LeishMANIAdb
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Putative sodium/sulphate symporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative sodium/sulphate symporter
Gene product:
phosphate transporter - putative
Species:
Leishmania infantum
UniProt:
A4I428_LEIIN
TriTrypDb:
LINF_280037500
Length:
734

Annotations

Annotations by Jardim et al.

Acidocalcisome, Low affinity phosphate Pho91 sodium/sulphate symporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0000331 contractile vacuole 6 1
GO:0005773 vacuole 5 1
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

A4I428
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I428

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006797 polyphosphate metabolic process 4 1
GO:0006810 transport 3 4
GO:0006811 monoatomic ion transport 4 1
GO:0006817 phosphate ion transport 7 1
GO:0006820 monoatomic anion transport 5 1
GO:0006873 intracellular monoatomic ion homeostasis 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 4
GO:0015698 inorganic anion transport 6 1
GO:0019725 cellular homeostasis 2 1
GO:0030002 intracellular monoatomic anion homeostasis 5 1
GO:0030643 intracellular phosphate ion homeostasis 7 1
GO:0034220 monoatomic ion transmembrane transport 3 1
GO:0042592 homeostatic process 3 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044281 small molecule metabolic process 2 1
GO:0048878 chemical homeostasis 4 1
GO:0050801 monoatomic ion homeostasis 5 1
GO:0051179 localization 1 4
GO:0051234 establishment of localization 2 4
GO:0055062 phosphate ion homeostasis 8 1
GO:0055081 monoatomic anion homeostasis 6 1
GO:0055082 intracellular chemical homeostasis 3 1
GO:0055085 transmembrane transport 2 4
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0072502 obsolete cellular trivalent inorganic anion homeostasis 6 1
GO:0072506 obsolete trivalent inorganic anion homeostasis 7 1
GO:0098656 monoatomic anion transmembrane transport 4 1
GO:0098771 inorganic ion homeostasis 6 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 7
GO:0022857 transmembrane transporter activity 2 7
GO:0005315 inorganic phosphate transmembrane transporter activity 4 1
GO:0015291 secondary active transmembrane transporter activity 4 1
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 1
GO:0022804 active transmembrane transporter activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 122 126 PF00656 0.765
CLV_C14_Caspase3-7 604 608 PF00656 0.370
