Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I472_LEIIN

TriTrypDb:

LINF_290006800

Length:

1015

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I472

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I472

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.809
CLV_C14_Caspase3-7	197	201	PF00656	0.587
CLV_C14_Caspase3-7	795	799	PF00656	0.480
CLV_NRD_NRD_1	177	179	PF00675	0.722
CLV_NRD_NRD_1	538	540	PF00675	0.722
CLV_NRD_NRD_1	678	680	PF00675	0.546
CLV_NRD_NRD_1	810	812	PF00675	0.589
CLV_NRD_NRD_1	849	851	PF00675	0.724
CLV_NRD_NRD_1	962	964	PF00675	0.502
CLV_NRD_NRD_1	984	986	PF00675	0.564
CLV_PCSK_KEX2_1	177	179	PF00082	0.722
CLV_PCSK_KEX2_1	232	234	PF00082	0.841
CLV_PCSK_KEX2_1	538	540	PF00082	0.722
CLV_PCSK_KEX2_1	582	584	PF00082	0.814
CLV_PCSK_KEX2_1	678	680	PF00082	0.546
CLV_PCSK_KEX2_1	810	812	PF00082	0.541
CLV_PCSK_KEX2_1	849	851	PF00082	0.736
CLV_PCSK_KEX2_1	961	963	PF00082	0.544
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.771
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.792
CLV_PCSK_SKI1_1	227	231	PF00082	0.797
CLV_PCSK_SKI1_1	386	390	PF00082	0.719
CLV_PCSK_SKI1_1	446	450	PF00082	0.592
CLV_PCSK_SKI1_1	669	673	PF00082	0.485
CLV_PCSK_SKI1_1	674	678	PF00082	0.513
CLV_PCSK_SKI1_1	679	683	PF00082	0.568
CLV_PCSK_SKI1_1	700	704	PF00082	0.514
CLV_PCSK_SKI1_1	810	814	PF00082	0.587
DEG_APCC_DBOX_1	176	184	PF00400	0.707
DEG_Nend_UBRbox_2	1	3	PF02207	0.793
DEG_ODPH_VHL_1	773	784	PF01847	0.566
DEG_SCF_FBW7_1	835	842	PF00400	0.671
DEG_SPOP_SBC_1	24	28	PF00917	0.751
DOC_ANK_TNKS_1	467	474	PF00023	0.782
DOC_ANK_TNKS_1	508	515	PF00023	0.709
DOC_CKS1_1	166	171	PF01111	0.583
DOC_CKS1_1	319	324	PF01111	0.701
DOC_CKS1_1	372	377	PF01111	0.745
DOC_CKS1_1	730	735	PF01111	0.672
DOC_CKS1_1	836	841	PF01111	0.614
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.798
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.757
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.727
DOC_CYCLIN_yCln2_LP_2	833	836	PF00134	0.664
DOC_MAPK_DCC_7	731	741	PF00069	0.443
DOC_MAPK_gen_1	177	185	PF00069	0.703
DOC_MAPK_gen_1	489	499	PF00069	0.677
DOC_PP1_RVXF_1	119	126	PF00149	0.658
DOC_PP2B_LxvP_1	349	352	PF13499	0.692
DOC_PP2B_LxvP_1	354	357	PF13499	0.629
DOC_PP2B_LxvP_1	418	421	PF13499	0.683
DOC_PP2B_LxvP_1	71	74	PF13499	0.728
DOC_PP2B_LxvP_1	833	836	PF13499	0.667
DOC_PP4_FxxP_1	221	224	PF00568	0.709
DOC_PP4_FxxP_1	895	898	PF00568	0.652
DOC_USP7_MATH_1	116	120	PF00917	0.673
DOC_USP7_MATH_1	133	137	PF00917	0.664
DOC_USP7_MATH_1	173	177	PF00917	0.775
DOC_USP7_MATH_1	249	253	PF00917	0.741
DOC_USP7_MATH_1	254	258	PF00917	0.745
DOC_USP7_MATH_1	278	282	PF00917	0.675
DOC_USP7_MATH_1	309	313	PF00917	0.808
DOC_USP7_MATH_1	345	349	PF00917	0.644
DOC_USP7_MATH_1	522	526	PF00917	0.703
DOC_USP7_MATH_1	527	531	PF00917	0.717
DOC_USP7_MATH_1	532	536	PF00917	0.714
DOC_USP7_MATH_1	586	590	PF00917	0.703
DOC_USP7_MATH_1	692	696	PF00917	0.671
DOC_USP7_MATH_1	856	860	PF00917	0.716
DOC_USP7_MATH_1	979	983	PF00917	0.641
DOC_WW_Pin1_4	165	170	PF00397	0.584
DOC_WW_Pin1_4	220	225	PF00397	0.767
DOC_WW_Pin1_4	236	241	PF00397	0.573
DOC_WW_Pin1_4	318	323	PF00397	0.721
DOC_WW_Pin1_4	337	342	PF00397	0.645
DOC_WW_Pin1_4	371	376	PF00397	0.760
DOC_WW_Pin1_4	402	407	PF00397	0.731
DOC_WW_Pin1_4	62	67	PF00397	0.710
DOC_WW_Pin1_4	729	734	PF00397	0.586
DOC_WW_Pin1_4	75	80	PF00397	0.699
DOC_WW_Pin1_4	815	820	PF00397	0.681
DOC_WW_Pin1_4	835	840	PF00397	0.616
DOC_WW_Pin1_4	89	94	PF00397	0.724
LIG_14-3-3_CanoR_1	139	144	PF00244	0.725
LIG_14-3-3_CanoR_1	209	214	PF00244	0.745
LIG_14-3-3_CanoR_1	433	438	PF00244	0.636
LIG_14-3-3_CanoR_1	492	498	PF00244	0.688
LIG_14-3-3_CanoR_1	700	708	PF00244	0.583
LIG_Actin_WH2_2	665	680	PF00022	0.574
LIG_BIR_III_2	727	731	PF00653	0.700
LIG_BIR_III_4	38	42	PF00653	0.595
LIG_BRCT_BRCA1_1	279	283	PF00533	0.622
LIG_BRCT_BRCA1_1	637	641	PF00533	0.722
LIG_FHA_1	19	25	PF00498	0.756
LIG_FHA_1	494	500	PF00498	0.777
LIG_FHA_1	836	842	PF00498	0.544
LIG_FHA_1	911	917	PF00498	0.456
LIG_FHA_2	11	17	PF00498	0.708
LIG_FHA_2	151	157	PF00498	0.725
LIG_FHA_2	166	172	PF00498	0.697
LIG_FHA_2	405	411	PF00498	0.814
LIG_FHA_2	680	686	PF00498	0.589
LIG_FHA_2	793	799	PF00498	0.422
LIG_FHA_2	801	807	PF00498	0.451
LIG_FHA_2	824	830	PF00498	0.619
LIG_FHA_2	930	936	PF00498	0.646
LIG_FHA_2	944	950	PF00498	0.534
LIG_GBD_Chelix_1	1001	1009	PF00786	0.571
LIG_GSK3_LRP6_1	835	840	PF00069	0.688
LIG_Integrin_RGD_1	744	746	PF01839	0.553
LIG_LIR_Apic_2	219	224	PF02991	0.709
LIG_LIR_Apic_2	893	898	PF02991	0.672
LIG_LIR_Gen_1	184	193	PF02991	0.607
LIG_LIR_Gen_1	280	290	PF02991	0.622
LIG_LIR_Gen_1	373	384	PF02991	0.587
LIG_LIR_Gen_1	663	672	PF02991	0.475
LIG_LIR_Gen_1	67	77	PF02991	0.695
LIG_LIR_Nem_3	184	188	PF02991	0.620
LIG_LIR_Nem_3	189	194	PF02991	0.640
LIG_LIR_Nem_3	280	286	PF02991	0.615
LIG_LIR_Nem_3	373	379	PF02991	0.684
LIG_LIR_Nem_3	663	668	PF02991	0.482
LIG_LIR_Nem_3	67	73	PF02991	0.695
LIG_LIR_Nem_3	734	740	PF02991	0.518
LIG_LIR_Nem_3	870	874	PF02991	0.719
LIG_LIR_Nem_3	934	939	PF02991	0.594
LIG_LYPXL_S_1	736	740	PF13949	0.573
LIG_LYPXL_yS_3	737	740	PF13949	0.569
LIG_LYPXL_yS_3	936	939	PF13949	0.599
LIG_MAD2	831	839	PF02301	0.652
LIG_MYND_1	352	356	PF01753	0.735
LIG_MYND_1	416	420	PF01753	0.726
LIG_PCNA_APIM_2	672	678	PF02747	0.517
LIG_SH2_CRK	665	669	PF00017	0.517
LIG_SH2_CRK	871	875	PF00017	0.721
LIG_SH2_GRB2like	634	637	PF00017	0.714
LIG_SH2_NCK_1	597	601	PF00017	0.699
LIG_SH2_NCK_1	726	730	PF00017	0.625
LIG_SH2_SRC	4	7	PF00017	0.653
LIG_SH2_SRC	422	425	PF00017	0.809
LIG_SH2_STAP1	4	8	PF00017	0.659
LIG_SH2_STAT5	634	637	PF00017	0.753
LIG_SH2_STAT5	675	678	PF00017	0.433
LIG_SH2_STAT5	70	73	PF00017	0.700
LIG_SH3_1	813	819	PF00018	0.493
LIG_SH3_3	163	169	PF00018	0.590
LIG_SH3_3	311	317	PF00018	0.711
LIG_SH3_3	324	330	PF00018	0.791
LIG_SH3_3	331	337	PF00018	0.741
LIG_SH3_3	349	355	PF00018	0.702
LIG_SH3_3	413	419	PF00018	0.694
LIG_SH3_3	507	513	PF00018	0.728
LIG_SH3_3	531	537	PF00018	0.664
LIG_SH3_3	691	697	PF00018	0.750
LIG_SH3_3	727	733	PF00018	0.667
LIG_SH3_3	73	79	PF00018	0.670
LIG_SH3_3	81	87	PF00018	0.664
LIG_SH3_3	813	819	PF00018	0.493
LIG_SH3_3	829	835	PF00018	0.624
LIG_SH3_4	294	301	PF00018	0.838
LIG_Sin3_3	707	714	PF02671	0.454
LIG_SUMO_SIM_par_1	53	60	PF11976	0.707
LIG_TRAF2_1	748	751	PF00917	0.592
LIG_WW_1	419	422	PF00397	0.728
LIG_WW_2	416	419	PF00397	0.721
MOD_CDK_SPK_2	236	241	PF00069	0.719
MOD_CDK_SPxxK_3	220	227	PF00069	0.714
MOD_CDK_SPxxK_3	402	409	PF00069	0.624
MOD_CDK_SPxxK_3	62	69	PF00069	0.688
MOD_CK1_1	109	115	PF00069	0.453
MOD_CK1_1	23	29	PF00069	0.614
MOD_CK1_1	252	258	PF00069	0.786
MOD_CK1_1	281	287	PF00069	0.617
MOD_CK1_1	318	324	PF00069	0.784
MOD_CK1_1	33	39	PF00069	0.663
MOD_CK1_1	360	366	PF00069	0.804
MOD_CK1_1	505	511	PF00069	0.643
MOD_CK1_1	517	523	PF00069	0.657
MOD_CK1_1	60	66	PF00069	0.735
MOD_CK1_1	618	624	PF00069	0.787
MOD_CK1_1	7	13	PF00069	0.721
MOD_CK1_1	859	865	PF00069	0.680
MOD_CK1_1	887	893	PF00069	0.713
MOD_CK1_1	910	916	PF00069	0.473
MOD_CK1_1	918	924	PF00069	0.575
MOD_CK1_1	92	98	PF00069	0.795
MOD_CK1_1	929	935	PF00069	0.693
MOD_CK2_1	150	156	PF00069	0.719
MOD_CK2_1	236	242	PF00069	0.703
MOD_CK2_1	404	410	PF00069	0.814
MOD_CK2_1	433	439	PF00069	0.499
MOD_CK2_1	541	547	PF00069	0.638
MOD_CK2_1	566	572	PF00069	0.805
MOD_CK2_1	679	685	PF00069	0.630
MOD_CK2_1	800	806	PF00069	0.474
MOD_CK2_1	887	893	PF00069	0.602
MOD_CK2_1	943	949	PF00069	0.576
MOD_Cter_Amidation	847	850	PF01082	0.697
MOD_GlcNHglycan	102	105	PF01048	0.601
MOD_GlcNHglycan	137	142	PF01048	0.733
MOD_GlcNHglycan	145	148	PF01048	0.748
MOD_GlcNHglycan	196	199	PF01048	0.653
MOD_GlcNHglycan	258	261	PF01048	0.748
MOD_GlcNHglycan	311	314	PF01048	0.763
MOD_GlcNHglycan	32	35	PF01048	0.748
MOD_GlcNHglycan	46	49	PF01048	0.498
MOD_GlcNHglycan	486	489	PF01048	0.688
MOD_GlcNHglycan	516	519	PF01048	0.693
MOD_GlcNHglycan	524	527	PF01048	0.604
MOD_GlcNHglycan	534	537	PF01048	0.673
MOD_GlcNHglycan	568	571	PF01048	0.794
MOD_GlcNHglycan	59	62	PF01048	0.618
MOD_GlcNHglycan	625	628	PF01048	0.784
MOD_GlcNHglycan	638	641	PF01048	0.598
MOD_GlcNHglycan	647	650	PF01048	0.623
MOD_GlcNHglycan	659	662	PF01048	0.493
MOD_GlcNHglycan	694	697	PF01048	0.682
MOD_GlcNHglycan	733	736	PF01048	0.639
MOD_GlcNHglycan	767	770	PF01048	0.636
MOD_GlcNHglycan	886	889	PF01048	0.725
MOD_GlcNHglycan	927	931	PF01048	0.660
MOD_GlcNHglycan	94	97	PF01048	0.777
MOD_GSK3_1	105	112	PF00069	0.776
MOD_GSK3_1	133	140	PF00069	0.737
MOD_GSK3_1	151	158	PF00069	0.576
MOD_GSK3_1	194	201	PF00069	0.660
MOD_GSK3_1	20	27	PF00069	0.783
MOD_GSK3_1	204	211	PF00069	0.691
MOD_GSK3_1	252	259	PF00069	0.792
MOD_GSK3_1	269	276	PF00069	0.580
MOD_GSK3_1	277	284	PF00069	0.625
MOD_GSK3_1	29	36	PF00069	0.712
MOD_GSK3_1	321	328	PF00069	0.745
MOD_GSK3_1	4	11	PF00069	0.618
MOD_GSK3_1	425	432	PF00069	0.691
MOD_GSK3_1	50	57	PF00069	0.797
MOD_GSK3_1	517	524	PF00069	0.668
MOD_GSK3_1	562	569	PF00069	0.707
MOD_GSK3_1	578	585	PF00069	0.651
MOD_GSK3_1	60	67	PF00069	0.604
MOD_GSK3_1	765	772	PF00069	0.597
MOD_GSK3_1	835	842	PF00069	0.609
MOD_GSK3_1	85	92	PF00069	0.787
MOD_GSK3_1	856	863	PF00069	0.748
MOD_GSK3_1	907	914	PF00069	0.433
MOD_GSK3_1	915	922	PF00069	0.514
MOD_GSK3_1	941	948	PF00069	0.526
MOD_N-GLC_1	366	371	PF02516	0.772
MOD_N-GLC_1	635	640	PF02516	0.674
MOD_N-GLC_1	765	770	PF02516	0.592
MOD_N-GLC_2	716	718	PF02516	0.464
MOD_NEK2_1	105	110	PF00069	0.729
MOD_NEK2_1	143	148	PF00069	0.811
MOD_NEK2_1	155	160	PF00069	0.602
MOD_NEK2_1	194	199	PF00069	0.680
MOD_NEK2_1	521	526	PF00069	0.700
MOD_NEK2_1	56	61	PF00069	0.709
MOD_NEK2_1	635	640	PF00069	0.648
MOD_NEK2_1	645	650	PF00069	0.720
MOD_NEK2_1	765	770	PF00069	0.608
MOD_NEK2_1	8	13	PF00069	0.607
MOD_NEK2_1	800	805	PF00069	0.443
MOD_NEK2_1	978	983	PF00069	0.560
MOD_NEK2_2	278	283	PF00069	0.687
MOD_NEK2_2	778	783	PF00069	0.522
MOD_NEK2_2	839	844	PF00069	0.562
MOD_PIKK_1	252	258	PF00454	0.785
MOD_PIKK_1	284	290	PF00454	0.624
MOD_PIKK_1	628	634	PF00454	0.710
MOD_PIKK_1	786	792	PF00454	0.535
MOD_PK_1	209	215	PF00069	0.771
MOD_PK_1	273	279	PF00069	0.721
MOD_PK_1	698	704	PF00069	0.520
MOD_PKA_1	582	588	PF00069	0.720
MOD_PKA_2	208	214	PF00069	0.711
MOD_PKA_2	24	30	PF00069	0.761
MOD_PKA_2	425	431	PF00069	0.647
MOD_PKA_2	432	438	PF00069	0.542
MOD_PKA_2	499	505	PF00069	0.666
MOD_PKA_2	562	568	PF00069	0.685
MOD_PKA_2	578	584	PF00069	0.526
MOD_PKA_2	615	621	PF00069	0.709
MOD_PKB_1	698	706	PF00069	0.510
MOD_Plk_1	18	24	PF00069	0.687
MOD_Plk_1	4	10	PF00069	0.665
MOD_Plk_1	429	435	PF00069	0.518
MOD_Plk_1	926	932	PF00069	0.640
MOD_Plk_1	952	958	PF00069	0.580
MOD_Plk_2-3	541	547	PF00069	0.681
MOD_Plk_4	10	16	PF00069	0.792
MOD_Plk_4	106	112	PF00069	0.668
MOD_Plk_4	209	215	PF00069	0.729
MOD_Plk_4	278	284	PF00069	0.621
MOD_Plk_4	907	913	PF00069	0.518
MOD_ProDKin_1	165	171	PF00069	0.585
MOD_ProDKin_1	220	226	PF00069	0.768
MOD_ProDKin_1	236	242	PF00069	0.573
MOD_ProDKin_1	318	324	PF00069	0.722
MOD_ProDKin_1	337	343	PF00069	0.644
MOD_ProDKin_1	371	377	PF00069	0.760
MOD_ProDKin_1	402	408	PF00069	0.732
MOD_ProDKin_1	62	68	PF00069	0.711
MOD_ProDKin_1	729	735	PF00069	0.585
MOD_ProDKin_1	75	81	PF00069	0.700
MOD_ProDKin_1	815	821	PF00069	0.680
MOD_ProDKin_1	835	841	PF00069	0.603
MOD_ProDKin_1	89	95	PF00069	0.725
MOD_SUMO_for_1	231	234	PF00179	0.614
TRG_ENDOCYTIC_2	457	460	PF00928	0.654
TRG_ENDOCYTIC_2	597	600	PF00928	0.701
TRG_ENDOCYTIC_2	665	668	PF00928	0.520
TRG_ENDOCYTIC_2	70	73	PF00928	0.700
TRG_ENDOCYTIC_2	737	740	PF00928	0.569
TRG_ENDOCYTIC_2	817	820	PF00928	0.606
TRG_ENDOCYTIC_2	871	874	PF00928	0.718
TRG_ENDOCYTIC_2	936	939	PF00928	0.584
TRG_ER_diArg_1	466	469	PF00400	0.775
TRG_ER_diArg_1	503	506	PF00400	0.648
TRG_ER_diArg_1	537	539	PF00400	0.630
TRG_ER_diArg_1	677	679	PF00400	0.540
TRG_ER_diArg_1	697	700	PF00400	0.662
TRG_ER_diArg_1	809	811	PF00400	0.538
TRG_ER_diArg_1	960	963	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.787

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C6	Leptomonas seymouri	46%	100%
A0A1X0NZF9	Trypanosomatidae	27%	100%
A0A3S7X251	Leishmania donovani	100%	100%
A4HH27	Leishmania braziliensis	64%	98%
E9ADM1	Leishmania major	89%	100%
E9AM60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BPW9	Trypanosoma cruzi	28%	100%