LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I420_LEIIN
TriTrypDb:
LINF_280036700
Length:
439

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4I420
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I420

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0005488 binding 1 1
GO:0005524 ATP binding 5 1
GO:0017076 purine nucleotide binding 4 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032559 adenyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 326 330 PF00656 0.605
CLV_NRD_NRD_1 123 125 PF00675 0.579
CLV_NRD_NRD_1 16 18 PF00675 0.611
CLV_NRD_NRD_1 233 235 PF00675 0.432
CLV_NRD_NRD_1 435 437 PF00675 0.664
CLV_NRD_NRD_1 93 95 PF00675 0.442
CLV_PCSK_KEX2_1 123 125 PF00082 0.487
CLV_PCSK_KEX2_1 151 153 PF00082 0.654
CLV_PCSK_KEX2_1 16 18 PF00082 0.611
CLV_PCSK_KEX2_1 233 235 PF00082 0.432
CLV_PCSK_KEX2_1 297 299 PF00082 0.495
CLV_PCSK_KEX2_1 434 436 PF00082 0.633
CLV_PCSK_KEX2_1 93 95 PF00082 0.421
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.684
CLV_PCSK_PC1ET2_1 297 299 PF00082 0.508
CLV_PCSK_PC1ET2_1 434 436 PF00082 0.655
CLV_PCSK_PC7_1 119 125 PF00082 0.514
CLV_PCSK_SKI1_1 123 127 PF00082 0.502
CLV_PCSK_SKI1_1 297 301 PF00082 0.423
CLV_PCSK_SKI1_1 93 97 PF00082 0.553
CLV_Separin_Metazoa 222 226 PF03568 0.486
DEG_APCC_DBOX_1 92 100 PF00400 0.493
DOC_ANK_TNKS_1 224 231 PF00023 0.475
DOC_CDC14_PxL_1 174 182 PF14671 0.472
DOC_CDC14_PxL_1 408 416 PF14671 0.477
DOC_CYCLIN_RxL_1 133 145 PF00134 0.518
DOC_CYCLIN_RxL_1 90 101 PF00134 0.550
DOC_CYCLIN_yCln2_LP_2 165 171 PF00134 0.471
DOC_CYCLIN_yCln2_LP_2 266 272 PF00134 0.427
DOC_CYCLIN_yCln2_LP_2 287 293 PF00134 0.419
DOC_CYCLIN_yCln2_LP_2 338 344 PF00134 0.621
DOC_MAPK_gen_1 123 129 PF00069 0.496
DOC_MAPK_gen_1 281 291 PF00069 0.436
DOC_MAPK_MEF2A_6 281 289 PF00069 0.495
DOC_PP1_RVXF_1 184 191 PF00149 0.369
DOC_PP2B_LxvP_1 163 166 PF13499 0.504
DOC_PP2B_LxvP_1 266 269 PF13499 0.427
DOC_PP2B_LxvP_1 287 290 PF13499 0.451
DOC_PP4_FxxP_1 74 77 PF00568 0.528
DOC_USP7_MATH_1 193 197 PF00917 0.578
DOC_USP7_MATH_1 344 348 PF00917 0.718
DOC_USP7_UBL2_3 434 438 PF12436 0.656
DOC_WW_Pin1_4 1 6 PF00397 0.656
DOC_WW_Pin1_4 155 160 PF00397 0.578
DOC_WW_Pin1_4 259 264 PF00397 0.685
DOC_WW_Pin1_4 337 342 PF00397 0.648
DOC_WW_Pin1_4 351 356 PF00397 0.667
DOC_WW_Pin1_4 52 57 PF00397 0.641
LIG_14-3-3_CanoR_1 124 130 PF00244 0.531
LIG_14-3-3_CanoR_1 16 24 PF00244 0.572
LIG_Actin_WH2_2 282 299 PF00022 0.470
LIG_APCC_ABBA_1 140 145 PF00400 0.443
LIG_BIR_II_1 1 5 PF00653 0.550
LIG_BIR_III_4 329 333 PF00653 0.601
LIG_BRCT_BRCA1_1 81 85 PF00533 0.510
LIG_CSL_BTD_1 287 290 PF09270 0.461
LIG_DLG_GKlike_1 23 30 PF00625 0.477
LIG_FHA_1 137 143 PF00498 0.538
LIG_FHA_1 333 339 PF00498 0.707
LIG_FHA_1 37 43 PF00498 0.613
LIG_FHA_1 385 391 PF00498 0.449
LIG_FHA_2 179 185 PF00498 0.410
LIG_FHA_2 347 353 PF00498 0.637
LIG_FHA_2 370 376 PF00498 0.717
LIG_FHA_2 387 393 PF00498 0.439
LIG_FHA_2 425 431 PF00498 0.680
LIG_LIR_Apic_2 245 250 PF02991 0.600
LIG_LIR_Gen_1 22 30 PF02991 0.518
LIG_LIR_Gen_1 271 279 PF02991 0.372
LIG_LIR_Gen_1 402 412 PF02991 0.512
LIG_LIR_LC3C_4 239 243 PF02991 0.465
LIG_LIR_Nem_3 22 27 PF02991 0.492
LIG_LIR_Nem_3 271 275 PF02991 0.361
LIG_LYPXL_S_1 381 385 PF13949 0.476
LIG_LYPXL_yS_3 382 385 PF13949 0.494
LIG_NRBOX 198 204 PF00104 0.475
LIG_SH2_CRK 308 312 PF00017 0.383
LIG_SH2_STAT5 179 182 PF00017 0.422
LIG_SH2_STAT5 201 204 PF00017 0.388
LIG_SH2_STAT5 247 250 PF00017 0.595
LIG_SH2_STAT5 272 275 PF00017 0.460
LIG_SH3_1 246 252 PF00018 0.492
LIG_SH3_3 103 109 PF00018 0.446
LIG_SH3_3 246 252 PF00018 0.528
LIG_SH3_CIN85_PxpxPR_1 52 57 PF14604 0.578
LIG_SUMO_SIM_anti_2 103 108 PF11976 0.473
LIG_SUMO_SIM_par_1 138 145 PF11976 0.559
LIG_SUMO_SIM_par_1 389 395 PF11976 0.519
LIG_SUMO_SIM_par_1 4 10 PF11976 0.648
LIG_SUMO_SIM_par_1 59 65 PF11976 0.580
LIG_TYR_ITIM 306 311 PF00017 0.393
LIG_WRC_WIRS_1 126 131 PF05994 0.411
LIG_WRC_WIRS_1 24 29 PF05994 0.509
MOD_CDK_SPK_2 52 57 PF00069 0.578
MOD_CDK_SPxxK_3 351 358 PF00069 0.628
MOD_CK1_1 115 121 PF00069 0.469
MOD_CK1_1 19 25 PF00069 0.523
MOD_CK1_1 254 260 PF00069 0.734
MOD_CK1_1 262 268 PF00069 0.619
MOD_CK1_1 351 357 PF00069 0.628
MOD_CK1_1 360 366 PF00069 0.544
MOD_CK1_1 424 430 PF00069 0.714
MOD_CK1_1 79 85 PF00069 0.417
MOD_CK2_1 261 267 PF00069 0.601
MOD_CK2_1 346 352 PF00069 0.692
MOD_CK2_1 369 375 PF00069 0.564
MOD_CK2_1 424 430 PF00069 0.665
MOD_Cter_Amidation 14 17 PF01082 0.575
MOD_GlcNHglycan 1 4 PF01048 0.584
MOD_GlcNHglycan 11 14 PF01048 0.481
MOD_GlcNHglycan 114 117 PF01048 0.568
MOD_GlcNHglycan 258 261 PF01048 0.698
MOD_GlcNHglycan 303 306 PF01048 0.573
MOD_GlcNHglycan 346 349 PF01048 0.713
MOD_GlcNHglycan 359 362 PF01048 0.598
MOD_GlcNHglycan 375 378 PF01048 0.599
MOD_GlcNHglycan 423 426 PF01048 0.524
MOD_GlcNHglycan 81 84 PF01048 0.513
MOD_GSK3_1 1 8 PF00069 0.579
MOD_GSK3_1 125 132 PF00069 0.509
MOD_GSK3_1 19 26 PF00069 0.507
MOD_GSK3_1 250 257 PF00069 0.699
MOD_GSK3_1 321 328 PF00069 0.516
MOD_GSK3_1 332 339 PF00069 0.637
MOD_GSK3_1 344 351 PF00069 0.620
MOD_GSK3_1 365 372 PF00069 0.571
MOD_N-GLC_1 236 241 PF02516 0.461
MOD_N-GLC_2 418 420 PF02516 0.530
MOD_NEK2_1 129 134 PF00069 0.425
MOD_NEK2_1 85 90 PF00069 0.461
MOD_NEK2_1 9 14 PF00069 0.559
MOD_OFUCOSY 320 325 PF10250 0.512
MOD_PIKK_1 172 178 PF00454 0.502
MOD_PIKK_1 193 199 PF00454 0.566
MOD_PKA_1 16 22 PF00069 0.609
MOD_PKA_2 118 124 PF00069 0.571
MOD_PKA_2 16 22 PF00069 0.609
MOD_PKA_2 357 363 PF00069 0.659
MOD_PKA_2 79 85 PF00069 0.564
MOD_Plk_1 236 242 PF00069 0.460
MOD_Plk_4 237 243 PF00069 0.523
MOD_Plk_4 386 392 PF00069 0.460
MOD_ProDKin_1 1 7 PF00069 0.651
MOD_ProDKin_1 155 161 PF00069 0.577
MOD_ProDKin_1 259 265 PF00069 0.665
MOD_ProDKin_1 337 343 PF00069 0.650
MOD_ProDKin_1 351 357 PF00069 0.666
MOD_ProDKin_1 52 58 PF00069 0.636
MOD_SUMO_for_1 150 153 PF00179 0.608
TRG_ENDOCYTIC_2 272 275 PF00928 0.477
TRG_ENDOCYTIC_2 308 311 PF00928 0.380
TRG_ENDOCYTIC_2 382 385 PF00928 0.494
TRG_ENDOCYTIC_2 404 407 PF00928 0.463
TRG_ER_diArg_1 122 124 PF00400 0.560
TRG_ER_diArg_1 232 234 PF00400 0.499
TRG_ER_diArg_1 92 94 PF00400 0.435
TRG_NES_CRM1_1 409 421 PF08389 0.443
TRG_NLS_MonoCore_2 432 437 PF00514 0.623
TRG_NLS_MonoExtC_3 433 438 PF00514 0.625
TRG_NLS_MonoExtN_4 433 438 PF00514 0.746

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4Z3 Leptomonas seymouri 45% 93%
A0A0S4IUX7 Bodo saltans 25% 98%
A0A1X0NQH2 Trypanosomatidae 28% 100%
A0A3S7X213 Leishmania donovani 100% 100%
A0A422N0P3 Trypanosoma rangeli 28% 99%
A4HGY8 Leishmania braziliensis 77% 100%
D0A8Y9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 98%
E9B0A7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q7X7 Leishmania major 94% 100%
V5ATM8 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS