WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I447_LEIIN

TriTrypDb:

LINF_290005900

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0030990	intraciliary transport particle	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4I447

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I447

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	521	525	PF00656	0.421
CLV_NRD_NRD_1	121	123	PF00675	0.541
CLV_NRD_NRD_1	300	302	PF00675	0.426
CLV_NRD_NRD_1	438	440	PF00675	0.347
CLV_NRD_NRD_1	65	67	PF00675	0.484
CLV_PCSK_FUR_1	298	302	PF00082	0.409
CLV_PCSK_KEX2_1	300	302	PF00082	0.458
CLV_PCSK_KEX2_1	438	440	PF00082	0.333
CLV_PCSK_KEX2_1	65	67	PF00082	0.484
CLV_PCSK_SKI1_1	106	110	PF00082	0.396
CLV_PCSK_SKI1_1	287	291	PF00082	0.492
CLV_PCSK_SKI1_1	384	388	PF00082	0.383
CLV_PCSK_SKI1_1	439	443	PF00082	0.479
CLV_PCSK_SKI1_1	506	510	PF00082	0.530
DEG_APCC_DBOX_1	403	411	PF00400	0.371
DEG_APCC_DBOX_1	437	445	PF00400	0.395
DOC_CYCLIN_RxL_1	381	392	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.374
DOC_MAPK_gen_1	122	129	PF00069	0.496
DOC_MAPK_gen_1	172	178	PF00069	0.349
DOC_MAPK_gen_1	298	307	PF00069	0.353
DOC_MAPK_gen_1	341	349	PF00069	0.470
DOC_MAPK_gen_1	438	444	PF00069	0.312
DOC_MAPK_MEF2A_6	298	307	PF00069	0.374
DOC_USP7_MATH_1	108	112	PF00917	0.445
DOC_USP7_MATH_1	259	263	PF00917	0.489
DOC_USP7_MATH_1	273	277	PF00917	0.473
DOC_USP7_MATH_1	373	377	PF00917	0.338
DOC_USP7_MATH_1	434	438	PF00917	0.277
DOC_USP7_MATH_1	458	462	PF00917	0.531
DOC_USP7_MATH_1	471	475	PF00917	0.372
DOC_USP7_MATH_1	508	512	PF00917	0.414
DOC_USP7_MATH_2	348	354	PF00917	0.489
DOC_USP7_UBL2_3	36	40	PF12436	0.527
DOC_WW_Pin1_4	114	119	PF00397	0.620
DOC_WW_Pin1_4	132	137	PF00397	0.242
DOC_WW_Pin1_4	280	285	PF00397	0.361
DOC_WW_Pin1_4	377	382	PF00397	0.262
DOC_WW_Pin1_4	402	407	PF00397	0.397
DOC_WW_Pin1_4	423	428	PF00397	0.309
LIG_14-3-3_CanoR_1	106	116	PF00244	0.475
LIG_14-3-3_CanoR_1	122	131	PF00244	0.381
LIG_14-3-3_CanoR_1	190	196	PF00244	0.517
LIG_14-3-3_CanoR_1	300	306	PF00244	0.437
LIG_14-3-3_CanoR_1	341	346	PF00244	0.528
LIG_14-3-3_CanoR_1	397	406	PF00244	0.410
LIG_14-3-3_CanoR_1	438	442	PF00244	0.347
LIG_14-3-3_CanoR_1	510	514	PF00244	0.499
LIG_14-3-3_CanoR_1	65	69	PF00244	0.598
LIG_Actin_WH2_2	174	189	PF00022	0.341
LIG_Actin_WH2_2	437	455	PF00022	0.270
LIG_Actin_WH2_2	494	512	PF00022	0.416
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_BIR_III_4	484	488	PF00653	0.391
LIG_BRCT_BRCA1_1	109	113	PF00533	0.389
LIG_BRCT_BRCA1_1	202	206	PF00533	0.324
LIG_BRCT_BRCA1_1	379	383	PF00533	0.274
LIG_Clathr_ClatBox_1	331	335	PF01394	0.388
LIG_Clathr_ClatBox_1	407	411	PF01394	0.481
LIG_FHA_1	10	16	PF00498	0.495
LIG_FHA_1	107	113	PF00498	0.582
LIG_FHA_1	245	251	PF00498	0.473
LIG_FHA_1	32	38	PF00498	0.491
LIG_FHA_1	342	348	PF00498	0.521
LIG_FHA_1	455	461	PF00498	0.393
LIG_FHA_1	517	523	PF00498	0.605
LIG_FHA_2	23	29	PF00498	0.571
LIG_FHA_2	388	394	PF00498	0.454
LIG_FHA_2	473	479	PF00498	0.442
LIG_FHA_2	500	506	PF00498	0.365
LIG_FHA_2	89	95	PF00498	0.513
LIG_LIR_Apic_2	344	348	PF02991	0.477
LIG_LIR_Nem_3	110	116	PF02991	0.393
LIG_LIR_Nem_3	311	315	PF02991	0.468
LIG_LIR_Nem_3	380	386	PF02991	0.279
LIG_LIR_Nem_3	422	428	PF02991	0.418
LIG_MLH1_MIPbox_1	379	383	PF16413	0.274
LIG_PDZ_Class_1	531	536	PF00595	0.467
LIG_Pex14_2	383	387	PF04695	0.422
LIG_REV1ctd_RIR_1	380	388	PF16727	0.363
LIG_SH2_CRK	312	316	PF00017	0.491
LIG_SH2_CRK	79	83	PF00017	0.502
LIG_SH2_PTP2	175	178	PF00017	0.409
LIG_SH2_SRC	322	325	PF00017	0.344
LIG_SH2_STAP1	237	241	PF00017	0.428
LIG_SH2_STAP1	456	460	PF00017	0.477
LIG_SH2_STAT5	131	134	PF00017	0.435
LIG_SH2_STAT5	175	178	PF00017	0.409
LIG_SH2_STAT5	237	240	PF00017	0.487
LIG_SH2_STAT5	268	271	PF00017	0.345
LIG_SH2_STAT5	322	325	PF00017	0.344
LIG_SH2_STAT5	419	422	PF00017	0.456
LIG_SH2_STAT5	456	459	PF00017	0.405
LIG_SH2_STAT5	77	80	PF00017	0.412
LIG_SH3_1	424	430	PF00018	0.423
LIG_SH3_3	205	211	PF00018	0.529
LIG_SH3_3	253	259	PF00018	0.456
LIG_SH3_3	424	430	PF00018	0.311
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.485
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.426
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.479
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.334
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.326
LIG_SUMO_SIM_par_1	212	218	PF11976	0.372
LIG_SUMO_SIM_par_1	360	365	PF11976	0.406
LIG_SUMO_SIM_par_1	405	416	PF11976	0.518
LIG_SUMO_SIM_par_1	431	437	PF11976	0.326
LIG_TRAF2_1	137	140	PF00917	0.335
LIG_TRAF2_1	412	415	PF00917	0.336
LIG_TYR_ITIM	310	315	PF00017	0.463
LIG_WRC_WIRS_1	89	94	PF05994	0.461
MOD_CDC14_SPxK_1	426	429	PF00782	0.296
MOD_CDK_SPxK_1	423	429	PF00069	0.296
MOD_CDK_SPxxK_3	280	287	PF00069	0.406
MOD_CDK_SPxxK_3	377	384	PF00069	0.389
MOD_CK1_1	239	245	PF00069	0.397
MOD_CK1_1	296	302	PF00069	0.405
MOD_CK1_1	392	398	PF00069	0.341
MOD_CK1_1	41	47	PF00069	0.598
MOD_CK1_1	413	419	PF00069	0.356
MOD_CK1_1	437	443	PF00069	0.305
MOD_CK1_1	499	505	PF00069	0.490
MOD_CK1_1	512	518	PF00069	0.540
MOD_CK2_1	22	28	PF00069	0.581
MOD_CK2_1	237	243	PF00069	0.385
MOD_CK2_1	397	403	PF00069	0.376
MOD_CK2_1	409	415	PF00069	0.432
MOD_CK2_1	472	478	PF00069	0.452
MOD_CK2_1	499	505	PF00069	0.354
MOD_CK2_1	515	521	PF00069	0.486
MOD_CK2_1	88	94	PF00069	0.435
MOD_GlcNHglycan	165	169	PF01048	0.449
MOD_GlcNHglycan	219	222	PF01048	0.293
MOD_GlcNHglycan	239	242	PF01048	0.504
MOD_GlcNHglycan	271	274	PF01048	0.273
MOD_GlcNHglycan	275	278	PF01048	0.296
MOD_GlcNHglycan	377	380	PF01048	0.450
MOD_GlcNHglycan	393	397	PF01048	0.225
MOD_GlcNHglycan	460	463	PF01048	0.485
MOD_GlcNHglycan	524	527	PF01048	0.463
MOD_GSK3_1	114	121	PF00069	0.467
MOD_GSK3_1	125	132	PF00069	0.335
MOD_GSK3_1	196	203	PF00069	0.375
MOD_GSK3_1	235	242	PF00069	0.378
MOD_GSK3_1	244	251	PF00069	0.312
MOD_GSK3_1	269	276	PF00069	0.412
MOD_GSK3_1	27	34	PF00069	0.533
MOD_GSK3_1	301	308	PF00069	0.411
MOD_GSK3_1	314	321	PF00069	0.520
MOD_GSK3_1	373	380	PF00069	0.327
MOD_GSK3_1	388	395	PF00069	0.248
MOD_GSK3_1	402	409	PF00069	0.444
MOD_GSK3_1	454	461	PF00069	0.426
MOD_GSK3_1	508	515	PF00069	0.615
MOD_GSK3_1	60	67	PF00069	0.581
MOD_N-GLC_1	106	111	PF02516	0.459
MOD_N-GLC_1	227	232	PF02516	0.368
MOD_N-GLC_1	472	477	PF02516	0.383
MOD_NEK2_1	146	151	PF00069	0.330
MOD_NEK2_1	163	168	PF00069	0.463
MOD_NEK2_1	186	191	PF00069	0.536
MOD_NEK2_1	386	391	PF00069	0.264
MOD_NEK2_1	472	477	PF00069	0.417
MOD_NEK2_1	509	514	PF00069	0.477
MOD_NEK2_1	531	536	PF00069	0.467
MOD_NEK2_1	93	98	PF00069	0.369
MOD_NEK2_2	108	113	PF00069	0.521
MOD_NEK2_2	293	298	PF00069	0.472
MOD_PIKK_1	16	22	PF00454	0.633
MOD_PIKK_1	271	277	PF00454	0.355
MOD_PIKK_1	29	35	PF00454	0.502
MOD_PIKK_1	314	320	PF00454	0.564
MOD_PIKK_1	350	356	PF00454	0.519
MOD_PIKK_1	41	47	PF00454	0.426
MOD_PIKK_1	496	502	PF00454	0.454
MOD_PIKK_1	509	515	PF00454	0.608
MOD_PK_1	301	307	PF00069	0.459
MOD_PKA_1	122	128	PF00069	0.446
MOD_PKA_1	22	28	PF00069	0.559
MOD_PKA_2	186	192	PF00069	0.528
MOD_PKA_2	318	324	PF00069	0.532
MOD_PKA_2	428	434	PF00069	0.339
MOD_PKA_2	437	443	PF00069	0.317
MOD_PKA_2	509	515	PF00069	0.461
MOD_PKA_2	64	70	PF00069	0.586
MOD_Plk_1	46	52	PF00069	0.553
MOD_Plk_1	496	502	PF00069	0.456
MOD_Plk_1	93	99	PF00069	0.531
MOD_Plk_4	108	114	PF00069	0.259
MOD_Plk_4	125	131	PF00069	0.481
MOD_Plk_4	248	254	PF00069	0.421
MOD_Plk_4	318	324	PF00069	0.505
MOD_Plk_4	355	361	PF00069	0.435
MOD_Plk_4	428	434	PF00069	0.305
MOD_Plk_4	88	94	PF00069	0.419
MOD_ProDKin_1	114	120	PF00069	0.621
MOD_ProDKin_1	132	138	PF00069	0.238
MOD_ProDKin_1	280	286	PF00069	0.365
MOD_ProDKin_1	377	383	PF00069	0.262
MOD_ProDKin_1	402	408	PF00069	0.396
MOD_ProDKin_1	423	429	PF00069	0.306
TRG_DiLeu_LyEn_5	403	408	PF01217	0.457
TRG_ENDOCYTIC_2	161	164	PF00928	0.307
TRG_ENDOCYTIC_2	175	178	PF00928	0.239
TRG_ENDOCYTIC_2	312	315	PF00928	0.476
TRG_ENDOCYTIC_2	399	402	PF00928	0.307
TRG_ENDOCYTIC_2	79	82	PF00928	0.432
TRG_ER_diArg_1	297	300	PF00400	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P997	Leptomonas seymouri	24%	89%
A0A0N1HUS1	Leptomonas seymouri	67%	100%
A0A0S4KLW0	Bodo saltans	41%	96%
A0A1X0NUK4	Trypanosomatidae	25%	89%
A0A1X0P0W1	Trypanosomatidae	47%	100%
A0A3S5IRX8	Trypanosoma rangeli	47%	100%
A0A3S7X1Z8	Leishmania donovani	99%	100%
A0A3S7X5B2	Leishmania donovani	24%	89%
A0A422P1D5	Trypanosoma rangeli	24%	89%
A2AC93	Mus musculus	25%	86%
A4HH18	Leishmania braziliensis	80%	100%
A4HK88	Leishmania braziliensis	24%	89%
A4I7S3	Leishmania infantum	24%	89%
C9ZKR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A9Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	89%
E9ADL2	Leishmania major	95%	100%
E9AM69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B2N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9PYY5	Mus musculus	23%	66%
Q16959	Heliocidaris crassispina	24%	76%
Q16960	Heliocidaris crassispina	25%	90%
Q24246	Drosophila melanogaster	26%	81%
Q32KS2	Bos taurus	22%	76%
Q39578	Chlamydomonas reinhardtii	25%	78%
Q4Q5H6	Leishmania major	23%	100%
Q4QR00	Xenopus laevis	23%	91%
Q4V8G4	Rattus norvegicus	23%	67%
Q5U4F6	Mus musculus	29%	100%
Q5XIL8	Rattus norvegicus	21%	76%
Q66HC9	Rattus norvegicus	23%	87%
Q8C0M8	Mus musculus	21%	76%
Q96EX3	Homo sapiens	31%	100%
Q9UI46	Homo sapiens	21%	77%
V5B145	Trypanosoma cruzi	25%	89%
V5BUI1	Trypanosoma cruzi	49%	100%