Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I433_LEIIN

TriTrypDb:

LINF_280039200

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I433

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I433

PDB structure(s): 7ane_ay

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	118	120	PF00082	0.420
CLV_PCSK_KEX2_1	26	28	PF00082	0.551
CLV_PCSK_KEX2_1	34	36	PF00082	0.459
CLV_PCSK_KEX2_1	75	77	PF00082	0.384
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.420
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.564
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.446
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.400
CLV_PCSK_SKI1_1	115	119	PF00082	0.425
CLV_PCSK_SKI1_1	12	16	PF00082	0.574
CLV_PCSK_SKI1_1	141	145	PF00082	0.447
CLV_PCSK_SKI1_1	154	158	PF00082	0.470
CLV_PCSK_SKI1_1	160	164	PF00082	0.468
DEG_Nend_UBRbox_3	1	3	PF02207	0.676
DOC_MAPK_gen_1	118	126	PF00069	0.434
DOC_MAPK_gen_1	89	97	PF00069	0.427
DOC_USP7_UBL2_3	33	37	PF12436	0.486
LIG_14-3-3_CanoR_1	19	29	PF00244	0.649
LIG_14-3-3_CanoR_1	3	11	PF00244	0.574
LIG_deltaCOP1_diTrp_1	78	87	PF00928	0.406
LIG_FHA_1	72	78	PF00498	0.549
LIG_FHA_1	97	103	PF00498	0.514
LIG_FHA_2	148	154	PF00498	0.589
LIG_LIR_Nem_3	134	140	PF02991	0.514
LIG_LIR_Nem_3	161	166	PF02991	0.551
LIG_LIR_Nem_3	81	87	PF02991	0.414
LIG_Pex14_1	49	53	PF04695	0.430
LIG_Pex14_1	80	84	PF04695	0.418
LIG_RPA_C_Fungi	54	66	PF08784	0.427
LIG_SH2_STAT5	101	104	PF00017	0.378
LIG_SH2_STAT5	53	56	PF00017	0.438
LIG_SH2_STAT5	68	71	PF00017	0.373
LIG_SH2_STAT5	96	99	PF00017	0.374
LIG_WRPW_2	137	140	PF00400	0.434
MOD_CK1_1	4	10	PF00069	0.655
MOD_CK2_1	147	153	PF00069	0.524
MOD_GlcNHglycan	7	10	PF01048	0.509
MOD_GSK3_1	1	8	PF00069	0.606
MOD_GSK3_1	154	161	PF00069	0.573
MOD_N-GLC_1	1	6	PF02516	0.588
MOD_N-GLC_1	147	152	PF02516	0.587
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	18	23	PF00069	0.542
MOD_NEK2_1	61	66	PF00069	0.430
MOD_NEK2_1	71	76	PF00069	0.426
MOD_PKA_2	18	24	PF00069	0.451
MOD_Plk_1	1	7	PF00069	0.581
MOD_Plk_1	152	158	PF00069	0.485
MOD_Plk_4	158	164	PF00069	0.465
TRG_ENDOCYTIC_2	68	71	PF00928	0.408
TRG_ER_diArg_1	57	60	PF00400	0.439
TRG_NLS_MonoCore_2	33	38	PF00514	0.481
TRG_NLS_MonoExtC_3	32	37	PF00514	0.487
TRG_NLS_MonoExtN_4	31	38	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J6	Leptomonas seymouri	90%	100%
A0A0S4IVN4	Bodo saltans	66%	84%
A0A1X0NQT8	Trypanosomatidae	76%	100%
A0A3Q8IDF2	Leishmania donovani	100%	100%
A0A3R7KDM2	Trypanosoma rangeli	75%	100%
A4HH01	Leishmania braziliensis	95%	100%
D0A8X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9B0C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7W4	Leishmania major	99%	100%
V5BDQ9	Trypanosoma cruzi	75%	78%