LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I474_LEIIN
TriTrypDb:
LINF_290007000
Length:
267

Annotations

LeishMANIAdb annotations

A protein of unknown function. Rare homologs are found outside Kinetoplastida, but also uncharacterized (e.g. E1ZIK9_CHLVA)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 2
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4I474
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I474

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 24 28 PF00656 0.607
CLV_NRD_NRD_1 104 106 PF00675 0.621
CLV_NRD_NRD_1 263 265 PF00675 0.642
CLV_PCSK_KEX2_1 104 106 PF00082 0.600
CLV_PCSK_KEX2_1 140 142 PF00082 0.610
CLV_PCSK_KEX2_1 263 265 PF00082 0.609
CLV_PCSK_KEX2_1 40 42 PF00082 0.639
CLV_PCSK_PC1ET2_1 140 142 PF00082 0.614
CLV_PCSK_PC1ET2_1 40 42 PF00082 0.625
CLV_PCSK_SKI1_1 111 115 PF00082 0.608
CLV_PCSK_SKI1_1 40 44 PF00082 0.528
DEG_APCC_DBOX_1 103 111 PF00400 0.391
DOC_MAPK_gen_1 104 110 PF00069 0.382
DOC_MAPK_gen_1 40 49 PF00069 0.379
DOC_USP7_MATH_1 21 25 PF00917 0.612
DOC_USP7_MATH_1 28 32 PF00917 0.626
DOC_USP7_MATH_1 75 79 PF00917 0.419
DOC_USP7_UBL2_3 36 40 PF12436 0.335
LIG_14-3-3_CanoR_1 104 108 PF00244 0.421
LIG_14-3-3_CanoR_1 141 150 PF00244 0.413
LIG_14-3-3_CanoR_1 6 11 PF00244 0.610
LIG_BRCT_BRCA1_1 131 135 PF00533 0.331
LIG_BRCT_BRCA1_1 160 164 PF00533 0.378
LIG_deltaCOP1_diTrp_1 156 164 PF00928 0.356
LIG_FHA_1 10 16 PF00498 0.511
LIG_FHA_1 239 245 PF00498 0.454
LIG_FHA_1 93 99 PF00498 0.414
LIG_FHA_2 104 110 PF00498 0.365
LIG_FHA_2 140 146 PF00498 0.400
LIG_GBD_Chelix_1 236 244 PF00786 0.398
LIG_LIR_Gen_1 170 180 PF02991 0.337
LIG_LIR_Gen_1 241 251 PF02991 0.566
LIG_LIR_Gen_1 63 74 PF02991 0.316
LIG_LIR_Nem_3 170 175 PF02991 0.409
LIG_LIR_Nem_3 241 246 PF02991 0.441
LIG_LIR_Nem_3 63 69 PF02991 0.390
LIG_NRBOX 12 18 PF00104 0.579
LIG_Pex14_1 183 187 PF04695 0.328
LIG_Pex14_2 179 183 PF04695 0.328
LIG_PTB_Apo_2 154 161 PF02174 0.408
LIG_PTB_Phospho_1 154 160 PF10480 0.408
LIG_REV1ctd_RIR_1 83 89 PF16727 0.467
LIG_SH2_CRK 128 132 PF00017 0.329
LIG_SH2_CRK 160 164 PF00017 0.337
LIG_SH2_CRK 66 70 PF00017 0.375
LIG_SH2_CRK 87 91 PF00017 0.479
LIG_SH2_GRB2like 155 158 PF00017 0.408
LIG_SH2_NCK_1 87 91 PF00017 0.460
LIG_SH2_SRC 155 158 PF00017 0.408
LIG_SH2_STAP1 155 159 PF00017 0.350
LIG_SH2_STAP1 160 164 PF00017 0.362
LIG_SH2_STAP1 198 202 PF00017 0.366
LIG_SH2_STAP1 208 212 PF00017 0.562
LIG_SH2_STAP1 224 228 PF00017 0.434
LIG_SH2_STAT3 249 252 PF00017 0.423
LIG_SH2_STAT5 210 213 PF00017 0.614
LIG_SH2_STAT5 243 246 PF00017 0.403
LIG_SH2_STAT5 87 90 PF00017 0.457
LIG_SUMO_SIM_anti_2 12 18 PF11976 0.451
LIG_SUMO_SIM_par_1 236 241 PF11976 0.454
LIG_TYR_ITIM 195 200 PF00017 0.376
LIG_TYR_ITSM 239 246 PF00017 0.475
LIG_UBA3_1 120 125 PF00899 0.339
MOD_CK1_1 146 152 PF00069 0.378
MOD_CK1_1 162 168 PF00069 0.439
MOD_CK1_1 22 28 PF00069 0.598
MOD_CK2_1 103 109 PF00069 0.406
MOD_CK2_1 139 145 PF00069 0.434
MOD_CK2_1 162 168 PF00069 0.456
MOD_CK2_1 203 209 PF00069 0.602
MOD_GlcNHglycan 21 24 PF01048 0.647
MOD_GlcNHglycan 77 80 PF01048 0.596
MOD_GSK3_1 139 146 PF00069 0.388
MOD_GSK3_1 158 165 PF00069 0.425
MOD_GSK3_1 5 12 PF00069 0.600
MOD_NEK2_1 19 24 PF00069 0.518
MOD_NEK2_1 238 243 PF00069 0.475
MOD_NEK2_1 85 90 PF00069 0.441
MOD_NEK2_2 129 134 PF00069 0.432
MOD_NEK2_2 159 164 PF00069 0.362
MOD_PKA_2 103 109 PF00069 0.400
MOD_PKA_2 5 11 PF00069 0.611
MOD_PKB_1 4 12 PF00069 0.645
MOD_Plk_2-3 168 174 PF00069 0.379
MOD_Plk_4 159 165 PF00069 0.359
MOD_Plk_4 238 244 PF00069 0.417
MOD_Plk_4 9 15 PF00069 0.465
MOD_SUMO_for_1 42 45 PF00179 0.317
MOD_SUMO_rev_2 132 142 PF00179 0.412
MOD_SUMO_rev_2 30 38 PF00179 0.410
TRG_DiLeu_BaEn_1 115 120 PF01217 0.412
TRG_DiLeu_BaLyEn_6 231 236 PF01217 0.449
TRG_DiLeu_BaLyEn_6 94 99 PF01217 0.427
TRG_DiLeu_LyEn_5 115 120 PF01217 0.431
TRG_ENDOCYTIC_2 128 131 PF00928 0.331
TRG_ENDOCYTIC_2 160 163 PF00928 0.330
TRG_ENDOCYTIC_2 197 200 PF00928 0.375
TRG_ENDOCYTIC_2 243 246 PF00928 0.534
TRG_ENDOCYTIC_2 66 69 PF00928 0.371
TRG_ER_diArg_1 103 105 PF00400 0.424
TRG_ER_diArg_1 4 7 PF00400 0.687
TRG_NLS_MonoExtC_3 39 45 PF00514 0.327
TRG_Pf-PMV_PEXEL_1 105 109 PF00026 0.571
TRG_Pf-PMV_PEXEL_1 111 115 PF00026 0.577
TRG_Pf-PMV_PEXEL_1 141 145 PF00026 0.624
TRG_Pf-PMV_PEXEL_1 97 101 PF00026 0.581

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3Y7 Leptomonas seymouri 70% 98%
A0A0S4JLZ3 Bodo saltans 38% 82%
A0A1X0NZF4 Trypanosomatidae 49% 100%
A0A3Q8IBA6 Leishmania donovani 100% 100%
A0A422NUT6 Trypanosoma rangeli 43% 100%
A4HH29 Leishmania braziliensis 85% 100%
C9ZKQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 99%
E9ADM3 Leishmania major 94% 100%
E9AM58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5B4T7 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS