.336
LIG_FHA_1 693 699 PF00498 0.332
LIG_FHA_2 428 434 PF00498 0.549
LIG_FHA_2 578 584 PF00498 0.334
LIG_FHA_2 58 64 PF00498 0.343
LIG_GBD_Chelix_1 686 694 PF00786 0.376
LIG_Integrin_RGD_1 294 296 PF01839 0.330
LIG_IRF3_LxIS_1 686 692 PF10401 0.342
LIG_LIR_Apic_2 113 119 PF02991 0.488
LIG_LIR_Apic_2 142 146 PF02991 0.307
LIG_LIR_Apic_2 287 293 PF02991 0.509
LIG_LIR_Apic_2 372 378 PF02991 0.502
LIG_LIR_Gen_1 204 215 PF02991 0.354
LIG_LIR_Gen_1 38 45 PF02991 0.518
LIG_LIR_Gen_1 569 579 PF02991 0.296
LIG_LIR_Gen_1 590 600 PF02991 0.296
LIG_LIR_Gen_1 60 70 PF02991 0.343
LIG_LIR_Nem_3 204 210 PF02991 0.354
LIG_LIR_Nem_3 38 44 PF02991 0.518
LIG_LIR_Nem_3 542 548 PF02991 0.483
LIG_LIR_Nem_3 569 575 PF02991 0.296
LIG_LIR_Nem_3 590 596 PF02991 0.296
LIG_LIR_Nem_3 60 65 PF02991 0.343
LIG_LIR_Nem_3 674 678 PF02991 0.491
LIG_NRBOX 197 203 PF00104 0.480
LIG_PCNA_PIPBox_1 20 29 PF02747 0.266
LIG_REV1ctd_RIR_1 288 292 PF16727 0.534
LIG_SH2_CRK 375 379 PF00017 0.502
LIG_SH2_CRK 58 62 PF00017 0.343
LIG_SH2_PTP2 143 146 PF00017 0.302
LIG_SH2_PTP2 230 233 PF00017 0.361
LIG_SH2_STAT3 314 317 PF00017 0.432
LIG_SH2_STAT5 111 114 PF00017 0.343
LIG_SH2_STAT5 143 146 PF00017 0.288
LIG_SH2_STAT5 172 175 PF00017 0.310
LIG_SH2_STAT5 230 233 PF00017 0.396
LIG_SH2_STAT5 543 546 PF00017 0.502
LIG_SH2_STAT5 58 61 PF00017 0.343
LIG_SH3_2 523 528 PF14604 0.479
LIG_SH3_3 306 312 PF00018 0.532
LIG_SH3_3 325 331 PF00018 0.520
LIG_SH3_3 336 342 PF00018 0.436
LIG_SH3_3 495 501 PF00018 0.496
LIG_SH3_3 520 526 PF00018 0.496
LIG_SH3_3 533 539 PF00018 0.496
LIG_SUMO_SIM_anti_2 93 98 PF11976 0.441
LIG_SUMO_SIM_par_1 118 123 PF11976 0.488
LIG_SUMO_SIM_par_1 620 625 PF11976 0.496
LIG_SUMO_SIM_par_1 648 653 PF11976 0.288
LIG_SUMO_SIM_par_1 687 692 PF11976 0.343
LIG_TYR_ITIM 228 233 PF00017 0.331
LIG_TYR_ITIM 56 61 PF00017 0.343
LIG_WRC_WIRS_1 23 28 PF05994 0.343
LIG_WRC_WIRS_1 555 560 PF05994 0.354
LIG_WW_3 308 312 PF00397 0.530
MOD_CDK_SPxK_1 622 628 PF00069 0.496
MOD_CK1_1 258 264 PF00069 0.530
MOD_CK1_1 368 374 PF00069 0.543
MOD_CK1_1 398 404 PF00069 0.568
MOD_CK1_1 434 440 PF00069 0.551
MOD_CK1_1 480 486 PF00069 0.484
MOD_CK1_1 554 560 PF00069 0.354
MOD_CK1_1 591 597 PF00069 0.408
MOD_CK1_1 692 698 PF00069 0.343
MOD_CK2_1 427 433 PF00069 0.549
MOD_CK2_1 457 463 PF00069 0.526
MOD_CK2_1 506 512 PF00069 0.514
MOD_CK2_1 57 63 PF00069 0.343
MOD_CK2_1 577 583 PF00069 0.334
MOD_GlcNHglycan 112 115 PF01048 0.329
MOD_GlcNHglycan 146 149 PF01048 0.505
MOD_GlcNHglycan 257 260 PF01048 0.305
MOD_GlcNHglycan 296 300 PF01048 0.320
MOD_GlcNHglycan 303 306 PF01048 0.297
MOD_GlcNHglycan 36 40 PF01048 0.288
MOD_GlcNHglycan 400 403 PF01048 0.378
MOD_GlcNHglycan 452 455 PF01048 0.259
MOD_GlcNHglycan 46 49 PF01048 0.288
MOD_GlcNHglycan 471 474 PF01048 0.328
MOD_GlcNHglycan 487 490 PF01048 0.282
MOD_GlcNHglycan 569 572 PF01048 0.565
MOD_GlcNHglycan 691 694 PF01048 0.317
MOD_GlcNHglycan 79 82 PF01048 0.541
MOD_GSK3_1 118 125 PF00069 0.488
MOD_GSK3_1 135 142 PF00069 0.343
MOD_GSK3_1 297 304 PF00069 0.516
MOD_GSK3_1 365 372 PF00069 0.516
MOD_GSK3_1 376 383 PF00069 0.493
MOD_GSK3_1 391 398 PF00069 0.503
MOD_GSK3_1 418 425 PF00069 0.516
MOD_GSK3_1 427 434 PF00069 0.502
MOD_GSK3_1 469 476 PF00069 0.519
MOD_GSK3_1 477 484 PF00069 0.455
MOD_GSK3_1 587 594 PF00069 0.347
MOD_GSK3_1 609 616 PF00069 0.408
MOD_GSK3_1 637 644 PF00069 0.349
MOD_GSK3_1 676 683 PF00069 0.474
MOD_GSK3_1 685 692 PF00069 0.343
MOD_GSK3_1 702 709 PF00069 0.426
MOD_N-GLC_1 11 16 PF02516 0.528
MOD_N-GLC_1 391 396 PF02516 0.365
MOD_N-GLC_1 566 571 PF02516 0.496
MOD_NEK2_1 110 115 PF00069 0.343
MOD_NEK2_1 135 140 PF00069 0.441
MOD_NEK2_1 197 202 PF00069 0.338
MOD_NEK2_1 216 221 PF00069 0.296
MOD_NEK2_1 276 281 PF00069 0.522
MOD_NEK2_1 395 400 PF00069 0.555
MOD_NEK2_1 609 614 PF00069 0.408
MOD_NEK2_1 641 646 PF00069 0.304
MOD_NEK2_1 689 694 PF00069 0.314
MOD_NMyristoyl 1 7 PF02799 0.403
MOD_PIKK_1 214 220 PF00454 0.334
MOD_PIKK_1 588 594 PF00454 0.334
MOD_PIKK_1 650 656 PF00454 0.343
MOD_PIKK_1 86 92 PF00454 0.302
MOD_Plk_1 11 17 PF00069 0.328
MOD_Plk_1 276 282 PF00069 0.553
MOD_Plk_1 286 292 PF00069 0.517
MOD_Plk_1 391 397 PF00069 0.520
MOD_Plk_1 403 409 PF00069 0.534
MOD_Plk_2-3 352 358 PF00069 0.502
MOD_Plk_4 122 128 PF00069 0.395
MOD_Plk_4 139 145 PF00069 0.288
MOD_Plk_4 19 25 PF00069 0.343
MOD_Plk_4 197 203 PF00069 0.400
MOD_Plk_4 286 292 PF00069 0.520
MOD_Plk_4 391 397 PF00069 0.507
MOD_Plk_4 403 409 PF00069 0.528
MOD_Plk_4 554 560 PF00069 0.354
MOD_Plk_4 57 63 PF00069 0.343
MOD_Plk_4 609 615 PF00069 0.389
MOD_Plk_4 634 640 PF00069 0.330
MOD_Plk_4 685 691 PF00069 0.308
MOD_Plk_4 696 702 PF00069 0.308
MOD_ProDKin_1 380 386 PF00069 0.523
MOD_ProDKin_1 422 428 PF00069 0.454
MOD_ProDKin_1 500 506 PF00069 0.509
MOD_ProDKin_1 622 628 PF00069 0.496
MOD_SUMO_rev_2 278 288 PF00179 0.580
TRG_ENDOCYTIC_2 230 233 PF00928 0.308
TRG_ENDOCYTIC_2 576 579 PF00928 0.296
TRG_ENDOCYTIC_2 58 61 PF00928 0.343
TRG_ER_diArg_1 174 176 PF00400 0.496
TRG_NES_CRM1_1 272 284 PF08389 0.432

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8C5 Leptomonas seymouri 64% 100%
A0A1X0P0T2 Trypanosomatidae 54% 100%
A0A3S7X2A5 Leishmania donovani 99% 100%
A4HH72 Leishmania braziliensis 77% 100%
E9ADR7 Leishmania major 94% 100%
E9AM13 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q28E01 Xenopus tropicalis 22% 100%
Q5R9L5 Pongo abelii 22% 100%
Q5XHF9 Xenopus laevis 22% 100%
Q63488 Rattus norvegicus 24% 100%
Q80UP8 Mus musculus 23% 100%
Q95L97 Felis catus 24% 100%
Q9ES44 Cricetulus griseus 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS