Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I491_LEIIN

TriTrypDb:

LINF_290009600

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I491

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I491

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.616
CLV_C14_Caspase3-7	702	706	PF00656	0.726
CLV_NRD_NRD_1	128	130	PF00675	0.656
CLV_NRD_NRD_1	169	171	PF00675	0.662
CLV_NRD_NRD_1	250	252	PF00675	0.549
CLV_NRD_NRD_1	302	304	PF00675	0.713
CLV_NRD_NRD_1	350	352	PF00675	0.641
CLV_NRD_NRD_1	420	422	PF00675	0.598
CLV_NRD_NRD_1	461	463	PF00675	0.690
CLV_NRD_NRD_1	521	523	PF00675	0.679
CLV_NRD_NRD_1	569	571	PF00675	0.561
CLV_NRD_NRD_1	587	589	PF00675	0.672
CLV_NRD_NRD_1	605	607	PF00675	0.732
CLV_NRD_NRD_1	626	628	PF00675	0.692
CLV_NRD_NRD_1	644	646	PF00675	0.680
CLV_NRD_NRD_1	657	659	PF00675	0.607
CLV_NRD_NRD_1	669	671	PF00675	0.611
CLV_NRD_NRD_1	675	677	PF00675	0.441
CLV_NRD_NRD_1	685	687	PF00675	0.727
CLV_NRD_NRD_1	84	86	PF00675	0.715
CLV_PCSK_FUR_1	167	171	PF00082	0.458
CLV_PCSK_FUR_1	655	659	PF00082	0.693
CLV_PCSK_KEX2_1	128	130	PF00082	0.656
CLV_PCSK_KEX2_1	169	171	PF00082	0.486
CLV_PCSK_KEX2_1	302	304	PF00082	0.713
CLV_PCSK_KEX2_1	419	421	PF00082	0.607
CLV_PCSK_KEX2_1	461	463	PF00082	0.688
CLV_PCSK_KEX2_1	521	523	PF00082	0.679
CLV_PCSK_KEX2_1	569	571	PF00082	0.594
CLV_PCSK_KEX2_1	587	589	PF00082	0.672
CLV_PCSK_KEX2_1	605	607	PF00082	0.732
CLV_PCSK_KEX2_1	626	628	PF00082	0.692
CLV_PCSK_KEX2_1	657	659	PF00082	0.651
CLV_PCSK_KEX2_1	669	671	PF00082	0.607
CLV_PCSK_KEX2_1	675	677	PF00082	0.433
CLV_PCSK_KEX2_1	685	687	PF00082	0.727
CLV_PCSK_KEX2_1	84	86	PF00082	0.715
CLV_PCSK_PC7_1	416	422	PF00082	0.559
CLV_PCSK_SKI1_1	131	135	PF00082	0.547
CLV_PCSK_SKI1_1	188	192	PF00082	0.573
CLV_PCSK_SKI1_1	247	251	PF00082	0.502
CLV_PCSK_SKI1_1	266	270	PF00082	0.394
CLV_PCSK_SKI1_1	542	546	PF00082	0.513
CLV_PCSK_SKI1_1	558	562	PF00082	0.520
CLV_PCSK_SKI1_1	588	592	PF00082	0.726
CLV_Separin_Metazoa	164	168	PF03568	0.474
CLV_Separin_Metazoa	226	230	PF03568	0.446
DEG_APCC_DBOX_1	130	138	PF00400	0.535
DEG_APCC_DBOX_1	187	195	PF00400	0.638
DEG_SPOP_SBC_1	46	50	PF00917	0.632
DEG_SPOP_SBC_1	698	702	PF00917	0.788
DOC_CKS1_1	332	337	PF01111	0.698
DOC_CYCLIN_RxL_1	276	284	PF00134	0.600
DOC_CYCLIN_RxL_1	348	359	PF00134	0.604
DOC_CYCLIN_RxL_1	536	546	PF00134	0.680
DOC_MAPK_gen_1	277	285	PF00069	0.612
DOC_MAPK_MEF2A_6	277	285	PF00069	0.652
DOC_USP7_MATH_1	14	18	PF00917	0.714
DOC_USP7_MATH_1	205	209	PF00917	0.544
DOC_USP7_MATH_1	289	293	PF00917	0.601
DOC_USP7_MATH_1	390	394	PF00917	0.689
DOC_USP7_MATH_1	46	50	PF00917	0.668
DOC_USP7_MATH_1	475	479	PF00917	0.728
DOC_USP7_MATH_1	482	486	PF00917	0.801
DOC_USP7_MATH_1	501	505	PF00917	0.546
DOC_USP7_MATH_1	571	575	PF00917	0.584
DOC_USP7_MATH_1	699	703	PF00917	0.740
DOC_USP7_MATH_1	714	718	PF00917	0.697
DOC_WW_Pin1_4	10	15	PF00397	0.679
DOC_WW_Pin1_4	144	149	PF00397	0.660
DOC_WW_Pin1_4	293	298	PF00397	0.716
DOC_WW_Pin1_4	331	336	PF00397	0.785
DOC_WW_Pin1_4	485	490	PF00397	0.726
DOC_WW_Pin1_4	720	725	PF00397	0.755
DOC_WW_Pin1_4	88	93	PF00397	0.732
LIG_14-3-3_CanoR_1	173	177	PF00244	0.489
LIG_14-3-3_CanoR_1	24	29	PF00244	0.574
LIG_14-3-3_CanoR_1	251	260	PF00244	0.537
LIG_14-3-3_CanoR_1	266	271	PF00244	0.539
LIG_14-3-3_CanoR_1	536	544	PF00244	0.570
LIG_14-3-3_CanoR_1	587	591	PF00244	0.768
LIG_14-3-3_CanoR_1	605	615	PF00244	0.719
LIG_14-3-3_CanoR_1	685	694	PF00244	0.736
LIG_14-3-3_CanoR_1	7	14	PF00244	0.635
LIG_14-3-3_CanoR_1	720	724	PF00244	0.690
LIG_14-3-3_CanoR_1	85	91	PF00244	0.628
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_BIR_III_1	1	5	PF00653	0.728
LIG_BIR_III_3	1	5	PF00653	0.728
LIG_BIR_III_4	155	159	PF00653	0.624
LIG_BIR_III_4	633	637	PF00653	0.719
LIG_BRCT_BRCA1_1	592	596	PF00533	0.597
LIG_FAT_LD_1	346	354	PF03623	0.537
LIG_FHA_1	222	228	PF00498	0.489
LIG_FHA_1	308	314	PF00498	0.709
LIG_FHA_1	361	367	PF00498	0.450
LIG_FHA_1	376	382	PF00498	0.459
LIG_FHA_1	427	433	PF00498	0.447
LIG_FHA_1	448	454	PF00498	0.626
LIG_FHA_1	550	556	PF00498	0.538
LIG_FHA_1	620	626	PF00498	0.772
LIG_FHA_1	721	727	PF00498	0.703
LIG_FHA_2	307	313	PF00498	0.677
LIG_FHA_2	409	415	PF00498	0.680
LIG_FHA_2	485	491	PF00498	0.738
LIG_FHA_2	574	580	PF00498	0.733
LIG_FHA_2	609	615	PF00498	0.610
LIG_GBD_Chelix_1	126	134	PF00786	0.647
LIG_LIR_Gen_1	659	668	PF02991	0.681
LIG_LIR_Gen_1	692	699	PF02991	0.638
LIG_LIR_Nem_3	659	665	PF02991	0.679
LIG_LIR_Nem_3	692	697	PF02991	0.740
LIG_LIR_Nem_3	77	81	PF02991	0.754
LIG_MYND_1	724	728	PF01753	0.690
LIG_PTB_Apo_2	544	551	PF02174	0.538
LIG_PTB_Phospho_1	544	550	PF10480	0.538
LIG_RPA_C_Fungi	517	529	PF08784	0.676
LIG_RPA_C_Fungi	653	665	PF08784	0.611
LIG_SH2_STAP1	592	596	PF00017	0.624
LIG_SH2_STAT3	550	553	PF00017	0.483
LIG_SH2_STAT5	112	115	PF00017	0.718
LIG_SH2_STAT5	550	553	PF00017	0.534
LIG_SH3_2	297	302	PF14604	0.640
LIG_SH3_3	294	300	PF00018	0.623
LIG_SH3_3	332	338	PF00018	0.691
LIG_SUMO_SIM_anti_2	222	229	PF11976	0.503
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.513
LIG_SUMO_SIM_par_1	189	196	PF11976	0.535
LIG_SxIP_EBH_1	690	704	PF03271	0.635
MOD_CDK_SPxK_1	724	730	PF00069	0.693
MOD_CDK_SPxxK_3	12	19	PF00069	0.614
MOD_CK1_1	27	33	PF00069	0.733
MOD_CK1_1	331	337	PF00069	0.681
MOD_CK1_1	393	399	PF00069	0.747
MOD_CK1_1	485	491	PF00069	0.710
MOD_CK1_1	693	699	PF00069	0.796
MOD_CK1_1	9	15	PF00069	0.745
MOD_CK2_1	113	119	PF00069	0.441
MOD_CK2_1	133	139	PF00069	0.336
MOD_CK2_1	172	178	PF00069	0.553
MOD_CK2_1	306	312	PF00069	0.678
MOD_CK2_1	400	406	PF00069	0.626
MOD_CK2_1	408	414	PF00069	0.692
MOD_CK2_1	460	466	PF00069	0.770
MOD_CK2_1	47	53	PF00069	0.605
MOD_CK2_1	484	490	PF00069	0.744
MOD_CK2_1	535	541	PF00069	0.689
MOD_CK2_1	675	681	PF00069	0.580
MOD_CK2_1	74	80	PF00069	0.759
MOD_CK2_1	96	102	PF00069	0.754
MOD_Cter_Amidation	585	588	PF01082	0.739
MOD_Cter_Amidation	82	85	PF01082	0.730
MOD_DYRK1A_RPxSP_1	720	724	PF00069	0.697
MOD_GlcNHglycan	253	256	PF01048	0.436
MOD_GlcNHglycan	287	290	PF01048	0.607
MOD_GlcNHglycan	291	294	PF01048	0.625
MOD_GlcNHglycan	314	317	PF01048	0.720
MOD_GlcNHglycan	32	35	PF01048	0.667
MOD_GlcNHglycan	322	325	PF01048	0.611
MOD_GlcNHglycan	392	395	PF01048	0.730
MOD_GlcNHglycan	439	442	PF01048	0.436
MOD_GlcNHglycan	456	459	PF01048	0.534
MOD_GlcNHglycan	462	465	PF01048	0.585
MOD_GlcNHglycan	477	481	PF01048	0.657
MOD_GlcNHglycan	482	485	PF01048	0.681
MOD_GlcNHglycan	494	497	PF01048	0.665
MOD_GlcNHglycan	537	540	PF01048	0.608
MOD_GlcNHglycan	572	576	PF01048	0.679
MOD_GlcNHglycan	600	603	PF01048	0.731
MOD_GlcNHglycan	710	713	PF01048	0.729
MOD_GlcNHglycan	716	719	PF01048	0.664
MOD_GlcNHglycan	97	101	PF01048	0.758
MOD_GSK3_1	140	147	PF00069	0.584
MOD_GSK3_1	251	258	PF00069	0.536
MOD_GSK3_1	281	288	PF00069	0.537
MOD_GSK3_1	289	296	PF00069	0.508
MOD_GSK3_1	30	37	PF00069	0.746
MOD_GSK3_1	304	311	PF00069	0.635
MOD_GSK3_1	330	337	PF00069	0.751
MOD_GSK3_1	356	363	PF00069	0.497
MOD_GSK3_1	47	54	PF00069	0.494
MOD_GSK3_1	476	483	PF00069	0.781
MOD_GSK3_1	531	538	PF00069	0.693
MOD_GSK3_1	586	593	PF00069	0.568
MOD_GSK3_1	594	601	PF00069	0.652
MOD_GSK3_1	6	13	PF00069	0.682
MOD_GSK3_1	675	682	PF00069	0.658
MOD_GSK3_1	685	692	PF00069	0.744
MOD_GSK3_1	693	700	PF00069	0.765
MOD_GSK3_1	714	721	PF00069	0.758
MOD_GSK3_1	722	729	PF00069	0.667
MOD_GSK3_1	84	91	PF00069	0.805
MOD_N-GLC_1	266	271	PF02516	0.564
MOD_N-GLC_1	289	294	PF02516	0.567
MOD_N-GLC_1	328	333	PF02516	0.733
MOD_NEK2_1	133	138	PF00069	0.595
MOD_NEK2_1	230	235	PF00069	0.523
MOD_NEK2_1	281	286	PF00069	0.608
MOD_NEK2_1	32	37	PF00069	0.785
MOD_NEK2_1	360	365	PF00069	0.520
MOD_NEK2_1	590	595	PF00069	0.685
MOD_NEK2_1	708	713	PF00069	0.733
MOD_PIKK_1	261	267	PF00454	0.640
MOD_PIKK_1	336	342	PF00454	0.574
MOD_PIKK_1	398	404	PF00454	0.659
MOD_PIKK_1	531	537	PF00454	0.654
MOD_PIKK_1	549	555	PF00454	0.398
MOD_PIKK_1	594	600	PF00454	0.548
MOD_PIKK_1	648	654	PF00454	0.660
MOD_PK_1	657	663	PF00069	0.680
MOD_PKA_1	251	257	PF00069	0.536
MOD_PKA_1	657	663	PF00069	0.680
MOD_PKA_1	669	675	PF00069	0.504
MOD_PKA_1	685	691	PF00069	0.731
MOD_PKA_1	84	90	PF00069	0.819
MOD_PKA_2	172	178	PF00069	0.493
MOD_PKA_2	30	36	PF00069	0.735
MOD_PKA_2	460	466	PF00069	0.669
MOD_PKA_2	535	541	PF00069	0.683
MOD_PKA_2	562	568	PF00069	0.537
MOD_PKA_2	586	592	PF00069	0.713
MOD_PKA_2	6	12	PF00069	0.681
MOD_PKA_2	657	663	PF00069	0.555
MOD_PKA_2	669	675	PF00069	0.600
MOD_PKA_2	684	690	PF00069	0.746
MOD_PKA_2	719	725	PF00069	0.703
MOD_PKA_2	84	90	PF00069	0.765
MOD_PKB_1	22	30	PF00069	0.764
MOD_PKB_1	655	663	PF00069	0.630
MOD_Plk_1	221	227	PF00069	0.507
MOD_Plk_1	266	272	PF00069	0.554
MOD_Plk_2-3	150	156	PF00069	0.693
MOD_Plk_2-3	172	178	PF00069	0.608
MOD_Plk_2-3	196	202	PF00069	0.538
MOD_Plk_4	620	626	PF00069	0.757
MOD_Plk_4	657	663	PF00069	0.680
MOD_ProDKin_1	10	16	PF00069	0.675
MOD_ProDKin_1	144	150	PF00069	0.662
MOD_ProDKin_1	293	299	PF00069	0.718
MOD_ProDKin_1	331	337	PF00069	0.771
MOD_ProDKin_1	485	491	PF00069	0.723
MOD_ProDKin_1	720	726	PF00069	0.754
MOD_ProDKin_1	88	94	PF00069	0.731
MOD_SUMO_for_1	137	140	PF00179	0.615
MOD_SUMO_for_1	245	248	PF00179	0.542
MOD_SUMO_for_1	256	259	PF00179	0.532
MOD_SUMO_rev_2	538	545	PF00179	0.584
TRG_AP2beta_CARGO_1	659	669	PF09066	0.508
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.556
TRG_ENDOCYTIC_2	78	81	PF00928	0.762
TRG_ER_diArg_1	128	131	PF00400	0.654
TRG_ER_diArg_1	166	169	PF00400	0.463
TRG_ER_diArg_1	418	421	PF00400	0.636
TRG_ER_diArg_1	521	523	PF00400	0.679
TRG_ER_diArg_1	555	558	PF00400	0.519
TRG_ER_diArg_1	604	606	PF00400	0.716
TRG_ER_diArg_1	625	627	PF00400	0.695
TRG_ER_diArg_1	654	657	PF00400	0.655
TRG_ER_diArg_1	84	86	PF00400	0.689
TRG_NES_CRM1_1	345	358	PF08389	0.509
TRG_NES_CRM1_1	369	383	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	521	526	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9M3	Leptomonas seymouri	35%	96%
A0A3Q8IH40	Leishmania donovani	100%	100%
A4HH47	Leishmania braziliensis	62%	100%
E9ADP7	Leishmania major	88%	100%
E9AM33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	94%