LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Uncharacterized ACR - COG1678 - putative
Species:
Leishmania infantum
UniProt:
A4I406_LEIIN
TriTrypDb:
LINF_280034600
Length:
606

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I406
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I406

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0008233 peptidase activity 3 1
GO:0008236 serine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0017171 serine hydrolase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 148 150 PF00675 0.592
CLV_NRD_NRD_1 208 210 PF00675 0.313
CLV_NRD_NRD_1 458 460 PF00675 0.480
CLV_NRD_NRD_1 567 569 PF00675 0.502
CLV_NRD_NRD_1 597 599 PF00675 0.565
CLV_PCSK_FUR_1 436 440 PF00082 0.383
CLV_PCSK_KEX2_1 148 150 PF00082 0.555
CLV_PCSK_KEX2_1 208 210 PF00082 0.313
CLV_PCSK_KEX2_1 24 26 PF00082 0.652
CLV_PCSK_KEX2_1 438 440 PF00082 0.401
CLV_PCSK_KEX2_1 457 459 PF00082 0.364
CLV_PCSK_KEX2_1 597 599 PF00082 0.457
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.652
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.534
CLV_PCSK_PC1ET2_1 597 599 PF00082 0.457
CLV_PCSK_SKI1_1 150 154 PF00082 0.572
CLV_PCSK_SKI1_1 178 182 PF00082 0.483
CLV_PCSK_SKI1_1 209 213 PF00082 0.250
CLV_PCSK_SKI1_1 25 29 PF00082 0.706
CLV_PCSK_SKI1_1 61 65 PF00082 0.433
CLV_PCSK_SKI1_1 9 13 PF00082 0.552
CLV_PCSK_SKI1_1 93 97 PF00082 0.368
DEG_APCC_DBOX_1 3 11 PF00400 0.520
DEG_Nend_Nbox_1 1 3 PF02207 0.479
DEG_SPOP_SBC_1 10 14 PF00917 0.598
DEG_SPOP_SBC_1 302 306 PF00917 0.496
DEG_SPOP_SBC_1 313 317 PF00917 0.451
DOC_CYCLIN_yCln2_LP_2 140 146 PF00134 0.411
DOC_MAPK_DCC_7 97 107 PF00069 0.482
DOC_MAPK_FxFP_2 230 233 PF00069 0.325
DOC_MAPK_gen_1 101 109 PF00069 0.514
DOC_MAPK_gen_1 182 190 PF00069 0.549
DOC_MAPK_gen_1 53 62 PF00069 0.476
DOC_MAPK_MEF2A_6 101 109 PF00069 0.453
DOC_MAPK_MEF2A_6 53 62 PF00069 0.440
DOC_PP1_RVXF_1 373 379 PF00149 0.282
DOC_PP1_RVXF_1 59 65 PF00149 0.484
DOC_PP2B_LxvP_1 80 83 PF13499 0.406
DOC_PP4_FxxP_1 230 233 PF00568 0.325
DOC_PP4_FxxP_1 260 263 PF00568 0.403
DOC_PP4_FxxP_1 332 335 PF00568 0.437
DOC_USP7_MATH_1 11 15 PF00917 0.580
DOC_USP7_MATH_1 184 188 PF00917 0.483
DOC_USP7_MATH_1 200 204 PF00917 0.350
DOC_USP7_MATH_1 27 31 PF00917 0.549
DOC_USP7_MATH_1 303 307 PF00917 0.607
DOC_USP7_MATH_1 308 312 PF00917 0.603
DOC_USP7_MATH_1 314 318 PF00917 0.592
DOC_USP7_MATH_1 323 327 PF00917 0.269
DOC_USP7_MATH_1 370 374 PF00917 0.306
DOC_USP7_MATH_1 530 534 PF00917 0.705
DOC_USP7_MATH_1 591 595 PF00917 0.702
DOC_USP7_UBL2_3 16 20 PF12436 0.569
DOC_USP7_UBL2_3 593 597 PF12436 0.624
DOC_WW_Pin1_4 139 144 PF00397 0.381
DOC_WW_Pin1_4 158 163 PF00397 0.649
DOC_WW_Pin1_4 214 219 PF00397 0.449
DOC_WW_Pin1_4 283 288 PF00397 0.516
DOC_WW_Pin1_4 319 324 PF00397 0.542
DOC_WW_Pin1_4 33 38 PF00397 0.453
DOC_WW_Pin1_4 400 405 PF00397 0.292
DOC_WW_Pin1_4 442 447 PF00397 0.557
DOC_WW_Pin1_4 484 489 PF00397 0.564
DOC_WW_Pin1_4 498 503 PF00397 0.545
DOC_WW_Pin1_4 559 564 PF00397 0.624
LIG_14-3-3_CanoR_1 135 141 PF00244 0.436
LIG_14-3-3_CanoR_1 148 153 PF00244 0.563
LIG_14-3-3_CanoR_1 185 189 PF00244 0.464
LIG_14-3-3_CanoR_1 236 241 PF00244 0.473
LIG_14-3-3_CanoR_1 25 33 PF00244 0.535
LIG_14-3-3_CanoR_1 371 375 PF00244 0.298
LIG_14-3-3_CanoR_1 382 392 PF00244 0.318
LIG_14-3-3_CanoR_1 489 494 PF00244 0.620
LIG_14-3-3_CanoR_1 568 575 PF00244 0.477
LIG_14-3-3_CanoR_1 85 95 PF00244 0.420
LIG_14-3-3_CanoR_1 9 17 PF00244 0.546
LIG_BIR_III_2 572 576 PF00653 0.646
LIG_BRCT_BRCA1_1 402 406 PF00533 0.285
LIG_BRCT_BRCA1_1 480 484 PF00533 0.521
LIG_deltaCOP1_diTrp_1 460 468 PF00928 0.366
LIG_DLG_GKlike_1 148 156 PF00625 0.449
LIG_DLG_GKlike_1 489 496 PF00625 0.554
LIG_EH_1 481 485 PF12763 0.393
LIG_EVH1_2 446 450 PF00568 0.581
LIG_FHA_1 17 23 PF00498 0.680
LIG_FHA_1 175 181 PF00498 0.512
LIG_FHA_1 192 198 PF00498 0.216
LIG_FHA_1 215 221 PF00498 0.323
LIG_FHA_1 229 235 PF00498 0.279
LIG_FHA_1 263 269 PF00498 0.351
LIG_FHA_1 348 354 PF00498 0.290
LIG_FHA_1 383 389 PF00498 0.314
LIG_FHA_1 554 560 PF00498 0.703
LIG_FHA_1 87 93 PF00498 0.492
LIG_FHA_2 16 22 PF00498 0.571
LIG_FHA_2 413 419 PF00498 0.511
LIG_GBD_Chelix_1 39 47 PF00786 0.363
LIG_LIR_Apic_2 227 233 PF02991 0.304
LIG_LIR_Gen_1 252 263 PF02991 0.400
LIG_LIR_Gen_1 460 470 PF02991 0.303
LIG_LIR_Gen_1 473 478 PF02991 0.379
LIG_LIR_Gen_1 487 498 PF02991 0.503
LIG_LIR_Nem_3 239 244 PF02991 0.414
LIG_LIR_Nem_3 252 258 PF02991 0.298
LIG_LIR_Nem_3 405 410 PF02991 0.344
LIG_LIR_Nem_3 42 47 PF02991 0.309
LIG_LIR_Nem_3 460 466 PF02991 0.303
LIG_LIR_Nem_3 473 477 PF02991 0.383
LIG_LIR_Nem_3 487 493 PF02991 0.472
LIG_PCNA_yPIPBox_3 61 74 PF02747 0.414
LIG_Pex14_2 241 245 PF04695 0.299
LIG_PTAP_UEV_1 584 589 PF05743 0.520
LIG_REV1ctd_RIR_1 150 156 PF16727 0.471
LIG_REV1ctd_RIR_1 404 412 PF16727 0.423
LIG_SH2_CRK 119 123 PF00017 0.482
LIG_SH2_CRK 44 48 PF00017 0.312
LIG_SH2_CRK 474 478 PF00017 0.459
LIG_SH2_GRB2like 119 122 PF00017 0.500
LIG_SH2_SRC 119 122 PF00017 0.500
LIG_SH2_STAP1 410 414 PF00017 0.477
LIG_SH2_STAP1 474 478 PF00017 0.513
LIG_SH2_STAP1 88 92 PF00017 0.464
LIG_SH2_STAT5 168 171 PF00017 0.569
LIG_SH2_STAT5 352 355 PF00017 0.285
LIG_SH2_STAT5 361 364 PF00017 0.311
LIG_SH2_STAT5 88 91 PF00017 0.361
LIG_SH3_1 154 160 PF00018 0.463
LIG_SH3_2 173 178 PF14604 0.594
LIG_SH3_3 154 160 PF00018 0.539
LIG_SH3_3 170 176 PF00018 0.563
LIG_SH3_3 446 452 PF00018 0.451
LIG_SH3_3 554 560 PF00018 0.718
LIG_SH3_3 582 588 PF00018 0.525
LIG_SH3_3 59 65 PF00018 0.471
LIG_SH3_3 73 79 PF00018 0.556
LIG_SH3_4 16 23 PF00018 0.527
LIG_SH3_CIN85_PxpxPR_1 162 167 PF14604 0.541
MOD_CDK_SPK_2 484 489 PF00069 0.564
MOD_CK1_1 139 145 PF00069 0.477
MOD_CK1_1 191 197 PF00069 0.483
MOD_CK1_1 276 282 PF00069 0.498
MOD_CK1_1 292 298 PF00069 0.530
MOD_CK1_1 317 323 PF00069 0.579
MOD_CK1_1 413 419 PF00069 0.497
MOD_CK2_1 351 357 PF00069 0.295
MOD_CK2_1 383 389 PF00069 0.379
MOD_CMANNOS 296 299 PF00535 0.428
MOD_Cter_Amidation 595 598 PF01082 0.469
MOD_DYRK1A_RPxSP_1 283 287 PF00069 0.495
MOD_GlcNHglycan 202 205 PF01048 0.558
MOD_GlcNHglycan 221 224 PF01048 0.378
MOD_GlcNHglycan 305 308 PF01048 0.699
MOD_GlcNHglycan 316 319 PF01048 0.629
MOD_GlcNHglycan 412 415 PF01048 0.452
MOD_GlcNHglycan 585 588 PF01048 0.593
MOD_GlcNHglycan 76 79 PF01048 0.430
MOD_GSK3_1 11 18 PF00069 0.563
MOD_GSK3_1 184 191 PF00069 0.576
MOD_GSK3_1 214 221 PF00069 0.439
MOD_GSK3_1 228 235 PF00069 0.186
MOD_GSK3_1 258 265 PF00069 0.402
MOD_GSK3_1 288 295 PF00069 0.589
MOD_GSK3_1 308 315 PF00069 0.434
MOD_GSK3_1 319 326 PF00069 0.448
MOD_GSK3_1 347 354 PF00069 0.319
MOD_GSK3_1 39 46 PF00069 0.481
MOD_GSK3_1 478 485 PF00069 0.523
MOD_NEK2_1 136 141 PF00069 0.369
MOD_NEK2_1 2 7 PF00069 0.487
MOD_NEK2_1 228 233 PF00069 0.350
MOD_NEK2_1 288 293 PF00069 0.465
MOD_NEK2_1 351 356 PF00069 0.287
MOD_NEK2_1 381 386 PF00069 0.442
MOD_NEK2_1 43 48 PF00069 0.382
MOD_NEK2_1 553 558 PF00069 0.571
