Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I430_LEIIN

TriTrypDb:

LINF_280037700

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 249, 250

Expansion

Sequence features

A4I430

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I430

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.589
CLV_NRD_NRD_1	12	14	PF00675	0.655
CLV_NRD_NRD_1	59	61	PF00675	0.579
CLV_PCSK_FUR_1	9	13	PF00082	0.749
CLV_PCSK_KEX2_1	11	13	PF00082	0.683
CLV_PCSK_KEX2_1	43	45	PF00082	0.486
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.486
CLV_PCSK_PC7_1	7	13	PF00082	0.745
CLV_PCSK_SKI1_1	216	220	PF00082	0.617
CLV_PCSK_SKI1_1	43	47	PF00082	0.408
CLV_PCSK_SKI1_1	68	72	PF00082	0.528
DEG_Nend_UBRbox_1	1	4	PF02207	0.678
DOC_ANK_TNKS_1	12	19	PF00023	0.728
DOC_CYCLIN_RxL_1	40	50	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.712
DOC_MAPK_gen_1	43	49	PF00069	0.530
DOC_PP2B_LxvP_1	218	221	PF13499	0.705
DOC_PP2B_LxvP_1	45	48	PF13499	0.375
DOC_USP7_MATH_1	153	157	PF00917	0.572
DOC_USP7_MATH_1	258	262	PF00917	0.725
DOC_USP7_MATH_1	305	309	PF00917	0.660
DOC_USP7_MATH_1	324	328	PF00917	0.409
DOC_USP7_MATH_1	48	52	PF00917	0.464
DOC_USP7_MATH_2	15	21	PF00917	0.762
DOC_WW_Pin1_4	180	185	PF00397	0.559
DOC_WW_Pin1_4	247	252	PF00397	0.739
DOC_WW_Pin1_4	272	277	PF00397	0.605
DOC_WW_Pin1_4	288	293	PF00397	0.612
DOC_WW_Pin1_4	301	306	PF00397	0.613
LIG_14-3-3_CanoR_1	209	213	PF00244	0.514
LIG_14-3-3_CanoR_1	309	319	PF00244	0.557
LIG_BRCT_BRCA1_1	307	311	PF00533	0.694
LIG_EVH1_2	276	280	PF00568	0.685
LIG_EVH1_2	31	35	PF00568	0.556
LIG_FHA_1	112	118	PF00498	0.518
LIG_FHA_1	142	148	PF00498	0.467
LIG_FHA_1	168	174	PF00498	0.441
LIG_FHA_1	209	215	PF00498	0.504
LIG_FHA_1	217	223	PF00498	0.583
LIG_FHA_1	25	31	PF00498	0.560
LIG_FHA_1	273	279	PF00498	0.669
LIG_FHA_2	236	242	PF00498	0.643
LIG_IBAR_NPY_1	323	325	PF08397	0.552
LIG_LIR_Gen_1	191	202	PF02991	0.376
LIG_LIR_Gen_1	230	240	PF02991	0.571
LIG_LIR_Nem_3	191	197	PF02991	0.368
LIG_LIR_Nem_3	230	236	PF02991	0.570
LIG_SH2_STAP1	233	237	PF00017	0.508
LIG_SH3_3	163	169	PF00018	0.433
LIG_SH3_3	259	265	PF00018	0.712
LIG_SH3_3	271	277	PF00018	0.706
LIG_SH3_3	34	40	PF00018	0.398
LIG_UBA3_1	34	43	PF00899	0.453
MOD_CDK_SPxxK_3	180	187	PF00069	0.547
MOD_CDK_SPxxK_3	272	279	PF00069	0.680
MOD_CK1_1	112	118	PF00069	0.501
MOD_CK1_1	247	253	PF00069	0.756
MOD_CK1_1	260	266	PF00069	0.661
MOD_CK1_1	310	316	PF00069	0.550
MOD_CK1_1	328	334	PF00069	0.618
MOD_CK2_1	329	335	PF00069	0.614
MOD_GlcNHglycan	113	117	PF01048	0.582
MOD_GlcNHglycan	155	158	PF01048	0.538
MOD_GlcNHglycan	170	173	PF01048	0.337
MOD_GlcNHglycan	177	180	PF01048	0.445
MOD_GlcNHglycan	246	249	PF01048	0.704
MOD_GlcNHglycan	268	271	PF01048	0.714
MOD_GlcNHglycan	315	318	PF01048	0.621
MOD_GSK3_1	260	267	PF00069	0.543
MOD_GSK3_1	301	308	PF00069	0.644
MOD_GSK3_1	309	316	PF00069	0.537
MOD_GSK3_1	324	331	PF00069	0.510
MOD_GSK3_1	48	55	PF00069	0.447
MOD_N-GLC_1	325	330	PF02516	0.626
MOD_NEK2_1	244	249	PF00069	0.666
MOD_NEK2_1	266	271	PF00069	0.684
MOD_NEK2_1	285	290	PF00069	0.740
MOD_NEK2_1	307	312	PF00069	0.573
MOD_NEK2_1	52	57	PF00069	0.446
MOD_PKA_2	208	214	PF00069	0.553
MOD_PKB_1	74	82	PF00069	0.495
MOD_Plk_2-3	235	241	PF00069	0.724
MOD_Plk_4	138	144	PF00069	0.499
MOD_Plk_4	235	241	PF00069	0.646
MOD_Plk_4	329	335	PF00069	0.609
MOD_Plk_4	48	54	PF00069	0.523
MOD_ProDKin_1	180	186	PF00069	0.549
MOD_ProDKin_1	247	253	PF00069	0.741
MOD_ProDKin_1	272	278	PF00069	0.604
MOD_ProDKin_1	288	294	PF00069	0.612
MOD_ProDKin_1	301	307	PF00069	0.609
MOD_SUMO_for_1	212	215	PF00179	0.627
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.359
TRG_ENDOCYTIC_2	233	236	PF00928	0.508
TRG_ER_diArg_1	9	12	PF00400	0.683
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY30	Leptomonas seymouri	30%	81%
A0A0N1I3L5	Leptomonas seymouri	68%	100%
A0A1X0NQH6	Trypanosomatidae	41%	100%
A0A3R7R5S5	Trypanosoma rangeli	32%	76%
A0A3S5IR49	Trypanosoma rangeli	39%	100%
A0A3S7X224	Leishmania donovani	99%	100%
A4HGZ8	Leishmania braziliensis	83%	100%
E9B0B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q7W7	Leishmania major	95%	100%
V5BI47	Trypanosoma cruzi	42%	100%