LeishMANIAdb
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D-lactate dehydrogenase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
D-lactate dehydrogenase-like protein
Gene product:
D-lactate dehydrogenase-like protein
Species:
Leishmania infantum
UniProt:
A4I481_LEIIN
TriTrypDb:
LINF_290007800
Length:
491

Annotations

Annotations by Jardim et al.

Glycolysis Proteins, D-lactate dehydrogenase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4I481
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I481

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 2
GO:0006089 lactate metabolic process 4 2
GO:0008152 metabolic process 1 2
GO:0009056 catabolic process 2 2
GO:0009987 cellular process 1 2
GO:0016054 organic acid catabolic process 4 2
GO:0019752 carboxylic acid metabolic process 5 2
GO:0032787 monocarboxylic acid metabolic process 6 2
GO:0043436 oxoacid metabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044248 cellular catabolic process 3 2
GO:0044281 small molecule metabolic process 2 2
GO:0044282 small molecule catabolic process 3 2
GO:0046395 carboxylic acid catabolic process 5 2
GO:0071704 organic substance metabolic process 2 2
GO:0072329 monocarboxylic acid catabolic process 6 2
GO:1901575 organic substance catabolic process 3 2
GO:1901615 organic hydroxy compound metabolic process 3 2
GO:1901616 organic hydroxy compound catabolic process 4 2
GO:1903457 lactate catabolic process 5 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0005488 binding 1 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0050660 flavin adenine dinucleotide binding 4 13
GO:0071949 FAD binding 5 13
GO:0097159 organic cyclic compound binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13
GO:0004457 lactate dehydrogenase activity 4 2
GO:0004458 D-lactate dehydrogenase (cytochrome) activity 5 2
GO:0008720 D-lactate dehydrogenase activity 5 2
GO:0016491 oxidoreductase activity 2 2
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 2
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 2
GO:0016898 oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 130 132 PF00675 0.420
CLV_NRD_NRD_1 198 200 PF00675 0.463
CLV_NRD_NRD_1 303 305 PF00675 0.313
CLV_NRD_NRD_1 341 343 PF00675 0.320
CLV_NRD_NRD_1 425 427 PF00675 0.280
CLV_NRD_NRD_1 43 45 PF00675 0.541
CLV_PCSK_KEX2_1 303 305 PF00082 0.395
CLV_PCSK_KEX2_1 341 343 PF00082 0.320
CLV_PCSK_KEX2_1 414 416 PF00082 0.383
CLV_PCSK_KEX2_1 425 427 PF00082 0.330
CLV_PCSK_PC1ET2_1 414 416 PF00082 0.359
CLV_PCSK_SKI1_1 131 135 PF00082 0.375
CLV_PCSK_SKI1_1 183 187 PF00082 0.316
CLV_PCSK_SKI1_1 326 330 PF00082 0.259
CLV_PCSK_SKI1_1 446 450 PF00082 0.432
CLV_PCSK_SKI1_1 464 468 PF00082 0.279
DEG_SCF_FBW7_1 184 190 PF00400 0.255
DEG_SIAH_1 58 66 PF03145 0.316
DOC_CKS1_1 184 189 PF01111 0.316
DOC_CKS1_1 84 89 PF01111 0.316
DOC_MAPK_gen_1 199 207 PF00069 0.434
DOC_MAPK_gen_1 414 421 PF00069 0.383
DOC_MAPK_MEF2A_6 176 184 PF00069 0.316
DOC_MAPK_MEF2A_6 287 296 PF00069 0.263
DOC_MAPK_MEF2A_6 414 423 PF00069 0.320
DOC_USP7_MATH_1 14 18 PF00917 0.515
DOC_USP7_MATH_1 148 152 PF00917 0.330
DOC_USP7_MATH_1 277 281 PF00917 0.462
DOC_USP7_MATH_1 340 344 PF00917 0.418
DOC_USP7_UBL2_3 137 141 PF12436 0.330
DOC_USP7_UBL2_3 319 323 PF12436 0.340
DOC_USP7_UBL2_3 355 359 PF12436 0.208
DOC_USP7_UBL2_3 45 49 PF12436 0.398
DOC_WW_Pin1_4 183 188 PF00397 0.316
DOC_WW_Pin1_4 83 88 PF00397 0.316
LIG_14-3-3_CanoR_1 131 136 PF00244 0.380
LIG_14-3-3_CanoR_1 199 207 PF00244 0.434
LIG_14-3-3_CanoR_1 287 294 PF00244 0.257
LIG_14-3-3_CanoR_1 341 349 PF00244 0.463
LIG_14-3-3_CanoR_1 64 74 PF00244 0.274
LIG_Actin_WH2_2 123 138 PF00022 0.274
LIG_Actin_WH2_2 398 416 PF00022 0.208
LIG_APCC_ABBA_1 404 409 PF00400 0.274
LIG_APCC_ABBAyCdc20_2 303 309 PF00400 0.227
LIG_BIR_II_1 1 5 PF00653 0.432
LIG_BRCT_BRCA1_1 342 346 PF00533 0.349
LIG_CtBP_PxDLS_1 28 34 PF00389 0.308
LIG_deltaCOP1_diTrp_1 335 345 PF00928 0.236
LIG_FHA_1 107 113 PF00498 0.316
LIG_FHA_1 192 198 PF00498 0.392
LIG_FHA_1 215 221 PF00498 0.330
LIG_FHA_1 36 42 PF00498 0.306
LIG_FHA_1 66 72 PF00498 0.274
LIG_FHA_2 111 117 PF00498 0.354
LIG_FHA_2 172 178 PF00498 0.316
LIG_FHA_2 334 340 PF00498 0.227
LIG_FHA_2 377 383 PF00498 0.360
LIG_FHA_2 90 96 PF00498 0.351
LIG_LIR_Gen_1 343 351 PF02991 0.274
LIG_LIR_Gen_1 398 407 PF02991 0.389
LIG_LIR_Nem_3 223 229 PF02991 0.428
LIG_LIR_Nem_3 309 313 PF02991 0.316
LIG_LIR_Nem_3 398 404 PF02991 0.399
LIG_LIR_Nem_3 6 12 PF02991 0.384
LIG_MLH1_MIPbox_1 342 346 PF16413 0.330
LIG_RPA_C_Insects 314 329 PF08784 0.208
LIG_SH2_CRK 310 314 PF00017 0.274
LIG_SH2_CRK 81 85 PF00017 0.274
LIG_SH2_NCK_1 407 411 PF00017 0.255
LIG_SH2_STAP1 407 411 PF00017 0.255
LIG_SH2_STAT3 479 482 PF00017 0.378
LIG_SH2_STAT5 211 214 PF00017 0.340
LIG_SH2_STAT5 327 330 PF00017 0.405
LIG_SH2_STAT5 407 410 PF00017 0.255
LIG_SH3_1 81 87 PF00018 0.274
LIG_SH3_3 142 148 PF00018 0.274
LIG_SH3_3 181 187 PF00018 0.321
LIG_SH3_3 362 368 PF00018 0.351
LIG_SH3_3 481 487 PF00018 0.421
LIG_SH3_3 81 87 PF00018 0.316
LIG_TRAF2_1 3 6 PF00917 0.565
LIG_TRAF2_1 378 381 PF00917 0.330
LIG_TRFH_1 226 230 PF08558 0.389
LIG_UBA3_1 228 233 PF00899 0.410
MOD_CDK_SPK_2 83 88 PF00069 0.351
MOD_CK1_1 214 220 PF00069 0.326
MOD_CK1_1 35 41 PF00069 0.409
MOD_CK2_1 171 177 PF00069 0.316
MOD_CK2_1 333 339 PF00069 0.324
MOD_CK2_1 89 95 PF00069 0.316
MOD_Cter_Amidation 301 304 PF01082 0.227
MOD_DYRK1A_RPxSP_1 183 187 PF00069 0.351
MOD_GlcNHglycan 1 4 PF01048 0.516
MOD_GlcNHglycan 162 165 PF01048 0.319
MOD_GlcNHglycan 201 204 PF01048 0.453
MOD_GlcNHglycan 235 238 PF01048 0.373
MOD_GlcNHglycan 288 291 PF01048 0.255
MOD_GlcNHglycan 346 349 PF01048 0.443
MOD_GlcNHglycan 355 358 PF01048 0.348
MOD_GlcNHglycan 434 437 PF01048 0.322
MOD_GSK3_1 10 17 PF00069 0.501
MOD_GSK3_1 106 113 PF00069 0.405
MOD_GSK3_1 162 169 PF00069 0.324
MOD_GSK3_1 183 190 PF00069 0.255
MOD_GSK3_1 277 284 PF00069 0.365
MOD_GSK3_1 340 347 PF00069 0.437
MOD_GSK3_1 35 42 PF00069 0.417
MOD_GSK3_1 45 52 PF00069 0.383
MOD_N-GLC_1 281 286 PF02516 0.275
MOD_N-GLC_1 65 70 PF02516 0.274
MOD_N-GLC_2 121 123 PF02516 0.351
MOD_NEK2_1 119 124 PF00069 0.274
MOD_NEK2_1 159 164 PF00069 0.345
MOD_NEK2_1 205 210 PF00069 0.394
MOD_NEK2_1 241 246 PF00069 0.381
MOD_NEK2_1 286 291 PF00069 0.350
MOD_NEK2_1 430 435 PF00069 0.408
MOD_NEK2_2 166 171 PF00069 0.316
MOD_NEK2_2 340 345 PF00069 0.420
MOD_PIKK_1 205 211 PF00454 0.384
MOD_PIKK_1 446 452 PF00454 0.255
MOD_PKA_1 131 137 PF00069 0.330
MOD_PKA_1 199 205 PF00069 0.446
MOD_PKA_2 110 116 PF00069 0.255
MOD_PKA_2 14 20 PF00069 0.349
MOD_PKA_2 198 204 PF00069 0.439
MOD_PKA_2 286 292 PF00069 0.278
MOD_PKA_2 340 346 PF00069 0.480
MOD_Plk_1 119 125 PF00069 0.274
MOD_Plk_1 205 211 PF00069 0.384
MOD_Plk_4 187 193 PF00069 0.273
MOD_Plk_4 260 266 PF00069 0.336
MOD_Plk_4 32 38 PF00069 0.467
MOD_Plk_4 333 339 PF00069 0.219
MOD_Plk_4 400 406 PF00069 0.274
MOD_ProDKin_1 183 189 PF00069 0.316
MOD_ProDKin_1 83 89 PF00069 0.316
MOD_SUMO_rev_2 324 334 PF00179 0.274
MOD_SUMO_rev_2 409 416 PF00179 0.350
TRG_ENDOCYTIC_2 310 313 PF00928 0.405
TRG_ER_diArg_1 424 426 PF00400 0.272
TRG_Pf-PMV_PEXEL_1 326 330 PF00026 0.326
TRG_PTS1 488 491 PF00515 0.414

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Q0 Leptomonas seymouri 26% 95%
A0A0N1PE88 Leptomonas seymouri 60% 99%
A0A0N1PEY1 Leptomonas seymouri 25% 79%
A0A0S4IT80 Bodo saltans 25% 100%
A0A0S4JD99 Bodo saltans 55% 100%
A0A0S4JV88 Bodo saltans 25% 77%
A0A1X0NXE7 Trypanosomatidae 25% 95%
A0A1X0P026 Trypanosomatidae 62% 100%
A0A1X0P2J0 Trypanosomatidae 24% 80%
A0A3Q8IDH3 Leishmania donovani 100% 100%
A0A3Q8IDH5 Leishmania donovani 62% 100%
A0A3Q8IEJ5 Leishmania donovani 26% 95%
A0A3Q8IRN9 Leishmania donovani 24% 79%
A0A422N649 Trypanosoma rangeli 26% 80%
A0A422N8Z9 Trypanosoma rangeli 27% 95%
A1L258 Danio rerio 24% 92%
A4HCV1 Leishmania braziliensis 26% 100%
A4HFX9 Leishmania braziliensis 61% 100%
A4HHV7 Leishmania braziliensis 25% 100%
A4I0D2 Leishmania infantum 26% 100%
A4I309 Leishmania infantum 62% 100%
A4I507 Leishmania infantum 24% 79%
A4VGK4 Pseudomonas stutzeri (strain A1501) 26% 100%
B8B7X6 Oryza sativa subsp. indica 26% 88%
C9ZQF7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 80%
D4MUV9 Anaerostipes hadrus 29% 100%
E9ADI2 Leishmania major 61% 100%
E9ADN0 Leishmania major 97% 100%
E9AM50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AW96 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AZA6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
E9B0D7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
F1QXM5 Danio rerio 34% 99%
H6LBS1 Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) 30% 100%
O23240 Arabidopsis thaliana 24% 88%
O29853 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 31% 100%
O96759 Dictyostelium discoideum 26% 80%
O97157 Trypanosoma brucei brucei 24% 80%
P0AEP9 Escherichia coli (strain K12) 29% 98%
P0AEQ0 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 29% 98%
P32891 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 84%
P39976 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 99%
P46681 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 93%
P84850 Rattus norvegicus 26% 92%
P94535 Bacillus subtilis (strain 168) 29% 100%
P9WIT0 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 30% 100%
P9WIT1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 30% 100%
Q12627 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 32% 85%
Q1JPD3 Bos taurus 27% 90%
Q46911 Escherichia coli (strain K12) 24% 100%
Q4QB82 Leishmania major 26% 100%
Q7TNG8 Mus musculus 34% 100%
Q7XI14 Oryza sativa subsp. japonica 26% 88%
Q7YWB6 Leishmania major 24% 100%
Q86WU2 Homo sapiens 32% 97%
Q8CIM3 Mus musculus 25% 92%
Q8N465 Homo sapiens 25% 94%
Q94AX4 Arabidopsis thaliana 35% 87%
Q9C1X2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 93%
V5BCB2 Trypanosoma cruzi 25% 80%
V5D7M3 Trypanosoma cruzi 26% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS