Protein transport protein Sec24C

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein transport protein Sec24A - putative

Species:

Leishmania infantum

UniProt:

A4I475_LEIIN

TriTrypDb:

LINF_290007100

Length:

966

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, transport Sec24A Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	11
GO:0030120	vesicle coat	4	11
GO:0030127	COPII vesicle coat	5	11
GO:0032991	protein-containing complex	1	11
GO:0070971	endoplasmic reticulum exit site	2	1
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I475

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I475

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	10
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	10
GO:0033036	macromolecule localization	2	11
GO:0035459	vesicle cargo loading	4	1
GO:0045184	establishment of protein localization	3	11

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	11
GO:0005515	protein binding	2	1
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.384
CLV_C14_Caspase3-7	388	392	PF00656	0.203
CLV_C14_Caspase3-7	496	500	PF00656	0.428
CLV_C14_Caspase3-7	514	518	PF00656	0.309
CLV_NRD_NRD_1	189	191	PF00675	0.589
CLV_NRD_NRD_1	359	361	PF00675	0.305
CLV_NRD_NRD_1	681	683	PF00675	0.272
CLV_NRD_NRD_1	955	957	PF00675	0.452
CLV_PCSK_FUR_1	679	683	PF00082	0.272
CLV_PCSK_KEX2_1	355	357	PF00082	0.417

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P662	Leptomonas seymouri	24%	93%
A0A0N1PA55	Leptomonas seymouri	70%	99%
A0A0S4KJI0	Bodo saltans	24%	87%
A0A1X0NMN7	Trypanosomatidae	25%	97%
A0A1X0NZG8	Trypanosomatidae	55%	100%
A0A3Q8IF67	Leishmania donovani	100%	100%
A0A3R7KKF1	Trypanosoma rangeli	50%	100%
A0A3R7MV46	Trypanosoma rangeli	26%	99%
A0A3S7WZ57	Leishmania donovani	24%	95%
A1CUC3	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	28%	100%

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