LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I403_LEIIN
TriTrypDb:
LINF_280034300
Length:
463

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 191, 241
Promastigote: 159, 195
Promastigote/Amastigote: 177, 189

Expansion

Sequence features

A4I403
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I403

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 157 161 PF00656 0.728
CLV_C14_Caspase3-7 429 433 PF00656 0.734
CLV_NRD_NRD_1 144 146 PF00675 0.782
CLV_NRD_NRD_1 193 195 PF00675 0.846
CLV_NRD_NRD_1 262 264 PF00675 0.723
CLV_NRD_NRD_1 295 297 PF00675 0.792
CLV_NRD_NRD_1 336 338 PF00675 0.656
CLV_NRD_NRD_1 423 425 PF00675 0.760
CLV_NRD_NRD_1 459 461 PF00675 0.713
CLV_PCSK_KEX2_1 144 146 PF00082 0.730
CLV_PCSK_KEX2_1 192 194 PF00082 0.848
CLV_PCSK_KEX2_1 262 264 PF00082 0.792
CLV_PCSK_KEX2_1 336 338 PF00082 0.656
CLV_PCSK_KEX2_1 423 425 PF00082 0.600
CLV_PCSK_KEX2_1 459 461 PF00082 0.713
CLV_PCSK_PC7_1 455 461 PF00082 0.691
CLV_PCSK_SKI1_1 174 178 PF00082 0.769
DEG_APCC_DBOX_1 14 22 PF00400 0.693
DEG_APCC_DBOX_1 192 200 PF00400 0.847
DEG_APCC_DBOX_1 423 431 PF00400 0.739
DEG_SCF_FBW7_2 163 169 PF00400 0.772
DEG_SPOP_SBC_1 205 209 PF00917 0.771
DEG_SPOP_SBC_1 298 302 PF00917 0.733
DEG_SPOP_SBC_1 370 374 PF00917 0.830
DOC_ANK_TNKS_1 289 296 PF00023 0.818
DOC_CKS1_1 163 168 PF01111 0.773
DOC_CKS1_1 175 180 PF01111 0.591
DOC_CYCLIN_yCln2_LP_2 176 182 PF00134 0.627
DOC_PP2B_LxvP_1 176 179 PF13499 0.629
DOC_PP2B_LxvP_1 225 228 PF13499 0.738
DOC_PP2B_LxvP_1 402 405 PF13499 0.710
DOC_PP4_FxxP_1 380 383 PF00568 0.787
DOC_USP7_MATH_1 154 158 PF00917 0.757
DOC_USP7_MATH_1 205 209 PF00917 0.775
DOC_USP7_MATH_1 238 242 PF00917 0.631
DOC_USP7_MATH_1 258 262 PF00917 0.638
DOC_USP7_MATH_1 298 302 PF00917 0.794
DOC_USP7_MATH_1 304 308 PF00917 0.712
DOC_USP7_MATH_1 316 320 PF00917 0.603
DOC_USP7_MATH_1 370 374 PF00917 0.756
DOC_USP7_MATH_1 70 74 PF00917 0.739
DOC_USP7_UBL2_3 121 125 PF12436 0.745
DOC_WW_Pin1_4 114 119 PF00397 0.684
DOC_WW_Pin1_4 125 130 PF00397 0.608
DOC_WW_Pin1_4 162 167 PF00397 0.715
DOC_WW_Pin1_4 174 179 PF00397 0.597
DOC_WW_Pin1_4 274 279 PF00397 0.806
DOC_WW_Pin1_4 418 423 PF00397 0.758
LIG_14-3-3_CanoR_1 144 149 PF00244 0.750
LIG_14-3-3_CanoR_1 156 164 PF00244 0.620
