DUF4205 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I422_LEIIN

TriTrypDb:

LINF_280036900

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I422

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I422

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.556
CLV_NRD_NRD_1	121	123	PF00675	0.713
CLV_NRD_NRD_1	124	126	PF00675	0.691
CLV_NRD_NRD_1	21	23	PF00675	0.471
CLV_NRD_NRD_1	73	75	PF00675	0.588
CLV_NRD_NRD_1	86	88	PF00675	0.498
CLV_PCSK_KEX2_1	121	123	PF00082	0.713
CLV_PCSK_KEX2_1	21	23	PF00082	0.471
CLV_PCSK_KEX2_1	73	75	PF00082	0.588
CLV_PCSK_KEX2_1	86	88	PF00082	0.498
CLV_PCSK_SKI1_1	207	211	PF00082	0.523
CLV_PCSK_SKI1_1	224	228	PF00082	0.450
CLV_PCSK_SKI1_1	73	77	PF00082	0.671
DEG_APCC_DBOX_1	73	81	PF00400	0.683
DEG_SPOP_SBC_1	159	163	PF00917	0.584
DOC_CYCLIN_RxL_1	71	81	PF00134	0.537
DOC_MAPK_gen_1	21	29	PF00069	0.451
DOC_MAPK_gen_1	86	94	PF00069	0.517
DOC_PP1_RVXF_1	237	244	PF00149	0.449
DOC_USP7_MATH_1	159	163	PF00917	0.597
DOC_USP7_MATH_1	197	201	PF00917	0.516
DOC_USP7_MATH_1	45	49	PF00917	0.480
DOC_USP7_MATH_1	66	70	PF00917	0.455
DOC_WW_Pin1_4	154	159	PF00397	0.612
DOC_WW_Pin1_4	161	166	PF00397	0.645
LIG_14-3-3_CanoR_1	24	28	PF00244	0.509
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_BRCT_BRCA1_1	199	203	PF00533	0.586
LIG_Clathr_ClatBox_1	146	150	PF01394	0.509
LIG_FHA_1	105	111	PF00498	0.504
LIG_FHA_1	180	186	PF00498	0.598
LIG_FHA_1	24	30	PF00498	0.613
LIG_FHA_2	215	221	PF00498	0.376
LIG_FHA_2	94	100	PF00498	0.590
LIG_LIR_Nem_3	200	206	PF02991	0.440
LIG_LIR_Nem_3	99	105	PF02991	0.526
LIG_REV1ctd_RIR_1	201	211	PF16727	0.460
LIG_SH2_NCK_1	194	198	PF00017	0.422
LIG_SH2_SRC	194	197	PF00017	0.415
LIG_SH3_2	120	125	PF14604	0.591
LIG_SH3_2	17	22	PF14604	0.470
LIG_SH3_3	117	123	PF00018	0.732
LIG_SH3_3	14	20	PF00018	0.452
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.490
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.532
LIG_SUMO_SIM_par_1	25	31	PF11976	0.463
LIG_TYR_ITIM	100	105	PF00017	0.482
MOD_CK1_1	154	160	PF00069	0.583
MOD_CK1_1	163	169	PF00069	0.570
MOD_CK1_1	213	219	PF00069	0.425
MOD_CK1_1	93	99	PF00069	0.595
MOD_CK2_1	173	179	PF00069	0.523
MOD_CK2_1	214	220	PF00069	0.374
MOD_CK2_1	45	51	PF00069	0.507
MOD_GlcNHglycan	153	156	PF01048	0.618
MOD_GlcNHglycan	212	215	PF01048	0.438
MOD_GlcNHglycan	47	50	PF01048	0.522
MOD_GlcNHglycan	68	71	PF01048	0.565
MOD_GSK3_1	150	157	PF00069	0.598
MOD_GSK3_1	159	166	PF00069	0.515
MOD_GSK3_1	169	176	PF00069	0.541
MOD_GSK3_1	210	217	PF00069	0.337
MOD_GSK3_1	45	52	PF00069	0.516
MOD_GSK3_1	88	95	PF00069	0.582
MOD_N-GLC_1	59	64	PF02516	0.523
MOD_NEK2_1	140	145	PF00069	0.474
MOD_NEK2_1	151	156	PF00069	0.585
MOD_NEK2_1	88	93	PF00069	0.653
MOD_PIKK_1	169	175	PF00454	0.601
MOD_PIKK_1	186	192	PF00454	0.346
MOD_PKA_2	220	226	PF00069	0.558
MOD_PKA_2	23	29	PF00069	0.518
MOD_Plk_2-3	53	59	PF00069	0.570
MOD_Plk_4	140	146	PF00069	0.463
MOD_Plk_4	163	169	PF00069	0.552
MOD_Plk_4	173	179	PF00069	0.410
MOD_Plk_4	189	195	PF00069	0.391
MOD_Plk_4	23	29	PF00069	0.518
MOD_ProDKin_1	154	160	PF00069	0.612
MOD_ProDKin_1	161	167	PF00069	0.639
TRG_DiLeu_BaEn_1	142	147	PF01217	0.480
TRG_ENDOCYTIC_2	102	105	PF00928	0.529
TRG_ER_diArg_1	120	122	PF00400	0.707
TRG_ER_diArg_1	20	22	PF00400	0.473
TRG_ER_diArg_1	72	74	PF00400	0.597
TRG_ER_diArg_1	86	88	PF00400	0.488
TRG_NES_CRM1_1	136	150	PF08389	0.475
TRG_NLS_MonoExtN_4	122	129	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6I3	Leptomonas seymouri	50%	95%
A0A3Q8IE62	Leishmania donovani	99%	100%
A4HGZ0	Leishmania braziliensis	82%	100%
E9B0A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7X5	Leishmania major	92%	100%