Transcription initiation factor IIF subunit alpha

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I416_LEIIN

TriTrypDb:

LINF_280036300

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I416

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I416

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.629
CLV_NRD_NRD_1	135	137	PF00675	0.541
CLV_NRD_NRD_1	183	185	PF00675	0.686
CLV_PCSK_KEX2_1	13	15	PF00082	0.629
CLV_PCSK_KEX2_1	137	139	PF00082	0.548
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.548
CLV_PCSK_SKI1_1	141	145	PF00082	0.536
CLV_PCSK_SKI1_1	184	188	PF00082	0.716
CLV_PCSK_SKI1_1	72	76	PF00082	0.565
DEG_SPOP_SBC_1	88	92	PF00917	0.670
DOC_MAPK_gen_1	136	145	PF00069	0.544
DOC_MAPK_gen_1	146	152	PF00069	0.570
DOC_PP1_RVXF_1	105	111	PF00149	0.609
DOC_PP1_RVXF_1	139	145	PF00149	0.541
DOC_PP1_SILK_1	159	164	PF00149	0.587
DOC_PP4_MxPP_1	1	4	PF00568	0.693
DOC_USP7_MATH_1	157	161	PF00917	0.523
DOC_USP7_MATH_1	173	177	PF00917	0.528
DOC_USP7_MATH_1	48	52	PF00917	0.732
DOC_USP7_MATH_1	55	59	PF00917	0.795
DOC_USP7_MATH_1	89	93	PF00917	0.595
DOC_WW_Pin1_4	100	105	PF00397	0.628
DOC_WW_Pin1_4	110	115	PF00397	0.591
LIG_14-3-3_CanoR_1	8	13	PF00244	0.731
LIG_CaM_IQ_9	161	177	PF13499	0.587
LIG_FHA_1	103	109	PF00498	0.620
LIG_FHA_1	157	163	PF00498	0.559
LIG_FHA_2	151	157	PF00498	0.703
LIG_FHA_2	63	69	PF00498	0.683
LIG_Integrin_isoDGR_2	139	141	PF01839	0.631
LIG_LIR_Gen_1	7	16	PF02991	0.754
LIG_LIR_Nem_3	7	12	PF02991	0.738
LIG_PDZ_Class_3	206	211	PF00595	0.800
LIG_Pex14_2	123	127	PF04695	0.507
LIG_SH2_CRK	9	13	PF00017	0.833
LIG_SH3_1	13	19	PF00018	0.739
LIG_SH3_3	13	19	PF00018	0.808
LIG_UBA3_1	161	169	PF00899	0.592
LIG_UBA3_1	193	201	PF00899	0.539
LIG_WW_3	3	7	PF00397	0.727
MOD_CDK_SPxxK_3	100	107	PF00069	0.622
MOD_CK1_1	58	64	PF00069	0.625
MOD_CK1_1	92	98	PF00069	0.718
MOD_CK2_1	150	156	PF00069	0.698
MOD_CK2_1	62	68	PF00069	0.694
MOD_CK2_1	87	93	PF00069	0.756
MOD_Cter_Amidation	40	43	PF01082	0.832
MOD_GlcNHglycan	44	47	PF01048	0.751
MOD_GlcNHglycan	50	53	PF01048	0.770
MOD_GlcNHglycan	55	58	PF01048	0.544
MOD_GSK3_1	58	65	PF00069	0.641
MOD_GSK3_1	88	95	PF00069	0.681
MOD_N-GLC_1	100	105	PF02516	0.577
MOD_NEK2_1	150	155	PF00069	0.621
MOD_NEK2_1	197	202	PF00069	0.573
MOD_PK_1	8	14	PF00069	0.836
MOD_PKA_1	42	48	PF00069	0.837
MOD_PKA_2	125	131	PF00069	0.593
MOD_PKB_1	6	14	PF00069	0.729
MOD_Plk_1	92	98	PF00069	0.684
MOD_Plk_4	157	163	PF00069	0.584
MOD_ProDKin_1	100	106	PF00069	0.619
MOD_ProDKin_1	110	116	PF00069	0.591
MOD_SUMO_for_1	186	189	PF00179	0.594
TRG_ENDOCYTIC_2	9	12	PF00928	0.756
TRG_ER_diArg_1	12	14	PF00400	0.714
TRG_NLS_Bipartite_1	136	150	PF00514	0.550
TRG_NLS_MonoExtC_3	183	189	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE59	Leptomonas seymouri	61%	100%
A0A3S7X1Y4	Leishmania donovani	98%	100%
A4HGY4	Leishmania braziliensis	77%	94%
E9B0A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
Q4Q7Y1	Leishmania major	93%	99%