LeishMANIAdb
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UBX_domain-containing_protein_-_putative

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
UBX_domain-containing_protein_-_putative
Gene product:
UBX domain-containing protein
Species:
Leishmania infantum
UniProt:
A4I486_LEIIN
TriTrypDb:
LINF_290008400
Length:
428

Annotations

Annotations by Jardim et al.

Protein modification, UBX domain-containing Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0005783 endoplasmic reticulum 5 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 101
Promastigote: 285

Expansion

Sequence features

A4I486
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I486

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010033 response to organic substance 3 1
GO:0010243 response to organonitrogen compound 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0030433 ubiquitin-dependent ERAD pathway 6 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0036503 ERAD pathway 5 1
GO:0042221 response to chemical 2 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0050896 response to stimulus 1 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0051716 cellular response to stimulus 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901698 response to nitrogen compound 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0032182 ubiquitin-like protein binding 3 1
GO:0043130 ubiquitin binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 141 145 PF00656 0.388
CLV_C14_Caspase3-7 281 285 PF00656 0.682
CLV_C14_Caspase3-7 335 339 PF00656 0.559
CLV_PCSK_SKI1_1 163 167 PF00082 0.501
CLV_PCSK_SKI1_1 398 402 PF00082 0.493
DEG_SPOP_SBC_1 303 307 PF00917 0.574
DEG_SPOP_SBC_1 350 354 PF00917 0.482
DOC_CKS1_1 360 365 PF01111 0.387
DOC_CKS1_1 89 94 PF01111 0.621
DOC_MAPK_DCC_7 382 391 PF00069 0.547
DOC_MAPK_FxFP_2 80 83 PF00069 0.597
DOC_MAPK_MEF2A_6 134 142 PF00069 0.352
DOC_MAPK_MEF2A_6 382 391 PF00069 0.509
DOC_MAPK_MEF2A_6 417 426 PF00069 0.342
DOC_PP2B_PxIxI_1 386 392 PF00149 0.501
DOC_PP4_FxxP_1 110 113 PF00568 0.375
DOC_PP4_FxxP_1 80 83 PF00568 0.688
DOC_USP7_MATH_1 161 165 PF00917 0.482
DOC_USP7_MATH_1 266 270 PF00917 0.581
DOC_USP7_MATH_1 302 306 PF00917 0.614
DOC_USP7_MATH_1 350 354 PF00917 0.545
DOC_USP7_MATH_1 97 101 PF00917 0.565
DOC_WW_Pin1_4 288 293 PF00397 0.685
DOC_WW_Pin1_4 319 324 PF00397 0.505
DOC_WW_Pin1_4 359 364 PF00397 0.408
DOC_WW_Pin1_4 44 49 PF00397 0.718
DOC_WW_Pin1_4 52 57 PF00397 0.713
DOC_WW_Pin1_4 62 67 PF00397 0.614
DOC_WW_Pin1_4 68 73 PF00397 0.606
DOC_WW_Pin1_4 88 93 PF00397 0.704
LIG_14-3-3_CanoR_1 121 125 PF00244 0.400
LIG_14-3-3_CanoR_1 163 171 PF00244 0.497
LIG_14-3-3_CanoR_1 348 358 PF00244 0.494
LIG_14-3-3_CanoR_1 96 106 PF00244 0.612
LIG_AP2alpha_2 244 246 PF02296 0.688
LIG_BIR_II_1 1 5 PF00653 0.524
LIG_BRCT_BRCA1_1 339 343 PF00533 0.541
LIG_deltaCOP1_diTrp_1 219 223 PF00928 0.549
LIG_FHA_1 151 157 PF00498 0.459
LIG_FHA_1 305 311 PF00498 0.732
LIG_FHA_1 353 359 PF00498 0.405
LIG_FHA_2 235 241 PF00498 0.481
LIG_FHA_2 323 329 PF00498 0.515
LIG_FHA_2 333 339 PF00498 0.570
LIG_FHA_2 399 405 PF00498 0.543
LIG_FHA_2 49 55 PF00498 0.624
LIG_LIR_Apic_2 327 332 PF02991 0.571
LIG_LIR_Apic_2 380 386 PF02991 0.525
LIG_LIR_Apic_2 78 83 PF02991 0.682
LIG_LIR_Gen_1 55 66 PF02991 0.596
LIG_LIR_Nem_3 369 373 PF02991 0.396
LIG_LIR_Nem_3 390 395 PF02991 0.514
LIG_LIR_Nem_3 411 416 PF02991 0.397
LIG_LIR_Nem_3 55 61 PF02991 0.605
LIG_NRBOX 370 376 PF00104 0.369
LIG_PDZ_Class_2 423 428 PF00595 0.474
LIG_Rb_LxCxE_1 166 187 PF01857 0.445
LIG_SH2_CRK 383 387 PF00017 0.443
LIG_SH2_NCK_1 329 333 PF00017 0.567
LIG_SH2_NCK_1 383 387 PF00017 0.443
LIG_SH2_NCK_1 58 62 PF00017 0.692
LIG_SH2_STAP1 173 177 PF00017 0.401
LIG_SH2_STAT5 115 118 PF00017 0.469
LIG_SH2_STAT5 24 27 PF00017 0.289
LIG_SH2_STAT5 329 332 PF00017 0.553
LIG_SH2_STAT5 370 373 PF00017 0.336
LIG_SH3_2 89 94 PF14604 0.606
LIG_SH3_3 239 245 PF00018 0.601
LIG_SH3_3 269 275 PF00018 0.704
LIG_SH3_3 287 293 PF00018 0.633
LIG_SH3_3 309 315 PF00018 0.601
LIG_SH3_3 357 363 PF00018 0.380
LIG_SH3_3 38 44 PF00018 0.471
LIG_SH3_3 86 92 PF00018 0.629
LIG_SUMO_SIM_anti_2 2 8 PF11976 0.445
LIG_SUMO_SIM_par_1 138 144 PF11976 0.439
LIG_SUMO_SIM_par_1 276 282 PF11976 0.602
LIG_SUMO_SIM_par_1 305 314 PF11976 0.655
LIG_SUMO_SIM_par_1 322 328 PF11976 0.355
LIG_WW_3 385 389 PF00397 0.439
LIG_WW_3 91 95 PF00397 0.578
MOD_CDK_SPxK_1 88 94 PF00069 0.574
MOD_CDK_SPxxK_3 359 366 PF00069 0.500
MOD_CK1_1 164 170 PF00069 0.423
MOD_CK1_1 262 268 PF00069 0.617
MOD_CK1_1 291 297 PF00069 0.677
MOD_CK1_1 305 311 PF00069 0.747
MOD_CK1_1 322 328 PF00069 0.525
MOD_CK1_1 352 358 PF00069 0.565
MOD_CK1_1 390 396 PF00069 0.456
MOD_CK1_1 60 66 PF00069 0.632
MOD_CK1_1 68 74 PF00069 0.630
MOD_CK2_1 282 288 PF00069 0.706
MOD_CK2_1 305 311 PF00069 0.753
MOD_CK2_1 322 328 PF00069 0.417
MOD_CK2_1 398 404 PF00069 0.580
MOD_CK2_1 98 104 PF00069 0.611
MOD_DYRK1A_RPxSP_1 359 363 PF00069 0.509
MOD_DYRK1A_RPxSP_1 88 92 PF00069 0.688
MOD_GlcNHglycan 166 169 PF01048 0.491
MOD_GlcNHglycan 224 227 PF01048 0.508
MOD_GlcNHglycan 261 264 PF01048 0.748
MOD_GlcNHglycan 266 269 PF01048 0.699
MOD_GlcNHglycan 392 395 PF01048 0.532
MOD_GlcNHglycan 417 420 PF01048 0.439
MOD_GlcNHglycan 67 70 PF01048 0.669
MOD_GSK3_1 116 123 PF00069 0.426
MOD_GSK3_1 262 269 PF00069 0.690
MOD_GSK3_1 291 298 PF00069 0.637
MOD_GSK3_1 302 309 PF00069 0.710
MOD_GSK3_1 333 340 PF00069 0.555
MOD_GSK3_1 44 51 PF00069 0.707
MOD_GSK3_1 52 59 PF00069 0.706
MOD_N-GLC_1 175 180 PF02516 0.421
MOD_N-GLC_1 398 403 PF02516 0.491
MOD_NEK2_1 234 239 PF00069 0.514
MOD_NEK2_1 98 103 PF00069 0.641
MOD_NEK2_2 268 273 PF00069 0.579
MOD_NEK2_2 387 392 PF00069 0.371
MOD_PIKK_1 203 209 PF00454 0.435
MOD_PKA_2 120 126 PF00069 0.508
MOD_PKA_2 387 393 PF00069 0.383
MOD_Plk_1 143 149 PF00069 0.469
MOD_Plk_1 327 333 PF00069 0.516
MOD_Plk_1 337 343 PF00069 0.510
MOD_Plk_1 378 384 PF00069 0.491
MOD_Plk_2-3 120 126 PF00069 0.402
MOD_Plk_2-3 282 288 PF00069 0.581
MOD_Plk_2-3 327 333 PF00069 0.488
MOD_Plk_4 138 144 PF00069 0.353
MOD_Plk_4 166 172 PF00069 0.414
MOD_Plk_4 338 344 PF00069 0.586
MOD_ProDKin_1 288 294 PF00069 0.686
MOD_ProDKin_1 319 325 PF00069 0.502
MOD_ProDKin_1 359 365 PF00069 0.408
MOD_ProDKin_1 44 50 PF00069 0.724
MOD_ProDKin_1 52 58 PF00069 0.712
MOD_ProDKin_1 62 68 PF00069 0.613
MOD_ProDKin_1 88 94 PF00069 0.706
TRG_DiLeu_BaLyEn_6 211 216 PF01217 0.441
TRG_DiLeu_BaLyEn_6 363 368 PF01217 0.385
TRG_ENDOCYTIC_2 58 61 PF00928 0.595
TRG_ER_diArg_1 343 346 PF00400 0.406
TRG_ER_diArg_1 93 96 PF00400 0.687

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7T7 Leptomonas seymouri 58% 100%
A0A0S4JDU8 Bodo saltans 26% 83%
A0A1X0NZG7 Trypanosomatidae 27% 97%
A0A3Q8IH33 Leishmania donovani 100% 100%
A0A3R7M3Q4 Trypanosoma rangeli 29% 100%
A4HH35 Leishmania braziliensis 83% 100%
C9ZKP3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9ADN5 Leishmania major 95% 100%
E9AM45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5B4U5 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS