QA-SNARE protein putative

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania infantum

UniProt:

A4I444_LEIIN

TriTrypDb:

LINF_290005600

Length:

254

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, QA-SNARE

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0031982	vesicle	4	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0097014	ciliary plasm	5	1
GO:0098796	membrane protein complex	2	1
GO:0099568	cytoplasmic region	3	1

Phosphorylation

Promastigote/Amastigote: 133

Expansion

Sequence features

A4I444

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I444

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.330
CLV_NRD_NRD_1	108	110	PF00675	0.353
CLV_NRD_NRD_1	221	223	PF00675	0.447
CLV_NRD_NRD_1	31	33	PF00675	0.313
CLV_NRD_NRD_1	36	38	PF00675	0.376
CLV_NRD_NRD_1	65	67	PF00675	0.366
CLV_PCSK_KEX2_1	10	12	PF00082	0.312
CLV_PCSK_KEX2_1	221	223	PF00082	0.439
CLV_PCSK_KEX2_1	31	33	PF00082	0.302
CLV_PCSK_KEX2_1	36	38	PF00082	0.364
CLV_PCSK_KEX2_1	51	53	PF00082	0.266
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.297
CLV_PCSK_PC7_1	32	38	PF00082	0.428
CLV_PCSK_PC7_1	47	53	PF00082	0.431
CLV_PCSK_SKI1_1	234	238	PF00082	0.334
CLV_PCSK_SKI1_1	31	35	PF00082	0.353
CLV_PCSK_SKI1_1	51	55	PF00082	0.254
CLV_PCSK_SKI1_1	67	71	PF00082	0.265
CLV_PCSK_SKI1_1	74	78	PF00082	0.365
CLV_PCSK_SKI1_1	88	92	PF00082	0.253
DOC_MAPK_gen_1	87	97	PF00069	0.537
DOC_MAPK_MEF2A_6	232	240	PF00069	0.450
DOC_PP1_RVXF_1	150	156	PF00149	0.678
DOC_PP1_RVXF_1	232	238	PF00149	0.488
DOC_USP7_MATH_1	228	232	PF00917	0.598
DOC_USP7_MATH_1	245	249	PF00917	0.383
DOC_USP7_UBL2_3	87	91	PF12436	0.561
DOC_WW_Pin1_4	146	151	PF00397	0.648
LIG_14-3-3_CanoR_1	36	41	PF00244	0.574
LIG_APCC_ABBAyCdc20_2	109	115	PF00400	0.551
LIG_FHA_1	169	175	PF00498	0.564
LIG_FHA_2	101	107	PF00498	0.555
LIG_FHA_2	43	49	PF00498	0.478
LIG_LIR_Gen_1	158	165	PF02991	0.664
LIG_LIR_Gen_1	183	192	PF02991	0.490
LIG_LIR_Gen_1	71	78	PF02991	0.484
LIG_LIR_Nem_3	158	163	PF02991	0.664
LIG_LIR_Nem_3	183	188	PF02991	0.481
LIG_LIR_Nem_3	71	75	PF02991	0.492
LIG_SH2_STAP1	160	164	PF00017	0.663
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.612
LIG_SUMO_SIM_par_1	242	248	PF11976	0.324
LIG_TRAF2_1	39	42	PF00917	0.599
LIG_WRC_WIRS_1	69	74	PF05994	0.571
MOD_CDC14_SPxK_1	149	152	PF00782	0.634
MOD_CDK_SPxK_1	146	152	PF00069	0.647
MOD_CK2_1	204	210	PF00069	0.643
MOD_CK2_1	35	41	PF00069	0.642
MOD_CK2_1	42	48	PF00069	0.571
MOD_Cter_Amidation	85	88	PF01082	0.395
MOD_GlcNHglycan	115	118	PF01048	0.432
MOD_GlcNHglycan	207	210	PF01048	0.378
MOD_GSK3_1	113	120	PF00069	0.595
MOD_GSK3_1	140	147	PF00069	0.727
MOD_GSK3_1	210	217	PF00069	0.569
MOD_GSK3_1	31	38	PF00069	0.545
MOD_N-GLC_1	204	209	PF02516	0.392
MOD_N-GLC_1	214	219	PF02516	0.356
MOD_N-GLC_1	57	62	PF02516	0.377
MOD_NEK2_1	78	83	PF00069	0.550
MOD_PIKK_1	214	220	PF00454	0.609
MOD_PK_1	36	42	PF00069	0.598
MOD_PKA_1	31	37	PF00069	0.510
MOD_PKA_1	51	57	PF00069	0.401
MOD_PKA_2	117	123	PF00069	0.618
MOD_PKA_2	168	174	PF00069	0.555
MOD_PKA_2	210	216	PF00069	0.597
MOD_PKA_2	31	37	PF00069	0.534
MOD_PKA_2	51	57	PF00069	0.401
MOD_Plk_1	78	84	PF00069	0.638
MOD_Plk_2-3	42	48	PF00069	0.611
MOD_Plk_4	140	146	PF00069	0.693
MOD_ProDKin_1	146	152	PF00069	0.647
MOD_SUMO_for_1	43	46	PF00179	0.571
MOD_SUMO_rev_2	38	45	PF00179	0.647
MOD_SUMO_rev_2	46	53	PF00179	0.591
MOD_SUMO_rev_2	79	89	PF00179	0.469
TRG_DiLeu_BaEn_1	140	145	PF01217	0.686
TRG_DiLeu_BaEn_1	73	78	PF01217	0.543
TRG_ENDOCYTIC_2	160	163	PF00928	0.664
TRG_ER_diArg_1	220	222	PF00400	0.673
TRG_ER_diArg_1	30	32	PF00400	0.505
TRG_ER_diArg_1	9	11	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V3	Leptomonas seymouri	69%	100%
A0A0S4IMX4	Bodo saltans	36%	100%
A0A1X0NZD7	Trypanosomatidae	41%	98%
A0A3Q8IF56	Leishmania donovani	100%	100%
A0A3R7NXH1	Trypanosoma rangeli	42%	98%
A4HH15	Leishmania braziliensis	88%	100%
C9ZKR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9ADK9	Leishmania major	95%	100%
E9AM72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O94651	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	97%
V5BPW1	Trypanosoma cruzi	42%	98%