Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I402_LEIIN

TriTrypDb:

LINF_280034200

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I402

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I402

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.702
CLV_NRD_NRD_1	310	312	PF00675	0.429
CLV_NRD_NRD_1	326	328	PF00675	0.448
CLV_NRD_NRD_1	338	340	PF00675	0.301
CLV_PCSK_KEX2_1	3	5	PF00082	0.722
CLV_PCSK_KEX2_1	326	328	PF00082	0.504
CLV_PCSK_KEX2_1	337	339	PF00082	0.320
CLV_PCSK_SKI1_1	192	196	PF00082	0.637
CLV_PCSK_SKI1_1	352	356	PF00082	0.503
CLV_PCSK_SKI1_1	357	361	PF00082	0.373
CLV_PCSK_SKI1_1	6	10	PF00082	0.667
DEG_APCC_DBOX_1	326	334	PF00400	0.707
DEG_SPOP_SBC_1	118	122	PF00917	0.542
DEG_SPOP_SBC_1	232	236	PF00917	0.495
DOC_CYCLIN_RxL_1	3	11	PF00134	0.568
DOC_MAPK_DCC_7	274	282	PF00069	0.432
DOC_MAPK_gen_1	274	282	PF00069	0.432
DOC_MAPK_MEF2A_6	276	284	PF00069	0.447
DOC_PP1_RVXF_1	131	138	PF00149	0.313
DOC_PP4_FxxP_1	137	140	PF00568	0.299
DOC_PP4_FxxP_1	359	362	PF00568	0.762
DOC_USP7_MATH_1	232	236	PF00917	0.419
DOC_USP7_MATH_1	260	264	PF00917	0.358
DOC_USP7_MATH_1	296	300	PF00917	0.473
DOC_USP7_MATH_1	353	357	PF00917	0.681
DOC_USP7_MATH_1	88	92	PF00917	0.548
DOC_WW_Pin1_4	136	141	PF00397	0.372
DOC_WW_Pin1_4	292	297	PF00397	0.480
DOC_WW_Pin1_4	93	98	PF00397	0.504
LIG_14-3-3_CanoR_1	106	116	PF00244	0.525
LIG_14-3-3_CanoR_1	206	215	PF00244	0.449
LIG_14-3-3_CanoR_1	327	335	PF00244	0.675
LIG_14-3-3_CanoR_1	338	344	PF00244	0.691
LIG_APCC_ABBA_1	138	143	PF00400	0.396
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BRCT_BRCA1_1	298	302	PF00533	0.402
LIG_BRCT_BRCA1_1	355	359	PF00533	0.678
LIG_BRCT_BRCA1_1	64	68	PF00533	0.436
LIG_deltaCOP1_diTrp_1	46	52	PF00928	0.393
LIG_FHA_1	188	194	PF00498	0.369
LIG_FHA_1	207	213	PF00498	0.224
LIG_FHA_1	236	242	PF00498	0.464
LIG_FHA_2	173	179	PF00498	0.458
LIG_FHA_2	197	203	PF00498	0.424
LIG_FHA_2	205	211	PF00498	0.382
LIG_LIR_Apic_2	356	362	PF02991	0.747
LIG_LIR_Gen_1	290	298	PF02991	0.284
LIG_LIR_Gen_1	299	310	PF02991	0.340
LIG_LIR_Gen_1	66	77	PF02991	0.386
LIG_LIR_Nem_3	131	137	PF02991	0.422
LIG_LIR_Nem_3	181	187	PF02991	0.418
LIG_LIR_Nem_3	290	294	PF02991	0.284
LIG_LIR_Nem_3	299	305	PF02991	0.340
LIG_LIR_Nem_3	66	72	PF02991	0.381
LIG_Pex14_1	134	138	PF04695	0.329
LIG_Pex14_1	64	68	PF04695	0.420
LIG_SH2_CRK	184	188	PF00017	0.390
LIG_SH2_SRC	266	269	PF00017	0.413
LIG_SH2_STAP1	130	134	PF00017	0.357
LIG_SH2_STAP1	208	212	PF00017	0.430
LIG_SH2_STAT5	130	133	PF00017	0.438
LIG_SH2_STAT5	184	187	PF00017	0.380
LIG_SH2_STAT5	208	211	PF00017	0.469
LIG_SH2_STAT5	266	269	PF00017	0.438
LIG_SH2_STAT5	348	351	PF00017	0.665
LIG_SH3_1	347	353	PF00018	0.654
LIG_SH3_2	350	355	PF14604	0.711
LIG_SH3_3	157	163	PF00018	0.451
LIG_SH3_3	347	353	PF00018	0.651
LIG_SH3_3	359	365	PF00018	0.748
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.559
LIG_SUMO_SIM_par_1	77	82	PF11976	0.399
LIG_TYR_ITIM	182	187	PF00017	0.373
LIG_UBA3_1	283	289	PF00899	0.476
LIG_UBA3_1	306	312	PF00899	0.441
MOD_CK1_1	120	126	PF00069	0.502
MOD_CK1_1	233	239	PF00069	0.502
MOD_CK2_1	172	178	PF00069	0.408
MOD_CK2_1	204	210	PF00069	0.378
MOD_GlcNHglycan	124	127	PF01048	0.691
MOD_GlcNHglycan	178	181	PF01048	0.550
MOD_GlcNHglycan	218	222	PF01048	0.597
MOD_GlcNHglycan	235	238	PF01048	0.643
MOD_GlcNHglycan	262	265	PF01048	0.607
MOD_GlcNHglycan	31	34	PF01048	0.619
MOD_GlcNHglycan	370	373	PF01048	0.530
MOD_GSK3_1	102	109	PF00069	0.581
MOD_GSK3_1	117	124	PF00069	0.447
MOD_GSK3_1	170	177	PF00069	0.412
MOD_GSK3_1	178	185	PF00069	0.366
MOD_GSK3_1	192	199	PF00069	0.305
MOD_GSK3_1	200	207	PF00069	0.436
MOD_GSK3_1	231	238	PF00069	0.444
MOD_GSK3_1	283	290	PF00069	0.416
MOD_GSK3_1	292	299	PF00069	0.342
MOD_GSK3_1	339	346	PF00069	0.747
MOD_GSK3_1	353	360	PF00069	0.565
MOD_GSK3_1	364	371	PF00069	0.657
MOD_GSK3_1	8	15	PF00069	0.565
MOD_GSK3_1	88	95	PF00069	0.520
MOD_N-GLC_1	156	161	PF02516	0.582
MOD_N-GLC_1	196	201	PF02516	0.545
MOD_N-GLC_1	246	251	PF02516	0.647
MOD_N-GLC_1	296	301	PF02516	0.402
MOD_N-GLC_1	313	318	PF02516	0.498
MOD_N-GLC_1	328	333	PF02516	0.502
MOD_NEK2_1	112	117	PF00069	0.527
MOD_NEK2_1	119	124	PF00069	0.578
MOD_NEK2_1	165	170	PF00069	0.472
MOD_NEK2_1	182	187	PF00069	0.346
MOD_NEK2_1	283	288	PF00069	0.500
MOD_NEK2_1	31	36	PF00069	0.486
MOD_NEK2_1	320	325	PF00069	0.654
MOD_NEK2_1	343	348	PF00069	0.683
MOD_NEK2_1	79	84	PF00069	0.380
MOD_NEK2_1	8	13	PF00069	0.571
MOD_NEK2_2	128	133	PF00069	0.323
MOD_NEK2_2	64	69	PF00069	0.330
MOD_PIKK_1	107	113	PF00454	0.516
MOD_PIKK_1	165	171	PF00454	0.432
MOD_PKB_1	337	345	PF00069	0.722
MOD_Plk_1	156	162	PF00069	0.412
MOD_Plk_1	296	302	PF00069	0.402
MOD_Plk_1	328	334	PF00069	0.702
MOD_Plk_4	156	162	PF00069	0.433
MOD_Plk_4	178	184	PF00069	0.404
MOD_Plk_4	296	302	PF00069	0.402
MOD_Plk_4	339	345	PF00069	0.721
MOD_Plk_4	64	70	PF00069	0.376
MOD_Plk_4	8	14	PF00069	0.552
MOD_ProDKin_1	136	142	PF00069	0.376
MOD_ProDKin_1	292	298	PF00069	0.480
MOD_ProDKin_1	93	99	PF00069	0.504
TRG_DiLeu_BaEn_1	178	183	PF01217	0.321
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.291
TRG_ENDOCYTIC_2	184	187	PF00928	0.365
TRG_ENDOCYTIC_2	348	351	PF00928	0.731
TRG_ER_diArg_1	3	6	PF00400	0.665
TRG_ER_diArg_1	325	327	PF00400	0.702
TRG_ER_diArg_1	337	339	PF00400	0.504
TRG_ER_diArg_1	365	368	PF00400	0.782
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M3	Leptomonas seymouri	48%	99%
A0A1X0NQJ6	Trypanosomatidae	35%	100%
A0A3S7X1V5	Leishmania donovani	99%	100%
A0A422MSP0	Trypanosoma rangeli	36%	100%
A4HGX2	Leishmania braziliensis	70%	100%
D0A972	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B092	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7Z3	Leishmania major	88%	99%
V5AWR0	Trypanosoma cruzi	36%	100%