MOD_NEK2_1 74 79 PF00069 0.500
MOD_NEK2_2 370 375 PF00069 0.321
MOD_PIKK_1 253 259 PF00454 0.343
MOD_PIKK_1 323 329 PF00454 0.317
MOD_PIKK_1 383 389 PF00454 0.362
MOD_PKA_1 148 154 PF00069 0.450
MOD_PKA_2 148 154 PF00069 0.540
MOD_PKA_2 184 190 PF00069 0.462
MOD_PKA_2 276 282 PF00069 0.454
MOD_PKA_2 370 376 PF00069 0.299
MOD_PKA_2 381 387 PF00069 0.313
MOD_PKA_2 488 494 PF00069 0.616
MOD_PKA_2 567 573 PF00069 0.555
MOD_PKA_2 86 92 PF00069 0.526
MOD_Plk_1 289 295 PF00069 0.647
MOD_Plk_1 49 55 PF00069 0.373
MOD_Plk_1 553 559 PF00069 0.726
MOD_Plk_1 97 103 PF00069 0.516
MOD_Plk_4 148 154 PF00069 0.543
MOD_Plk_4 191 197 PF00069 0.431
MOD_Plk_4 236 242 PF00069 0.481
MOD_Plk_4 289 295 PF00069 0.570
MOD_Plk_4 347 353 PF00069 0.438
MOD_Plk_4 402 408 PF00069 0.318
MOD_Plk_4 553 559 PF00069 0.592
MOD_ProDKin_1 139 145 PF00069 0.376
MOD_ProDKin_1 158 164 PF00069 0.653
MOD_ProDKin_1 214 220 PF00069 0.447
MOD_ProDKin_1 283 289 PF00069 0.510
MOD_ProDKin_1 319 325 PF00069 0.527
MOD_ProDKin_1 33 39 PF00069 0.446
MOD_ProDKin_1 400 406 PF00069 0.291
MOD_ProDKin_1 442 448 PF00069 0.563
MOD_ProDKin_1 484 490 PF00069 0.573
MOD_ProDKin_1 498 504 PF00069 0.546
MOD_ProDKin_1 559 565 PF00069 0.624
MOD_SUMO_rev_2 562 571 PF00179 0.719
TRG_DiLeu_BaEn_1 192 197 PF01217 0.281
TRG_DiLeu_BaEn_1 473 478 PF01217 0.397
TRG_DiLeu_BaLyEn_6 132 137 PF01217 0.401
TRG_DiLeu_BaLyEn_6 332 337 PF01217 0.300
TRG_ENDOCYTIC_2 119 122 PF00928 0.500
TRG_ENDOCYTIC_2 44 47 PF00928 0.308
TRG_ENDOCYTIC_2 474 477 PF00928 0.464
TRG_ENDOCYTIC_2 48 51 PF00928 0.317
TRG_ENDOCYTIC_2 88 91 PF00928 0.334
TRG_ER_diArg_1 133 136 PF00400 0.497
TRG_ER_diArg_1 208 210 PF00400 0.313
TRG_ER_diArg_1 456 459 PF00400 0.479
TRG_ER_diArg_1 85 88 PF00400 0.347
TRG_Pf-PMV_PEXEL_1 433 437 PF00026 0.490
TRG_Pf-PMV_PEXEL_1 45 50 PF00026 0.320

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2F0 Leptomonas seymouri 71% 98%
A0A1X0NQL7 Trypanosomatidae 56% 100%
A0A3Q8IE54 Leishmania donovani 100% 100%
A0A422MYL5 Trypanosoma rangeli 50% 100%
A4HGX6 Leishmania braziliensis 86% 100%
D0A900 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9B096 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q7Y9 Leishmania major 94% 100%
V5BI69 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS