Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I419_LEIIN

TriTrypDb:

LINF_280036600

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I419

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I419

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.677
CLV_C14_Caspase3-7	408	412	PF00656	0.681
CLV_NRD_NRD_1	175	177	PF00675	0.425
CLV_NRD_NRD_1	263	265	PF00675	0.483
CLV_NRD_NRD_1	272	274	PF00675	0.465
CLV_NRD_NRD_1	305	307	PF00675	0.474
CLV_NRD_NRD_1	324	326	PF00675	0.706
CLV_NRD_NRD_1	359	361	PF00675	0.617
CLV_NRD_NRD_1	53	55	PF00675	0.434
CLV_PCSK_FUR_1	273	277	PF00082	0.483
CLV_PCSK_KEX2_1	174	176	PF00082	0.357
CLV_PCSK_KEX2_1	272	274	PF00082	0.514
CLV_PCSK_KEX2_1	275	277	PF00082	0.521
CLV_PCSK_KEX2_1	305	307	PF00082	0.498
CLV_PCSK_KEX2_1	324	326	PF00082	0.572
CLV_PCSK_KEX2_1	361	363	PF00082	0.674
CLV_PCSK_KEX2_1	52	54	PF00082	0.436
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.482
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.674
CLV_PCSK_SKI1_1	161	165	PF00082	0.420
CLV_PCSK_SKI1_1	168	172	PF00082	0.429
CLV_PCSK_SKI1_1	175	179	PF00082	0.425
CLV_PCSK_SKI1_1	285	289	PF00082	0.429
DEG_COP1_1	130	138	PF00400	0.588
DEG_SCF_FBW7_1	7	14	PF00400	0.445
DEG_SPOP_SBC_1	227	231	PF00917	0.520
DEG_SPOP_SBC_1	342	346	PF00917	0.694
DOC_ANK_TNKS_1	73	80	PF00023	0.521
DOC_CKS1_1	135	140	PF01111	0.574
DOC_CKS1_1	251	256	PF01111	0.440
DOC_CYCLIN_RxL_1	165	172	PF00134	0.372
DOC_CYCLIN_yClb3_PxF_3	445	453	PF00134	0.412
DOC_MAPK_gen_1	360	371	PF00069	0.601
DOC_MAPK_MEF2A_6	415	423	PF00069	0.633
DOC_PP2B_LxvP_1	35	38	PF13499	0.384
DOC_USP7_MATH_1	11	15	PF00917	0.538
DOC_USP7_MATH_1	136	140	PF00917	0.641
DOC_USP7_MATH_1	143	147	PF00917	0.481
DOC_USP7_MATH_1	226	230	PF00917	0.605
DOC_USP7_MATH_1	312	316	PF00917	0.655
DOC_USP7_MATH_1	317	321	PF00917	0.699
DOC_USP7_MATH_1	340	344	PF00917	0.652
DOC_USP7_MATH_1	356	360	PF00917	0.578
DOC_USP7_MATH_1	390	394	PF00917	0.789
DOC_USP7_MATH_1	433	437	PF00917	0.702
DOC_USP7_MATH_1	86	90	PF00917	0.778
DOC_WW_Pin1_4	134	139	PF00397	0.606
DOC_WW_Pin1_4	250	255	PF00397	0.423
DOC_WW_Pin1_4	3	8	PF00397	0.597
DOC_WW_Pin1_4	313	318	PF00397	0.660
DOC_WW_Pin1_4	373	378	PF00397	0.640
DOC_WW_Pin1_4	392	397	PF00397	0.676
LIG_14-3-3_CanoR_1	166	171	PF00244	0.423
LIG_14-3-3_CanoR_1	239	249	PF00244	0.418
LIG_14-3-3_CanoR_1	276	281	PF00244	0.402
LIG_14-3-3_CanoR_1	313	317	PF00244	0.616
LIG_14-3-3_CanoR_1	90	96	PF00244	0.565
LIG_Actin_WH2_2	105	123	PF00022	0.479
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BIR_III_3	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	5	9	PF00533	0.472
LIG_Clathr_ClatBox_1	58	62	PF01394	0.504
LIG_eIF4E_1	438	444	PF01652	0.557
LIG_FHA_1	111	117	PF00498	0.377
LIG_FHA_1	130	136	PF00498	0.590
LIG_FHA_1	251	257	PF00498	0.443
LIG_FHA_1	272	278	PF00498	0.553
LIG_FHA_2	121	127	PF00498	0.585
LIG_FHA_2	241	247	PF00498	0.465
LIG_FHA_2	257	263	PF00498	0.461
LIG_FHA_2	398	404	PF00498	0.654
LIG_FHA_2	406	412	PF00498	0.620
LIG_FHA_2	429	435	PF00498	0.555
LIG_Integrin_RGD_1	364	366	PF01839	0.677
LIG_LIR_Apic_2	435	441	PF02991	0.583
LIG_LIR_Gen_1	467	475	PF02991	0.362
LIG_LIR_Nem_3	150	156	PF02991	0.430
LIG_LIR_Nem_3	202	208	PF02991	0.482
LIG_LIR_Nem_3	467	473	PF02991	0.341
LIG_MYND_1	441	445	PF01753	0.553
LIG_NRBOX	457	463	PF00104	0.353
LIG_NRBOX	468	474	PF00104	0.337
LIG_Pex14_2	5	9	PF04695	0.472
LIG_Rb_pABgroove_1	165	173	PF01858	0.354
LIG_RPA_C_Fungi	301	313	PF08784	0.485
LIG_SH2_CRK	153	157	PF00017	0.420
LIG_SH2_CRK	470	474	PF00017	0.355
LIG_SH2_NCK_1	438	442	PF00017	0.559
LIG_SH2_NCK_1	446	450	PF00017	0.533
LIG_SH2_SRC	442	445	PF00017	0.524
LIG_SH2_SRC	446	449	PF00017	0.502
LIG_SH2_STAT3	248	251	PF00017	0.491
LIG_SH2_STAT5	119	122	PF00017	0.517
LIG_SH2_STAT5	442	445	PF00017	0.590
LIG_SH3_1	442	448	PF00018	0.436
LIG_SH3_3	132	138	PF00018	0.581
LIG_SH3_3	442	448	PF00018	0.436
LIG_SUMO_SIM_anti_2	378	384	PF11976	0.788
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.602
LIG_SUMO_SIM_par_1	378	384	PF11976	0.592
LIG_SUMO_SIM_par_1	400	406	PF11976	0.614
LIG_TRAF2_1	67	70	PF00917	0.642
MOD_CDK_SPK_2	7	12	PF00069	0.454
MOD_CK1_1	131	137	PF00069	0.661
MOD_CK1_1	139	145	PF00069	0.560
MOD_CK1_1	230	236	PF00069	0.558
MOD_CK1_1	3	9	PF00069	0.615
MOD_CK1_1	343	349	PF00069	0.613
MOD_CK1_1	464	470	PF00069	0.452
MOD_CK1_1	73	79	PF00069	0.612
MOD_CK1_1	89	95	PF00069	0.516
MOD_CK2_1	240	246	PF00069	0.451
MOD_CK2_1	256	262	PF00069	0.517
MOD_CK2_1	347	353	PF00069	0.790
MOD_CK2_1	381	387	PF00069	0.649
MOD_CK2_1	433	439	PF00069	0.596
MOD_GlcNHglycan	13	16	PF01048	0.401
MOD_GlcNHglycan	145	148	PF01048	0.450
MOD_GlcNHglycan	2	5	PF01048	0.623
MOD_GlcNHglycan	210	213	PF01048	0.597
MOD_GlcNHglycan	224	227	PF01048	0.567
MOD_GlcNHglycan	345	348	PF01048	0.747
MOD_GlcNHglycan	349	352	PF01048	0.813
MOD_GlcNHglycan	383	386	PF01048	0.751
MOD_GlcNHglycan	391	395	PF01048	0.670
MOD_GlcNHglycan	434	438	PF01048	0.702
MOD_GlcNHglycan	465	469	PF01048	0.442
MOD_GlcNHglycan	75	78	PF01048	0.612
MOD_GSK3_1	139	146	PF00069	0.528
MOD_GSK3_1	222	229	PF00069	0.650
MOD_GSK3_1	3	10	PF00069	0.530
MOD_GSK3_1	313	320	PF00069	0.629
MOD_GSK3_1	343	350	PF00069	0.823
MOD_GSK3_1	381	388	PF00069	0.630
MOD_GSK3_1	85	92	PF00069	0.708
MOD_LATS_1	303	309	PF00433	0.481
MOD_N-GLC_1	90	95	PF02516	0.486
MOD_NEK2_1	208	213	PF00069	0.618
MOD_NEK2_1	256	261	PF00069	0.471
MOD_NEK2_2	319	324	PF00069	0.621
MOD_PIKK_1	107	113	PF00454	0.415
MOD_PIKK_1	136	142	PF00454	0.525
MOD_PIKK_1	256	262	PF00454	0.458
MOD_PIKK_1	27	33	PF00454	0.406
MOD_PKA_1	175	181	PF00069	0.429
MOD_PKA_1	305	311	PF00069	0.489
MOD_PKA_2	11	17	PF00069	0.458
MOD_PKA_2	120	126	PF00069	0.572
MOD_PKA_2	175	181	PF00069	0.432
MOD_PKA_2	271	277	PF00069	0.562
MOD_PKA_2	305	311	PF00069	0.511
MOD_PKA_2	312	318	PF00069	0.537
MOD_PKA_2	73	79	PF00069	0.731
MOD_PKA_2	89	95	PF00069	0.613
MOD_Plk_1	397	403	PF00069	0.628
MOD_Plk_1	433	439	PF00069	0.655
MOD_Plk_1	464	470	PF00069	0.335
MOD_Plk_1	90	96	PF00069	0.448
MOD_Plk_2-3	428	434	PF00069	0.600
MOD_Plk_4	397	403	PF00069	0.680
MOD_ProDKin_1	134	140	PF00069	0.604
MOD_ProDKin_1	250	256	PF00069	0.426
MOD_ProDKin_1	3	9	PF00069	0.592
MOD_ProDKin_1	313	319	PF00069	0.664
MOD_ProDKin_1	373	379	PF00069	0.641
MOD_ProDKin_1	392	398	PF00069	0.678
MOD_SUMO_rev_2	211	219	PF00179	0.487
TRG_DiLeu_BaEn_1	439	444	PF01217	0.555
TRG_ENDOCYTIC_2	153	156	PF00928	0.424
TRG_ENDOCYTIC_2	284	287	PF00928	0.448
TRG_ENDOCYTIC_2	470	473	PF00928	0.361
TRG_ER_diArg_1	174	176	PF00400	0.481
TRG_ER_diArg_1	323	325	PF00400	0.727
TRG_ER_diArg_1	51	54	PF00400	0.489
TRG_NLS_MonoExtC_3	359	364	PF00514	0.611
TRG_NLS_MonoExtN_4	358	365	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA9	Leptomonas seymouri	48%	100%
A0A3Q8IE22	Leishmania donovani	100%	97%
A4HGY7	Leishmania braziliensis	71%	100%
E9B0A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q7X8	Leishmania major	91%	100%