LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Exonuclease - putative
Species:
Leishmania infantum
UniProt:
A4I4A7_LEIIN
TriTrypDb:
LINF_290010500
Length:
880

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I4A7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4A7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0005488 binding 1 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7
GO:0003824 catalytic activity 1 1
GO:0004518 nuclease activity 4 1
GO:0004527 exonuclease activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 453 457 PF00656 0.632
CLV_NRD_NRD_1 552 554 PF00675 0.505
CLV_PCSK_FUR_1 679 683 PF00082 0.313
CLV_PCSK_KEX2_1 551 553 PF00082 0.474
CLV_PCSK_KEX2_1 681 683 PF00082 0.313
CLV_PCSK_PC1ET2_1 681 683 PF00082 0.313
CLV_PCSK_PC7_1 677 683 PF00082 0.313
CLV_PCSK_SKI1_1 725 729 PF00082 0.268
CLV_PCSK_SKI1_1 778 782 PF00082 0.374
CLV_Separin_Metazoa 268 272 PF03568 0.456
CLV_Separin_Metazoa 548 552 PF03568 0.473
DEG_SCF_FBW7_2 506 512 PF00400 0.612
DEG_SPOP_SBC_1 373 377 PF00917 0.665
DEG_SPOP_SBC_1 388 392 PF00917 0.528
DEG_SPOP_SBC_1 457 461 PF00917 0.657
DEG_SPOP_SBC_1 99 103 PF00917 0.506
DOC_ANK_TNKS_1 87 94 PF00023 0.674
DOC_CKS1_1 295 300 PF01111 0.541
DOC_CKS1_1 345 350 PF01111 0.597
DOC_CKS1_1 506 511 PF01111 0.611
DOC_CKS1_1 92 97 PF01111 0.677
DOC_CYCLIN_RxL_1 149 160 PF00134 0.581
DOC_CYCLIN_RxL_1 266 279 PF00134 0.409
DOC_CYCLIN_yClb1_LxF_4 821 826 PF00134 0.434
DOC_CYCLIN_yCln2_LP_2 332 338 PF00134 0.580
DOC_CYCLIN_yCln2_LP_2 625 631 PF00134 0.591
DOC_CYCLIN_yCln2_LP_2 844 847 PF00134 0.590
DOC_MAPK_gen_1 776 783 PF00069 0.490
DOC_MAPK_MEF2A_6 800 809 PF00069 0.468
DOC_PP2B_LxvP_1 332 335 PF13499 0.580
DOC_PP2B_LxvP_1 784 787 PF13499 0.459
DOC_PP2B_LxvP_1 843 846 PF13499 0.573
DOC_PP4_FxxP_1 675 678 PF00568 0.468
DOC_USP7_MATH_1 135 139 PF00917 0.724
DOC_USP7_MATH_1 146 150 PF00917 0.739
DOC_USP7_MATH_1 188 192 PF00917 0.557
DOC_USP7_MATH_1 246 250 PF00917 0.641
DOC_USP7_MATH_1 316 320 PF00917 0.678
DOC_USP7_MATH_1 339 343 PF00917 0.655
DOC_USP7_MATH_1 357 361 PF00917 0.498
DOC_USP7_MATH_1 373 377 PF00917 0.561
DOC_USP7_MATH_1 378 382 PF00917 0.596
DOC_USP7_MATH_1 419 423 PF00917 0.598
DOC_USP7_MATH_1 457 461 PF00917 0.709
DOC_USP7_MATH_1 519 523 PF00917 0.675
DOC_USP7_MATH_1 533 537 PF00917 0.541
DOC_USP7_MATH_1 562 566 PF00917 0.691
DOC_USP7_MATH_1 614 618 PF00917 0.583
DOC_USP7_MATH_1 851 855 PF00917 0.599
DOC_WW_Pin1_4 111 116 PF00397 0.800
DOC_WW_Pin1_4 29 34 PF00397 0.605
DOC_WW_Pin1_4 294 299 PF00397 0.580
DOC_WW_Pin1_4 312 317 PF00397 0.495
DOC_WW_Pin1_4 344 349 PF00397 0.594
DOC_WW_Pin1_4 352 357 PF00397 0.605
DOC_WW_Pin1_4 369 374 PF00397 0.507
DOC_WW_Pin1_4 382 387 PF00397 0.607
DOC_WW_Pin1_4 407 412 PF00397 0.711
DOC_WW_Pin1_4 423 428 PF00397 0.567
DOC_WW_Pin1_4 446 451 PF00397 0.745
DOC_WW_Pin1_4 470 475 PF00397 0.548
DOC_WW_Pin1_4 484 489 PF00397 0.723
DOC_WW_Pin1_4 505 510 PF00397 0.615
DOC_WW_Pin1_4 524 529 PF00397 0.772
DOC_WW_Pin1_4 579 584 PF00397 0.591
DOC_WW_Pin1_4 610 615 PF00397 0.740
DOC_WW_Pin1_4 617 622 PF00397 0.547
DOC_WW_Pin1_4 64 69 PF00397 0.562
DOC_WW_Pin1_4 682 687 PF00397 0.463
DOC_WW_Pin1_4 860 865 PF00397 0.565
DOC_WW_Pin1_4 91 96 PF00397 0.625
LIG_14-3-3_CanoR_1 143 151 PF00244 0.591
LIG_14-3-3_CanoR_1 18 22 PF00244 0.476
LIG_14-3-3_CanoR_1 293 298 PF00244 0.567
LIG_14-3-3_CanoR_1 434 439 PF00244 0.736
LIG_14-3-3_CanoR_1 551 560 PF00244 0.523
LIG_14-3-3_CanoR_1 567 576 PF00244 0.599
LIG_14-3-3_CanoR_1 584 593 PF00244 0.479
LIG_14-3-3_CanoR_1 714 722 PF00244 0.513
LIG_14-3-3_CanoR_1 771 777 PF00244 0.543
LIG_14-3-3_CanoR_1 83 92 PF00244 0.615
LIG_14-3-3_CanoR_1 858 864 PF00244 0.566
LIG_Actin_WH2_2 180 198 PF00022 0.545
LIG_BIR_II_1 1 5 PF00653 0.618
LIG_BIR_III_2 199 203 PF00653 0.611
LIG_BRCT_BRCA1_1 190 194 PF00533 0.612
LIG_BRCT_BRCA1_1 434 438 PF00533 0.659
LIG_BRCT_BRCA1_1 537 541 PF00533 0.587
LIG_BRCT_BRCA1_1 618 622 PF00533 0.508
LIG_Clathr_ClatBox_1 632 636 PF01394 0.365
LIG_CtBP_PxDLS_1 733 737 PF00389 0.468
LIG_deltaCOP1_diTrp_1 256 267 PF00928 0.492
LIG_FHA_1 104 110 PF00498 0.490
LIG_FHA_1 159 165 PF00498 0.442
LIG_FHA_1 203 209 PF00498 0.573
LIG_FHA_1 214 220 PF00498 0.535
LIG_FHA_1 279 285 PF00498 0.481
LIG_FHA_1 398 404 PF00498 0.669
LIG_FHA_1 568 574 PF00498 0.584
LIG_FHA_1 57 63 PF00498 0.659
LIG_FHA_1 85 91 PF00498 0.661
LIG_FHA_1 92 98 PF00498 0.604
LIG_FHA_2 253 259 PF00498 0.503
LIG_FHA_2 295 301 PF00498 0.615
LIG_FHA_2 451 457 PF00498 0.604
LIG_FHA_2 492 498 PF00498 0.780
LIG_FHA_2 543 549 PF00498 0.547
LIG_FHA_2 638 644 PF00498 0.468
LIG_Integrin_isoDGR_2 81 83 PF01839 0.607
LIG_LIR_Apic_2 617 621 PF02991 0.548
LIG_LIR_Gen_1 257 267 PF02991 0.426
LIG_LIR_Gen_1 630 639 PF02991 0.303
LIG_LIR_Gen_1 671 680 PF02991 0.468
LIG_LIR_Gen_1 754 762 PF02991 0.496
LIG_LIR_Gen_1 765 770 PF02991 0.458
LIG_LIR_Gen_1 815 824 PF02991 0.377
LIG_LIR_Nem_3 257 263 PF02991 0.457
LIG_LIR_Nem_3 291 295 PF02991 0.503
LIG_LIR_Nem_3 619 625 PF02991 0.567
LIG_LIR_Nem_3 630 634 PF02991 0.307
LIG_LIR_Nem_3 655 659 PF02991 0.503
LIG_LIR_Nem_3 671 675 PF02991 0.503
LIG_LIR_Nem_3 738 742 PF02991 0.511
LIG_LIR_Nem_3 754 760 PF02991 0.484
LIG_LIR_Nem_3 765 769 PF02991 0.482
LIG_LIR_Nem_3 815 819 PF02991 0.362
LIG_MYND_1 842 846 PF01753 0.594
LIG_NRBOX 166 172 PF00104 0.370
LIG_PCNA_yPIPBox_3 771 781 PF02747 0.583
LIG_Pex14_2 752 756 PF04695 0.468
LIG_Pex14_2 766 770 PF04695 0.468
LIG_PTAP_UEV_1 147 152 PF05743 0.635
LIG_REV1ctd_RIR_1 767 775 PF16727 0.483
LIG_SH2_CRK 561 565 PF00017 0.526
LIG_SH2_CRK 618 622 PF00017 0.543
LIG_SH2_CRK 629 633 PF00017 0.334
LIG_SH2_CRK 742 746 PF00017 0.508
LIG_SH2_NCK_1 561 565 PF00017 0.526
LIG_SH2_NCK_1 618 622 PF00017 0.508
LIG_SH2_NCK_1 651 655 PF00017 0.454
LIG_SH2_SRC 304 307 PF00017 0.615
LIG_SH2_SRC 517 520 PF00017 0.670
LIG_SH2_SRC 651 654 PF00017 0.454
LIG_SH2_STAP1 629 633 PF00017 0.334
LIG_SH2_STAT5 631 634 PF00017 0.303
LIG_SH2_STAT5 649 652 PF00017 0.468
LIG_SH3_1 608 614 PF00018 0.552
LIG_SH3_3 109 115 PF00018 0.560
LIG_SH3_3 145 151 PF00018 0.643
LIG_SH3_3 292 298 PF00018 0.503
LIG_SH3_3 342 348 PF00018 0.599
LIG_SH3_3 353 359 PF00018 0.598
LIG_SH3_3 427 433 PF00018 0.626
LIG_SH3_3 45 51 PF00018 0.675
LIG_SH3_3 503 509 PF00018 0.612
LIG_SH3_3 513 519 PF00018 0.598
LIG_SH3_3 570 576 PF00018 0.725
LIG_SH3_3 590 596 PF00018 0.530
LIG_SH3_3 608 614 PF00018 0.553
LIG_SH3_3 89 95 PF00018 0.619
LIG_SUMO_SIM_anti_2 630 636 PF11976 0.303
LIG_SUMO_SIM_par_1 105 110 PF11976 0.605
LIG_SUMO_SIM_par_1 25 32 PF11976 0.587
LIG_SUMO_SIM_par_1 630 636 PF11976 0.303
LIG_SUMO_SIM_par_1 655 662 PF11976 0.509
LIG_TRAF2_1 255 258 PF00917 0.536
LIG_TRAF2_1 303 306 PF00917 0.776
LIG_TRAF2_1 545 548 PF00917 0.496
LIG_TRAF2_1 640 643 PF00917 0.468
LIG_TRAF2_1 704 707 PF00917 0.468
LIG_TYR_ITIM 755 760 PF00017 0.503
LIG_WW_1 646 649 PF00397 0.454
MOD_CDK_SPK_2 369 374 PF00069 0.557
MOD_CDK_SPK_2 579 584 PF00069 0.555
MOD_CK1_1 103 109 PF00069 0.753
MOD_CK1_1 129 135 PF00069 0.586
MOD_CK1_1 138 144 PF00069 0.625
MOD_CK1_1 177 183 PF00069 0.522
MOD_CK1_1 229 235 PF00069 0.643
MOD_CK1_1 38 44 PF00069 0.709
MOD_CK1_1 382 388 PF00069 0.599
MOD_CK1_1 392 398 PF00069 0.573
MOD_CK1_1 407 413 PF00069 0.547
MOD_CK1_1 437 443 PF00069 0.558
MOD_CK1_1 466 472 PF00069 0.736
MOD_CK1_1 57 63 PF00069 0.651
MOD_CK1_1 578 584 PF00069 0.669
MOD_CK1_1 617 623 PF00069 0.543
MOD_CK1_1 67 73 PF00069 0.462
MOD_CK1_1 854 860 PF00069 0.744
MOD_CK2_1 252 258 PF00069 0.518
MOD_CK2_1 491 497 PF00069 0.770
