Conserved oligomeric Golgi complex subunit 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligomeric golgi complex component 8 - putative

Species:

Leishmania infantum

UniProt:

A4I425_LEIIN

TriTrypDb:

LINF_280037200

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0017119	Golgi transport complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0099023	vesicle tethering complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000139	Golgi membrane	5	3
GO:0031090	organelle membrane	3	3
GO:0098588	bounding membrane of organelle	4	3

Expansion

Sequence features

A4I425

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I425

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.308
CLV_NRD_NRD_1	382	384	PF00675	0.366
CLV_PCSK_KEX2_1	170	172	PF00082	0.308
CLV_PCSK_SKI1_1	180	184	PF00082	0.324
CLV_PCSK_SKI1_1	192	196	PF00082	0.324
CLV_PCSK_SKI1_1	210	214	PF00082	0.236
CLV_PCSK_SKI1_1	239	243	PF00082	0.377
CLV_PCSK_SKI1_1	384	388	PF00082	0.519
CLV_PCSK_SKI1_1	424	428	PF00082	0.422
CLV_PCSK_SKI1_1	48	52	PF00082	0.401
DEG_SCF_FBW7_1	505	510	PF00400	0.597
DOC_CDC14_PxL_1	410	418	PF14671	0.570
DOC_CKS1_1	502	507	PF01111	0.599
DOC_CYCLIN_RxL_1	187	199	PF00134	0.443
DOC_CYCLIN_RxL_1	381	391	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	437	443	PF00134	0.452
DOC_USP7_MATH_1	198	202	PF00917	0.324
DOC_USP7_MATH_1	35	39	PF00917	0.305
DOC_USP7_MATH_1	484	488	PF00917	0.663
DOC_USP7_MATH_1	496	500	PF00917	0.702
DOC_USP7_MATH_1	515	519	PF00917	0.693
DOC_USP7_MATH_1	67	71	PF00917	0.430
DOC_USP7_MATH_1	81	85	PF00917	0.292
DOC_WW_Pin1_4	172	177	PF00397	0.428
DOC_WW_Pin1_4	354	359	PF00397	0.449
DOC_WW_Pin1_4	475	480	PF00397	0.548
DOC_WW_Pin1_4	501	506	PF00397	0.637
DOC_WW_Pin1_4	91	96	PF00397	0.455
LIG_14-3-3_CanoR_1	103	107	PF00244	0.462
LIG_14-3-3_CanoR_1	239	248	PF00244	0.419
LIG_14-3-3_CanoR_1	289	298	PF00244	0.399
LIG_14-3-3_CanoR_1	318	322	PF00244	0.462
LIG_14-3-3_CanoR_1	331	335	PF00244	0.452
LIG_APCC_ABBAyCdc20_2	103	109	PF00400	0.308
LIG_Clathr_ClatBox_1	111	115	PF01394	0.308
LIG_Clathr_ClatBox_1	473	477	PF01394	0.505
LIG_EH1_1	443	451	PF00400	0.486
LIG_EH1_1	466	474	PF00400	0.528
LIG_eIF4E_1	163	169	PF01652	0.428
LIG_eIF4E_1	467	473	PF01652	0.407
LIG_FHA_1	240	246	PF00498	0.455
LIG_FHA_1	290	296	PF00498	0.362
LIG_FHA_1	355	361	PF00498	0.538
LIG_FHA_1	460	466	PF00498	0.548
LIG_FHA_1	49	55	PF00498	0.410
LIG_FHA_2	351	357	PF00498	0.606
LIG_FHA_2	44	50	PF00498	0.396
LIG_GBD_Chelix_1	368	376	PF00786	0.377
LIG_LIR_Gen_1	21	31	PF02991	0.428
LIG_LIR_Gen_1	378	387	PF02991	0.374
LIG_LIR_Gen_1	59	67	PF02991	0.455
LIG_LIR_LC3C_4	272	277	PF02991	0.455
LIG_LIR_Nem_3	160	166	PF02991	0.372
LIG_LIR_Nem_3	21	26	PF02991	0.368
LIG_LIR_Nem_3	378	382	PF02991	0.353
LIG_LIR_Nem_3	59	63	PF02991	0.455
LIG_LRP6_Inhibitor_1	377	383	PF00058	0.299
LIG_LYPXL_yS_3	439	442	PF13949	0.392
LIG_MAD2	87	95	PF02301	0.455
LIG_Pex14_2	430	434	PF04695	0.347
LIG_SH2_CRK	163	167	PF00017	0.428
LIG_SH2_CRK	205	209	PF00017	0.308
LIG_SH2_PTP2	211	214	PF00017	0.428
LIG_SH2_STAP1	205	209	PF00017	0.324
LIG_SH2_STAT3	128	131	PF00017	0.416
LIG_SH2_STAT3	190	193	PF00017	0.447
LIG_SH2_STAT3	66	69	PF00017	0.377
LIG_SH2_STAT5	128	131	PF00017	0.416
LIG_SH2_STAT5	190	193	PF00017	0.347
LIG_SH2_STAT5	211	214	PF00017	0.324
LIG_SH2_STAT5	335	338	PF00017	0.587
LIG_SH2_STAT5	441	444	PF00017	0.416
LIG_SH3_3	387	393	PF00018	0.363
LIG_SH3_3	473	479	PF00018	0.514
LIG_SH3_3	490	496	PF00018	0.673
LIG_SH3_3	514	520	PF00018	0.744
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.417
LIG_SUMO_SIM_par_1	87	94	PF11976	0.428
LIG_TRAF2_1	241	244	PF00917	0.417
LIG_TRAF2_1	5	8	PF00917	0.568
LIG_TYR_ITIM	203	208	PF00017	0.365
LIG_TYR_ITIM	209	214	PF00017	0.365
LIG_TYR_ITIM	437	442	PF00017	0.452
LIG_TYR_ITSM	159	166	PF00017	0.428
LIG_UBA3_1	208	216	PF00899	0.416
LIG_UBA3_1	297	305	PF00899	0.416
LIG_WRC_WIRS_1	376	381	PF05994	0.470
LIG_WRC_WIRS_1	427	432	PF05994	0.442
MOD_CK1_1	175	181	PF00069	0.464
MOD_CK1_1	281	287	PF00069	0.398
MOD_CK1_1	340	346	PF00069	0.640
MOD_CK1_1	38	44	PF00069	0.388
MOD_CK1_1	478	484	PF00069	0.631
MOD_CK1_1	487	493	PF00069	0.643
MOD_CK1_1	523	529	PF00069	0.539
MOD_CK1_1	53	59	PF00069	0.258
MOD_CK2_1	1	7	PF00069	0.602
MOD_CK2_1	229	235	PF00069	0.332
MOD_CK2_1	38	44	PF00069	0.362
MOD_GlcNHglycan	153	156	PF01048	0.351
MOD_GlcNHglycan	284	287	PF01048	0.343
MOD_GlcNHglycan	4	7	PF01048	0.649
MOD_GlcNHglycan	420	423	PF01048	0.546
MOD_GlcNHglycan	486	489	PF01048	0.679
MOD_GlcNHglycan	525	528	PF01048	0.728
MOD_GlcNHglycan	79	82	PF01048	0.425
MOD_GSK3_1	151	158	PF00069	0.428
MOD_GSK3_1	239	246	PF00069	0.439
MOD_GSK3_1	278	285	PF00069	0.303
MOD_GSK3_1	320	327	PF00069	0.449
MOD_GSK3_1	337	344	PF00069	0.673
MOD_GSK3_1	350	357	PF00069	0.414
MOD_GSK3_1	497	504	PF00069	0.645
MOD_GSK3_1	77	84	PF00069	0.384
MOD_N-GLC_1	268	273	PF02516	0.324
MOD_N-GLC_1	337	342	PF02516	0.642
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	183	188	PF00069	0.428
MOD_NEK2_1	297	302	PF00069	0.377
MOD_NEK2_1	325	330	PF00069	0.460
MOD_NEK2_1	342	347	PF00069	0.567
MOD_NEK2_1	375	380	PF00069	0.511
MOD_NEK2_1	415	420	PF00069	0.532
MOD_NEK2_1	50	55	PF00069	0.303
MOD_NEK2_2	330	335	PF00069	0.549
MOD_PIKK_1	459	465	PF00454	0.568
MOD_PIKK_1	58	64	PF00454	0.343
MOD_PKA_2	102	108	PF00069	0.435
MOD_PKA_2	11	17	PF00069	0.406
MOD_PKA_2	317	323	PF00069	0.478
MOD_PKA_2	330	336	PF00069	0.429
MOD_Plk_1	198	204	PF00069	0.369
MOD_Plk_1	220	226	PF00069	0.428
MOD_Plk_1	243	249	PF00069	0.428
MOD_Plk_1	337	343	PF00069	0.645
MOD_Plk_4	102	108	PF00069	0.437
MOD_Plk_4	11	17	PF00069	0.393
MOD_Plk_4	198	204	PF00069	0.435
MOD_Plk_4	243	249	PF00069	0.428
MOD_Plk_4	297	303	PF00069	0.385
MOD_Plk_4	330	336	PF00069	0.535
MOD_Plk_4	415	421	PF00069	0.537
MOD_Plk_4	426	432	PF00069	0.398
MOD_Plk_4	497	503	PF00069	0.556
MOD_ProDKin_1	172	178	PF00069	0.428
MOD_ProDKin_1	354	360	PF00069	0.452
MOD_ProDKin_1	475	481	PF00069	0.560
MOD_ProDKin_1	501	507	PF00069	0.633
MOD_ProDKin_1	91	97	PF00069	0.455
TRG_DiLeu_BaEn_1	397	402	PF01217	0.449
TRG_DiLeu_BaEn_1	93	98	PF01217	0.428
TRG_DiLeu_BaEn_2	422	428	PF01217	0.521
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.537
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.437
TRG_ENDOCYTIC_2	163	166	PF00928	0.428
TRG_ENDOCYTIC_2	205	208	PF00928	0.308
TRG_ENDOCYTIC_2	211	214	PF00928	0.308
TRG_ENDOCYTIC_2	23	26	PF00928	0.324
TRG_ENDOCYTIC_2	439	442	PF00928	0.420
TRG_ER_diArg_1	169	171	PF00400	0.308
TRG_ER_diArg_1	184	187	PF00400	0.308
TRG_ER_diArg_1	9	12	PF00400	0.443
TRG_NES_CRM1_1	109	122	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS6	Leptomonas seymouri	72%	88%
A0A0S4IRC0	Bodo saltans	34%	100%
A0A1X0NS75	Trypanosomatidae	39%	100%
A0A3R7LW05	Trypanosoma rangeli	37%	100%
A0A3S7X1Y9	Leishmania donovani	100%	100%
A4HGZ3	Leishmania braziliensis	86%	100%
D0A8Y2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B0B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q2TBH9	Bos taurus	25%	85%
Q4Q7X2	Leishmania major	93%	100%
Q55BB8	Dictyostelium discoideum	20%	68%
Q84K25	Arabidopsis thaliana	23%	93%
Q96MW5	Homo sapiens	24%	86%
Q9JJA2	Mus musculus	24%	83%
V5BI51	Trypanosoma cruzi	38%	100%