Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I471_LEIIN

TriTrypDb:

LINF_290006700

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I471

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I471

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.470
CLV_NRD_NRD_1	264	266	PF00675	0.605
CLV_NRD_NRD_1	313	315	PF00675	0.411
CLV_NRD_NRD_1	414	416	PF00675	0.490
CLV_NRD_NRD_1	61	63	PF00675	0.644
CLV_PCSK_KEX2_1	195	197	PF00082	0.470
CLV_PCSK_KEX2_1	313	315	PF00082	0.411
CLV_PCSK_KEX2_1	333	335	PF00082	0.346
CLV_PCSK_KEX2_1	410	412	PF00082	0.452
CLV_PCSK_KEX2_1	61	63	PF00082	0.651
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.411
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.444
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.452
CLV_PCSK_SKI1_1	314	318	PF00082	0.499
CLV_PCSK_SKI1_1	341	345	PF00082	0.437
DEG_SCF_TRCP1_1	19	25	PF00400	0.626
DEG_SPOP_SBC_1	102	106	PF00917	0.662
DEG_SPOP_SBC_1	384	388	PF00917	0.621
DEG_SPOP_SBC_1	47	51	PF00917	0.665
DOC_CKS1_1	134	139	PF01111	0.572
DOC_CKS1_1	389	394	PF01111	0.659
DOC_CKS1_1	474	479	PF01111	0.652
DOC_CYCLIN_RxL_1	339	347	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.685
DOC_CYCLIN_yCln2_LP_2	519	522	PF00134	0.533
DOC_MAPK_DCC_7	504	513	PF00069	0.630
DOC_MAPK_gen_1	8	17	PF00069	0.557
DOC_MAPK_HePTP_8	5	17	PF00069	0.558
DOC_MAPK_MEF2A_6	212	219	PF00069	0.453
DOC_MAPK_MEF2A_6	504	513	PF00069	0.630
DOC_MAPK_MEF2A_6	8	17	PF00069	0.557
DOC_PP1_RVXF_1	250	256	PF00149	0.482
DOC_PP2B_LxvP_1	131	134	PF13499	0.676
DOC_PP2B_LxvP_1	169	172	PF13499	0.534
DOC_PP2B_LxvP_1	519	522	PF13499	0.533
DOC_PP4_FxxP_1	296	299	PF00568	0.464
DOC_PP4_FxxP_1	490	493	PF00568	0.461
DOC_USP7_MATH_1	102	106	PF00917	0.662
DOC_USP7_MATH_1	199	203	PF00917	0.554
DOC_USP7_MATH_1	350	354	PF00917	0.725
DOC_USP7_MATH_1	37	41	PF00917	0.636
DOC_USP7_MATH_1	384	388	PF00917	0.684
DOC_USP7_MATH_1	475	479	PF00917	0.638
DOC_USP7_UBL2_3	396	400	PF12436	0.668
DOC_USP7_UBL2_3	416	420	PF12436	0.385
DOC_WW_Pin1_4	133	138	PF00397	0.646
DOC_WW_Pin1_4	33	38	PF00397	0.623
DOC_WW_Pin1_4	361	366	PF00397	0.648
DOC_WW_Pin1_4	380	385	PF00397	0.664
DOC_WW_Pin1_4	388	393	PF00397	0.679
DOC_WW_Pin1_4	473	478	PF00397	0.620
DOC_WW_Pin1_4	64	69	PF00397	0.640
LIG_14-3-3_CanoR_1	250	256	PF00244	0.488
LIG_14-3-3_CanoR_1	274	281	PF00244	0.406
LIG_14-3-3_CanoR_1	39	44	PF00244	0.684
LIG_14-3-3_CanoR_1	510	516	PF00244	0.531
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	13	17	PF00533	0.646
LIG_BRCT_BRCA1_1	29	33	PF00533	0.628
LIG_BRCT_BRCA1_1	469	473	PF00533	0.703
LIG_DLG_GKlike_1	39	47	PF00625	0.715
LIG_FHA_1	184	190	PF00498	0.495
LIG_FHA_1	224	230	PF00498	0.386
LIG_FHA_1	352	358	PF00498	0.574
LIG_FHA_1	373	379	PF00498	0.600
LIG_FHA_2	134	140	PF00498	0.617
LIG_FHA_2	206	212	PF00498	0.503
LIG_LIR_Apic_2	301	305	PF02991	0.483
LIG_LIR_Apic_2	488	493	PF02991	0.601
LIG_LIR_Gen_1	22	31	PF02991	0.691
LIG_LIR_Gen_1	322	331	PF02991	0.450
LIG_LIR_Nem_3	22	27	PF02991	0.686
LIG_LIR_Nem_3	322	328	PF02991	0.445
LIG_MYND_1	108	112	PF01753	0.712
LIG_NRBOX	461	467	PF00104	0.520
LIG_NRP_CendR_1	533	536	PF00754	0.643
LIG_SH2_CRK	496	500	PF00017	0.548
LIG_SH2_SRC	164	167	PF00017	0.505
LIG_SH2_STAP1	164	168	PF00017	0.495
LIG_SH2_STAP1	174	178	PF00017	0.403
LIG_SH2_STAP1	29	33	PF00017	0.531
LIG_SH2_STAP1	336	340	PF00017	0.484
LIG_SH2_STAP1	43	47	PF00017	0.573
LIG_SH2_STAT5	205	208	PF00017	0.419
LIG_SH2_STAT5	216	219	PF00017	0.351
LIG_SH2_STAT5	496	499	PF00017	0.466
LIG_SH3_3	10	16	PF00018	0.719
LIG_SH3_3	105	111	PF00018	0.667
LIG_SH3_3	131	137	PF00018	0.599
LIG_SH3_3	303	309	PF00018	0.475
LIG_SH3_3	371	377	PF00018	0.606
LIG_SH3_3	471	477	PF00018	0.704
LIG_SH3_3	506	512	PF00018	0.629
LIG_TRAF2_1	221	224	PF00917	0.512
LIG_TRFH_1	255	259	PF08558	0.535
LIG_TYR_ITIM	494	499	PF00017	0.552
LIG_WW_1	96	99	PF00397	0.716
MOD_CDC14_SPxK_1	36	39	PF00782	0.628
MOD_CDC14_SPxK_1	364	367	PF00782	0.670
MOD_CDK_SPxK_1	33	39	PF00069	0.626
MOD_CDK_SPxK_1	361	367	PF00069	0.668
MOD_CK1_1	103	109	PF00069	0.525
MOD_CK1_1	20	26	PF00069	0.601
MOD_CK1_1	307	313	PF00069	0.486
MOD_CK1_1	319	325	PF00069	0.480
MOD_CK1_1	379	385	PF00069	0.675
MOD_CK1_1	388	394	PF00069	0.661
MOD_CK1_1	42	48	PF00069	0.631
MOD_CK1_1	453	459	PF00069	0.664
MOD_CK1_1	49	55	PF00069	0.661
MOD_CK1_1	69	75	PF00069	0.406
MOD_CK1_1	91	97	PF00069	0.668
MOD_CK2_1	133	139	PF00069	0.628
MOD_CK2_1	205	211	PF00069	0.502
MOD_CK2_1	217	223	PF00069	0.350
MOD_CK2_1	229	235	PF00069	0.405
MOD_CK2_1	48	54	PF00069	0.726
MOD_CK2_1	511	517	PF00069	0.581
MOD_CK2_1	64	70	PF00069	0.703
MOD_DYRK1A_RPxSP_1	64	68	PF00069	0.641
MOD_GlcNHglycan	105	108	PF01048	0.482
MOD_GlcNHglycan	18	22	PF01048	0.709
MOD_GlcNHglycan	240	244	PF01048	0.428
MOD_GlcNHglycan	309	312	PF01048	0.591
MOD_GlcNHglycan	321	324	PF01048	0.365
MOD_GlcNHglycan	378	381	PF01048	0.736
MOD_GlcNHglycan	416	419	PF01048	0.645
MOD_GlcNHglycan	452	455	PF01048	0.633
MOD_GlcNHglycan	469	472	PF01048	0.477
MOD_GlcNHglycan	90	93	PF01048	0.685
MOD_GSK3_1	144	151	PF00069	0.406
MOD_GSK3_1	19	26	PF00069	0.595
MOD_GSK3_1	27	34	PF00069	0.509
MOD_GSK3_1	344	351	PF00069	0.597
MOD_GSK3_1	35	42	PF00069	0.404
MOD_GSK3_1	372	379	PF00069	0.715
MOD_GSK3_1	380	387	PF00069	0.650
MOD_GSK3_1	395	402	PF00069	0.486
MOD_GSK3_1	43	50	PF00069	0.623
MOD_GSK3_1	449	456	PF00069	0.636
MOD_GSK3_1	62	69	PF00069	0.455
MOD_GSK3_1	87	94	PF00069	0.634
MOD_LATS_1	263	269	PF00433	0.660
MOD_LATS_1	447	453	PF00433	0.747
MOD_LATS_1	60	66	PF00433	0.635
MOD_LATS_1	9	15	PF00433	0.662
MOD_N-GLC_1	199	204	PF02516	0.553
MOD_NEK2_1	17	22	PF00069	0.646
MOD_NEK2_1	229	234	PF00069	0.413
MOD_NEK2_1	253	258	PF00069	0.446
MOD_NEK2_1	317	322	PF00069	0.486
MOD_NEK2_1	344	349	PF00069	0.642
MOD_NEK2_1	494	499	PF00069	0.489
MOD_NEK2_1	87	92	PF00069	0.654
MOD_NEK2_2	199	204	PF00069	0.491
MOD_PIKK_1	435	441	PF00454	0.665
MOD_PIKK_1	475	481	PF00454	0.708
MOD_PK_1	78	84	PF00069	0.648
MOD_PKA_1	265	271	PF00069	0.605
MOD_PKA_2	153	159	PF00069	0.527
MOD_PKA_2	251	257	PF00069	0.538
MOD_PKA_2	273	279	PF00069	0.595
MOD_PKA_2	414	420	PF00069	0.566
MOD_PKB_1	64	72	PF00069	0.651
MOD_Plk_1	174	180	PF00069	0.516
MOD_Plk_1	199	205	PF00069	0.551
MOD_Plk_1	69	75	PF00069	0.738
MOD_Plk_2-3	326	332	PF00069	0.501
MOD_Plk_4	126	132	PF00069	0.661
MOD_Plk_4	164	170	PF00069	0.469
MOD_Plk_4	461	467	PF00069	0.520
MOD_Plk_4	78	84	PF00069	0.682
MOD_ProDKin_1	133	139	PF00069	0.643
MOD_ProDKin_1	33	39	PF00069	0.626
MOD_ProDKin_1	361	367	PF00069	0.648
MOD_ProDKin_1	380	386	PF00069	0.665
MOD_ProDKin_1	388	394	PF00069	0.678
MOD_ProDKin_1	473	479	PF00069	0.620
MOD_ProDKin_1	64	70	PF00069	0.640
MOD_SUMO_rev_2	337	343	PF00179	0.498
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.526
TRG_ENDOCYTIC_2	216	219	PF00928	0.395
TRG_ENDOCYTIC_2	496	499	PF00928	0.540
TRG_ER_diArg_1	194	196	PF00400	0.454
TRG_ER_diArg_1	249	252	PF00400	0.475
TRG_ER_diArg_1	5	8	PF00400	0.644
TRG_ER_diArg_1	61	64	PF00400	0.627
TRG_NLS_MonoExtC_3	408	414	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y5	Leptomonas seymouri	46%	100%
A0A3Q8IE82	Leishmania donovani	100%	100%
A0A422NUU8	Trypanosoma rangeli	32%	100%
A4HH26	Leishmania braziliensis	78%	100%
E9ADM0	Leishmania major	93%	100%
E9AM61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DLD2	Trypanosoma cruzi	27%	100%