ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies) - putative

Species:

Leishmania infantum

UniProt:

A4I4A9_LEIIN

TriTrypDb:

LINF_290010700

Length:

845

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	832	836	PF00656	0.575
CLV_NRD_NRD_1	445	447	PF00675	0.510
CLV_NRD_NRD_1	489	491	PF00675	0.627
CLV_NRD_NRD_1	5	7	PF00675	0.671
CLV_PCSK_KEX2_1	445	447	PF00082	0.510
CLV_PCSK_KEX2_1	468	470	PF00082	0.751
CLV_PCSK_KEX2_1	491	493	PF00082	0.564
CLV_PCSK_KEX2_1	5	7	PF00082	0.671
CLV_PCSK_KEX2_1	789	791	PF00082	0.606
CLV_PCSK_KEX2_1	833	835	PF00082	0.650
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.755
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.603
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.551
CLV_PCSK_PC1ET2_1	833	835	PF00082	0.616
CLV_PCSK_SKI1_1	182	186	PF00082	0.681
CLV_PCSK_SKI1_1	46	50	PF00082	0.496
CLV_PCSK_SKI1_1	492	496	PF00082	0.527
CLV_PCSK_SKI1_1	605	609	PF00082	0.382
CLV_PCSK_SKI1_1	61	65	PF00082	0.539
CLV_PCSK_SKI1_1	683	687	PF00082	0.367
DEG_APCC_DBOX_1	489	497	PF00400	0.678
DEG_APCC_DBOX_1	73	81	PF00400	0.609
DEG_APCC_DBOX_1	822	830	PF00400	0.563
DEG_SPOP_SBC_1	474	478	PF00917	0.612
DOC_CYCLIN_RxL_1	680	687	PF00134	0.424
DOC_CYCLIN_yClb5_NLxxxL_5	390	399	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	551	557	PF00134	0.668
DOC_MAPK_gen_1	490	496	PF00069	0.529
DOC_PP2B_LxvP_1	110	113	PF13499	0.477
DOC_PP4_FxxP_1	531	534	PF00568	0.525
DOC_USP7_MATH_1	187	191	PF00917	0.663
DOC_USP7_MATH_1	192	196	PF00917	0.738
DOC_USP7_MATH_1	218	222	PF00917	0.781
DOC_USP7_MATH_1	224	228	PF00917	0.601
DOC_USP7_MATH_1	237	241	PF00917	0.709
DOC_USP7_MATH_1	286	290	PF00917	0.437
DOC_USP7_MATH_1	418	422	PF00917	0.527
DOC_USP7_MATH_1	474	478	PF00917	0.675
DOC_USP7_MATH_1	570	574	PF00917	0.783
DOC_USP7_MATH_1	623	627	PF00917	0.410
DOC_USP7_MATH_1	735	739	PF00917	0.516
DOC_USP7_MATH_1	744	748	PF00917	0.483
DOC_USP7_UBL2_3	753	757	PF12436	0.529
DOC_WW_Pin1_4	197	202	PF00397	0.696
DOC_WW_Pin1_4	228	233	PF00397	0.735
DOC_WW_Pin1_4	478	483	PF00397	0.759
DOC_WW_Pin1_4	574	579	PF00397	0.751
DOC_WW_Pin1_4	629	634	PF00397	0.376
DOC_WW_Pin1_4	692	697	PF00397	0.555
DOC_WW_Pin1_4	86	91	PF00397	0.558
LIG_14-3-3_CanoR_1	152	158	PF00244	0.469
LIG_14-3-3_CanoR_1	206	211	PF00244	0.593
LIG_14-3-3_CanoR_1	338	348	PF00244	0.457
LIG_14-3-3_CanoR_1	380	385	PF00244	0.446
LIG_14-3-3_CanoR_1	472	482	PF00244	0.760
LIG_14-3-3_CanoR_1	492	497	PF00244	0.553
LIG_14-3-3_CanoR_1	540	548	PF00244	0.566
LIG_14-3-3_CanoR_1	602	608	PF00244	0.353
LIG_14-3-3_CanoR_1	772	776	PF00244	0.619
LIG_Actin_WH2_2	105	122	PF00022	0.514
LIG_Actin_WH2_2	429	447	PF00022	0.525
LIG_BIR_III_4	827	831	PF00653	0.643
LIG_BRCT_BRCA1_1	406	410	PF00533	0.488
LIG_BRCT_BRCA1_1	625	629	PF00533	0.424
LIG_CtBP_PxDLS_1	10	14	PF00389	0.670
LIG_CtBP_PxDLS_1	645	649	PF00389	0.501
LIG_CtBP_PxDLS_1	839	843	PF00389	0.565
LIG_eIF4E_1	697	703	PF01652	0.526
LIG_FAT_LD_1	147	155	PF03623	0.388
LIG_FHA_1	122	128	PF00498	0.526
LIG_FHA_1	265	271	PF00498	0.638
LIG_FHA_1	355	361	PF00498	0.479
LIG_FHA_1	431	437	PF00498	0.508
LIG_FHA_1	47	53	PF00498	0.514
LIG_FHA_1	630	636	PF00498	0.376
LIG_FHA_1	679	685	PF00498	0.406
LIG_FHA_1	696	702	PF00498	0.439
LIG_FHA_1	724	730	PF00498	0.565
LIG_FHA_1	783	789	PF00498	0.544
LIG_FHA_1	79	85	PF00498	0.606
LIG_FHA_2	116	122	PF00498	0.457
LIG_FHA_2	171	177	PF00498	0.633
LIG_FHA_2	261	267	PF00498	0.794
LIG_FHA_2	340	346	PF00498	0.489
LIG_FHA_2	746	752	PF00498	0.550
LIG_FHA_2	779	785	PF00498	0.518
LIG_LIR_Apic_2	529	534	PF02991	0.526
LIG_LIR_Apic_2	694	700	PF02991	0.575
LIG_LIR_Gen_1	295	305	PF02991	0.447
LIG_LIR_Gen_1	407	418	PF02991	0.497
LIG_LIR_Gen_1	515	525	PF02991	0.601
LIG_LIR_Nem_3	25	31	PF02991	0.621
LIG_LIR_Nem_3	295	301	PF02991	0.441
LIG_LIR_Nem_3	343	349	PF02991	0.509
LIG_LIR_Nem_3	383	388	PF02991	0.515
LIG_LIR_Nem_3	407	413	PF02991	0.455
LIG_LIR_Nem_3	515	520	PF02991	0.579
LIG_LIR_Nem_3	62	66	PF02991	0.482
LIG_LIR_Nem_3	628	634	PF02991	0.430
LIG_LIR_Nem_3	668	674	PF02991	0.376
LIG_MYND_1	29	33	PF01753	0.620
LIG_Pex14_2	349	353	PF04695	0.450
LIG_Pex14_2	381	385	PF04695	0.353
LIG_Pex14_2	527	531	PF04695	0.532
LIG_SH2_CRK	697	701	PF00017	0.536
LIG_SH2_NCK_1	672	676	PF00017	0.376
LIG_SH2_NCK_1	780	784	PF00017	0.558
LIG_SH2_SRC	672	675	PF00017	0.402
LIG_SH2_STAP1	736	740	PF00017	0.511
LIG_SH2_STAP1	814	818	PF00017	0.519
LIG_SH2_STAT3	376	379	PF00017	0.541
LIG_SH2_STAT3	814	817	PF00017	0.582
LIG_SH2_STAT5	125	128	PF00017	0.454
LIG_SH2_STAT5	304	307	PF00017	0.434
LIG_SH2_STAT5	314	317	PF00017	0.488
LIG_SH2_STAT5	412	415	PF00017	0.487
LIG_SH2_STAT5	428	431	PF00017	0.408
LIG_SH2_STAT5	498	501	PF00017	0.534
LIG_SH2_STAT5	603	606	PF00017	0.376
LIG_SH2_STAT5	697	700	PF00017	0.548
LIG_SH2_STAT5	767	770	PF00017	0.502
LIG_SH2_STAT5	780	783	PF00017	0.493
LIG_SH3_1	229	235	PF00018	0.639
LIG_SH3_3	229	235	PF00018	0.639
LIG_SH3_3	345	351	PF00018	0.540
LIG_SH3_3	381	387	PF00018	0.510
LIG_SH3_3	483	489	PF00018	0.716
LIG_SH3_3	543	549	PF00018	0.696
LIG_SH3_3	553	559	PF00018	0.682
LIG_SH3_3	569	575	PF00018	0.723
LIG_SH3_3	635	641	PF00018	0.398
LIG_SH3_CIN85_PxpxPR_1	458	463	PF14604	0.686
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.799
LIG_SUMO_SIM_anti_2	643	650	PF11976	0.429
LIG_SUMO_SIM_anti_2	737	744	PF11976	0.567
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.486
LIG_SUMO_SIM_par_1	124	131	PF11976	0.521
LIG_SUMO_SIM_par_1	371	377	PF11976	0.403
LIG_SUMO_SIM_par_1	492	497	PF11976	0.429
LIG_SUMO_SIM_par_1	741	748	PF11976	0.482
LIG_SUMO_SIM_par_1	838	844	PF11976	0.565
LIG_TRAF2_1	342	345	PF00917	0.579
LIG_TRAF2_1	513	516	PF00917	0.613
LIG_TRAF2_1	69	72	PF00917	0.520
LIG_UBA3_1	361	368	PF00899	0.489
MOD_CDK_SPK_2	197	202	PF00069	0.676
MOD_CDK_SPK_2	228	233	PF00069	0.735
MOD_CK1_1	213	219	PF00069	0.627
MOD_CK1_1	374	380	PF00069	0.410
MOD_CK1_1	464	470	PF00069	0.819
MOD_CK1_1	477	483	PF00069	0.715
MOD_CK1_1	501	507	PF00069	0.621
MOD_CK1_1	573	579	PF00069	0.641
MOD_CK1_1	695	701	PF00069	0.501
MOD_CK1_1	760	766	PF00069	0.556
MOD_CK1_1	782	788	PF00069	0.516
MOD_CK2_1	115	121	PF00069	0.504
MOD_CK2_1	197	203	PF00069	0.710
MOD_CK2_1	233	239	PF00069	0.707
MOD_CK2_1	339	345	PF00069	0.564
MOD_CK2_1	56	62	PF00069	0.511
MOD_CK2_1	745	751	PF00069	0.485
MOD_CK2_1	759	765	PF00069	0.557
MOD_CK2_1	778	784	PF00069	0.521
MOD_CK2_1	838	844	PF00069	0.718
MOD_CMANNOS	822	825	PF00535	0.552
MOD_GlcNHglycan	194	197	PF01048	0.805
MOD_GlcNHglycan	235	238	PF01048	0.831
MOD_GlcNHglycan	273	276	PF01048	0.641
MOD_GlcNHglycan	42	45	PF01048	0.642
MOD_GlcNHglycan	564	567	PF01048	0.604
MOD_GlcNHglycan	58	61	PF01048	0.364
MOD_GlcNHglycan	589	592	PF01048	0.590
MOD_GlcNHglycan	754	757	PF01048	0.588
MOD_GlcNHglycan	762	765	PF01048	0.537
MOD_GlcNHglycan	773	776	PF01048	0.375
MOD_GlcNHglycan	781	784	PF01048	0.467
MOD_GlcNHglycan	86	89	PF01048	0.578
MOD_GSK3_1	170	177	PF00069	0.697
MOD_GSK3_1	18	25	PF00069	0.596
MOD_GSK3_1	206	213	PF00069	0.718
MOD_GSK3_1	224	231	PF00069	0.750
MOD_GSK3_1	233	240	PF00069	0.781
MOD_GSK3_1	260	267	PF00069	0.633
MOD_GSK3_1	463	470	PF00069	0.778
MOD_GSK3_1	473	480	PF00069	0.705
MOD_GSK3_1	492	499	PF00069	0.445
MOD_GSK3_1	560	567	PF00069	0.771
MOD_GSK3_1	570	577	PF00069	0.640
MOD_GSK3_1	625	632	PF00069	0.501
MOD_GSK3_1	688	695	PF00069	0.601
MOD_GSK3_1	778	785	PF00069	0.528
MOD_N-GLC_1	587	592	PF02516	0.542
MOD_N-GLC_2	212	214	PF02516	0.633
MOD_NEK2_1	108	113	PF00069	0.503
MOD_NEK2_1	153	158	PF00069	0.339
MOD_NEK2_1	413	418	PF00069	0.500
MOD_NEK2_1	539	544	PF00069	0.631
MOD_NEK2_1	560	565	PF00069	0.663
MOD_NEK2_1	745	750	PF00069	0.478
MOD_NEK2_2	224	229	PF00069	0.549
MOD_NEK2_2	371	376	PF00069	0.403
MOD_PIKK_1	170	176	PF00454	0.622
MOD_PIKK_1	264	270	PF00454	0.641
MOD_PIKK_1	793	799	PF00454	0.500
MOD_PK_1	206	212	PF00069	0.513
MOD_PK_1	380	386	PF00069	0.455
MOD_PK_1	757	763	PF00069	0.555
MOD_PKA_2	174	180	PF00069	0.676
MOD_PKA_2	251	257	PF00069	0.819
MOD_PKA_2	539	545	PF00069	0.601
MOD_PKA_2	771	777	PF00069	0.630
MOD_PKB_1	490	498	PF00069	0.539
MOD_Plk_1	187	193	PF00069	0.718
MOD_Plk_1	238	244	PF00069	0.737
MOD_Plk_1	587	593	PF00069	0.529
MOD_Plk_1	665	671	PF00069	0.413
MOD_Plk_1	679	685	PF00069	0.460
MOD_Plk_1	736	742	PF00069	0.512
MOD_Plk_1	757	763	PF00069	0.572
MOD_Plk_2-3	167	173	PF00069	0.533
MOD_Plk_4	121	127	PF00069	0.548
MOD_Plk_4	153	159	PF00069	0.443
MOD_Plk_4	380	386	PF00069	0.528
MOD_Plk_4	611	617	PF00069	0.395
MOD_Plk_4	745	751	PF00069	0.558
MOD_ProDKin_1	197	203	PF00069	0.697
MOD_ProDKin_1	228	234	PF00069	0.737
MOD_ProDKin_1	478	484	PF00069	0.756
MOD_ProDKin_1	574	580	PF00069	0.752
MOD_ProDKin_1	629	635	PF00069	0.376
MOD_ProDKin_1	692	698	PF00069	0.545
MOD_ProDKin_1	86	92	PF00069	0.547
MOD_SUMO_for_1	185	188	PF00179	0.675
MOD_SUMO_rev_2	51	58	PF00179	0.604
MOD_SUMO_rev_2	59	66	PF00179	0.522
MOD_SUMO_rev_2	747	755	PF00179	0.503
TRG_DiLeu_BaEn_3	344	350	PF01217	0.501
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.589
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.556
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.376
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.528
TRG_ENDOCYTIC_2	412	415	PF00928	0.487
TRG_ENDOCYTIC_2	671	674	PF00928	0.376
TRG_ER_diArg_1	444	446	PF00400	0.533
TRG_ER_diArg_1	489	492	PF00400	0.583
TRG_ER_diArg_1	800	803	PF00400	0.517
TRG_ER_FFAT_2	774	786	PF00635	0.538
TRG_NES_CRM1_1	389	405	PF08389	0.527
TRG_NLS_MonoExtN_4	489	494	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G5	Leptomonas seymouri	58%	95%
A0A3Q8IF85	Leishmania donovani	99%	100%
A4HH65	Leishmania braziliensis	73%	99%
C9ZKL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ADQ9	Leishmania major	91%	100%
E9AM21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%