DNA repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA repair protein

Gene product:

Rad51/recA bacterial DNA recombination protein/KaiC - putative

Species:

Leishmania infantum

UniProt:

A4I499_LEIIN

TriTrypDb:

LINF_290009500

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I499

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I499

Function

Biological processes
Term	Name	Level	Count
GO:0000730	DNA recombinase assembly	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042148	strand invasion	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090735	DNA repair complex assembly	6	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000150	DNA strand exchange activity	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.600
CLV_NRD_NRD_1	167	169	PF00675	0.592
CLV_NRD_NRD_1	222	224	PF00675	0.619
CLV_NRD_NRD_1	225	227	PF00675	0.621
CLV_NRD_NRD_1	613	615	PF00675	0.269
CLV_PCSK_FUR_1	164	168	PF00082	0.524
CLV_PCSK_KEX2_1	164	166	PF00082	0.582
CLV_PCSK_KEX2_1	167	169	PF00082	0.573
CLV_PCSK_KEX2_1	575	577	PF00082	0.269
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.269
CLV_PCSK_PC7_1	160	166	PF00082	0.525
CLV_PCSK_SKI1_1	106	110	PF00082	0.479
CLV_PCSK_SKI1_1	160	164	PF00082	0.668
CLV_PCSK_SKI1_1	168	172	PF00082	0.566
CLV_PCSK_SKI1_1	446	450	PF00082	0.325
CLV_PCSK_SKI1_1	610	614	PF00082	0.316
CLV_PCSK_SKI1_1	65	69	PF00082	0.489
CLV_Separin_Metazoa	453	457	PF03568	0.441
DEG_APCC_DBOX_1	105	113	PF00400	0.484
DEG_APCC_DBOX_1	166	174	PF00400	0.597
DEG_MDM2_SWIB_1	296	304	PF02201	0.469
DEG_SPOP_SBC_1	486	490	PF00917	0.496
DOC_CKS1_1	229	234	PF01111	0.515
DOC_CYCLIN_RxL_1	607	616	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	457	463	PF00134	0.530
DOC_MAPK_DCC_7	593	601	PF00069	0.472
DOC_MAPK_MEF2A_6	593	601	PF00069	0.472
DOC_PP2B_LxvP_1	171	174	PF13499	0.646
DOC_PP4_FxxP_1	252	255	PF00568	0.573
DOC_USP7_MATH_1	265	269	PF00917	0.594
DOC_USP7_MATH_1	273	277	PF00917	0.449
DOC_USP7_MATH_1	336	340	PF00917	0.358
DOC_USP7_MATH_1	467	471	PF00917	0.590
DOC_USP7_MATH_1	486	490	PF00917	0.417
DOC_USP7_MATH_1	586	590	PF00917	0.474
DOC_USP7_MATH_1	635	639	PF00917	0.516
DOC_USP7_MATH_1	95	99	PF00917	0.669
DOC_WW_Pin1_4	228	233	PF00397	0.575
DOC_WW_Pin1_4	357	362	PF00397	0.576
DOC_WW_Pin1_4	576	581	PF00397	0.479
DOC_WW_Pin1_4	84	89	PF00397	0.718
LIG_14-3-3_CanoR_1	140	146	PF00244	0.577
LIG_14-3-3_CanoR_1	206	212	PF00244	0.483
LIG_14-3-3_CanoR_1	235	245	PF00244	0.492
LIG_14-3-3_CanoR_1	247	252	PF00244	0.490
LIG_14-3-3_CanoR_1	432	437	PF00244	0.364
LIG_14-3-3_CanoR_1	446	452	PF00244	0.434
LIG_14-3-3_CanoR_1	485	495	PF00244	0.465
LIG_14-3-3_CanoR_1	56	64	PF00244	0.550
LIG_14-3-3_CanoR_1	578	584	PF00244	0.430
LIG_14-3-3_CanoR_1	614	624	PF00244	0.469
LIG_Actin_WH2_2	145	162	PF00022	0.467
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BRCT_BRCA1_1	248	252	PF00533	0.469
LIG_BRCT_BRCA1_1	586	590	PF00533	0.430
LIG_Clathr_ClatBox_1	506	510	PF01394	0.422
LIG_DLG_GKlike_1	487	495	PF00625	0.292
LIG_EH1_1	618	626	PF00400	0.516
LIG_EVH1_1	171	175	PF00568	0.648
LIG_FAT_LD_1	145	153	PF03623	0.521
LIG_FHA_1	246	252	PF00498	0.495
LIG_FHA_1	389	395	PF00498	0.401
LIG_FHA_1	431	437	PF00498	0.396
LIG_FHA_1	474	480	PF00498	0.564
LIG_FHA_1	552	558	PF00498	0.484
LIG_FHA_2	109	115	PF00498	0.471
LIG_FHA_2	179	185	PF00498	0.659
LIG_LIR_Apic_2	249	255	PF02991	0.550
LIG_LIR_Gen_1	546	557	PF02991	0.500
LIG_LIR_Gen_1	59	69	PF02991	0.484
LIG_LIR_Nem_3	425	430	PF02991	0.417
LIG_LIR_Nem_3	546	552	PF02991	0.500
LIG_LIR_Nem_3	59	64	PF02991	0.482
LIG_MYND_1	88	92	PF01753	0.650
LIG_NRBOX	316	322	PF00104	0.469
LIG_PCNA_yPIPBox_3	312	321	PF02747	0.469
LIG_PDZ_Class_3	644	649	PF00595	0.469
LIG_Pex14_2	296	300	PF04695	0.469
LIG_RPA_C_Fungi	373	385	PF08784	0.413
LIG_SH2_STAT5	383	386	PF00017	0.340
LIG_SH2_STAT5	639	642	PF00017	0.304
LIG_SH3_2	51	56	PF14604	0.595
LIG_SH3_3	169	175	PF00018	0.660
LIG_SH3_3	226	232	PF00018	0.550
LIG_SH3_3	48	54	PF00018	0.601
LIG_SH3_3	627	633	PF00018	0.352
LIG_SH3_3	89	95	PF00018	0.800
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.551
LIG_SUMO_SIM_anti_2	196	205	PF11976	0.431
LIG_SUMO_SIM_anti_2	241	250	PF11976	0.477
LIG_SUMO_SIM_par_1	505	511	PF11976	0.304
LIG_TRAF2_1	194	197	PF00917	0.486
LIG_WW_3	173	177	PF00397	0.618
MOD_CDK_SPxxK_3	228	235	PF00069	0.564
MOD_CDK_SPxxK_3	357	364	PF00069	0.602
MOD_CK1_1	138	144	PF00069	0.594
MOD_CK1_1	40	46	PF00069	0.565
MOD_CK1_1	470	476	PF00069	0.610
MOD_CK1_1	579	585	PF00069	0.308
MOD_CK1_1	591	597	PF00069	0.295
MOD_CK1_1	602	608	PF00069	0.242
MOD_CK1_1	78	84	PF00069	0.584
MOD_CK2_1	178	184	PF00069	0.777
MOD_CK2_1	447	453	PF00069	0.446
MOD_CK2_1	487	493	PF00069	0.401
MOD_DYRK1A_RPxSP_1	576	580	PF00069	0.369
MOD_GlcNHglycan	1	4	PF01048	0.628
MOD_GlcNHglycan	123	126	PF01048	0.676
MOD_GlcNHglycan	137	140	PF01048	0.563
MOD_GlcNHglycan	267	270	PF01048	0.601
MOD_GlcNHglycan	274	278	PF01048	0.382
MOD_GlcNHglycan	297	300	PF01048	0.304
MOD_GlcNHglycan	39	42	PF01048	0.655
MOD_GlcNHglycan	469	472	PF01048	0.506
MOD_GlcNHglycan	58	61	PF01048	0.465
MOD_GlcNHglycan	583	586	PF01048	0.311
MOD_GlcNHglycan	590	593	PF01048	0.294
MOD_GlcNHglycan	604	607	PF01048	0.366
MOD_GlcNHglycan	97	100	PF01048	0.687
MOD_GSK3_1	241	248	PF00069	0.536
MOD_GSK3_1	295	302	PF00069	0.304
MOD_GSK3_1	389	396	PF00069	0.343
MOD_GSK3_1	467	474	PF00069	0.586
MOD_GSK3_1	584	591	PF00069	0.314
MOD_GSK3_1	635	642	PF00069	0.304
MOD_GSK3_1	95	102	PF00069	0.681
MOD_N-GLC_2	548	550	PF02516	0.304
MOD_NEK2_1	1	6	PF00069	0.549
MOD_NEK2_1	245	250	PF00069	0.550
MOD_NEK2_1	355	360	PF00069	0.660
MOD_NEK2_1	438	443	PF00069	0.347
MOD_NEK2_1	498	503	PF00069	0.304
MOD_NEK2_1	599	604	PF00069	0.313
MOD_NEK2_1	613	618	PF00069	0.282
MOD_OFUCOSY	429	434	PF10250	0.426
MOD_PIKK_1	310	316	PF00454	0.304
MOD_PKA_2	141	147	PF00069	0.605
MOD_PKA_2	246	252	PF00069	0.538
MOD_PKA_2	486	492	PF00069	0.460
MOD_PKA_2	613	619	PF00069	0.304
MOD_PKA_2	78	84	PF00069	0.602
MOD_PKB_1	485	493	PF00069	0.429
MOD_PKB_1	576	584	PF00069	0.304
MOD_Plk_1	273	279	PF00069	0.334
MOD_Plk_1	341	347	PF00069	0.428
MOD_Plk_1	529	535	PF00069	0.304
MOD_Plk_4	108	114	PF00069	0.515
MOD_Plk_4	241	247	PF00069	0.473
MOD_Plk_4	422	428	PF00069	0.451
MOD_Plk_4	487	493	PF00069	0.445
MOD_Plk_4	635	641	PF00069	0.315
MOD_Plk_4	86	92	PF00069	0.674
MOD_ProDKin_1	228	234	PF00069	0.569
MOD_ProDKin_1	357	363	PF00069	0.568
MOD_ProDKin_1	576	582	PF00069	0.317
MOD_ProDKin_1	84	90	PF00069	0.717
MOD_SUMO_rev_2	220	229	PF00179	0.559
TRG_DiLeu_BaEn_1	453	458	PF01217	0.440
TRG_DiLeu_BaEn_4	196	202	PF01217	0.435
TRG_DiLeu_LyEn_5	453	458	PF01217	0.440
TRG_ER_diArg_1	140	143	PF00400	0.611
TRG_ER_diArg_1	163	166	PF00400	0.529
TRG_ER_diArg_1	538	541	PF00400	0.313
TRG_NLS_MonoExtN_4	573	579	PF00514	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U1	Leptomonas seymouri	45%	100%
A0A3Q8IE59	Leishmania donovani	99%	100%
A4HH46	Leishmania braziliensis	70%	98%
E9ADP6	Leishmania major	87%	100%
E9AM34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%