Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc-finger double-stranded RNA-binding - putative

Species:

Leishmania infantum

UniProt:

A4I4B3_LEIIN

TriTrypDb:

LINF_290011100

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I4B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4B3

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	427	431	PF00656	0.594
CLV_NRD_NRD_1	114	116	PF00675	0.740
CLV_NRD_NRD_1	154	156	PF00675	0.515
CLV_NRD_NRD_1	187	189	PF00675	0.580
CLV_NRD_NRD_1	190	192	PF00675	0.594
CLV_NRD_NRD_1	220	222	PF00675	0.538
CLV_NRD_NRD_1	230	232	PF00675	0.615
CLV_NRD_NRD_1	276	278	PF00675	0.720
CLV_NRD_NRD_1	37	39	PF00675	0.609
CLV_NRD_NRD_1	583	585	PF00675	0.696
CLV_NRD_NRD_1	588	590	PF00675	0.672
CLV_PCSK_FUR_1	188	192	PF00082	0.654
CLV_PCSK_FUR_1	274	278	PF00082	0.742
CLV_PCSK_KEX2_1	189	191	PF00082	0.660
CLV_PCSK_KEX2_1	219	221	PF00082	0.549
CLV_PCSK_KEX2_1	232	234	PF00082	0.647
CLV_PCSK_KEX2_1	276	278	PF00082	0.650
CLV_PCSK_KEX2_1	37	39	PF00082	0.609
CLV_PCSK_KEX2_1	583	585	PF00082	0.696
CLV_PCSK_KEX2_1	588	590	PF00082	0.672
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.660
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.647
CLV_PCSK_PC7_1	584	590	PF00082	0.682
CLV_PCSK_SKI1_1	449	453	PF00082	0.668
CLV_PCSK_SKI1_1	564	568	PF00082	0.638
CLV_PCSK_SKI1_1	622	626	PF00082	0.619
DOC_CYCLIN_RxL_1	69	80	PF00134	0.734
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.689
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.611
DOC_MAPK_gen_1	158	168	PF00069	0.646
DOC_MAPK_gen_1	231	242	PF00069	0.705
DOC_MAPK_MEF2A_6	20	29	PF00069	0.568
DOC_PP1_RVXF_1	433	440	PF00149	0.651
DOC_PP2B_LxvP_1	74	77	PF13499	0.742
DOC_PP4_FxxP_1	305	308	PF00568	0.687
DOC_SPAK_OSR1_1	617	621	PF12202	0.658
DOC_USP7_MATH_1	106	110	PF00917	0.682
DOC_USP7_MATH_1	247	251	PF00917	0.693
DOC_USP7_MATH_1	255	259	PF00917	0.791
DOC_USP7_MATH_1	261	265	PF00917	0.716
DOC_USP7_MATH_1	290	294	PF00917	0.664
DOC_USP7_MATH_1	331	335	PF00917	0.818
DOC_USP7_MATH_1	354	358	PF00917	0.787
DOC_USP7_MATH_1	361	365	PF00917	0.707
DOC_USP7_MATH_1	484	488	PF00917	0.825
DOC_USP7_MATH_1	505	509	PF00917	0.698
DOC_USP7_MATH_1	75	79	PF00917	0.651
DOC_USP7_MATH_2	518	524	PF00917	0.712
DOC_WW_Pin1_4	249	254	PF00397	0.687
DOC_WW_Pin1_4	266	271	PF00397	0.611
DOC_WW_Pin1_4	327	332	PF00397	0.748
DOC_WW_Pin1_4	355	360	PF00397	0.675
DOC_WW_Pin1_4	384	389	PF00397	0.600
DOC_WW_Pin1_4	524	529	PF00397	0.808
DOC_WW_Pin1_4	532	537	PF00397	0.588
DOC_WW_Pin1_4	54	59	PF00397	0.755
DOC_WW_Pin1_4	8	13	PF00397	0.568
LIG_14-3-3_CanoR_1	104	112	PF00244	0.677
LIG_14-3-3_CanoR_1	151	159	PF00244	0.623
LIG_14-3-3_CanoR_1	233	242	PF00244	0.646
LIG_14-3-3_CanoR_1	274	283	PF00244	0.723
LIG_14-3-3_CanoR_1	309	315	PF00244	0.513
LIG_14-3-3_CanoR_1	599	606	PF00244	0.600
LIG_14-3-3_CanoR_1	79	85	PF00244	0.763
LIG_BIR_III_4	297	301	PF00653	0.704
LIG_BIR_III_4	342	346	PF00653	0.733
LIG_FHA_1	339	345	PF00498	0.762
LIG_FHA_1	373	379	PF00498	0.694
LIG_FHA_1	501	507	PF00498	0.769
LIG_FHA_2	29	35	PF00498	0.716
LIG_FHA_2	40	46	PF00498	0.490
LIG_FHA_2	425	431	PF00498	0.530
LIG_FHA_2	593	599	PF00498	0.620
LIG_LIR_Gen_1	141	152	PF02991	0.513
LIG_LIR_Gen_1	45	54	PF02991	0.592
LIG_LIR_Gen_1	595	604	PF02991	0.611
LIG_LIR_Nem_3	141	147	PF02991	0.583
LIG_LIR_Nem_3	45	49	PF02991	0.552
LIG_LIR_Nem_3	595	600	PF02991	0.621
LIG_Pex14_1	36	40	PF04695	0.595
LIG_REV1ctd_RIR_1	616	626	PF16727	0.575
LIG_SH2_CRK	144	148	PF00017	0.620
LIG_SH2_CRK	40	44	PF00017	0.676
LIG_SH2_CRK	578	582	PF00017	0.583
LIG_SH2_SRC	314	317	PF00017	0.726
LIG_SH2_STAP1	135	139	PF00017	0.508
LIG_SH2_STAP1	22	26	PF00017	0.640
LIG_SH2_STAP1	433	437	PF00017	0.635
LIG_SH2_STAT3	184	187	PF00017	0.572
LIG_SH2_STAT5	121	124	PF00017	0.628
LIG_SH2_STAT5	144	147	PF00017	0.485
LIG_SH2_STAT5	184	187	PF00017	0.572
LIG_SH2_STAT5	409	412	PF00017	0.411
LIG_SH3_1	376	382	PF00018	0.646
LIG_SH3_1	588	594	PF00018	0.651
LIG_SH3_3	170	176	PF00018	0.539
LIG_SH3_3	210	216	PF00018	0.548
LIG_SH3_3	280	286	PF00018	0.752
LIG_SH3_3	376	382	PF00018	0.716
LIG_SH3_3	462	468	PF00018	0.823
LIG_SH3_3	499	505	PF00018	0.799
LIG_SH3_3	512	518	PF00018	0.631
LIG_SH3_3	547	553	PF00018	0.696
LIG_SH3_3	587	593	PF00018	0.662
LIG_SUMO_SIM_anti_2	163	170	PF11976	0.447
LIG_TRAF2_1	130	133	PF00917	0.640
LIG_TRAF2_1	313	316	PF00917	0.768
LIG_TRAF2_1	474	477	PF00917	0.718
LIG_TRAF2_1	517	520	PF00917	0.749
LIG_WW_2	550	553	PF00397	0.597
LIG_WW_3	1	5	PF00397	0.739
MOD_CDK_SPK_2	384	389	PF00069	0.604
MOD_CDK_SPxxK_3	384	391	PF00069	0.595
MOD_CK1_1	254	260	PF00069	0.710
MOD_CK1_1	263	269	PF00069	0.701
MOD_CK1_1	293	299	PF00069	0.813
MOD_CK1_1	310	316	PF00069	0.752
MOD_CK1_1	317	323	PF00069	0.695
MOD_CK1_1	327	333	PF00069	0.630
MOD_CK1_1	357	363	PF00069	0.716
MOD_CK1_1	78	84	PF00069	0.765
MOD_CK2_1	266	272	PF00069	0.809
MOD_CK2_1	28	34	PF00069	0.727
MOD_CK2_1	293	299	PF00069	0.704
MOD_CK2_1	310	316	PF00069	0.688
MOD_CK2_1	39	45	PF00069	0.497
MOD_CK2_1	442	448	PF00069	0.701
MOD_CK2_1	484	490	PF00069	0.734
MOD_CK2_1	592	598	PF00069	0.623
MOD_CK2_1	8	14	PF00069	0.686
MOD_GlcNHglycan	108	111	PF01048	0.657
MOD_GlcNHglycan	253	256	PF01048	0.697
MOD_GlcNHglycan	257	260	PF01048	0.737
MOD_GlcNHglycan	363	366	PF01048	0.788
MOD_GlcNHglycan	444	447	PF01048	0.766
MOD_GlcNHglycan	486	489	PF01048	0.723
MOD_GlcNHglycan	520	525	PF01048	0.835
MOD_GlcNHglycan	64	68	PF01048	0.662
MOD_GlcNHglycan	81	84	PF01048	0.652
MOD_GSK3_1	247	254	PF00069	0.682
MOD_GSK3_1	255	262	PF00069	0.710
MOD_GSK3_1	264	271	PF00069	0.708
MOD_GSK3_1	310	317	PF00069	0.664
MOD_GSK3_1	327	334	PF00069	0.625
MOD_GSK3_1	357	364	PF00069	0.722
MOD_GSK3_1	420	427	PF00069	0.474
MOD_GSK3_1	478	485	PF00069	0.747
MOD_GSK3_1	520	527	PF00069	0.620
MOD_GSK3_1	75	82	PF00069	0.675
MOD_N-GLC_1	327	332	PF02516	0.709
MOD_N-GLC_1	382	387	PF02516	0.620
MOD_N-GLC_1	524	529	PF02516	0.687
MOD_NEK2_1	143	148	PF00069	0.540
MOD_NEK2_2	150	155	PF00069	0.502
MOD_NEK2_2	39	44	PF00069	0.679
MOD_PIKK_1	128	134	PF00454	0.555
MOD_PIKK_1	191	197	PF00454	0.532
MOD_PIKK_1	284	290	PF00454	0.607
MOD_PKA_1	276	282	PF00069	0.663
MOD_PKA_2	150	156	PF00069	0.609
MOD_PKA_2	264	270	PF00069	0.733
MOD_PKA_2	275	281	PF00069	0.681
MOD_PKA_2	598	604	PF00069	0.606
MOD_PKA_2	78	84	PF00069	0.675
MOD_PKB_1	231	239	PF00069	0.742
MOD_PKB_1	274	282	PF00069	0.647
MOD_Plk_1	236	242	PF00069	0.623
MOD_Plk_1	429	435	PF00069	0.616
MOD_Plk_1	564	570	PF00069	0.687
MOD_Plk_2-3	543	549	PF00069	0.695
MOD_Plk_2-3	598	604	PF00069	0.606
MOD_Plk_4	236	242	PF00069	0.644
MOD_Plk_4	592	598	PF00069	0.623
MOD_ProDKin_1	249	255	PF00069	0.691
MOD_ProDKin_1	266	272	PF00069	0.612
MOD_ProDKin_1	327	333	PF00069	0.748
MOD_ProDKin_1	355	361	PF00069	0.674
MOD_ProDKin_1	384	390	PF00069	0.592
MOD_ProDKin_1	524	530	PF00069	0.812
MOD_ProDKin_1	532	538	PF00069	0.587
MOD_ProDKin_1	54	60	PF00069	0.760
MOD_ProDKin_1	8	14	PF00069	0.566
MOD_SUMO_for_1	200	203	PF00179	0.626
TRG_DiLeu_BaEn_1	164	169	PF01217	0.663
TRG_DiLeu_BaEn_1	608	613	PF01217	0.554
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.708
TRG_ENDOCYTIC_2	144	147	PF00928	0.513
TRG_ENDOCYTIC_2	22	25	PF00928	0.647
TRG_ENDOCYTIC_2	40	43	PF00928	0.672
TRG_ENDOCYTIC_2	597	600	PF00928	0.613
TRG_ER_diArg_1	188	191	PF00400	0.656
TRG_ER_diArg_1	219	221	PF00400	0.549
TRG_ER_diArg_1	230	233	PF00400	0.626
TRG_ER_diArg_1	274	277	PF00400	0.801
TRG_ER_diArg_1	3	6	PF00400	0.703
TRG_ER_diArg_1	36	38	PF00400	0.600
TRG_ER_diArg_1	388	391	PF00400	0.593
TRG_ER_diArg_1	588	590	PF00400	0.677
TRG_NLS_Bipartite_1	219	236	PF00514	0.585
TRG_NLS_MonoCore_2	187	192	PF00514	0.650
TRG_NLS_MonoCore_2	231	236	PF00514	0.740
TRG_NLS_MonoExtC_3	154	159	PF00514	0.624
TRG_NLS_MonoExtC_3	188	193	PF00514	0.653
TRG_NLS_MonoExtC_3	230	235	PF00514	0.637
TRG_NLS_MonoExtN_4	188	193	PF00514	0.653
TRG_NLS_MonoExtN_4	231	236	PF00514	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y7	Leptomonas seymouri	48%	100%
A0A3Q8IDJ2	Leishmania donovani	99%	100%
E9ADR3	Leishmania major	85%	100%
E9AIT5	Leishmania braziliensis	71%	99%
E9AM17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%