LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I498_LEIIN
TriTrypDb:
LINF_290009400
Length:
379

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Annotations by Jardim et al.

Hydrolase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 14, no: 13
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16

Expansion

Sequence features

A4I498
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I498

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 28
GO:0016787 hydrolase activity 2 28

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 117 119 PF00675 0.315
CLV_NRD_NRD_1 16 18 PF00675 0.432
CLV_NRD_NRD_1 232 234 PF00675 0.542
CLV_NRD_NRD_1 347 349 PF00675 0.648
CLV_NRD_NRD_1 4 6 PF00675 0.493
CLV_PCSK_KEX2_1 232 234 PF00082 0.521
CLV_PCSK_KEX2_1 347 349 PF00082 0.646
CLV_PCSK_PC1ET2_1 347 349 PF00082 0.512
CLV_PCSK_SKI1_1 158 162 PF00082 0.282
CLV_PCSK_SKI1_1 316 320 PF00082 0.422
CLV_PCSK_SKI1_1 344 348 PF00082 0.661
DEG_APCC_KENBOX_2 288 292 PF00400 0.177
DOC_ANK_TNKS_1 85 92 PF00023 0.517
DOC_CKS1_1 373 378 PF01111 0.459
DOC_CKS1_1 47 52 PF01111 0.357
DOC_CKS1_1 68 73 PF01111 0.215
DOC_CYCLIN_RxL_1 178 186 PF00134 0.392
DOC_MAPK_gen_1 118 126 PF00069 0.377
DOC_MAPK_gen_1 287 296 PF00069 0.330
DOC_MAPK_gen_1 5 11 PF00069 0.497
DOC_MAPK_HePTP_8 286 298 PF00069 0.192
DOC_MAPK_MEF2A_6 119 128 PF00069 0.377
DOC_MAPK_MEF2A_6 289 298 PF00069 0.369
DOC_MAPK_MEF2A_6 316 324 PF00069 0.354
DOC_MAPK_RevD_3 335 350 PF00069 0.238
DOC_USP7_MATH_1 152 156 PF00917 0.502
DOC_USP7_MATH_1 335 339 PF00917 0.345
DOC_USP7_MATH_1 63 67 PF00917 0.359
DOC_USP7_UBL2_3 345 349 PF12436 0.338
DOC_WW_Pin1_4 257 262 PF00397 0.273
DOC_WW_Pin1_4 372 377 PF00397 0.431
DOC_WW_Pin1_4 46 51 PF00397 0.445
DOC_WW_Pin1_4 67 72 PF00397 0.227
LIG_14-3-3_CanoR_1 158 163 PF00244 0.530
LIG_14-3-3_CanoR_1 353 359 PF00244 0.412
LIG_14-3-3_CanoR_1 370 374 PF00244 0.343
LIG_14-3-3_CanoR_1 99 105 PF00244 0.561
LIG_Actin_WH2_2 90 107 PF00022 0.448
LIG_BIR_II_1 1 5 PF00653 0.532
LIG_BIR_III_1 1 5 PF00653 0.517
LIG_BIR_III_3 1 5 PF00653 0.517
LIG_BRCT_BRCA1_1 21 25 PF00533 0.377
LIG_Clathr_ClatBox_1 317 321 PF01394 0.246
LIG_eIF4E_1 177 183 PF01652 0.359
LIG_FHA_1 317 323 PF00498 0.369
LIG_FHA_1 35 41 PF00498 0.365
LIG_FHA_1 47 53 PF00498 0.365
LIG_FHA_2 373 379 PF00498 0.469
LIG_LIR_Apic_2 176 180 PF02991 0.509
LIG_LIR_Gen_1 334 343 PF02991 0.356
LIG_LIR_Nem_3 186 192 PF02991 0.465
LIG_LIR_Nem_3 334 339 PF02991 0.356
LIG_PDZ_Class_1 374 379 PF00595 0.361
LIG_Pex14_2 34 38 PF04695 0.186
LIG_PTB_Apo_2 327 334 PF02174 0.247
LIG_PTB_Phospho_1 327 333 PF10480 0.251
LIG_SH2_PTP2 177 180 PF00017 0.438
LIG_SH2_PTP2 189 192 PF00017 0.438
LIG_SH2_SRC 177 180 PF00017 0.439
LIG_SH2_SRC 194 197 PF00017 0.511
LIG_SH2_STAP1 333 337 PF00017 0.357
LIG_SH2_STAT5 177 180 PF00017 0.458
LIG_SH2_STAT5 189 192 PF00017 0.459
LIG_SH2_STAT5 194 197 PF00017 0.447
LIG_SH2_STAT5 327 330 PF00017 0.375
LIG_SH2_STAT5 48 51 PF00017 0.533
LIG_SH3_3 133 139 PF00018 0.392
LIG_SH3_3 361 367 PF00018 0.320
LIG_SH3_3 65 71 PF00018 0.203
LIG_SUMO_SIM_anti_2 208 215 PF11976 0.367
LIG_SUMO_SIM_anti_2 28 34 PF11976 0.212
LIG_SUMO_SIM_par_1 158 163 PF11976 0.392
LIG_SUMO_SIM_par_1 167 172 PF11976 0.364
LIG_SUMO_SIM_par_1 212 218 PF11976 0.427
LIG_SUMO_SIM_par_1 86 92 PF11976 0.462
LIG_TRFH_1 363 367 PF08558 0.247
LIG_UBA3_1 141 149 PF00899 0.433
LIG_WRC_WIRS_1 336 341 PF05994 0.215
MOD_CDC14_SPxK_1 3 6 PF00782 0.484
MOD_CDK_SPxxK_3 70 77 PF00069 0.196
MOD_CK2_1 351 357 PF00069 0.326
MOD_CK2_1 372 378 PF00069 0.425
MOD_GlcNHglycan 154 157 PF01048 0.325
MOD_GlcNHglycan 162 165 PF01048 0.269
MOD_GlcNHglycan 171 174 PF01048 0.234
MOD_GlcNHglycan 185 188 PF01048 0.249
MOD_GlcNHglycan 21 24 PF01048 0.192
MOD_GlcNHglycan 279 282 PF01048 0.519
MOD_GSK3_1 158 165 PF00069 0.390
MOD_GSK3_1 34 41 PF00069 0.384
MOD_GSK3_1 63 70 PF00069 0.348
MOD_N-GLC_1 183 188 PF02516 0.302
MOD_N-GLC_1 248 253 PF02516 0.443
MOD_NEK2_1 100 105 PF00069 0.467
MOD_NEK2_1 169 174 PF00069 0.521
MOD_NEK2_1 183 188 PF00069 0.443
MOD_NEK2_1 248 253 PF00069 0.284
MOD_NEK2_1 25 30 PF00069 0.418
MOD_NEK2_1 34 39 PF00069 0.339
MOD_NEK2_1 351 356 PF00069 0.362
MOD_PIKK_1 162 168 PF00454 0.576
MOD_PKA_2 100 106 PF00069 0.505
MOD_PKA_2 352 358 PF00069 0.416
MOD_PKA_2 369 375 PF00069 0.284
MOD_Plk_1 263 269 PF00069 0.352
MOD_Plk_4 263 269 PF00069 0.353
MOD_Plk_4 335 341 PF00069 0.356
MOD_Plk_4 34 40 PF00069 0.380
MOD_Plk_4 369 375 PF00069 0.365
MOD_ProDKin_1 257 263 PF00069 0.273
MOD_ProDKin_1 372 378 PF00069 0.435
MOD_ProDKin_1 46 52 PF00069 0.444
MOD_ProDKin_1 67 73 PF00069 0.227
MOD_SUMO_rev_2 146 150 PF00179 0.548
TRG_DiLeu_BaEn_1 140 145 PF01217 0.377
TRG_DiLeu_BaLyEn_6 155 160 PF01217 0.550
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.517
TRG_ENDOCYTIC_2 189 192 PF00928 0.521
TRG_ENDOCYTIC_2 202 205 PF00928 0.566
TRG_ENDOCYTIC_2 333 336 PF00928 0.300
TRG_NLS_MonoCore_2 346 351 PF00514 0.287
TRG_NLS_MonoExtC_3 343 348 PF00514 0.271
TRG_NLS_MonoExtN_4 341 348 PF00514 0.271

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3V2 Leptomonas seymouri 29% 100%
A0A0N1P9R1 Leptomonas seymouri 26% 100%
A0A0S4JMN0 Bodo saltans 32% 94%
A0A0S4KJG1 Bodo saltans 27% 100%
A0A1X0NU01 Trypanosomatidae 27% 100%
A0A1X0NZX7 Trypanosomatidae 35% 85%
A0A1X0P2G6 Trypanosomatidae 29% 100%
A0A3Q8IBB4 Leishmania donovani 28% 100%
A0A3Q8IIK0 Leishmania donovani 99% 100%
A0A3R7NTC0 Trypanosoma rangeli 27% 100%
A0A3S5IRW3 Trypanosoma rangeli 34% 92%
A0A3S7X3U9 Leishmania donovani 27% 100%
A4HCJ2 Leishmania braziliensis 29% 100%
A4HH45 Leishmania braziliensis 73% 100%
A4HIR7 Leishmania braziliensis 29% 100%
A4I008 Leishmania infantum 28% 100%
A4I612 Leishmania infantum 29% 100%
C9ZQ86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
C9ZRD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 85%
E9ADP5 Leishmania major 94% 100%
E9AM35 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AVY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B1A3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
O74480 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
Q4Q6W1 Leishmania major 30% 100%
Q4QBJ8 Leishmania major 28% 100%
Q944L7 Arabidopsis thaliana 26% 97%
V5ARZ9 Trypanosoma cruzi 26% 100%
V5BPY7 Trypanosoma cruzi 33% 86%
V5BX32 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS