Uncharacterized protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4I484_LEIIN

TriTrypDb:

LINF_290008200

Length:

352

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 345, 346, 38

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I484

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I484

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.545
CLV_NRD_NRD_1	179	181	PF00675	0.417
CLV_NRD_NRD_1	194	196	PF00675	0.564
CLV_NRD_NRD_1	200	202	PF00675	0.465
CLV_NRD_NRD_1	347	349	PF00675	0.551
CLV_PCSK_FUR_1	177	181	PF00082	0.498
CLV_PCSK_KEX2_1	179	181	PF00082	0.451
CLV_PCSK_KEX2_1	194	196	PF00082	0.502
CLV_PCSK_KEX2_1	200	202	PF00082	0.418
CLV_PCSK_KEX2_1	347	349	PF00082	0.551
CLV_PCSK_SKI1_1	111	115	PF00082	0.429
CLV_PCSK_SKI1_1	180	184	PF00082	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.500
DOC_ANK_TNKS_1	335	342	PF00023	0.559
DOC_PP4_FxxP_1	107	110	PF00568	0.432
DOC_USP7_MATH_1	219	223	PF00917	0.490
DOC_USP7_MATH_1	278	282	PF00917	0.474
DOC_USP7_MATH_1	342	346	PF00917	0.605
DOC_USP7_UBL2_3	294	298	PF12436	0.419
LIG_14-3-3_CanoR_1	34	42	PF00244	0.461
LIG_APCC_ABBA_1	68	73	PF00400	0.391
LIG_FHA_2	34	40	PF00498	0.513
LIG_FHA_2	344	350	PF00498	0.599
LIG_LIR_Apic_2	106	110	PF02991	0.434
LIG_PCNA_yPIPBox_3	287	300	PF02747	0.462
LIG_SH2_STAT5	169	172	PF00017	0.547
LIG_TRAF2_1	187	190	PF00917	0.462
MOD_CK1_1	172	178	PF00069	0.431
MOD_CK1_1	343	349	PF00069	0.591
MOD_CK2_1	27	33	PF00069	0.527
MOD_CK2_1	35	41	PF00069	0.624
MOD_GlcNHglycan	15	18	PF01048	0.569
MOD_GlcNHglycan	150	154	PF01048	0.461
MOD_GlcNHglycan	219	222	PF01048	0.535
MOD_GlcNHglycan	342	345	PF01048	0.728
MOD_GSK3_1	215	222	PF00069	0.434
MOD_GSK3_1	85	92	PF00069	0.434
MOD_N-GLC_1	163	168	PF02516	0.447
MOD_NEK2_2	144	149	PF00069	0.448
MOD_PKA_2	133	139	PF00069	0.341
MOD_PKA_2	172	178	PF00069	0.439
MOD_PKA_2	33	39	PF00069	0.461
MOD_Plk_1	144	150	PF00069	0.518
MOD_Plk_1	163	169	PF00069	0.487
MOD_Plk_2-3	25	31	PF00069	0.525
MOD_Plk_2-3	33	39	PF00069	0.487
MOD_Plk_4	246	252	PF00069	0.476
MOD_Plk_4	278	284	PF00069	0.502
MOD_SUMO_for_1	63	66	PF00179	0.447
MOD_SUMO_rev_2	158	163	PF00179	0.433
MOD_SUMO_rev_2	281	288	PF00179	0.474
TRG_ENDOCYTIC_2	96	99	PF00928	0.376
TRG_ER_diArg_1	131	134	PF00400	0.345
TRG_ER_diArg_1	177	180	PF00400	0.419
TRG_ER_diArg_1	199	201	PF00400	0.425
TRG_NES_CRM1_1	271	285	PF08389	0.474
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NZI2	Trypanosomatidae	48%	95%
A0A3Q8III7	Leishmania donovani	100%	100%
A4HH33	Leishmania braziliensis	73%	100%
C4NYP8	Drosophila melanogaster	28%	93%
E9ADN3	Leishmania major	87%	98%
E9AM47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
P50502	Homo sapiens	32%	95%
P50503	Rattus norvegicus	29%	96%
Q5RF31	Pongo abelii	32%	95%
Q5ZLF0	Gallus gallus	36%	98%
Q86DS1	Drosophila melanogaster	28%	93%
Q99L47	Mus musculus	30%	95%
V5BUJ8	Trypanosoma cruzi	44%	92%