LeishMANIAdb
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DUF3168 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF3168 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I445_LEIIN
TriTrypDb:
LINF_290005700
Length:
124

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I445
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I445

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_SPOP_SBC_1 35 39 PF00917 0.358
DOC_WW_Pin1_4 1 6 PF00397 0.634
LIG_BIR_II_1 1 5 PF00653 0.460
LIG_deltaCOP1_diTrp_1 70 78 PF00928 0.472
LIG_FHA_1 21 27 PF00498 0.418
LIG_FHA_1 58 64 PF00498 0.447
LIG_FHA_1 67 73 PF00498 0.368
LIG_FHA_2 37 43 PF00498 0.452
LIG_LIR_Apic_2 22 28 PF02991 0.403
LIG_LIR_Gen_1 69 77 PF02991 0.473
LIG_LIR_Gen_1 8 19 PF02991 0.398
LIG_LIR_Nem_3 69 74 PF02991 0.472
LIG_LIR_Nem_3 8 14 PF02991 0.391
LIG_LIR_Nem_3 88 93 PF02991 0.415
LIG_Pex14_1 21 25 PF04695 0.374
LIG_SH2_NCK_1 11 15 PF00017 0.359
LIG_SH2_PTP2 25 28 PF00017 0.361
LIG_SH2_SRC 11 14 PF00017 0.341
LIG_SH2_STAT5 25 28 PF00017 0.364
LIG_SUMO_SIM_anti_2 69 76 PF11976 0.419
MOD_CK1_1 38 44 PF00069 0.423
MOD_GlcNHglycan 42 46 PF01048 0.527
MOD_GSK3_1 1 8 PF00069 0.514
MOD_GSK3_1 34 41 PF00069 0.378
MOD_GSK3_1 57 64 PF00069 0.608
MOD_N-GLC_1 61 66 PF02516 0.472
MOD_NEK2_1 20 25 PF00069 0.447
MOD_NEK2_1 34 39 PF00069 0.246
MOD_NEK2_1 96 101 PF00069 0.452
MOD_PIKK_1 20 26 PF00454 0.389
MOD_Plk_1 85 91 PF00069 0.451
MOD_Plk_4 98 104 PF00069 0.369
MOD_ProDKin_1 1 7 PF00069 0.621
TRG_DiLeu_BaEn_1 70 75 PF01217 0.412
TRG_DiLeu_BaEn_2 85 91 PF01217 0.355
TRG_ENDOCYTIC_2 11 14 PF00928 0.391

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1F2 Leptomonas seymouri 42% 100%
A0A3Q8IEY1 Leishmania donovani 98% 100%
A4HH16 Leishmania braziliensis 80% 100%
E9ADL0 Leishmania major 90% 100%
E9AM71 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS