SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I429_LEIIN

TriTrypDb:

LINF_280037600

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I429

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I429

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.617
CLV_C14_Caspase3-7	60	64	PF00656	0.616
CLV_NRD_NRD_1	388	390	PF00675	0.539
CLV_NRD_NRD_1	467	469	PF00675	0.479
CLV_NRD_NRD_1	490	492	PF00675	0.563
CLV_PCSK_KEX2_1	390	392	PF00082	0.557
CLV_PCSK_KEX2_1	467	469	PF00082	0.517
CLV_PCSK_KEX2_1	480	482	PF00082	0.540
CLV_PCSK_KEX2_1	490	492	PF00082	0.559
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.611
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.572
CLV_PCSK_SKI1_1	114	118	PF00082	0.626
CLV_PCSK_SKI1_1	119	123	PF00082	0.398
CLV_PCSK_SKI1_1	348	352	PF00082	0.557
CLV_PCSK_SKI1_1	382	386	PF00082	0.529
CLV_PCSK_SKI1_1	72	76	PF00082	0.507
CLV_Separin_Metazoa	506	510	PF03568	0.661
DEG_APCC_DBOX_1	240	248	PF00400	0.506
DEG_APCC_DBOX_1	399	407	PF00400	0.471
DEG_SPOP_SBC_1	177	181	PF00917	0.735
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.751
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.418
DOC_MAPK_gen_1	114	123	PF00069	0.549
DOC_MAPK_gen_1	272	280	PF00069	0.658
DOC_MAPK_gen_1	480	488	PF00069	0.440
DOC_MAPK_MEF2A_6	480	488	PF00069	0.529
DOC_PP1_RVXF_1	117	123	PF00149	0.521
DOC_PP1_RVXF_1	241	247	PF00149	0.538
DOC_PP1_RVXF_1	465	472	PF00149	0.470
DOC_PP1_RVXF_1	479	486	PF00149	0.551
DOC_PP4_FxxP_1	122	125	PF00568	0.503
DOC_PP4_FxxP_1	148	151	PF00568	0.668
DOC_USP7_MATH_1	133	137	PF00917	0.542
DOC_USP7_MATH_1	151	155	PF00917	0.643
DOC_USP7_MATH_1	156	160	PF00917	0.644
DOC_USP7_MATH_1	17	21	PF00917	0.769
DOC_USP7_MATH_1	177	181	PF00917	0.758
DOC_USP7_MATH_1	216	220	PF00917	0.751
DOC_USP7_MATH_1	291	295	PF00917	0.692
DOC_USP7_MATH_2	24	30	PF00917	0.647
DOC_USP7_UBL2_3	348	352	PF12436	0.557
DOC_USP7_UBL2_3	72	76	PF12436	0.581
DOC_WW_Pin1_4	147	152	PF00397	0.615
DOC_WW_Pin1_4	492	497	PF00397	0.678
LIG_14-3-3_CanoR_1	252	256	PF00244	0.482
LIG_14-3-3_CanoR_1	440	444	PF00244	0.679
LIG_14-3-3_CanoR_1	65	71	PF00244	0.547
LIG_14-3-3_CanoR_1	84	90	PF00244	0.348
LIG_BIR_II_1	1	5	PF00653	0.746
LIG_BIR_III_4	331	335	PF00653	0.713
LIG_BRCT_BRCA1_1	46	50	PF00533	0.588
LIG_CaM_NSCaTE_8	471	478	PF13499	0.511
LIG_Clathr_ClatBox_1	162	166	PF01394	0.659
LIG_eIF4E_1	197	203	PF01652	0.567
LIG_FHA_1	102	108	PF00498	0.449
LIG_FHA_1	275	281	PF00498	0.617
LIG_FHA_1	403	409	PF00498	0.443
LIG_FHA_1	439	445	PF00498	0.690
LIG_FHA_1	80	86	PF00498	0.545
LIG_FHA_2	126	132	PF00498	0.490
LIG_FHA_2	271	277	PF00498	0.593
LIG_FHA_2	299	305	PF00498	0.653
LIG_FHA_2	30	36	PF00498	0.546
LIG_GBD_Chelix_1	316	324	PF00786	0.600
LIG_Integrin_RGD_1	302	304	PF01839	0.661
LIG_LIR_Apic_2	51	56	PF02991	0.589
LIG_LIR_Gen_1	254	263	PF02991	0.400
LIG_LIR_Gen_1	321	328	PF02991	0.501
LIG_LIR_Gen_1	417	428	PF02991	0.568
LIG_LIR_Nem_3	194	200	PF02991	0.602
LIG_LIR_Nem_3	254	258	PF02991	0.414
LIG_LIR_Nem_3	261	266	PF02991	0.420
LIG_LIR_Nem_3	321	326	PF02991	0.489
LIG_LIR_Nem_3	383	387	PF02991	0.421
LIG_LIR_Nem_3	417	423	PF02991	0.545
LIG_LIR_Nem_3	47	53	PF02991	0.575
LIG_NRP_CendR_1	511	514	PF00754	0.745
LIG_PCNA_yPIPBox_3	310	320	PF02747	0.612
LIG_PCNA_yPIPBox_3	84	97	PF02747	0.532
LIG_Pex14_2	148	152	PF04695	0.686
LIG_Pex14_2	384	388	PF04695	0.426
LIG_Pex14_2	419	423	PF04695	0.457
LIG_SH2_CRK	197	201	PF00017	0.595
LIG_SH2_CRK	239	243	PF00017	0.509
LIG_SH2_CRK	53	57	PF00017	0.616
LIG_SH2_PTP2	263	266	PF00017	0.528
LIG_SH2_STAT5	239	242	PF00017	0.466
LIG_SH2_STAT5	263	266	PF00017	0.533
LIG_SH2_STAT5	319	322	PF00017	0.469
LIG_SH2_STAT5	420	423	PF00017	0.539
LIG_SH2_STAT5	80	83	PF00017	0.545
LIG_SH3_3	158	164	PF00018	0.716
LIG_SH3_3	443	449	PF00018	0.734
LIG_SUMO_SIM_par_1	127	136	PF11976	0.482
LIG_TRAF2_1	185	188	PF00917	0.647
LIG_TRAF2_1	311	314	PF00917	0.608
LIG_TYR_ITIM	237	242	PF00017	0.553
MOD_CK1_1	101	107	PF00069	0.510
MOD_CK1_1	180	186	PF00069	0.616
MOD_CK1_1	191	197	PF00069	0.549
MOD_CK1_1	2	8	PF00069	0.653
MOD_CK1_1	220	226	PF00069	0.759
MOD_CK1_1	270	276	PF00069	0.528
MOD_CK1_1	29	35	PF00069	0.583
MOD_CK1_1	298	304	PF00069	0.729
MOD_CK1_1	336	342	PF00069	0.707
MOD_CK1_1	79	85	PF00069	0.541
MOD_CK2_1	133	139	PF00069	0.463
MOD_CK2_1	182	188	PF00069	0.704
MOD_CK2_1	245	251	PF00069	0.439
MOD_CK2_1	29	35	PF00069	0.573
MOD_CMANNOS	471	474	PF00535	0.380
MOD_GlcNHglycan	153	156	PF01048	0.658
MOD_GlcNHglycan	18	22	PF01048	0.666
MOD_GlcNHglycan	194	197	PF01048	0.595
MOD_GlcNHglycan	224	227	PF01048	0.718
MOD_GlcNHglycan	297	300	PF01048	0.657
MOD_GlcNHglycan	326	329	PF01048	0.600
MOD_GlcNHglycan	4	7	PF01048	0.731
MOD_GlcNHglycan	413	417	PF01048	0.525
MOD_GlcNHglycan	497	500	PF01048	0.713
MOD_GlcNHglycan	59	62	PF01048	0.672
MOD_GSK3_1	147	154	PF00069	0.640
MOD_GSK3_1	173	180	PF00069	0.696
MOD_GSK3_1	188	195	PF00069	0.580
MOD_GSK3_1	216	223	PF00069	0.751
MOD_GSK3_1	270	277	PF00069	0.600
MOD_GSK3_1	286	293	PF00069	0.729
MOD_GSK3_1	305	312	PF00069	0.447
MOD_GSK3_1	434	441	PF00069	0.700
MOD_GSK3_1	66	73	PF00069	0.557
MOD_GSK3_1	76	83	PF00069	0.516
MOD_N-GLC_1	101	106	PF02516	0.513
MOD_N-GLC_1	336	341	PF02516	0.690
MOD_N-GLC_1	85	90	PF02516	0.530
MOD_NEK2_1	165	170	PF00069	0.701
MOD_NEK2_1	267	272	PF00069	0.474
MOD_NEK2_1	295	300	PF00069	0.719
MOD_NEK2_1	322	327	PF00069	0.501
MOD_NEK2_1	414	419	PF00069	0.464
MOD_NEK2_1	475	480	PF00069	0.523
MOD_NEK2_1	57	62	PF00069	0.605
MOD_NEK2_1	70	75	PF00069	0.408
MOD_NEK2_2	274	279	PF00069	0.667
MOD_PIKK_1	309	315	PF00454	0.643
MOD_PK_1	19	25	PF00069	0.664
MOD_PKA_2	216	222	PF00069	0.713
MOD_PKA_2	24	30	PF00069	0.735
MOD_PKA_2	251	257	PF00069	0.469
MOD_PKA_2	274	280	PF00069	0.658
MOD_PKA_2	439	445	PF00069	0.666
MOD_PKA_2	57	63	PF00069	0.649
MOD_PKA_2	66	72	PF00069	0.618
MOD_Plk_1	101	107	PF00069	0.507
MOD_Plk_1	438	444	PF00069	0.750
MOD_Plk_1	475	481	PF00069	0.526
MOD_Plk_1	85	91	PF00069	0.618
MOD_Plk_4	125	131	PF00069	0.407
MOD_Plk_4	133	139	PF00069	0.445
MOD_Plk_4	251	257	PF00069	0.511
MOD_Plk_4	274	280	PF00069	0.616
MOD_Plk_4	29	35	PF00069	0.562
MOD_Plk_4	439	445	PF00069	0.719
MOD_Plk_4	76	82	PF00069	0.605
MOD_ProDKin_1	147	153	PF00069	0.615
MOD_ProDKin_1	492	498	PF00069	0.686
TRG_DiLeu_BaEn_1	439	444	PF01217	0.742
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.530
TRG_ENDOCYTIC_2	197	200	PF00928	0.553
TRG_ENDOCYTIC_2	239	242	PF00928	0.464
TRG_ENDOCYTIC_2	263	266	PF00928	0.458
TRG_ENDOCYTIC_2	319	322	PF00928	0.469
TRG_ENDOCYTIC_2	420	423	PF00928	0.515
TRG_ER_diArg_1	241	244	PF00400	0.547
TRG_ER_diArg_1	388	391	PF00400	0.517
TRG_ER_diArg_1	467	469	PF00400	0.473
TRG_ER_diArg_1	508	511	PF00400	0.656
TRG_ER_diArg_1	65	68	PF00400	0.689
TRG_NES_CRM1_1	341	357	PF08389	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC67	Leptomonas seymouri	46%	92%
A0A1X0NQG3	Trypanosomatidae	24%	100%
A0A3Q8IF46	Leishmania donovani	100%	100%
A0A3R7NCN5	Trypanosoma rangeli	26%	100%
E9B0B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5B927	Trypanosoma cruzi	24%	100%