CLV_NRD_NRD_1 187 189 PF00675 0.356
CLV_NRD_NRD_1 198 200 PF00675 0.422
CLV_NRD_NRD_1 236 238 PF00675 0.349
CLV_NRD_NRD_1 87 89 PF00675 0.478
CLV_NRD_NRD_1 92 94 PF00675 0.497
CLV_PCSK_KEX2_1 142 144 PF00082 0.461
CLV_PCSK_KEX2_1 198 200 PF00082 0.438
CLV_PCSK_KEX2_1 23 25 PF00082 0.348
CLV_PCSK_KEX2_1 273 275 PF00082 0.348
CLV_PCSK_KEX2_1 327 329 PF00082 0.287
CLV_PCSK_KEX2_1 5 7 PF00082 0.375
CLV_PCSK_KEX2_1 92 94 PF00082 0.508
CLV_PCSK_PC1ET2_1 142 144 PF00082 0.461
CLV_PCSK_PC1ET2_1 23 25 PF00082 0.348
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.348
CLV_PCSK_PC1ET2_1 327 329 PF00082 0.287
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.375
CLV_PCSK_PC7_1 88 94 PF00082 0.496
CLV_PCSK_SKI1_1 142 146 PF00082 0.416
CLV_PCSK_SKI1_1 163 167 PF00082 0.426
CLV_PCSK_SKI1_1 189 193 PF00082 0.364
CLV_PCSK_SKI1_1 216 220 PF00082 0.394
CLV_PCSK_SKI1_1 225 229 PF00082 0.400
CLV_PCSK_SKI1_1 23 27 PF00082 0.356
CLV_PCSK_SKI1_1 237 241 PF00082 0.378
CLV_PCSK_SKI1_1 260 264 PF00082 0.352
CLV_PCSK_SKI1_1 701 705 PF00082 0.269
CLV_PCSK_SKI1_1 71 75 PF00082 0.478
DEG_APCC_DBOX_1 133 141 PF00400 0.653
DEG_APCC_DBOX_1 142 150 PF00400 0.582
DEG_APCC_DBOX_1 213 221 PF00400 0.565
DEG_APCC_DBOX_1 224 232 PF00400 0.563
DEG_APCC_DBOX_1 381 389 PF00400 0.287
DEG_Nend_UBRbox_1 1 4 PF02207 0.601
DOC_CYCLIN_RxL_1 160 171 PF00134 0.630
DOC_CYCLIN_RxL_1 222 232 PF00134 0.627
DOC_MAPK_DCC_7 494 504 PF00069 0.514
DOC_MAPK_gen_1 142 149 PF00069 0.631
DOC_MAPK_gen_1 223 231 PF00069 0.578
DOC_MAPK_gen_1 237 243 PF00069 0.570
DOC_MAPK_gen_1 5 13 PF00069 0.660
DOC_MAPK_gen_1 71 81 PF00069 0.646
DOC_MAPK_HePTP_8 340 352 PF00069 0.469
DOC_MAPK_MEF2A_6 223 231 PF00069 0.556
DOC_MAPK_MEF2A_6 343 352 PF00069 0.469
DOC_MAPK_MEF2A_6 74 81 PF00069 0.658
DOC_PP1_RVXF_1 462 468 PF00149 0.332
DOC_PP1_RVXF_1 641 647 PF00149 0.348
DOC_PP4_FxxP_1 239 242 PF00568 0.624
DOC_PP4_FxxP_1 315 318 PF00568 0.416
DOC_PP4_FxxP_1 646 649 PF00568 0.287
DOC_USP7_MATH_1 114 118 PF00917 0.752
DOC_USP7_MATH_1 399 403 PF00917 0.323
DOC_USP7_MATH_1 588 592 PF00917 0.269
DOC_USP7_MATH_1 677 681 PF00917 0.323
DOC_USP7_MATH_1 689 693 PF00917 0.469
DOC_USP7_UBL2_3 189 193 PF12436 0.564
DOC_WW_Pin1_4 158 163 PF00397 0.605
DOC_WW_Pin1_4 443 448 PF00397 0.307
DOC_WW_Pin1_4 605 610 PF00397 0.310
DOC_WW_Pin1_4 655 660 PF00397 0.266
LIG_14-3-3_CanoR_1 131 141 PF00244 0.579
LIG_14-3-3_CanoR_1 188 194 PF00244 0.587
LIG_14-3-3_CanoR_1 216 221 PF00244 0.547
LIG_14-3-3_CanoR_1 377 385 PF00244 0.269
LIG_Actin_WH2_2 22 37 PF00022 0.598
LIG_BIR_III_2 127 131 PF00653 0.630
LIG_BRCT_BRCA1_1 231 235 PF00533 0.617
LIG_deltaCOP1_diTrp_1 254 259 PF00928 0.604
LIG_EH1_1 629 637 PF00400 0.323
LIG_FHA_1 106 112 PF00498 0.792
LIG_FHA_1 113 119 PF00498 0.692
LIG_FHA_1 203 209 PF00498 0.572
LIG_FHA_1 294 300 PF00498 0.331
LIG_FHA_1 306 312 PF00498 0.279
LIG_FHA_1 330 336 PF00498 0.482
LIG_FHA_1 46 52 PF00498 0.630
LIG_FHA_1 517 523 PF00498 0.490
LIG_FHA_1 528 534 PF00498 0.283
LIG_FHA_1 543 549 PF00498 0.348
LIG_FHA_1 611 617 PF00498 0.311
LIG_FHA_1 623 629 PF00498 0.352
LIG_FHA_1 713 719 PF00498 0.337
LIG_FHA_1 724 730 PF00498 0.309
LIG_FHA_2 324 330 PF00498 0.514
LIG_FHA_2 363 369 PF00498 0.323
LIG_FHA_2 415 421 PF00498 0.469
LIG_FHA_2 507 513 PF00498 0.519
LIG_FHA_2 602 608 PF00498 0.370
LIG_GBD_Chelix_1 525 533 PF00786 0.387
LIG_LIR_Apic_2 236 242 PF02991 0.622
LIG_LIR_Apic_2 417 422 PF02991 0.469
LIG_LIR_Apic_2 532 537 PF02991 0.464
LIG_LIR_Apic_2 720 724 PF02991 0.324
LIG_LIR_Apic_2 726 731 PF02991 0.318
LIG_LIR_Gen_1 244 251 PF02991 0.671
LIG_LIR_Gen_1 266 277 PF02991 0.391
LIG_LIR_Gen_1 42 52 PF02991 0.545
LIG_LIR_Gen_1 55 65 PF02991 0.551
LIG_LIR_Gen_1 565 575 PF02991 0.469
LIG_LIR_Gen_1 608 619 PF02991 0.381
LIG_LIR_LC3C_4 613 617 PF02991 0.365
LIG_LIR_Nem_3 14 18 PF02991 0.560
LIG_LIR_Nem_3 21 25 PF02991 0.534
LIG_LIR_Nem_3 244 249 PF02991 0.620
LIG_LIR_Nem_3 266 272 PF02991 0.391
LIG_LIR_Nem_3 42 47 PF02991 0.523
LIG_LIR_Nem_3 461 465 PF02991 0.295
LIG_LIR_Nem_3 498 504 PF02991 0.515
LIG_LIR_Nem_3 55 61 PF02991 0.539
LIG_LIR_Nem_3 565 570 PF02991 0.469
LIG_LIR_Nem_3 608 614 PF02991 0.381
LIG_LIR_Nem_3 679 684 PF02991 0.323
LIG_NRBOX 136 142 PF00104 0.671
LIG_NRBOX 143 149 PF00104 0.651
LIG_NRBOX 223 229 PF00104 0.626
LIG_NRBOX 573 579 PF00104 0.323
LIG_PCNA_PIPBox_1 338 347 PF02747 0.522
LIG_Pex14_1 15 19 PF04695 0.547
LIG_Pex14_1 259 263 PF04695 0.465
LIG_Pex14_1 572 576 PF04695 0.323
LIG_Pex14_2 235 239 PF04695 0.606
LIG_SH2_CRK 22 26 PF00017 0.548
LIG_SH2_CRK 246 250 PF00017 0.626
LIG_SH2_GRB2like 246 249 PF00017 0.675
LIG_SH2_NCK_1 246 250 PF00017 0.679
LIG_SH2_PTP2 261 264 PF00017 0.380
LIG_SH2_PTP2 501 504 PF00017 0.540
LIG_SH2_PTP2 728 731 PF00017 0.399
LIG_SH2_SRC 246 249 PF00017 0.675
LIG_SH2_STAP1 246 250 PF00017 0.640
LIG_SH2_STAP1 370 374 PF00017 0.309
LIG_SH2_STAT5 19 22 PF00017 0.509
LIG_SH2_STAT5 261 264 PF00017 0.380
LIG_SH2_STAT5 386 389 PF00017 0.323
LIG_SH2_STAT5 501 504 PF00017 0.540
LIG_SH2_STAT5 611 614 PF00017 0.323
LIG_SH2_STAT5 697 700 PF00017 0.469
LIG_SH2_STAT5 728 731 PF00017 0.370
LIG_SH3_1 74 80 PF00018 0.716
LIG_SH3_3 115 121 PF00018 0.771
LIG_SH3_3 319 325 PF00018 0.500
LIG_SH3_3 401 407 PF00018 0.318
LIG_SH3_3 470 476 PF00018 0.346
LIG_SH3_3 489 495 PF00018 0.193
LIG_SH3_3 497 503 PF00018 0.469
LIG_SH3_3 74 80 PF00018 0.633
LIG_SH3_3 81 87 PF00018 0.660
LIG_SUMO_SIM_anti_2 613 619 PF11976 0.324
LIG_SUMO_SIM_anti_2 708 715 PF11976 0.380
LIG_SUMO_SIM_par_1 145 152 PF11976 0.715
LIG_SUMO_SIM_par_1 227 232 PF11976 0.584
LIG_SUMO_SIM_par_1 291 296 PF11976 0.408
LIG_SUMO_SIM_par_1 475 481 PF11976 0.380
LIG_SUMO_SIM_par_1 521 527 PF11976 0.328
LIG_SUMO_SIM_par_1 661 666 PF11976 0.300
LIG_TRAF2_1 104 107 PF00917 0.767
LIG_TRAF2_1 510 513 PF00917 0.570
LIG_TYR_ITIM 20 25 PF00017 0.539
LIG_TYR_ITIM 499 504 PF00017 0.540
LIG_UBA3_1 593 602 PF00899 0.340
LIG_UBA3_1 635 643 PF00899 0.325
LIG_Vh1_VBS_1 617 635 PF01044 0.318
LIG_WRC_WIRS_1 624 629 PF05994 0.469
LIG_WRPW_2 493 496 PF00400 0.452
MOD_CDK_SPK_2 158 163 PF00069 0.605
MOD_CK1_1 112 118 PF00069 0.766
MOD_CK1_1 37 43 PF00069 0.581
MOD_CK1_1 458 464 PF00069 0.295
MOD_CK1_1 516 522 PF00069 0.501
MOD_CK1_1 527 533 PF00069 0.267
MOD_CK1_1 600 606 PF00069 0.370
MOD_CK2_1 323 329 PF00069 0.514
MOD_CK2_1 362 368 PF00069 0.305
MOD_CK2_1 414 420 PF00069 0.469
MOD_CK2_1 506 512 PF00069 0.540
MOD_Cter_Amidation 3 6 PF01082 0.378
MOD_GlcNHglycan 189 192 PF01048 0.409
MOD_GlcNHglycan 329 332 PF01048 0.319
MOD_GlcNHglycan 457 460 PF01048 0.540
MOD_GlcNHglycan 516 519 PF01048 0.340
MOD_GlcNHglycan 526 529 PF01048 0.423
MOD_GlcNHglycan 650 653 PF01048 0.473
MOD_GlcNHglycan 665 668 PF01048 0.306
MOD_GlcNHglycan 670 673 PF01048 0.318
MOD_GlcNHglycan 97 100 PF01048 0.580
MOD_GSK3_1 105 112 PF00069 0.733
MOD_GSK3_1 212 219 PF00069 0.567
MOD_GSK3_1 293 300 PF00069 0.323
MOD_GSK3_1 323 330 PF00069 0.481
MOD_GSK3_1 443 450 PF00069 0.323
MOD_GSK3_1 597 604 PF00069 0.301
MOD_GSK3_1 622 629 PF00069 0.350
MOD_GSK3_1 708 715 PF00069 0.408
MOD_NEK2_1 110 115 PF00069 0.771
MOD_NEK2_1 212 217 PF00069 0.596
MOD_NEK2_1 263 268 PF00069 0.251
MOD_NEK2_1 293 298 PF00069 0.338
MOD_NEK2_1 305 310 PF00069 0.290
MOD_NEK2_1 362 367 PF00069 0.348
MOD_NEK2_1 391 396 PF00069 0.341
MOD_NEK2_1 524 529 PF00069 0.408
MOD_NEK2_1 542 547 PF00069 0.180
MOD_NEK2_1 601 606 PF00069 0.269
MOD_NEK2_1 668 673 PF00069 0.323
MOD_NEK2_1 705 710 PF00069 0.300
MOD_NEK2_1 712 717 PF00069 0.300
MOD_PIKK_1 149 155 PF00454 0.671
MOD_PIKK_1 249 255 PF00454 0.683
MOD_PIKK_1 334 340 PF00454 0.535
MOD_PKA_1 327 333 PF00069 0.487
MOD_PKA_1 94 100 PF00069 0.742
MOD_PKA_2 133 139 PF00069 0.576
MOD_PKA_2 187 193 PF00069 0.583
MOD_PKA_2 327 333 PF00069 0.487
MOD_PKA_2 34 40 PF00069 0.618
MOD_PKA_2 376 382 PF00069 0.255
MOD_PKA_2 588 594 PF00069 0.270
MOD_PKB_1 214 222 PF00069 0.564
MOD_Plk_1 229 235 PF00069 0.612
MOD_Plk_4 119 125 PF00069 0.730
MOD_Plk_4 216 222 PF00069 0.563
MOD_Plk_4 370 376 PF00069 0.337
MOD_Plk_4 381 387 PF00069 0.234
MOD_Plk_4 458 464 PF00069 0.280
MOD_Plk_4 610 616 PF00069 0.345
MOD_Plk_4 623 629 PF00069 0.323
MOD_Plk_4 658 664 PF00069 0.287
MOD_Plk_4 683 689 PF00069 0.469
MOD_Plk_4 705 711 PF00069 0.310
MOD_Plk_4 717 723 PF00069 0.349
MOD_ProDKin_1 158 164 PF00069 0.601
MOD_ProDKin_1 443 449 PF00069 0.307
MOD_ProDKin_1 605 611 PF00069 0.310
MOD_ProDKin_1 655 661 PF00069 0.266
MOD_SUMO_for_1 52 55 PF00179 0.624
MOD_SUMO_rev_2 230 239 PF00179 0.552
TRG_DiLeu_BaEn_1 68 73 PF01217 0.638
TRG_DiLeu_BaEn_2 105 111 PF01217 0.710
TRG_DiLeu_BaLyEn_6 404 409 PF01217 0.323
TRG_DiLeu_BaLyEn_6 589 594 PF01217 0.342
TRG_ENDOCYTIC_2 22 25 PF00928 0.535
TRG_ENDOCYTIC_2 246 249 PF00928 0.621
TRG_ENDOCYTIC_2 261 264 PF00928 0.348
TRG_ENDOCYTIC_2 501 504 PF00928 0.540
TRG_ENDOCYTIC_2 611 614 PF00928 0.323
TRG_ER_diArg_1 198 200 PF00400 0.636
TRG_ER_diArg_1 214 217 PF00400 0.492
TRG_ER_diArg_1 222 225 PF00400 0.533
TRG_NES_CRM1_1 175 185 PF08389 0.593
TRG_NLS_Bipartite_1 5 27 PF00514 0.583
TRG_NLS_MonoExtC_3 191 196 PF00514 0.581
TRG_NLS_MonoExtN_4 189 196 PF00514 0.573
TRG_NLS_MonoExtN_4 92 97 PF00514 0.759
TRG_Pf-PMV_PEXEL_1 163 168 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 225 230 PF00026 0.403
TRG_Pf-PMV_PEXEL_1 416 420 PF00026 0.309

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWP2 Leptomonas seymouri 81% 99%
A0A1X0NQK1 Trypanosomatidae 64% 100%
A0A3Q8IB88 Leishmania donovani 100% 100%
A0A422NG32 Trypanosoma rangeli 71% 100%
A4HGZ6 Leishmania braziliensis 91% 100%
D0A8X9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9B0B5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P27514 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 82%
Q21339 Caenorhabditis elegans 25% 100%
Q4Q7W9 Leishmania major 98% 100%
Q93655 Caenorhabditis elegans 21% 100%
Q9ES88 Mus musculus 22% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS