LeishMANIAdb
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Tetratricopeptide repeat protein 30

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Tetratricopeptide repeat protein 30
Gene product:
Putative intraflagellar transport protein B2
Species:
Leishmania infantum
UniProt:
A4I452_LEIIN
TriTrypDb:
LINF_290006400
Length:
693

Annotations

Annotations by Jardim et al.

Flagella, intraflagellar transport B2 (PIFTB2) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 11
GO:0042995 cell projection 2 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0110165 cellular anatomical entity 1 11
GO:0120025 plasma membrane bounded cell projection 3 11
GO:0005737 cytoplasm 2 1
GO:0005815 microtubule organizing center 2 1
GO:0005874 microtubule 6 1
GO:0005879 axonemal microtubule 8 1
GO:0005881 cytoplasmic microtubule 7 1
GO:0030990 intraciliary transport particle 2 1
GO:0030992 intraciliary transport particle B 2 1
GO:0032991 protein-containing complex 1 1
GO:0036064 ciliary basal body 3 1
GO:0099080 supramolecular complex 2 1
GO:0099081 supramolecular polymer 3 1
GO:0099512 supramolecular fiber 4 1
GO:0099513 polymeric cytoskeletal fiber 5 1
GO:0031514 motile cilium 5 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I452
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I452

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 10
GO:0030030 cell projection organization 4 10
GO:0071840 cellular component organization or biogenesis 2 10
GO:0006810 transport 3 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0010970 transport along microtubule 4 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0035720 intraciliary anterograde transport 4 1
GO:0035735 intraciliary transport involved in cilium assembly 4 1
GO:0042073 intraciliary transport 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0099111 microtubule-based transport 4 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0044877 protein-containing complex binding 2 1
GO:0120170 intraciliary transport particle B binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 392 396 PF00656 0.321
CLV_C14_Caspase3-7 635 639 PF00656 0.417
CLV_NRD_NRD_1 408 410 PF00675 0.342
CLV_NRD_NRD_1 427 429 PF00675 0.380
CLV_NRD_NRD_1 554 556 PF00675 0.339
CLV_NRD_NRD_1 607 609 PF00675 0.335
CLV_PCSK_KEX2_1 427 429 PF00082 0.472
CLV_PCSK_KEX2_1 554 556 PF00082 0.354
CLV_PCSK_KEX2_1 619 621 PF00082 0.305
CLV_PCSK_PC1ET2_1 619 621 PF00082 0.305
CLV_PCSK_PC7_1 423 429 PF00082 0.489
CLV_PCSK_SKI1_1 172 176 PF00082 0.497
CLV_PCSK_SKI1_1 300 304 PF00082 0.372
CLV_PCSK_SKI1_1 423 427 PF00082 0.367
CLV_PCSK_SKI1_1 598 602 PF00082 0.311
CLV_PCSK_SKI1_1 609 613 PF00082 0.281
CLV_PCSK_SKI1_1 620 624 PF00082 0.323
CLV_PCSK_SKI1_1 682 686 PF00082 0.334
CLV_Separin_Metazoa 551 555 PF03568 0.365
DOC_CYCLIN_RxL_1 682 693 PF00134 0.353
DOC_CYCLIN_yClb1_LxF_4 353 359 PF00134 0.299
DOC_MAPK_DCC_7 309 319 PF00069 0.379
DOC_MAPK_gen_1 619 625 PF00069 0.302
DOC_MAPK_gen_1 682 691 PF00069 0.344
DOC_MAPK_gen_1 83 90 PF00069 0.419
DOC_MAPK_MEF2A_6 570 577 PF00069 0.317
DOC_MAPK_MEF2A_6 619 627 PF00069 0.304
DOC_MAPK_MEF2A_6 682 691 PF00069 0.329
DOC_MAPK_NFAT4_5 620 628 PF00069 0.321
DOC_PP4_FxxP_1 661 664 PF00568 0.431
DOC_PP4_MxPP_1 10 13 PF00568 0.572
DOC_USP7_MATH_1 21 25 PF00917 0.689
DOC_USP7_MATH_1 432 436 PF00917 0.451
DOC_USP7_MATH_1 664 668 PF00917 0.457
DOC_USP7_MATH_1 86 90 PF00917 0.501
DOC_WW_Pin1_4 144 149 PF00397 0.538
DOC_WW_Pin1_4 400 405 PF00397 0.369
DOC_WW_Pin1_4 512 517 PF00397 0.370
DOC_WW_Pin1_4 669 674 PF00397 0.551
LIG_14-3-3_CanoR_1 140 145 PF00244 0.481
LIG_14-3-3_CanoR_1 31 37 PF00244 0.696
LIG_14-3-3_CanoR_1 562 566 PF00244 0.534
LIG_14-3-3_CanoR_1 598 604 PF00244 0.305
LIG_14-3-3_CanoR_1 608 617 PF00244 0.294
LIG_14-3-3_CanoR_1 85 91 PF00244 0.426
LIG_Actin_WH2_2 622 639 PF00022 0.329
LIG_BRCT_BRCA1_1 481 485 PF00533 0.343
LIG_Clathr_ClatBox_1 324 328 PF01394 0.499
LIG_Clathr_ClatBox_1 645 649 PF01394 0.391
LIG_DCNL_PONY_1 1 4 PF03556 0.490
LIG_deltaCOP1_diTrp_1 613 622 PF00928 0.305
LIG_EH1_1 593 601 PF00400 0.367
LIG_EVH1_2 348 352 PF00568 0.314
LIG_FHA_1 181 187 PF00498 0.429
LIG_FHA_1 269 275 PF00498 0.360
LIG_FHA_1 320 326 PF00498 0.342
LIG_FHA_1 424 430 PF00498 0.371
LIG_FHA_1 53 59 PF00498 0.368
LIG_FHA_2 179 185 PF00498 0.518
LIG_FHA_2 256 262 PF00498 0.577
LIG_FHA_2 308 314 PF00498 0.540
LIG_FHA_2 449 455 PF00498 0.456
LIG_FHA_2 562 568 PF00498 0.417
LIG_FHA_2 74 80 PF00498 0.488
LIG_GBD_Chelix_1 625 633 PF00786 0.342
LIG_HCF-1_HBM_1 64 67 PF13415 0.283
LIG_LIR_Apic_2 564 568 PF02991 0.389
LIG_LIR_Gen_1 106 116 PF02991 0.485
LIG_LIR_Gen_1 350 359 PF02991 0.302
LIG_LIR_Gen_1 389 398 PF02991 0.355
LIG_LIR_Gen_1 638 648 PF02991 0.298
LIG_LIR_Gen_1 656 666 PF02991 0.191
LIG_LIR_Nem_3 106 111 PF02991 0.468
LIG_LIR_Nem_3 119 124 PF02991 0.322
LIG_LIR_Nem_3 332 338 PF02991 0.344
LIG_LIR_Nem_3 350 355 PF02991 0.308
LIG_LIR_Nem_3 389 394 PF02991 0.363
LIG_LIR_Nem_3 406 411 PF02991 0.239
LIG_LIR_Nem_3 453 458 PF02991 0.305
LIG_LIR_Nem_3 470 475 PF02991 0.316
LIG_LIR_Nem_3 56 62 PF02991 0.358
LIG_LIR_Nem_3 638 644 PF02991 0.318
LIG_LIR_Nem_3 656 662 PF02991 0.169
LIG_LYPXL_yS_3 472 475 PF13949 0.316
LIG_PCNA_yPIPBox_3 579 589 PF02747 0.306
LIG_PTB_Apo_2 341 348 PF02174 0.370
LIG_SH2_CRK 514 518 PF00017 0.382
LIG_SH2_CRK 59 63 PF00017 0.374
LIG_SH2_NCK_1 365 369 PF00017 0.379
LIG_SH2_NCK_1 565 569 PF00017 0.418
LIG_SH2_PTP2 455 458 PF00017 0.297
LIG_SH2_SRC 135 138 PF00017 0.415
LIG_SH2_SRC 199 202 PF00017 0.364
LIG_SH2_SRC 455 458 PF00017 0.314
LIG_SH2_SRC 565 568 PF00017 0.423
LIG_SH2_SRC 67 70 PF00017 0.426
LIG_SH2_STAP1 125 129 PF00017 0.476
LIG_SH2_STAP1 199 203 PF00017 0.358
LIG_SH2_STAP1 365 369 PF00017 0.379
LIG_SH2_STAP1 448 452 PF00017 0.309
LIG_SH2_STAP1 606 610 PF00017 0.440
LIG_SH2_STAP1 67 71 PF00017 0.426
LIG_SH2_STAT3 124 127 PF00017 0.415
LIG_SH2_STAT3 382 385 PF00017 0.353
LIG_SH2_STAT5 359 362 PF00017 0.307
LIG_SH2_STAT5 382 385 PF00017 0.388
LIG_SH2_STAT5 455 458 PF00017 0.297
LIG_SH2_STAT5 540 543 PF00017 0.309
LIG_SH2_STAT5 586 589 PF00017 0.326
LIG_SH2_STAT5 61 64 PF00017 0.425
LIG_SH2_STAT5 688 691 PF00017 0.321
LIG_SH2_STAT5 93 96 PF00017 0.418
LIG_SH3_3 342 348 PF00018 0.346
LIG_SUMO_SIM_anti_2 68 76 PF11976 0.425
LIG_SUMO_SIM_par_1 632 640 PF11976 0.343
LIG_TRAF2_1 198 201 PF00917 0.414
LIG_TRAF2_1 451 454 PF00917 0.340
LIG_TRAF2_1 640 643 PF00917 0.345
LIG_TYR_ITSM 55 62 PF00017 0.393
LIG_WW_3 306 310 PF00397 0.364
MOD_CDK_SPK_2 669 674 PF00069 0.551
MOD_CK2_1 103 109 PF00069 0.520
MOD_CK2_1 170 176 PF00069 0.364
MOD_CK2_1 195 201 PF00069 0.414
MOD_CK2_1 255 261 PF00069 0.438
MOD_CK2_1 307 313 PF00069 0.511
MOD_CK2_1 400 406 PF00069 0.368
MOD_CK2_1 448 454 PF00069 0.451
MOD_CK2_1 636 642 PF00069 0.342
MOD_CK2_1 687 693 PF00069 0.459
MOD_CK2_1 73 79 PF00069 0.516
MOD_GlcNHglycan 19 22 PF01048 0.649
MOD_GlcNHglycan 215 218 PF01048 0.401
MOD_GlcNHglycan 481 484 PF01048 0.335
MOD_GlcNHglycan 528 531 PF01048 0.313
MOD_GSK3_1 140 147 PF00069 0.379
MOD_GSK3_1 17 24 PF00069 0.661
MOD_GSK3_1 191 198 PF00069 0.420
MOD_GSK3_1 213 220 PF00069 0.445
MOD_GSK3_1 26 33 PF00069 0.592
MOD_GSK3_1 264 271 PF00069 0.407
MOD_GSK3_1 315 322 PF00069 0.348
MOD_GSK3_1 396 403 PF00069 0.333
MOD_GSK3_1 440 447 PF00069 0.479
MOD_GSK3_1 50 57 PF00069 0.460
MOD_GSK3_1 536 543 PF00069 0.377
MOD_GSK3_1 581 588 PF00069 0.290
MOD_GSK3_1 632 639 PF00069 0.420
MOD_GSK3_1 664 671 PF00069 0.407
MOD_N-GLC_1 149 154 PF02516 0.434
MOD_N-GLC_1 386 391 PF02516 0.368
MOD_N-GLC_1 423 428 PF02516 0.479
MOD_N-GLC_1 526 531 PF02516 0.298
MOD_N-GLC_2 535 537 PF02516 0.276
MOD_NEK2_1 17 22 PF00069 0.620
MOD_NEK2_1 274 279 PF00069 0.327
MOD_NEK2_1 319 324 PF00069 0.338
MOD_NEK2_1 502 507 PF00069 0.365
MOD_NEK2_1 526 531 PF00069 0.321
MOD_NEK2_1 536 541 PF00069 0.281
MOD_NEK2_1 54 59 PF00069 0.388
MOD_NEK2_1 585 590 PF00069 0.332
MOD_NEK2_1 594 599 PF00069 0.294
MOD_NEK2_1 611 616 PF00069 0.260
MOD_NEK2_1 636 641 PF00069 0.369
MOD_NEK2_1 687 692 PF00069 0.444
MOD_NEK2_1 73 78 PF00069 0.390
MOD_NEK2_2 125 130 PF00069 0.476
MOD_PIKK_1 268 274 PF00454 0.373
MOD_PIKK_1 381 387 PF00454 0.362
MOD_PIKK_1 432 438 PF00454 0.509
MOD_PIKK_1 73 79 PF00454 0.501
MOD_PKA_2 274 280 PF00069 0.432
MOD_PKA_2 30 36 PF00069 0.612
MOD_PKA_2 4 10 PF00069 0.562
MOD_PKA_2 479 485 PF00069 0.341
MOD_PKA_2 561 567 PF00069 0.531
MOD_PKA_2 673 679 PF00069 0.427
MOD_Plk_1 149 155 PF00069 0.432
MOD_Plk_1 386 392 PF00069 0.368
MOD_Plk_1 448 454 PF00069 0.451
MOD_Plk_1 526 532 PF00069 0.291
MOD_Plk_1 637 643 PF00069 0.363
MOD_Plk_2-3 103 109 PF00069 0.520
MOD_Plk_2-3 484 490 PF00069 0.346
MOD_Plk_2-3 561 567 PF00069 0.419
MOD_Plk_4 103 109 PF00069 0.520
MOD_Plk_4 125 131 PF00069 0.433
MOD_Plk_4 140 146 PF00069 0.311
MOD_Plk_4 170 176 PF00069 0.395
MOD_Plk_4 386 392 PF00069 0.368
MOD_Plk_4 536 542 PF00069 0.361
MOD_Plk_4 54 60 PF00069 0.365
MOD_Plk_4 581 587 PF00069 0.297
MOD_Plk_4 611 617 PF00069 0.304
MOD_Plk_4 86 92 PF00069 0.476
MOD_ProDKin_1 144 150 PF00069 0.531
MOD_ProDKin_1 400 406 PF00069 0.368
MOD_ProDKin_1 512 518 PF00069 0.364
MOD_ProDKin_1 669 675 PF00069 0.543
MOD_SUMO_rev_2 602 611 PF00179 0.440
TRG_DiLeu_BaEn_1 69 74 PF01217 0.476
TRG_ENDOCYTIC_2 108 111 PF00928 0.415
TRG_ENDOCYTIC_2 227 230 PF00928 0.334
TRG_ENDOCYTIC_2 364 367 PF00928 0.330
TRG_ENDOCYTIC_2 391 394 PF00928 0.321
TRG_ENDOCYTIC_2 408 411 PF00928 0.266
TRG_ENDOCYTIC_2 455 458 PF00928 0.287
TRG_ENDOCYTIC_2 466 469 PF00928 0.299
TRG_ENDOCYTIC_2 472 475 PF00928 0.298
TRG_ENDOCYTIC_2 514 517 PF00928 0.319
TRG_ENDOCYTIC_2 59 62 PF00928 0.347
TRG_ENDOCYTIC_2 688 691 PF00928 0.321
TRG_ENDOCYTIC_2 95 98 PF00928 0.412
TRG_ER_diArg_1 427 429 PF00400 0.511
TRG_ER_diArg_1 553 555 PF00400 0.359
TRG_ER_diArg_1 82 85 PF00400 0.426
TRG_Pf-PMV_PEXEL_1 238 242 PF00026 0.368
TRG_Pf-PMV_PEXEL_1 427 431 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2B4 Leptomonas seymouri 87% 100%
A0A0S4J480 Bodo saltans 73% 100%
A0A1X0NZF0 Trypanosomatidae 74% 100%
A0A3Q8IE38 Leishmania donovani 100% 100%
A0A3R7MWT3 Trypanosoma rangeli 75% 100%
A2AKQ8 Mus musculus 55% 100%
A2VE45 Bos taurus 55% 100%
A4HH23 Leishmania braziliensis 95% 100%
A4IHR1 Xenopus tropicalis 57% 100%
A6H739 Bos taurus 54% 100%
A7YE96 Danio rerio 56% 100%
A8XBR9 Caenorhabditis briggsae 42% 100%
B2RYD6 Rattus norvegicus 56% 100%
C9ZKR0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 74% 100%
E9ADL7 Leishmania major 99% 100%
E9AM64 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
Q16JL4 Aedes aegypti 44% 100%
Q29L58 Drosophila pseudoobscura pseudoobscura 43% 100%
Q4QQS2 Rattus norvegicus 55% 100%
Q6INU8 Xenopus laevis 56% 100%
Q7PRA4 Anopheles gambiae 44% 100%
Q86WT1 Homo sapiens 55% 100%
Q8I7G4 Caenorhabditis elegans 43% 100%
Q8N4P2 Homo sapiens 56% 100%
Q99J38 Mus musculus 56% 100%
Q9CY00 Mus musculus 56% 100%
Q9VK41 Drosophila melanogaster 42% 100%
V5BKA3 Trypanosoma cruzi 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS