tRNA synthetase, tryptophanyl-tRNA synthetase
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | yes | yes: 3 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 8 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005737 | cytoplasm | 2 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 1 |
Related structures:
AlphaFold database: A4I443
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 12 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 12 |
| GO:0006399 | tRNA metabolic process | 7 | 12 |
| GO:0006418 | tRNA aminoacylation for protein translation | 6 | 12 |
| GO:0006436 | tryptophanyl-tRNA aminoacylation | 7 | 12 |
| GO:0006520 | amino acid metabolic process | 3 | 12 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 12 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 12 |
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0009987 | cellular process | 1 | 12 |
| GO:0016070 | RNA metabolic process | 5 | 12 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 12 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 12 |
| GO:0034660 | ncRNA metabolic process | 6 | 12 |
| GO:0043038 | amino acid activation | 4 | 12 |
| GO:0043039 | tRNA aminoacylation | 5 | 12 |
| GO:0043170 | macromolecule metabolic process | 3 | 12 |
| GO:0043436 | oxoacid metabolic process | 4 | 12 |
| GO:0044237 | cellular metabolic process | 2 | 12 |
| GO:0044238 | primary metabolic process | 2 | 12 |
| GO:0044281 | small molecule metabolic process | 2 | 12 |
| GO:0046483 | heterocycle metabolic process | 3 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 12 |
| GO:0090304 | nucleic acid metabolic process | 4 | 12 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 12 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000166 | nucleotide binding | 3 | 12 |
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0004812 | aminoacyl-tRNA ligase activity | 4 | 12 |
| GO:0004830 | tryptophan-tRNA ligase activity | 5 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0005524 | ATP binding | 5 | 12 |
| GO:0016874 | ligase activity | 2 | 12 |
| GO:0016875 | ligase activity, forming carbon-oxygen bonds | 3 | 12 |
| GO:0017076 | purine nucleotide binding | 4 | 12 |
| GO:0030554 | adenyl nucleotide binding | 5 | 12 |
| GO:0032553 | ribonucleotide binding | 3 | 12 |
| GO:0032555 | purine ribonucleotide binding | 4 | 12 |
| GO:0032559 | adenyl ribonucleotide binding | 5 | 12 |
| GO:0035639 | purine ribonucleoside triphosphate binding | 4 | 12 |
| GO:0036094 | small molecule binding | 2 | 12 |
| GO:0043167 | ion binding | 2 | 12 |
| GO:0043168 | anion binding | 3 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:0097367 | carbohydrate derivative binding | 2 | 12 |
| GO:0140098 | catalytic activity, acting on RNA | 3 | 12 |
| GO:0140101 | catalytic activity, acting on a tRNA | 4 | 12 |
| GO:0140640 | catalytic activity, acting on a nucleic acid | 2 | 12 |
| GO:1901265 | nucleoside phosphate binding | 3 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 367 | 369 | PF00675 | 0.380 |
| CLV_NRD_NRD_1 | 394 | 396 | PF00675 | 0.622 |
| CLV_NRD_NRD_1 | 46 | 48 | PF00675 | 0.299 |
| CLV_NRD_NRD_1 | 55 | 57 | PF00675 | 0.313 |
| CLV_PCSK_KEX2_1 | 55 | 57 | PF00082 | 0.313 |
| CLV_PCSK_SKI1_1 | 122 | 126 | PF00082 | 0.286 |
| CLV_PCSK_SKI1_1 | 196 | 200 | PF00082 | 0.235 |
| CLV_PCSK_SKI1_1 | 24 | 28 | PF00082 | 0.410 |
| CLV_PCSK_SKI1_1 | 285 | 289 | PF00082 | 0.230 |
| CLV_PCSK_SKI1_1 | 293 | 297 | PF00082 | 0.255 |
| CLV_PCSK_SKI1_1 | 323 | 327 | PF00082 | 0.333 |
| CLV_PCSK_SKI1_1 | 343 | 347 | PF00082 | 0.141 |
| CLV_PCSK_SKI1_1 | 350 | 354 | PF00082 | 0.223 |
| CLV_PCSK_SKI1_1 | 369 | 373 | PF00082 | 0.391 |
| CLV_PCSK_SKI1_1 | 56 | 60 | PF00082 | 0.306 |
| DEG_Nend_UBRbox_2 | 1 | 3 | PF02207 | 0.555 |
| DOC_AGCK_PIF_2 | 157 | 162 | PF00069 | 0.428 |
| DOC_CKS1_1 | 10 | 15 | PF01111 | 0.387 |
| DOC_MAPK_gen_1 | 303 | 309 | PF00069 | 0.474 |
| DOC_PP1_RVXF_1 | 150 | 156 | PF00149 | 0.443 |
| DOC_PP1_RVXF_1 | 54 | 61 | PF00149 | 0.322 |
| DOC_PP4_FxxP_1 | 109 | 112 | PF00568 | 0.428 |
| DOC_USP7_MATH_1 | 204 | 208 | PF00917 | 0.438 |
| DOC_USP7_UBL2_3 | 122 | 126 | PF12436 | 0.526 |
| DOC_WW_Pin1_4 | 280 | 285 | PF00397 | 0.532 |
| DOC_WW_Pin1_4 | 9 | 14 | PF00397 | 0.393 |
| LIG_14-3-3_CanoR_1 | 368 | 378 | PF00244 | 0.398 |
| LIG_14-3-3_CanoR_1 | 84 | 93 | PF00244 | 0.428 |
| LIG_Actin_WH2_2 | 126 | 144 | PF00022 | 0.532 |
| LIG_Actin_WH2_2 | 236 | 253 | PF00022 | 0.428 |
| LIG_BRCT_BRCA1_1 | 208 | 212 | PF00533 | 0.428 |
| LIG_BRCT_BRCA1_1 | 256 | 260 | PF00533 | 0.428 |
| LIG_FHA_1 | 100 | 106 | PF00498 | 0.447 |
| LIG_FHA_1 | 136 | 142 | PF00498 | 0.428 |
| LIG_FHA_1 | 238 | 244 | PF00498 | 0.436 |
| LIG_FHA_1 | 344 | 350 | PF00498 | 0.439 |
| LIG_FHA_1 | 356 | 362 | PF00498 | 0.495 |
| LIG_FHA_2 | 116 | 122 | PF00498 | 0.429 |
| LIG_FHA_2 | 127 | 133 | PF00498 | 0.428 |
| LIG_FHA_2 | 311 | 317 | PF00498 | 0.465 |
| LIG_FHA_2 | 370 | 376 | PF00498 | 0.390 |
| LIG_LIR_Apic_2 | 107 | 112 | PF02991 | 0.428 |
| LIG_LIR_Gen_1 | 159 | 167 | PF02991 | 0.452 |
| LIG_LIR_Gen_1 | 19 | 29 | PF02991 | 0.370 |
| LIG_LIR_Gen_1 | 377 | 387 | PF02991 | 0.502 |
| LIG_LIR_Nem_3 | 154 | 160 | PF02991 | 0.428 |
| LIG_LIR_Nem_3 | 19 | 25 | PF02991 | 0.371 |
| LIG_LIR_Nem_3 | 209 | 215 | PF02991 | 0.457 |
| LIG_LIR_Nem_3 | 234 | 239 | PF02991 | 0.455 |
| LIG_LIR_Nem_3 | 257 | 263 | PF02991 | 0.428 |
| LIG_LIR_Nem_3 | 377 | 382 | PF02991 | 0.502 |
| LIG_MLH1_MIPbox_1 | 256 | 260 | PF16413 | 0.428 |
| LIG_Pex14_1 | 321 | 325 | PF04695 | 0.428 |
| LIG_Pex14_2 | 208 | 212 | PF04695 | 0.428 |
| LIG_REV1ctd_RIR_1 | 121 | 130 | PF16727 | 0.470 |
| LIG_REV1ctd_RIR_1 | 57 | 67 | PF16727 | 0.292 |
| LIG_SH2_CRK | 167 | 171 | PF00017 | 0.428 |
| LIG_SH2_CRK | 22 | 26 | PF00017 | 0.357 |
| LIG_SH2_STAP1 | 22 | 26 | PF00017 | 0.347 |
| LIG_SH2_STAT5 | 162 | 165 | PF00017 | 0.495 |
| LIG_SH2_STAT5 | 177 | 180 | PF00017 | 0.495 |
| LIG_SH2_STAT5 | 236 | 239 | PF00017 | 0.444 |
| LIG_SH2_STAT5 | 249 | 252 | PF00017 | 0.428 |
| LIG_SH2_STAT5 | 79 | 82 | PF00017 | 0.436 |
| LIG_SH3_3 | 312 | 318 | PF00018 | 0.428 |
| LIG_SH3_3 | 7 | 13 | PF00018 | 0.418 |
| LIG_TRAF2_1 | 363 | 366 | PF00917 | 0.430 |
| LIG_TRAF2_1 | 388 | 391 | PF00917 | 0.425 |
| LIG_TRAF2_1 | 5 | 8 | PF00917 | 0.554 |
| LIG_TYR_ITIM | 20 | 25 | PF00017 | 0.364 |
| LIG_UBA3_1 | 96 | 103 | PF00899 | 0.439 |
| MOD_CDK_SPK_2 | 280 | 285 | PF00069 | 0.532 |
| MOD_CK1_1 | 271 | 277 | PF00069 | 0.439 |
| MOD_CK1_1 | 359 | 365 | PF00069 | 0.485 |
| MOD_CK1_1 | 87 | 93 | PF00069 | 0.435 |
| MOD_CK2_1 | 115 | 121 | PF00069 | 0.432 |
| MOD_CK2_1 | 126 | 132 | PF00069 | 0.428 |
| MOD_GlcNHglycan | 208 | 211 | PF01048 | 0.271 |
| MOD_GlcNHglycan | 263 | 266 | PF01048 | 0.251 |
| MOD_GlcNHglycan | 296 | 299 | PF01048 | 0.228 |
| MOD_GSK3_1 | 355 | 362 | PF00069 | 0.533 |
| MOD_NEK2_1 | 105 | 110 | PF00069 | 0.455 |
| MOD_NEK2_1 | 263 | 268 | PF00069 | 0.454 |
| MOD_NEK2_1 | 270 | 275 | PF00069 | 0.461 |
| MOD_NEK2_1 | 99 | 104 | PF00069 | 0.452 |
| MOD_PIKK_1 | 177 | 183 | PF00454 | 0.428 |
| MOD_PKA_1 | 369 | 375 | PF00069 | 0.464 |
| MOD_PKA_2 | 237 | 243 | PF00069 | 0.433 |
| MOD_PKA_2 | 43 | 49 | PF00069 | 0.502 |
| MOD_Plk_1 | 126 | 132 | PF00069 | 0.467 |
| MOD_Plk_1 | 330 | 336 | PF00069 | 0.415 |
| MOD_Plk_4 | 151 | 157 | PF00069 | 0.428 |
| MOD_Plk_4 | 356 | 362 | PF00069 | 0.427 |
| MOD_ProDKin_1 | 280 | 286 | PF00069 | 0.532 |
| MOD_ProDKin_1 | 9 | 15 | PF00069 | 0.393 |
| MOD_SUMO_for_1 | 188 | 191 | PF00179 | 0.437 |
| MOD_SUMO_for_1 | 388 | 391 | PF00179 | 0.425 |
| MOD_SUMO_rev_2 | 119 | 124 | PF00179 | 0.428 |
| TRG_DiLeu_BaEn_4 | 330 | 336 | PF01217 | 0.532 |
| TRG_ENDOCYTIC_2 | 167 | 170 | PF00928 | 0.428 |
| TRG_ENDOCYTIC_2 | 22 | 25 | PF00928 | 0.414 |
| TRG_ENDOCYTIC_2 | 236 | 239 | PF00928 | 0.428 |
| TRG_ER_diArg_1 | 54 | 56 | PF00400 | 0.302 |
| TRG_NLS_Bipartite_1 | 350 | 372 | PF00514 | 0.576 |
| TRG_NLS_MonoExtC_3 | 367 | 373 | PF00514 | 0.460 |
| TRG_NLS_MonoExtN_4 | 44 | 51 | PF00514 | 0.285 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P3G3 | Leptomonas seymouri | 86% | 100% |
| A0A0N1HXL2 | Leptomonas seymouri | 40% | 84% |
| A0A0S4IN16 | Bodo saltans | 76% | 100% |
| A0A0S4JC70 | Bodo saltans | 43% | 87% |
| A0A1X0NGJ6 | Trypanosomatidae | 40% | 86% |
| A0A1X0NZB4 | Trypanosomatidae | 78% | 100% |
| A0A3R7MPN7 | Trypanosoma rangeli | 79% | 100% |
| A0A3S7WXL2 | Leishmania donovani | 44% | 96% |
| A0A3S7X238 | Leishmania donovani | 99% | 100% |
| A0A422NW64 | Trypanosoma rangeli | 41% | 89% |
| A2BLD4 | Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) | 30% | 100% |
| A3MX72 | Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) | 38% | 100% |
| A4HCP4 | Leishmania braziliensis | 38% | 100% |
| A4HH14 | Leishmania braziliensis | 90% | 100% |
| A4I070 | Leishmania infantum | 42% | 100% |
| A4WL99 | Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) | 35% | 100% |
| B6YUH1 | Thermococcus onnurineus (strain NA1) | 46% | 100% |
| C6A032 | Thermococcus sibiricus (strain DSM 12597 / MM 739) | 46% | 100% |
| C9ZKR9 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 79% | 100% |
| E9ADK8 | Leishmania major | 97% | 100% |
| E9AM73 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 96% | 100% |
| E9AW33 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 44% | 100% |
| O26352 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 29% | 100% |
| O59584 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 46% | 100% |
| O96771 | Encephalitozoon cuniculi (strain GB-M1) | 42% | 100% |
| P17248 | Bos taurus | 56% | 83% |
| P23381 | Homo sapiens | 56% | 84% |
| P23612 | Oryctolagus cuniculus | 56% | 83% |
| P32921 | Mus musculus | 56% | 82% |
| Q09692 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 55% | 100% |
| Q12109 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 50% | 92% |
| Q4JBG7 | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 47% | 100% |
| Q4QBE4 | Leishmania major | 42% | 100% |
| Q55DZ8 | Dictyostelium discoideum | 53% | 99% |
| Q58810 | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 29% | 100% |
| Q5JEP3 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 46% | 100% |
| Q5R4J1 | Pongo abelii | 56% | 84% |
| Q6P7B0 | Rattus norvegicus | 56% | 82% |
| Q8TYF7 | Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 32% | 100% |
| Q8U453 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 47% | 100% |
| Q8ZTU5 | Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) | 36% | 100% |
| Q976M1 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 47% | 100% |
| Q97ZX0 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 47% | 100% |
| Q9HN66 | Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) | 36% | 100% |
| Q9SR15 | Arabidopsis thaliana | 55% | 99% |
| Q9UY11 | Pyrococcus abyssi (strain GE5 / Orsay) | 46% | 100% |
| Q9Y924 | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) | 30% | 100% |
| V5B4S5 | Trypanosoma cruzi | 79% | 100% |