Tubulin-tyrosine ligase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin-tyrosine ligase family - putative

Species:

Leishmania infantum

UniProt:

A4I479_LEIIN

TriTrypDb:

LINF_290007600

Length:

617

Annotations

Annotations by Jardim et al.

Protein modification, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4I479

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I479

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0016874	ligase activity	2	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016881	acid-amino acid ligase activity	4	1
GO:0070739	protein-glutamic acid ligase activity	3	1
GO:0070740	tubulin-glutamic acid ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.252
CLV_NRD_NRD_1	150	152	PF00675	0.252
CLV_NRD_NRD_1	210	212	PF00675	0.302
CLV_NRD_NRD_1	256	258	PF00675	0.338
CLV_NRD_NRD_1	277	279	PF00675	0.266
CLV_NRD_NRD_1	298	300	PF00675	0.651
CLV_NRD_NRD_1	435	437	PF00675	0.384
CLV_NRD_NRD_1	454	456	PF00675	0.437
CLV_NRD_NRD_1	571	573	PF00675	0.492
CLV_NRD_NRD_1	614	616	PF00675	0.538
CLV_PCSK_FUR_1	165	169	PF00082	0.297
CLV_PCSK_FUR_1	433	437	PF00082	0.440
CLV_PCSK_KEX2_1	150	152	PF00082	0.264
CLV_PCSK_KEX2_1	167	169	PF00082	0.264
CLV_PCSK_KEX2_1	21	23	PF00082	0.701
CLV_PCSK_KEX2_1	210	212	PF00082	0.302
CLV_PCSK_KEX2_1	256	258	PF00082	0.343
CLV_PCSK_KEX2_1	260	262	PF00082	0.329
CLV_PCSK_KEX2_1	298	300	PF00082	0.650
CLV_PCSK_KEX2_1	435	437	PF00082	0.404
CLV_PCSK_KEX2_1	454	456	PF00082	0.437
CLV_PCSK_KEX2_1	571	573	PF00082	0.492
CLV_PCSK_KEX2_1	614	616	PF00082	0.538
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.340
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.701
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.338
CLV_PCSK_PC7_1	256	262	PF00082	0.338
CLV_PCSK_PC7_1	294	300	PF00082	0.587
CLV_PCSK_SKI1_1	102	106	PF00082	0.594
CLV_PCSK_SKI1_1	144	148	PF00082	0.254
CLV_PCSK_SKI1_1	224	228	PF00082	0.334
CLV_PCSK_SKI1_1	271	275	PF00082	0.338
CLV_PCSK_SKI1_1	365	369	PF00082	0.333
CLV_PCSK_SKI1_1	571	575	PF00082	0.463
CLV_Separin_Metazoa	451	455	PF03568	0.511
DEG_APCC_DBOX_1	12	20	PF00400	0.559
DEG_APCC_DBOX_1	340	348	PF00400	0.518
DEG_Nend_UBRbox_4	1	3	PF02207	0.467
DOC_CKS1_1	103	108	PF01111	0.538
DOC_CYCLIN_RxL_1	184	192	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.407
DOC_MAPK_DCC_7	484	493	PF00069	0.538
DOC_MAPK_gen_1	11	19	PF00069	0.559
DOC_MAPK_gen_1	256	267	PF00069	0.519
DOC_MAPK_gen_1	278	286	PF00069	0.463
DOC_MAPK_MEF2A_6	260	269	PF00069	0.485
DOC_MAPK_MEF2A_6	278	286	PF00069	0.355
DOC_MAPK_MEF2A_6	330	339	PF00069	0.452
DOC_MAPK_NFAT4_5	279	287	PF00069	0.557
DOC_PP1_RVXF_1	143	150	PF00149	0.464
DOC_PP1_RVXF_1	222	229	PF00149	0.557
DOC_PP1_RVXF_1	71	78	PF00149	0.497
DOC_PP2B_LxvP_1	191	194	PF13499	0.557
DOC_PP2B_LxvP_1	378	381	PF13499	0.573
DOC_PP2B_LxvP_1	425	428	PF13499	0.474
DOC_USP7_MATH_1	217	221	PF00917	0.502
DOC_USP7_MATH_1	304	308	PF00917	0.723
DOC_USP7_MATH_1	41	45	PF00917	0.755
DOC_USP7_MATH_1	417	421	PF00917	0.499
DOC_USP7_MATH_1	510	514	PF00917	0.538
DOC_WW_Pin1_4	1	6	PF00397	0.519
DOC_WW_Pin1_4	102	107	PF00397	0.585
DOC_WW_Pin1_4	215	220	PF00397	0.499
DOC_WW_Pin1_4	243	248	PF00397	0.466
DOC_WW_Pin1_4	300	305	PF00397	0.765
DOC_WW_Pin1_4	394	399	PF00397	0.641
DOC_WW_Pin1_4	495	500	PF00397	0.452
DOC_WW_Pin1_4	96	101	PF00397	0.557
LIG_14-3-3_CanoR_1	157	166	PF00244	0.420
LIG_14-3-3_CanoR_1	242	247	PF00244	0.538
LIG_14-3-3_CanoR_1	298	304	PF00244	0.766
LIG_14-3-3_CanoR_1	374	379	PF00244	0.524
LIG_14-3-3_CanoR_1	433	439	PF00244	0.430
LIG_Actin_WH2_2	470	486	PF00022	0.499
LIG_Actin_WH2_2	504	519	PF00022	0.515
LIG_APCC_ABBA_1	265	270	PF00400	0.538
LIG_APCC_ABBA_1	337	342	PF00400	0.452
LIG_Clathr_ClatBox_1	476	480	PF01394	0.452
LIG_eIF4E_1	268	274	PF01652	0.513
LIG_EVH1_2	88	92	PF00568	0.469
LIG_FHA_1	373	379	PF00498	0.550
LIG_FHA_1	441	447	PF00498	0.485
LIG_FHA_1	517	523	PF00498	0.538
LIG_FHA_1	584	590	PF00498	0.655
LIG_FHA_2	232	238	PF00498	0.538
LIG_FHA_2	243	249	PF00498	0.482
LIG_FHA_2	250	256	PF00498	0.376
LIG_FHA_2	503	509	PF00498	0.493
LIG_FHA_2	561	567	PF00498	0.573
LIG_FHA_2	76	82	PF00498	0.535
LIG_LIR_Gen_1	186	195	PF02991	0.554
LIG_LIR_Gen_1	196	203	PF02991	0.513
LIG_LIR_Gen_1	472	482	PF02991	0.540
LIG_LIR_Gen_1	62	72	PF02991	0.382
LIG_LIR_Nem_3	186	191	PF02991	0.554
LIG_LIR_Nem_3	196	200	PF02991	0.513
LIG_LIR_Nem_3	472	477	PF02991	0.538
LIG_LIR_Nem_3	518	523	PF02991	0.457
LIG_LIR_Nem_3	62	68	PF02991	0.394
LIG_LIR_Nem_3	76	80	PF02991	0.410
LIG_NRBOX	283	289	PF00104	0.557
LIG_REV1ctd_RIR_1	225	231	PF16727	0.493
LIG_SH2_CRK	130	134	PF00017	0.538
LIG_SH2_CRK	352	356	PF00017	0.452
LIG_SH2_CRK	65	69	PF00017	0.344
LIG_SH2_GRB2like	322	325	PF00017	0.479
LIG_SH2_NCK_1	352	356	PF00017	0.452
LIG_SH2_PTP2	285	288	PF00017	0.523
LIG_SH2_SRC	379	382	PF00017	0.563
LIG_SH2_STAP1	540	544	PF00017	0.559
LIG_SH2_STAT5	268	271	PF00017	0.455
LIG_SH2_STAT5	285	288	PF00017	0.452
LIG_SH2_STAT5	338	341	PF00017	0.500
LIG_SH2_STAT5	379	382	PF00017	0.563
LIG_SH3_3	100	106	PF00018	0.625
LIG_SH3_3	163	169	PF00018	0.510
LIG_SH3_3	266	272	PF00018	0.452
LIG_SH3_3	37	43	PF00018	0.553
LIG_SH3_3	395	401	PF00018	0.721
LIG_SUMO_SIM_anti_2	443	448	PF11976	0.452
LIG_SUMO_SIM_par_1	285	291	PF11976	0.545
LIG_SUMO_SIM_par_1	442	448	PF11976	0.317
LIG_SUMO_SIM_par_1	608	613	PF11976	0.534
LIG_TRAF2_1	25	28	PF00917	0.501
LIG_TYR_ITSM	61	68	PF00017	0.399
LIG_WRC_WIRS_1	418	423	PF05994	0.474
MOD_CDC14_SPxK_1	99	102	PF00782	0.606
MOD_CDK_SPxK_1	96	102	PF00069	0.567
MOD_CK1_1	196	202	PF00069	0.457
MOD_CK1_1	218	224	PF00069	0.405
MOD_CK1_1	297	303	PF00069	0.729
MOD_CK1_1	323	329	PF00069	0.510
MOD_CK1_1	96	102	PF00069	0.660
MOD_CK2_1	180	186	PF00069	0.564
MOD_CK2_1	231	237	PF00069	0.560
MOD_CK2_1	242	248	PF00069	0.499
MOD_CK2_1	249	255	PF00069	0.396
MOD_CK2_1	417	423	PF00069	0.491
MOD_CK2_1	434	440	PF00069	0.421
MOD_CK2_1	445	451	PF00069	0.280
MOD_CK2_1	469	475	PF00069	0.557
MOD_CK2_1	560	566	PF00069	0.370
MOD_CK2_1	79	85	PF00069	0.514
MOD_Cter_Amidation	276	279	PF01082	0.313
MOD_DYRK1A_RPxSP_1	102	106	PF00069	0.571
MOD_GlcNHglycan	159	162	PF01048	0.316
MOD_GlcNHglycan	43	46	PF01048	0.730
MOD_GlcNHglycan	447	450	PF01048	0.324
MOD_GlcNHglycan	51	55	PF01048	0.623
MOD_GlcNHglycan	512	515	PF01048	0.311
MOD_GlcNHglycan	577	580	PF01048	0.552
MOD_GSK3_1	115	122	PF00069	0.454
MOD_GSK3_1	153	160	PF00069	0.522
MOD_GSK3_1	189	196	PF00069	0.471
MOD_GSK3_1	294	301	PF00069	0.671
MOD_GSK3_1	3	10	PF00069	0.494
MOD_GSK3_1	318	325	PF00069	0.639
MOD_GSK3_1	361	368	PF00069	0.497
MOD_GSK3_1	407	414	PF00069	0.541
MOD_GSK3_1	417	424	PF00069	0.486
MOD_GSK3_1	75	82	PF00069	0.479
MOD_N-GLC_1	318	323	PF02516	0.687
MOD_N-GLC_1	372	377	PF02516	0.281
MOD_N-GLC_1	495	500	PF02516	0.252
MOD_NEK2_1	153	158	PF00069	0.504
MOD_NEK2_1	189	194	PF00069	0.530
MOD_NEK2_1	288	293	PF00069	0.486
MOD_NEK2_1	421	426	PF00069	0.511
MOD_NEK2_1	502	507	PF00069	0.477
MOD_NEK2_1	516	521	PF00069	0.477
MOD_NEK2_1	522	527	PF00069	0.321
MOD_NEK2_1	560	565	PF00069	0.519
MOD_PKA_1	298	304	PF00069	0.766
MOD_PKA_2	241	247	PF00069	0.538
MOD_PKA_2	297	303	PF00069	0.751
MOD_PKA_2	373	379	PF00069	0.444
MOD_PKA_2	434	440	PF00069	0.420
MOD_PKA_2	516	522	PF00069	0.557
MOD_PKA_2	560	566	PF00069	0.552
MOD_PKA_2	60	66	PF00069	0.530
MOD_Plk_1	115	121	PF00069	0.394
MOD_Plk_1	181	187	PF00069	0.502
MOD_Plk_1	318	324	PF00069	0.554
MOD_Plk_1	75	81	PF00069	0.529
MOD_Plk_2-3	81	87	PF00069	0.577
MOD_Plk_4	115	121	PF00069	0.394
MOD_Plk_4	374	380	PF00069	0.557
MOD_Plk_4	417	423	PF00069	0.487
MOD_Plk_4	442	448	PF00069	0.325
MOD_Plk_4	497	503	PF00069	0.452
MOD_ProDKin_1	1	7	PF00069	0.517
MOD_ProDKin_1	215	221	PF00069	0.499
MOD_ProDKin_1	243	249	PF00069	0.466
MOD_ProDKin_1	300	306	PF00069	0.765
MOD_ProDKin_1	394	400	PF00069	0.635
MOD_ProDKin_1	495	501	PF00069	0.452
MOD_ProDKin_1	96	102	PF00069	0.567
MOD_SUMO_rev_2	541	550	PF00179	0.575
TRG_DiLeu_BaEn_3	553	559	PF01217	0.426
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.513
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.477
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.486
TRG_ENDOCYTIC_2	130	133	PF00928	0.538
TRG_ENDOCYTIC_2	136	139	PF00928	0.538
TRG_ENDOCYTIC_2	285	288	PF00928	0.452
TRG_ENDOCYTIC_2	65	68	PF00928	0.352
TRG_ER_diArg_1	120	123	PF00400	0.450
TRG_ER_diArg_1	149	151	PF00400	0.499
TRG_ER_diArg_1	209	211	PF00400	0.502
TRG_ER_diArg_1	432	435	PF00400	0.424
TRG_ER_diArg_1	453	455	PF00400	0.424
TRG_ER_diArg_1	570	572	PF00400	0.490
TRG_ER_diArg_1	614	616	PF00400	0.582
TRG_NES_CRM1_1	440	456	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.272
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAP5	Leptomonas seymouri	25%	83%
A0A0N1IH77	Leptomonas seymouri	56%	100%
A0A0S4J7C9	Bodo saltans	25%	93%
A0A0S4JH38	Bodo saltans	33%	100%
A0A0S4KQK8	Bodo saltans	27%	94%
A0A1X0P0Y5	Trypanosomatidae	37%	100%
A0A1X0P6A0	Trypanosomatidae	26%	93%
A0A3Q8IDL7	Leishmania donovani	23%	100%
A0A3Q8III2	Leishmania donovani	27%	85%
A0A3S7X261	Leishmania donovani	100%	100%
A0A422N064	Trypanosoma rangeli	42%	100%
A0A422N932	Trypanosoma rangeli	26%	100%
A0A422P136	Trypanosoma rangeli	25%	94%
A4HH59	Leishmania braziliensis	75%	100%
A4HYN9	Leishmania infantum	23%	100%
A4IC28	Leishmania infantum	27%	85%
A4Q9E8	Mus musculus	26%	75%
A4Q9F6	Mus musculus	24%	77%
A6NNM8	Homo sapiens	25%	76%
A8CVX7	Danio rerio	27%	79%
B6DTF7	Bodo saltans	22%	100%
C9ZI96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	90%
C9ZKP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZPR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	94%
D0A044	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9ADM8	Leishmania major	92%	100%
E9AFW7	Leishmania major	26%	85%
E9AID0	Leishmania braziliensis	24%	100%
E9AM52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B720	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	85%
Q8N841	Homo sapiens	25%	73%
V5ARK1	Trypanosoma cruzi	26%	100%
V5B4U2	Trypanosoma cruzi	42%	100%