Zinc-finger of a C2HC-type family protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type - putative

Species:

Leishmania infantum

UniProt:

A4I482_LEIIN

TriTrypDb:

LINF_290007900

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 135, 143

Expansion

Sequence features

A4I482

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I482

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.617
CLV_C14_Caspase3-7	66	70	PF00656	0.533
CLV_NRD_NRD_1	159	161	PF00675	0.650
CLV_NRD_NRD_1	187	189	PF00675	0.742
CLV_NRD_NRD_1	286	288	PF00675	0.687
CLV_NRD_NRD_1	331	333	PF00675	0.536
CLV_PCSK_KEX2_1	158	160	PF00082	0.627
CLV_PCSK_KEX2_1	187	189	PF00082	0.742
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.601
CLV_PCSK_SKI1_1	19	23	PF00082	0.546
DEG_SPOP_SBC_1	172	176	PF00917	0.522
DEG_SPOP_SBC_1	203	207	PF00917	0.482
DOC_MAPK_MEF2A_6	227	234	PF00069	0.611
DOC_USP7_MATH_1	299	303	PF00917	0.725
DOC_USP7_MATH_1	343	347	PF00917	0.604
DOC_USP7_MATH_1	355	359	PF00917	0.308
DOC_USP7_MATH_1	67	71	PF00917	0.527
DOC_USP7_MATH_1	94	98	PF00917	0.549
DOC_USP7_UBL2_3	275	279	PF12436	0.625
DOC_WW_Pin1_4	137	142	PF00397	0.637
DOC_WW_Pin1_4	30	35	PF00397	0.485
LIG_14-3-3_CanoR_1	132	141	PF00244	0.602
LIG_14-3-3_CanoR_1	19	29	PF00244	0.519
LIG_14-3-3_CanoR_1	266	272	PF00244	0.591
LIG_14-3-3_CanoR_1	52	60	PF00244	0.466
LIG_14-3-3_CanoR_1	9	16	PF00244	0.613
LIG_Actin_WH2_2	33	48	PF00022	0.489
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_FHA_1	166	172	PF00498	0.613
LIG_FHA_1	24	30	PF00498	0.545
LIG_FHA_2	272	278	PF00498	0.615
LIG_FHA_2	31	37	PF00498	0.461
LIG_LIR_Gen_1	148	157	PF02991	0.610
LIG_LIR_Gen_1	168	178	PF02991	0.603
LIG_LIR_Gen_1	36	47	PF02991	0.427
LIG_LIR_Nem_3	103	107	PF02991	0.560
LIG_LIR_Nem_3	118	124	PF02991	0.467
LIG_LIR_Nem_3	148	152	PF02991	0.676
LIG_LIR_Nem_3	168	173	PF02991	0.607
LIG_LIR_Nem_3	36	42	PF02991	0.424
LIG_SH2_NCK_1	209	213	PF00017	0.569
LIG_SH2_STAP1	209	213	PF00017	0.613
LIG_SH2_STAT5	199	202	PF00017	0.530
LIG_SH3_2	314	319	PF14604	0.674
LIG_SH3_3	136	142	PF00018	0.596
LIG_SH3_3	186	192	PF00018	0.628
LIG_SH3_3	197	203	PF00018	0.495
LIG_SH3_3	225	231	PF00018	0.647
LIG_SH3_3	311	317	PF00018	0.681
LIG_SH3_3	351	357	PF00018	0.317
LIG_SUMO_SIM_par_1	230	236	PF11976	0.607
LIG_TRFH_1	199	203	PF08558	0.578
MOD_CK1_1	103	109	PF00069	0.577
MOD_CK1_1	117	123	PF00069	0.590
MOD_CK1_1	165	171	PF00069	0.594
MOD_CK1_1	20	26	PF00069	0.508
MOD_CK1_1	205	211	PF00069	0.591
MOD_CK2_1	171	177	PF00069	0.602
MOD_CK2_1	94	100	PF00069	0.563
MOD_Cter_Amidation	285	288	PF01082	0.581
MOD_GlcNHglycan	1	4	PF01048	0.622
MOD_GlcNHglycan	189	192	PF01048	0.693
MOD_GlcNHglycan	209	212	PF01048	0.637
MOD_GlcNHglycan	279	282	PF01048	0.640
MOD_GlcNHglycan	284	287	PF01048	0.621
MOD_GlcNHglycan	301	304	PF01048	0.674
MOD_GlcNHglycan	334	337	PF01048	0.494
MOD_GlcNHglycan	47	50	PF01048	0.405
MOD_GlcNHglycan	86	89	PF01048	0.743
MOD_GSK3_1	116	123	PF00069	0.629
MOD_GSK3_1	172	179	PF00069	0.563
MOD_GSK3_1	203	210	PF00069	0.724
MOD_GSK3_1	267	274	PF00069	0.614
MOD_GSK3_1	299	306	PF00069	0.632
MOD_GSK3_1	90	97	PF00069	0.679
MOD_N-GLC_1	182	187	PF02516	0.621
MOD_NEK2_1	114	119	PF00069	0.599
MOD_NEK2_1	131	136	PF00069	0.650
MOD_NEK2_1	204	209	PF00069	0.597
MOD_NEK2_1	29	34	PF00069	0.470
MOD_NEK2_1	45	50	PF00069	0.342
MOD_PIKK_1	182	188	PF00454	0.660
MOD_PKA_1	187	193	PF00069	0.663
MOD_PKA_1	332	338	PF00069	0.471
MOD_PKA_2	131	137	PF00069	0.613
MOD_PKA_2	187	193	PF00069	0.745
MOD_PKA_2	29	35	PF00069	0.528
MOD_PKA_2	45	51	PF00069	0.357
MOD_ProDKin_1	137	143	PF00069	0.637
MOD_ProDKin_1	30	36	PF00069	0.482
MOD_SUMO_for_1	326	329	PF00179	0.587
MOD_SUMO_rev_2	233	240	PF00179	0.600
TRG_AP2beta_CARGO_1	36	46	PF09066	0.479
TRG_DiLeu_BaEn_1	24	29	PF01217	0.463
TRG_DiLeu_BaEn_2	165	171	PF01217	0.569
TRG_ER_diArg_1	187	189	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM20	Leptomonas seymouri	39%	100%
A0A3S7X263	Leishmania donovani	100%	100%
A4HH62	Leishmania braziliensis	67%	98%
E9ADN1	Leishmania major	85%	100%
E9AM49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BIK2	Trypanosoma cruzi	30%	68%