Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I434_LEIIN

TriTrypDb:

LINF_280039300

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I434

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I434

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.409
CLV_NRD_NRD_1	165	167	PF00675	0.553
CLV_NRD_NRD_1	17	19	PF00675	0.629
CLV_NRD_NRD_1	176	178	PF00675	0.419
CLV_PCSK_FUR_1	145	149	PF00082	0.421
CLV_PCSK_KEX2_1	147	149	PF00082	0.421
CLV_PCSK_KEX2_1	165	167	PF00082	0.460
CLV_PCSK_KEX2_1	17	19	PF00082	0.643
CLV_PCSK_KEX2_1	176	178	PF00082	0.419
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.421
CLV_PCSK_PC7_1	13	19	PF00082	0.444
CLV_PCSK_SKI1_1	105	109	PF00082	0.562
CLV_PCSK_SKI1_1	193	197	PF00082	0.648
CLV_Separin_Metazoa	228	232	PF03568	0.490
DEG_APCC_DBOX_1	66	74	PF00400	0.566
DOC_ANK_TNKS_1	52	59	PF00023	0.555
DOC_USP7_MATH_1	221	225	PF00917	0.566
DOC_USP7_UBL2_3	135	139	PF12436	0.380
DOC_WW_Pin1_4	186	191	PF00397	0.646
DOC_WW_Pin1_4	195	200	PF00397	0.577
DOC_WW_Pin1_4	72	77	PF00397	0.493
LIG_14-3-3_CterR_2	231	234	PF00244	0.502
LIG_CaM_IQ_9	39	55	PF13499	0.496
LIG_FHA_1	23	29	PF00498	0.641
LIG_FHA_1	52	58	PF00498	0.570
LIG_FHA_2	109	115	PF00498	0.447
LIG_FHA_2	39	45	PF00498	0.510
LIG_LIR_Gen_1	91	100	PF02991	0.435
LIG_LIR_Nem_3	130	136	PF02991	0.447
LIG_LIR_Nem_3	91	97	PF02991	0.489
LIG_NRBOX	225	231	PF00104	0.478
LIG_SH2_STAT5	161	164	PF00017	0.504
LIG_SH2_STAT5	64	67	PF00017	0.590
LIG_SH3_2	100	105	PF14604	0.496
LIG_SH3_3	184	190	PF00018	0.595
LIG_SH3_3	97	103	PF00018	0.442
LIG_SUMO_SIM_par_1	181	186	PF11976	0.610
LIG_TRAF2_1	111	114	PF00917	0.449
LIG_TRAF2_1	115	118	PF00917	0.432
LIG_TRAF2_1	208	211	PF00917	0.516
LIG_TRAF2_1	41	44	PF00917	0.504
LIG_TRAF2_2	199	204	PF00917	0.602
MOD_CDK_SPxxK_3	186	193	PF00069	0.652
MOD_CK1_1	205	211	PF00069	0.509
MOD_CK2_1	108	114	PF00069	0.456
MOD_CK2_1	205	211	PF00069	0.542
MOD_CK2_1	221	227	PF00069	0.322
MOD_CK2_1	38	44	PF00069	0.512
MOD_CK2_1	68	74	PF00069	0.569
MOD_GlcNHglycan	20	23	PF01048	0.617
MOD_GlcNHglycan	207	210	PF01048	0.533
MOD_GSK3_1	18	25	PF00069	0.650
MOD_GSK3_1	30	37	PF00069	0.482
MOD_GSK3_1	47	54	PF00069	0.474
MOD_GSK3_1	68	75	PF00069	0.563
MOD_N-GLC_1	221	226	PF02516	0.430
MOD_NEK2_1	34	39	PF00069	0.556
MOD_PKA_2	5	11	PF00069	0.587
MOD_PKB_1	169	177	PF00069	0.419
MOD_Plk_1	203	209	PF00069	0.571
MOD_Plk_1	221	227	PF00069	0.305
MOD_Plk_1	68	74	PF00069	0.569
MOD_Plk_4	24	30	PF00069	0.498
MOD_Plk_4	34	40	PF00069	0.527
MOD_Plk_4	5	11	PF00069	0.602
MOD_ProDKin_1	186	192	PF00069	0.648
MOD_ProDKin_1	195	201	PF00069	0.576
MOD_ProDKin_1	72	78	PF00069	0.486
MOD_SUMO_for_1	115	118	PF00179	0.461
MOD_SUMO_rev_2	83	90	PF00179	0.622
TRG_DiLeu_BaEn_4	214	220	PF01217	0.369
TRG_ER_diArg_1	17	19	PF00400	0.650
TRG_ER_diArg_1	176	178	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA2	Leptomonas seymouri	59%	95%
A0A3S7X226	Leishmania donovani	99%	100%
A4HH02	Leishmania braziliensis	78%	100%
D0A8X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B0C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q7W3	Leishmania major	90%	100%