MOD_CK2_1 542 548 PF00069 0.496
MOD_CK2_1 637 643 PF00069 0.468
MOD_CK2_1 701 707 PF00069 0.513
MOD_CK2_1 71 77 PF00069 0.534
MOD_CK2_1 812 818 PF00069 0.368
MOD_CK2_1 869 875 PF00069 0.560
MOD_GlcNHglycan 1 4 PF01048 0.705
MOD_GlcNHglycan 102 105 PF01048 0.607
MOD_GlcNHglycan 109 112 PF01048 0.810
MOD_GlcNHglycan 128 131 PF01048 0.516
MOD_GlcNHglycan 144 147 PF01048 0.585
MOD_GlcNHglycan 148 151 PF01048 0.528
MOD_GlcNHglycan 190 193 PF01048 0.568
MOD_GlcNHglycan 211 214 PF01048 0.717
MOD_GlcNHglycan 228 231 PF01048 0.541
MOD_GlcNHglycan 235 238 PF01048 0.618
MOD_GlcNHglycan 312 315 PF01048 0.589
MOD_GlcNHglycan 318 321 PF01048 0.614
MOD_GlcNHglycan 381 384 PF01048 0.599
MOD_GlcNHglycan 406 409 PF01048 0.656
MOD_GlcNHglycan 417 420 PF01048 0.721
MOD_GlcNHglycan 434 437 PF01048 0.554
MOD_GlcNHglycan 439 442 PF01048 0.647
MOD_GlcNHglycan 519 522 PF01048 0.695
MOD_GlcNHglycan 537 540 PF01048 0.531
MOD_GlcNHglycan 553 556 PF01048 0.433
MOD_GlcNHglycan 577 580 PF01048 0.716
MOD_GlcNHglycan 793 796 PF01048 0.303
MOD_GlcNHglycan 837 840 PF01048 0.621
MOD_GlcNHglycan 867 870 PF01048 0.658
MOD_GSK3_1 107 114 PF00069 0.586
MOD_GSK3_1 129 136 PF00069 0.610
MOD_GSK3_1 138 145 PF00069 0.670
MOD_GSK3_1 156 163 PF00069 0.347
MOD_GSK3_1 209 216 PF00069 0.560
MOD_GSK3_1 222 229 PF00069 0.619
MOD_GSK3_1 238 245 PF00069 0.609
MOD_GSK3_1 25 32 PF00069 0.549
MOD_GSK3_1 312 319 PF00069 0.618
MOD_GSK3_1 369 376 PF00069 0.584
MOD_GSK3_1 378 385 PF00069 0.693
MOD_GSK3_1 38 45 PF00069 0.771
MOD_GSK3_1 388 395 PF00069 0.511
MOD_GSK3_1 407 414 PF00069 0.518
MOD_GSK3_1 415 422 PF00069 0.590
MOD_GSK3_1 446 453 PF00069 0.604
MOD_GSK3_1 463 470 PF00069 0.696
MOD_GSK3_1 504 511 PF00069 0.615
MOD_GSK3_1 519 526 PF00069 0.614
MOD_GSK3_1 531 538 PF00069 0.603
MOD_GSK3_1 562 569 PF00069 0.566
MOD_GSK3_1 575 582 PF00069 0.755
MOD_GSK3_1 606 613 PF00069 0.696
MOD_GSK3_1 67 74 PF00069 0.595
MOD_GSK3_1 829 836 PF00069 0.563
MOD_GSK3_1 856 863 PF00069 0.647
MOD_GSK3_1 865 872 PF00069 0.591
MOD_GSK3_1 98 105 PF00069 0.717
MOD_N-GLC_1 397 402 PF02516 0.674
MOD_N-GLC_1 524 529 PF02516 0.651
MOD_N-GLC_1 531 536 PF02516 0.595
MOD_NEK2_1 27 32 PF00069 0.601
MOD_NEK2_1 415 420 PF00069 0.586
MOD_NEK2_1 465 470 PF00069 0.601
MOD_NEK2_1 523 528 PF00069 0.715
MOD_NEK2_1 560 565 PF00069 0.548
MOD_NEK2_1 586 591 PF00069 0.614
MOD_NEK2_1 616 621 PF00069 0.685
MOD_NEK2_1 71 76 PF00069 0.540
MOD_NEK2_1 716 721 PF00069 0.468
MOD_NEK2_1 770 775 PF00069 0.468
MOD_NEK2_1 829 834 PF00069 0.663
MOD_NEK2_2 42 47 PF00069 0.655
MOD_NEK2_2 458 463 PF00069 0.685
MOD_NEK2_2 851 856 PF00069 0.576
MOD_PIKK_1 35 41 PF00454 0.622
MOD_PIKK_1 419 425 PF00454 0.581
MOD_PIKK_1 472 478 PF00454 0.519
MOD_PIKK_1 491 497 PF00454 0.714
MOD_PIKK_1 770 776 PF00454 0.513
MOD_PKA_1 551 557 PF00069 0.519
MOD_PKA_2 142 148 PF00069 0.601
MOD_PKA_2 17 23 PF00069 0.488
MOD_PKA_2 195 201 PF00069 0.602
MOD_PKA_2 373 379 PF00069 0.669
MOD_PKA_2 419 425 PF00069 0.592
MOD_PKA_2 483 489 PF00069 0.649
MOD_PKA_2 551 557 PF00069 0.515
MOD_PKA_2 566 572 PF00069 0.683
MOD_PKA_2 770 776 PF00069 0.543
MOD_PKA_2 857 863 PF00069 0.572
MOD_Plk_1 54 60 PF00069 0.644
MOD_Plk_4 166 172 PF00069 0.426
MOD_Plk_4 190 196 PF00069 0.616
MOD_Plk_4 22 28 PF00069 0.485
MOD_Plk_4 327 333 PF00069 0.605
MOD_Plk_4 434 440 PF00069 0.558
MOD_Plk_4 519 525 PF00069 0.793
MOD_Plk_4 71 77 PF00069 0.558
MOD_Plk_4 751 757 PF00069 0.533
MOD_Plk_4 801 807 PF00069 0.468
MOD_ProDKin_1 111 117 PF00069 0.801
MOD_ProDKin_1 29 35 PF00069 0.609
MOD_ProDKin_1 294 300 PF00069 0.584
MOD_ProDKin_1 312 318 PF00069 0.497
MOD_ProDKin_1 344 350 PF00069 0.594
MOD_ProDKin_1 352 358 PF00069 0.605
MOD_ProDKin_1 369 375 PF00069 0.507
MOD_ProDKin_1 382 388 PF00069 0.605
MOD_ProDKin_1 407 413 PF00069 0.713
MOD_ProDKin_1 423 429 PF00069 0.567
MOD_ProDKin_1 446 452 PF00069 0.746
MOD_ProDKin_1 470 476 PF00069 0.544
MOD_ProDKin_1 484 490 PF00069 0.727
MOD_ProDKin_1 505 511 PF00069 0.613
MOD_ProDKin_1 524 530 PF00069 0.774
MOD_ProDKin_1 579 585 PF00069 0.589
MOD_ProDKin_1 610 616 PF00069 0.567
MOD_ProDKin_1 617 623 PF00069 0.546
MOD_ProDKin_1 64 70 PF00069 0.558
MOD_ProDKin_1 682 688 PF00069 0.463
MOD_ProDKin_1 860 866 PF00069 0.564
MOD_ProDKin_1 91 97 PF00069 0.622
TRG_DiLeu_BaEn_1 22 27 PF01217 0.478
TRG_DiLeu_BaEn_2 670 676 PF01217 0.468
TRG_DiLeu_BaLyEn_6 839 844 PF01217 0.588
TRG_ENDOCYTIC_2 561 564 PF00928 0.543
TRG_ENDOCYTIC_2 629 632 PF00928 0.338
TRG_ENDOCYTIC_2 651 654 PF00928 0.454
TRG_ENDOCYTIC_2 742 745 PF00928 0.553
TRG_ENDOCYTIC_2 757 760 PF00928 0.478
TRG_ER_diArg_1 550 553 PF00400 0.477
TRG_ER_diArg_1 676 679 PF00400 0.468
TRG_NES_CRM1_1 279 291 PF08389 0.472
TRG_Pf-PMV_PEXEL_1 282 286 PF00026 0.610
TRG_Pf-PMV_PEXEL_1 463 467 PF00026 0.624

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7U4 Leptomonas seymouri 50% 77%
A0A3S7X257 Leishmania donovani 100% 100%
A4HH56 Leishmania braziliensis 74% 100%
E9ADQ6 Leishmania major 90% 100%
E9AM24 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS