Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I495_LEIIN

TriTrypDb:

LINF_290009100

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I495

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I495

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.652
CLV_NRD_NRD_1	274	276	PF00675	0.558
CLV_NRD_NRD_1	441	443	PF00675	0.637
CLV_NRD_NRD_1	534	536	PF00675	0.611
CLV_PCSK_FUR_1	439	443	PF00082	0.616
CLV_PCSK_KEX2_1	392	394	PF00082	0.524
CLV_PCSK_KEX2_1	441	443	PF00082	0.637
CLV_PCSK_KEX2_1	534	536	PF00082	0.612
CLV_PCSK_KEX2_1	573	575	PF00082	0.569
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.586
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.569
CLV_PCSK_SKI1_1	393	397	PF00082	0.502
CLV_PCSK_SKI1_1	447	451	PF00082	0.655
CLV_PCSK_SKI1_1	482	486	PF00082	0.630
CLV_Separin_Metazoa	507	511	PF03568	0.677
DEG_APCC_DBOX_1	450	458	PF00400	0.604
DEG_APCC_DBOX_1	563	571	PF00400	0.637
DEG_Nend_Nbox_1	1	3	PF02207	0.465
DEG_SCF_FBW7_1	74	80	PF00400	0.555
DEG_SCF_FBW7_2	402	408	PF00400	0.573
DOC_CKS1_1	340	345	PF01111	0.555
DOC_CKS1_1	402	407	PF01111	0.569
DOC_CKS1_1	489	494	PF01111	0.627
DOC_CKS1_1	74	79	PF01111	0.612
DOC_CYCLIN_yCln2_LP_2	200	206	PF00134	0.639
DOC_MAPK_RevD_3	558	574	PF00069	0.602
DOC_PP2B_LxvP_1	200	203	PF13499	0.643
DOC_PP2B_LxvP_1	450	453	PF13499	0.608
DOC_PP2B_LxvP_1	54	57	PF13499	0.771
DOC_USP7_MATH_1	11	15	PF00917	0.563
DOC_USP7_MATH_1	124	128	PF00917	0.665
DOC_USP7_MATH_1	359	363	PF00917	0.520
DOC_USP7_MATH_1	430	434	PF00917	0.609
DOC_USP7_MATH_1	543	547	PF00917	0.702
DOC_USP7_MATH_1	75	79	PF00917	0.637
DOC_USP7_UBL2_3	157	161	PF12436	0.624
DOC_WW_Pin1_4	130	135	PF00397	0.683
DOC_WW_Pin1_4	183	188	PF00397	0.637
DOC_WW_Pin1_4	223	228	PF00397	0.618
DOC_WW_Pin1_4	265	270	PF00397	0.657
DOC_WW_Pin1_4	314	319	PF00397	0.638
DOC_WW_Pin1_4	329	334	PF00397	0.645
DOC_WW_Pin1_4	336	341	PF00397	0.590
DOC_WW_Pin1_4	377	382	PF00397	0.674
DOC_WW_Pin1_4	39	44	PF00397	0.651
DOC_WW_Pin1_4	401	406	PF00397	0.572
DOC_WW_Pin1_4	409	414	PF00397	0.584
DOC_WW_Pin1_4	488	493	PF00397	0.623
DOC_WW_Pin1_4	520	525	PF00397	0.644
DOC_WW_Pin1_4	73	78	PF00397	0.625
LIG_14-3-3_CanoR_1	360	368	PF00244	0.613
LIG_14-3-3_CanoR_1	375	382	PF00244	0.550
LIG_14-3-3_CanoR_1	385	394	PF00244	0.646
LIG_14-3-3_CanoR_1	441	450	PF00244	0.654
LIG_14-3-3_CanoR_1	475	479	PF00244	0.628
LIG_14-3-3_CanoR_1	534	540	PF00244	0.616
LIG_BRCT_BRCA1_1	215	219	PF00533	0.532
LIG_DCNL_PONY_1	1	4	PF03556	0.532
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.609
LIG_FHA_1	179	185	PF00498	0.700
LIG_FHA_1	293	299	PF00498	0.617
LIG_FHA_1	329	335	PF00498	0.629
LIG_FHA_1	362	368	PF00498	0.555
LIG_FHA_1	402	408	PF00498	0.614
LIG_FHA_1	547	553	PF00498	0.633
LIG_FHA_1	74	80	PF00498	0.815
LIG_FHA_2	311	317	PF00498	0.665
LIG_FHA_2	502	508	PF00498	0.688
LIG_FHA_2	63	69	PF00498	0.643
LIG_LIR_Apic_2	465	470	PF02991	0.542
LIG_LIR_Gen_1	396	407	PF02991	0.498
LIG_LIR_Nem_3	129	135	PF02991	0.757
LIG_LIR_Nem_3	396	402	PF02991	0.487
LIG_MLH1_MIPbox_1	215	219	PF16413	0.532
LIG_MYND_1	568	572	PF01753	0.574
LIG_NRBOX	110	116	PF00104	0.532
LIG_NRBOX	88	94	PF00104	0.476
LIG_Pex14_2	390	394	PF04695	0.507
LIG_RPA_C_Fungi	355	367	PF08784	0.609
LIG_SH2_CRK	467	471	PF00017	0.543
LIG_SH2_NCK_1	399	403	PF00017	0.489
LIG_SH2_STAT5	218	221	PF00017	0.628
LIG_SH3_1	337	343	PF00018	0.579
LIG_SH3_1	513	519	PF00018	0.592
LIG_SH3_2	508	513	PF14604	0.592
LIG_SH3_3	181	187	PF00018	0.624
LIG_SH3_3	191	197	PF00018	0.641
LIG_SH3_3	202	208	PF00018	0.525
LIG_SH3_3	266	272	PF00018	0.674
LIG_SH3_3	293	299	PF00018	0.674
LIG_SH3_3	330	336	PF00018	0.668
LIG_SH3_3	337	343	PF00018	0.619
LIG_SH3_3	399	405	PF00018	0.507
LIG_SH3_3	505	511	PF00018	0.651
LIG_SH3_3	513	519	PF00018	0.587
LIG_SH3_3	566	572	PF00018	0.619
LIG_SH3_3	71	77	PF00018	0.613
LIG_SH3_4	157	164	PF00018	0.626
LIG_Sin3_3	148	155	PF02671	0.612
LIG_SUMO_SIM_anti_2	474	480	PF11976	0.547
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.629
LIG_SUMO_SIM_par_1	294	300	PF11976	0.614
LIG_TRAF2_1	28	31	PF00917	0.552
LIG_TRAF2_1	471	474	PF00917	0.622
MOD_CDC14_SPxK_1	133	136	PF00782	0.684
MOD_CDK_SPxK_1	130	136	PF00069	0.683
MOD_CDK_SPxK_1	329	335	PF00069	0.630
MOD_CDK_SPxK_1	78	84	PF00069	0.580
MOD_CK1_1	240	246	PF00069	0.628
MOD_CK1_1	258	264	PF00069	0.513
MOD_CK1_1	300	306	PF00069	0.570
MOD_CK1_1	445	451	PF00069	0.655
MOD_CK1_1	546	552	PF00069	0.644
MOD_CK1_1	78	84	PF00069	0.574
MOD_CK2_1	300	306	PF00069	0.613
MOD_CK2_1	310	316	PF00069	0.643
MOD_CK2_1	501	507	PF00069	0.630
MOD_CK2_1	62	68	PF00069	0.638
MOD_Cter_Amidation	439	442	PF01082	0.641
MOD_DYRK1A_RPxSP_1	265	269	PF00069	0.655
MOD_GlcNHglycan	191	194	PF01048	0.748
MOD_GlcNHglycan	239	242	PF01048	0.603
MOD_GlcNHglycan	272	275	PF01048	0.816
MOD_GlcNHglycan	361	364	PF01048	0.542
MOD_GlcNHglycan	432	435	PF01048	0.603
MOD_GlcNHglycan	528	531	PF01048	0.656
MOD_GlcNHglycan	541	544	PF01048	0.579
MOD_GlcNHglycan	546	549	PF01048	0.543
MOD_GSK3_1	179	186	PF00069	0.686
MOD_GSK3_1	30	37	PF00069	0.630
MOD_GSK3_1	310	317	PF00069	0.633
MOD_GSK3_1	371	378	PF00069	0.670
MOD_GSK3_1	381	388	PF00069	0.595
MOD_GSK3_1	39	46	PF00069	0.601
MOD_GSK3_1	441	448	PF00069	0.640
MOD_GSK3_1	535	542	PF00069	0.666
MOD_GSK3_1	73	80	PF00069	0.620
MOD_N-GLC_1	130	135	PF02516	0.704
MOD_N-GLC_1	258	263	PF02516	0.562
MOD_NEK2_1	178	183	PF00069	0.584
MOD_NEK2_1	328	333	PF00069	0.599
MOD_NEK2_1	457	462	PF00069	0.607
MOD_PIKK_1	43	49	PF00454	0.752
MOD_PKA_1	441	447	PF00069	0.629
MOD_PKA_1	534	540	PF00069	0.618
MOD_PKA_2	359	365	PF00069	0.745
MOD_PKA_2	441	447	PF00069	0.629
MOD_PKA_2	474	480	PF00069	0.627
MOD_PKA_2	534	540	PF00069	0.613
MOD_PKB_1	439	447	PF00069	0.609
MOD_Plk_1	124	130	PF00069	0.556
MOD_Plk_1	445	451	PF00069	0.655
MOD_Plk_1	84	90	PF00069	0.487
MOD_Plk_4	214	220	PF00069	0.703
MOD_Plk_4	292	298	PF00069	0.645
MOD_Plk_4	474	480	PF00069	0.603
MOD_ProDKin_1	130	136	PF00069	0.685
MOD_ProDKin_1	183	189	PF00069	0.637
MOD_ProDKin_1	223	229	PF00069	0.617
MOD_ProDKin_1	265	271	PF00069	0.655
MOD_ProDKin_1	314	320	PF00069	0.639
MOD_ProDKin_1	329	335	PF00069	0.645
MOD_ProDKin_1	336	342	PF00069	0.590
MOD_ProDKin_1	377	383	PF00069	0.673
MOD_ProDKin_1	39	45	PF00069	0.650
MOD_ProDKin_1	401	407	PF00069	0.572
MOD_ProDKin_1	409	415	PF00069	0.584
MOD_ProDKin_1	488	494	PF00069	0.623
MOD_ProDKin_1	520	526	PF00069	0.646
MOD_ProDKin_1	73	79	PF00069	0.616
MOD_SUMO_rev_2	277	287	PF00179	0.628
MOD_SUMO_rev_2	322	331	PF00179	0.707
TRG_DiLeu_BaEn_1	474	479	PF01217	0.604
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.559
TRG_ENDOCYTIC_2	399	402	PF00928	0.490
TRG_ER_diArg_1	334	337	PF00400	0.643
TRG_ER_diArg_1	439	442	PF00400	0.618
TRG_ER_diArg_1	533	535	PF00400	0.614
TRG_ER_diArg_1	563	566	PF00400	0.566
TRG_NLS_MonoCore_2	572	577	PF00514	0.616
TRG_NLS_MonoExtN_4	572	577	PF00514	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFI2	Leptomonas seymouri	30%	100%
A0A3Q8IDI0	Leishmania donovani	100%	100%
A4HH42	Leishmania braziliensis	58%	99%
E9ADP2	Leishmania major	88%	100%
E9AM38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%