LIG_14-3-3_CanoR_1 192 197 PF00244 0.843
LIG_14-3-3_CanoR_1 206 212 PF00244 0.594
LIG_14-3-3_CanoR_1 262 270 PF00244 0.780
LIG_14-3-3_CanoR_1 296 304 PF00244 0.750
LIG_14-3-3_CanoR_1 455 463 PF00244 0.731
LIG_14-3-3_CanoR_1 84 88 PF00244 0.610
LIG_BIR_II_1 1 5 PF00653 0.779
LIG_deltaCOP1_diTrp_1 413 416 PF00928 0.702
LIG_FHA_1 175 181 PF00498 0.669
LIG_FHA_1 275 281 PF00498 0.776
LIG_FHA_1 398 404 PF00498 0.654
LIG_FHA_1 98 104 PF00498 0.658
LIG_FHA_2 251 257 PF00498 0.737
LIG_GBD_Chelix_1 95 103 PF00786 0.649
LIG_LIR_Apic_2 378 383 PF02991 0.784
LIG_LIR_Gen_1 221 229 PF02991 0.613
LIG_LIR_Gen_1 241 249 PF02991 0.606
LIG_LIR_Nem_3 221 225 PF02991 0.618
LIG_LIR_Nem_3 241 246 PF02991 0.609
LIG_SH2_CRK 222 226 PF00017 0.650
LIG_SH2_NCK_1 243 247 PF00017 0.604
LIG_SH2_STAP1 222 226 PF00017 0.650
LIG_SH2_STAT3 439 442 PF00017 0.704
LIG_SH2_STAT5 164 167 PF00017 0.776
LIG_SH2_STAT5 439 442 PF00017 0.756
LIG_SH2_STAT5 50 53 PF00017 0.700
LIG_SH2_STAT5 55 58 PF00017 0.567
LIG_SH2_STAT5 78 81 PF00017 0.539
LIG_SH3_3 160 166 PF00018 0.680
LIG_SH3_3 172 178 PF00018 0.840
LIG_SH3_3 213 219 PF00018 0.736
LIG_SH3_3 380 386 PF00018 0.659
LIG_SH3_3 444 450 PF00018 0.679
LIG_SUMO_SIM_par_1 99 106 PF11976 0.679
LIG_TRAF2_1 11 14 PF00917 0.710
MOD_CDC14_SPxK_1 421 424 PF00782 0.749
MOD_CDK_SPK_2 162 167 PF00069 0.777
MOD_CDK_SPK_2 418 423 PF00069 0.758
MOD_CDK_SPxK_1 418 424 PF00069 0.758
MOD_CDK_SPxxK_3 114 121 PF00069 0.691
MOD_CK1_1 117 123 PF00069 0.637
MOD_CK1_1 195 201 PF00069 0.775
MOD_CK1_1 204 210 PF00069 0.659
MOD_CK1_1 261 267 PF00069 0.802
MOD_CK1_1 281 287 PF00069 0.601
MOD_CK1_1 299 305 PF00069 0.555
MOD_CK1_1 307 313 PF00069 0.741
MOD_CK1_1 326 332 PF00069 0.601
MOD_CK1_1 357 363 PF00069 0.869
MOD_CK1_1 369 375 PF00069 0.636
MOD_CK2_1 238 244 PF00069 0.665
MOD_CK2_1 250 256 PF00069 0.624
MOD_CK2_1 372 378 PF00069 0.764
MOD_CK2_1 443 449 PF00069 0.581
MOD_CK2_1 68 74 PF00069 0.741
MOD_CMANNOS 411 414 PF00535 0.756
MOD_Cter_Amidation 294 297 PF01082 0.783
MOD_DYRK1A_RPxSP_1 174 178 PF00069 0.730
MOD_GlcNHglycan 1 4 PF01048 0.750
MOD_GlcNHglycan 139 142 PF01048 0.808
MOD_GlcNHglycan 188 191 PF01048 0.841
MOD_GlcNHglycan 203 206 PF01048 0.569
MOD_GlcNHglycan 313 316 PF01048 0.793
MOD_GlcNHglycan 317 321 PF01048 0.792
MOD_GlcNHglycan 323 326 PF01048 0.685
MOD_GlcNHglycan 356 359 PF01048 0.803
MOD_GlcNHglycan 368 371 PF01048 0.637
MOD_GlcNHglycan 70 73 PF01048 0.754
MOD_GSK3_1 188 195 PF00069 0.809
MOD_GSK3_1 201 208 PF00069 0.624
MOD_GSK3_1 257 264 PF00069 0.695
MOD_GSK3_1 274 281 PF00069 0.562
MOD_GSK3_1 298 305 PF00069 0.835
MOD_GSK3_1 307 314 PF00069 0.699
MOD_GSK3_1 321 328 PF00069 0.659
MOD_GSK3_1 366 373 PF00069 0.801
MOD_GSK3_1 70 77 PF00069 0.711
MOD_GSK3_1 79 86 PF00069 0.645
MOD_N-GLC_1 326 331 PF02516 0.765
MOD_N-GLC_2 438 440 PF02516 0.557
MOD_NEK2_1 103 108 PF00069 0.648
MOD_NEK2_1 188 193 PF00069 0.766
MOD_NEK2_1 4 9 PF00069 0.711
MOD_NEK2_1 443 448 PF00069 0.578
MOD_NEK2_1 79 84 PF00069 0.678
MOD_NEK2_2 238 243 PF00069 0.631
MOD_NEK2_2 304 309 PF00069 0.741
MOD_NEK2_2 415 420 PF00069 0.571
MOD_PIKK_1 228 234 PF00454 0.778
MOD_PIKK_1 278 284 PF00454 0.812
MOD_PIKK_1 336 342 PF00454 0.746
MOD_PK_1 58 64 PF00069 0.711
MOD_PKA_1 144 150 PF00069 0.751
MOD_PKA_1 192 198 PF00069 0.770
MOD_PKA_1 262 268 PF00069 0.782
MOD_PKA_1 296 302 PF00069 0.777
MOD_PKA_1 336 342 PF00069 0.649
MOD_PKA_2 144 150 PF00069 0.751
MOD_PKA_2 155 161 PF00069 0.625
MOD_PKA_2 192 198 PF00069 0.848
MOD_PKA_2 205 211 PF00069 0.605
MOD_PKA_2 256 262 PF00069 0.654
MOD_PKA_2 336 342 PF00069 0.649
MOD_PKA_2 366 372 PF00069 0.802
MOD_PKA_2 454 460 PF00069 0.731
MOD_PKA_2 79 85 PF00069 0.627
MOD_PKB_1 255 263 PF00069 0.758
MOD_PKB_1 309 317 PF00069 0.861
MOD_Plk_1 103 109 PF00069 0.596
MOD_Plk_4 74 80 PF00069 0.540
MOD_Plk_4 97 103 PF00069 0.530
MOD_ProDKin_1 114 120 PF00069 0.681
MOD_ProDKin_1 125 131 PF00069 0.611
MOD_ProDKin_1 162 168 PF00069 0.713
MOD_ProDKin_1 174 180 PF00069 0.598
MOD_ProDKin_1 274 280 PF00069 0.805
MOD_ProDKin_1 418 424 PF00069 0.758
TRG_ENDOCYTIC_2 222 225 PF00928 0.651
TRG_ENDOCYTIC_2 243 246 PF00928 0.819
TRG_ER_diArg_1 144 146 PF00400 0.786
TRG_ER_diArg_1 15 18 PF00400 0.694
TRG_ER_diArg_1 192 194 PF00400 0.775
TRG_ER_diArg_1 308 311 PF00400 0.865
TRG_ER_diArg_1 422 424 PF00400 0.733

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IID2 Leishmania donovani 100% 100%
A4HGX3 Leishmania braziliensis 59% 93%
E9B093 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q7Z2 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS