LeishMANIAdb
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Putative molybdenum cofactor biosynthesis protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative molybdenum cofactor biosynthesis protein
Gene product:
molybdenum cofactor biosynthesis protein - putative
Species:
Leishmania infantum
UniProt:
A4I3Z7_LEIIN
TriTrypDb:
LINF_280033700 *
Length:
900

Annotations

Annotations by Jardim et al.

Coenzyme/cofactor biosynthesis, molybdenum cofactor biosynthesis

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3Z7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Z7

Function

Biological processes
Term Name Level Count
GO:0006777 Mo-molybdopterin cofactor biosynthetic process 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009058 biosynthetic process 2 7
GO:0009987 cellular process 1 7
GO:0018130 heterocycle biosynthetic process 4 7
GO:0019637 organophosphate metabolic process 3 7
GO:0019720 Mo-molybdopterin cofactor metabolic process 4 7
GO:0032324 molybdopterin cofactor biosynthetic process 4 7
GO:0043545 molybdopterin cofactor metabolic process 3 7
GO:0044237 cellular metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0046483 heterocycle metabolic process 3 7
GO:0051189 prosthetic group metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
GO:0090407 organophosphate biosynthetic process 4 7
GO:1901360 organic cyclic compound metabolic process 3 7
GO:1901362 organic cyclic compound biosynthetic process 4 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:1901566 organonitrogen compound biosynthetic process 4 7
GO:1901576 organic substance biosynthetic process 3 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016829 lyase activity 2 1
GO:0016830 carbon-carbon lyase activity 3 1
GO:0016849 phosphorus-oxygen lyase activity 3 1
GO:0061798 GTP 3',8'-cyclase activity 4 1
GO:0061799 cyclic pyranopterin monophosphate synthase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 380 384 PF00656 0.588
CLV_C14_Caspase3-7 432 436 PF00656 0.709
CLV_C14_Caspase3-7 76 80 PF00656 0.533
CLV_C14_Caspase3-7 846 850 PF00656 0.681
CLV_NRD_NRD_1 119 121 PF00675 0.261
CLV_NRD_NRD_1 18 20 PF00675 0.588
CLV_NRD_NRD_1 220 222 PF00675 0.339
CLV_NRD_NRD_1 23 25 PF00675 0.562
CLV_NRD_NRD_1 240 242 PF00675 0.233
CLV_NRD_NRD_1 27 29 PF00675 0.551
CLV_NRD_NRD_1 41 43 PF00675 0.573
CLV_NRD_NRD_1 421 423 PF00675 0.649
CLV_NRD_NRD_1 462 464 PF00675 0.635
CLV_NRD_NRD_1 548 550 PF00675 0.750
CLV_NRD_NRD_1 572 574 PF00675 0.644
CLV_NRD_NRD_1 643 645 PF00675 0.681
CLV_NRD_NRD_1 717 719 PF00675 0.727
CLV_NRD_NRD_1 729 731 PF00675 0.596
CLV_NRD_NRD_1 747 749 PF00675 0.564
CLV_NRD_NRD_1 757 759 PF00675 0.656
CLV_NRD_NRD_1 807 809 PF00675 0.639
CLV_NRD_NRD_1 841 843 PF00675 0.737
CLV_NRD_NRD_1 884 886 PF00675 0.756
CLV_PCSK_KEX2_1 119 121 PF00082 0.261
CLV_PCSK_KEX2_1 18 20 PF00082 0.588
CLV_PCSK_KEX2_1 219 221 PF00082 0.338
CLV_PCSK_KEX2_1 23 25 PF00082 0.562
CLV_PCSK_KEX2_1 239 241 PF00082 0.236
CLV_PCSK_KEX2_1 27 29 PF00082 0.551
CLV_PCSK_KEX2_1 311 313 PF00082 0.334
CLV_PCSK_KEX2_1 41 43 PF00082 0.573
CLV_PCSK_KEX2_1 417 419 PF00082 0.674
CLV_PCSK_KEX2_1 421 423 PF00082 0.630
CLV_PCSK_KEX2_1 454 456 PF00082 0.528
CLV_PCSK_KEX2_1 462 464 PF00082 0.635
CLV_PCSK_KEX2_1 548 550 PF00082 0.713
CLV_PCSK_KEX2_1 572 574 PF00082 0.629
CLV_PCSK_KEX2_1 641 643 PF00082 0.645
CLV_PCSK_KEX2_1 668 670 PF00082 0.639
CLV_PCSK_KEX2_1 729 731 PF00082 0.689
CLV_PCSK_KEX2_1 806 808 PF00082 0.647
CLV_PCSK_KEX2_1 841 843 PF00082 0.744
CLV_PCSK_KEX2_1 893 895 PF00082 0.624
CLV_PCSK_KEX2_1 898 900 PF00082 0.600
CLV_PCSK_PC1ET2_1 311 313 PF00082 0.334
CLV_PCSK_PC1ET2_1 417 419 PF00082 0.769
CLV_PCSK_PC1ET2_1 454 456 PF00082 0.528
CLV_PCSK_PC1ET2_1 641 643 PF00082 0.645
CLV_PCSK_PC1ET2_1 668 670 PF00082 0.639
CLV_PCSK_PC1ET2_1 893 895 PF00082 0.624
CLV_PCSK_PC1ET2_1 898 900 PF00082 0.600
CLV_PCSK_PC7_1 19 25 PF00082 0.600
CLV_PCSK_PC7_1 235 241 PF00082 0.334
CLV_PCSK_PC7_1 894 900 PF00082 0.611
CLV_PCSK_SKI1_1 124 128 PF00082 0.286
CLV_PCSK_SKI1_1 146 150 PF00082 0.334
CLV_PCSK_SKI1_1 19 23 PF00082 0.590
CLV_PCSK_SKI1_1 221 225 PF00082 0.434
CLV_PCSK_SKI1_1 235 239 PF00082 0.248
CLV_PCSK_SKI1_1 4 8 PF00082 0.410
CLV_PCSK_SKI1_1 579 583 PF00082 0.628
CLV_PCSK_SKI1_1 886 890 PF00082 0.636
CLV_PCSK_SKI1_1 894 898 PF00082 0.616
DEG_APCC_DBOX_1 118 126 PF00400 0.261
DEG_APCC_DBOX_1 3 11 PF00400 0.421
DEG_Nend_Nbox_1 1 3 PF02207 0.459
DEG_SCF_FBW7_1 151 157 PF00400 0.348
DEG_SPOP_SBC_1 616 620 PF00917 0.777
DOC_CKS1_1 148 153 PF01111 0.334
DOC_CKS1_1 207 212 PF01111 0.317
DOC_CKS1_1 478 483 PF01111 0.671
DOC_CYCLIN_yCln2_LP_2 148 154 PF00134 0.449
DOC_CYCLIN_yCln2_LP_2 471 474 PF00134 0.714
DOC_MAPK_FxFP_2 205 208 PF00069 0.317
DOC_MAPK_gen_1 729 738 PF00069 0.695
DOC_PP2B_LxvP_1 224 227 PF13499 0.449
DOC_PP2B_LxvP_1 471 474 PF13499 0.714
DOC_PP4_FxxP_1 205 208 PF00568 0.317
DOC_USP7_MATH_1 112 116 PF00917 0.569
DOC_USP7_MATH_1 12 16 PF00917 0.547
DOC_USP7_MATH_1 166 170 PF00917 0.448
DOC_USP7_MATH_1 247 251 PF00917 0.510
DOC_USP7_MATH_1 36 40 PF00917 0.782
DOC_USP7_MATH_1 366 370 PF00917 0.720
DOC_USP7_MATH_1 47 51 PF00917 0.481
DOC_USP7_MATH_1 494 498 PF00917 0.647
DOC_USP7_MATH_1 581 585 PF00917 0.649
DOC_USP7_MATH_1 587 591 PF00917 0.727
DOC_USP7_MATH_1 660 664 PF00917 0.639
DOC_USP7_UBL2_3 810 814 PF12436 0.763
DOC_USP7_UBL2_3 886 890 PF12436 0.644
DOC_WW_Pin1_4 13 18 PF00397 0.545
DOC_WW_Pin1_4 147 152 PF00397 0.334
DOC_WW_Pin1_4 206 211 PF00397 0.340
DOC_WW_Pin1_4 364 369 PF00397 0.724
DOC_WW_Pin1_4 472 477 PF00397 0.644
DOC_WW_Pin1_4 480 485 PF00397 0.640
DOC_WW_Pin1_4 753 758 PF00397 0.702
LIG_14-3-3_CanoR_1 124 133 PF00244 0.296
LIG_14-3-3_CanoR_1 213 219 PF00244 0.334
LIG_14-3-3_CanoR_1 239 245 PF00244 0.334
LIG_14-3-3_CanoR_1 378 383 PF00244 0.674
LIG_14-3-3_CanoR_1 521 525 PF00244 0.625
LIG_14-3-3_CanoR_1 572 576 PF00244 0.599
LIG_14-3-3_CanoR_1 642 652 PF00244 0.643
LIG_14-3-3_CanoR_1 718 726 PF00244 0.682
LIG_14-3-3_CanoR_1 72 82 PF00244 0.520
LIG_14-3-3_CanoR_1 761 769 PF00244 0.746
LIG_BIR_III_4 383 387 PF00653 0.709
LIG_BRCT_BRCA1_1 156 160 PF00533 0.416
LIG_BRCT_BRCA1_1 214 218 PF00533 0.334
LIG_BRCT_BRCA1_1 739 743 PF00533 0.673
LIG_deltaCOP1_diTrp_1 833 839 PF00928 0.757
LIG_Dynein_DLC8_1 666 672 PF01221 0.699
LIG_FHA_1 129 135 PF00498 0.261
LIG_FHA_1 185 191 PF00498 0.348
LIG_FHA_1 317 323 PF00498 0.528
LIG_FHA_1 538 544 PF00498 0.687
LIG_FHA_1 551 557 PF00498 0.564
LIG_FHA_2 283 289 PF00498 0.334
LIG_FHA_2 370 376 PF00498 0.645
LIG_FHA_2 378 384 PF00498 0.579
LIG_FHA_2 427 433 PF00498 0.707
LIG_FHA_2 620 626 PF00498 0.709
LIG_FHA_2 685 691 PF00498 0.627
LIG_FHA_2 74 80 PF00498 0.534
LIG_FHA_2 864 870 PF00498 0.739
LIG_LIR_Gen_1 253 260 PF02991 0.334
LIG_LIR_Gen_1 285 294 PF02991 0.334
LIG_LIR_Gen_1 317 326 PF02991 0.559
LIG_LIR_Nem_3 253 257 PF02991 0.334
LIG_LIR_Nem_3 285 290 PF02991 0.334
LIG_LIR_Nem_3 317 321 PF02991 0.523
LIG_NRP_CendR_1 898 900 PF00754 0.618
LIG_Pex14_1 835 839 PF04695 0.764
LIG_RPA_C_Fungi 803 815 PF08784 0.709
LIG_SH2_CRK 254 258 PF00017 0.334
LIG_SH2_CRK 287 291 PF00017 0.334
LIG_SH2_STAP1 254 258 PF00017 0.334
LIG_SH2_STAT5 141 144 PF00017 0.261
LIG_SH2_STAT5 177 180 PF00017 0.353
LIG_SH2_STAT5 258 261 PF00017 0.334
LIG_SH2_STAT5 677 680 PF00017 0.760
LIG_SH3_1 470 476 PF00018 0.633
LIG_SH3_2 818 823 PF14604 0.714
LIG_SH3_2 881 886 PF14604 0.632
LIG_SH3_3 129 135 PF00018 0.267
LIG_SH3_3 148 154 PF00018 0.509
LIG_SH3_3 162 168 PF00018 0.216
LIG_SH3_3 220 226 PF00018 0.513
LIG_SH3_3 323 329 PF00018 0.721
LIG_SH3_3 354 360 PF00018 0.694
LIG_SH3_3 470 476 PF00018 0.633
LIG_SH3_3 478 484 PF00018 0.621
LIG_SH3_3 815 821 PF00018 0.716
LIG_SH3_3 876 882 PF00018 0.634
LIG_SUMO_SIM_anti_2 169 175 PF11976 0.449
LIG_TRAF2_1 402 405 PF00917 0.844
LIG_TRAF2_1 562 565 PF00917 0.638
LIG_TRAF2_1 606 609 PF00917 0.666
LIG_TRAF2_1 612 615 PF00917 0.603
LIG_TRAF2_1 627 630 PF00917 0.690
LIG_TRAF2_1 687 690 PF00917 0.677
LIG_TRAF2_1 701 704 PF00917 0.623
LIG_TRAF2_1 777 780 PF00917 0.697
LIG_UBA3_1 6 13 PF00899 0.434
LIG_WW_3 225 229 PF00397 0.449
LIG_WW_3 882 886 PF00397 0.706
MOD_CDK_SPK_2 13 18 PF00069 0.545
MOD_CDK_SPK_2 753 758 PF00069 0.716
MOD_CDK_SPxK_1 13 19 PF00069 0.572
MOD_CDK_SPxK_1 753 759 PF00069 0.704
MOD_CDK_SPxxK_3 206 213 PF00069 0.317
MOD_CDK_SPxxK_3 480 487 PF00069 0.609
MOD_CK1_1 107 113 PF00069 0.580
MOD_CK1_1 114 120 PF00069 0.520
MOD_CK1_1 29 35 PF00069 0.636
MOD_CK1_1 369 375 PF00069 0.700
MOD_CK1_1 377 383 PF00069 0.565
MOD_CK1_1 483 489 PF00069 0.742
MOD_CK1_1 495 501 PF00069 0.570
MOD_CK1_1 50 56 PF00069 0.576
MOD_CK1_1 520 526 PF00069 0.623
MOD_CK1_1 57 63 PF00069 0.526
MOD_CK1_1 654 660 PF00069 0.670
MOD_CK1_1 663 669 PF00069 0.649
MOD_CK1_1 74 80 PF00069 0.592
MOD_CK1_1 840 846 PF00069 0.750
MOD_CK2_1 168 174 PF00069 0.496
MOD_CK2_1 247 253 PF00069 0.399
MOD_CK2_1 299 305 PF00069 0.334
MOD_CK2_1 321 327 PF00069 0.570
MOD_CK2_1 447 453 PF00069 0.550
MOD_CK2_1 497 503 PF00069 0.700
MOD_CK2_1 587 593 PF00069 0.753
MOD_CK2_1 684 690 PF00069 0.602
MOD_CK2_1 773 779 PF00069 0.641
MOD_CK2_1 863 869 PF00069 0.739
MOD_Cter_Amidation 666 669 PF01082 0.642
MOD_Cter_Amidation 727 730 PF01082 0.759
MOD_Cter_Amidation 746 749 PF01082 0.715
MOD_GlcNHglycan 114 117 PF01048 0.535
MOD_GlcNHglycan 156 159 PF01048 0.423
MOD_GlcNHglycan 28 31 PF01048 0.588
MOD_GlcNHglycan 33 36 PF01048 0.754
MOD_GlcNHglycan 332 335 PF01048 0.629
MOD_GlcNHglycan 336 339 PF01048 0.630
MOD_GlcNHglycan 348 351 PF01048 0.592
MOD_GlcNHglycan 368 371 PF01048 0.730
MOD_GlcNHglycan 38 41 PF01048 0.523
MOD_GlcNHglycan 388 391 PF01048 0.725
MOD_GlcNHglycan 413 416 PF01048 0.663
MOD_GlcNHglycan 43 46 PF01048 0.488
MOD_GlcNHglycan 435 439 PF01048 0.767
MOD_GlcNHglycan 49 52 PF01048 0.534
MOD_GlcNHglycan 494 497 PF01048 0.654
MOD_GlcNHglycan 499 502 PF01048 0.601
MOD_GlcNHglycan 530 533 PF01048 0.630
MOD_GlcNHglycan 56 59 PF01048 0.558
MOD_GlcNHglycan 583 586 PF01048 0.767
MOD_GlcNHglycan 589 592 PF01048 0.746
MOD_GlcNHglycan 665 668 PF01048 0.665
MOD_GlcNHglycan 745 748 PF01048 0.741
MOD_GlcNHglycan 762 765 PF01048 0.507
MOD_GlcNHglycan 774 778 PF01048 0.589
MOD_GlcNHglycan 800 803 PF01048 0.678
MOD_GSK3_1 104 111 PF00069 0.572
MOD_GSK3_1 124 131 PF00069 0.183
MOD_GSK3_1 150 157 PF00069 0.348
MOD_GSK3_1 330 337 PF00069 0.627
MOD_GSK3_1 36 43 PF00069 0.578
MOD_GSK3_1 369 376 PF00069 0.781
MOD_GSK3_1 483 490 PF00069 0.705
MOD_GSK3_1 50 57 PF00069 0.634
MOD_GSK3_1 571 578 PF00069 0.780
MOD_GSK3_1 615 622 PF00069 0.802
MOD_GSK3_1 642 649 PF00069 0.644
MOD_GSK3_1 651 658 PF00069 0.664
MOD_GSK3_1 663 670 PF00069 0.584
MOD_GSK3_1 71 78 PF00069 0.642
MOD_GSK3_1 724 731 PF00069 0.642
MOD_GSK3_1 739 746 PF00069 0.741
MOD_GSK3_1 840 847 PF00069 0.598
MOD_N-GLC_1 575 580 PF02516 0.624
MOD_NEK2_1 184 189 PF00069 0.334
MOD_NEK2_1 26 31 PF00069 0.591
MOD_NEK2_1 280 285 PF00069 0.436
MOD_NEK2_1 330 335 PF00069 0.639
MOD_NEK2_1 52 57 PF00069 0.585
MOD_NEK2_1 575 580 PF00069 0.506
MOD_NEK2_1 743 748 PF00069 0.681
MOD_NEK2_2 214 219 PF00069 0.334
MOD_NEK2_2 282 287 PF00069 0.334
MOD_PIKK_1 667 673 PF00454 0.765
MOD_PKA_1 239 245 PF00069 0.334
MOD_PKA_1 41 47 PF00069 0.573
MOD_PKA_1 642 648 PF00069 0.664
MOD_PKA_2 212 218 PF00069 0.334
MOD_PKA_2 239 245 PF00069 0.412
MOD_PKA_2 26 32 PF00069 0.609
MOD_PKA_2 377 383 PF00069 0.617
MOD_PKA_2 40 46 PF00069 0.661
MOD_PKA_2 447 453 PF00069 0.533
MOD_PKA_2 520 526 PF00069 0.572
MOD_PKA_2 571 577 PF00069 0.665
MOD_PKA_2 642 648 PF00069 0.663
MOD_PKA_2 71 77 PF00069 0.584
MOD_PKA_2 717 723 PF00069 0.638
MOD_PKA_2 728 734 PF00069 0.610
MOD_PKA_2 760 766 PF00069 0.765
MOD_PKA_2 840 846 PF00069 0.677
MOD_PKB_1 487 495 PF00069 0.718
MOD_PKB_1 842 850 PF00069 0.599
MOD_Plk_1 252 258 PF00069 0.334
MOD_Plk_1 575 581 PF00069 0.621
MOD_Plk_1 773 779 PF00069 0.639
MOD_Plk_2-3 299 305 PF00069 0.334
MOD_Plk_4 128 134 PF00069 0.276
MOD_Plk_4 168 174 PF00069 0.456
MOD_Plk_4 198 204 PF00069 0.334
MOD_Plk_4 252 258 PF00069 0.334
MOD_Plk_4 282 288 PF00069 0.336
MOD_Plk_4 520 526 PF00069 0.612
MOD_ProDKin_1 13 19 PF00069 0.550
MOD_ProDKin_1 147 153 PF00069 0.334
MOD_ProDKin_1 206 212 PF00069 0.340
MOD_ProDKin_1 364 370 PF00069 0.727
MOD_ProDKin_1 472 478 PF00069 0.645
MOD_ProDKin_1 480 486 PF00069 0.642
MOD_ProDKin_1 753 759 PF00069 0.704
MOD_SUMO_rev_2 593 602 PF00179 0.611
MOD_SUMO_rev_2 74 83 PF00179 0.534
TRG_ENDOCYTIC_2 254 257 PF00928 0.334
TRG_ENDOCYTIC_2 287 290 PF00928 0.353
TRG_ER_diArg_1 119 121 PF00400 0.261
TRG_ER_diArg_1 17 19 PF00400 0.592
TRG_ER_diArg_1 218 221 PF00400 0.337
TRG_ER_diArg_1 22 24 PF00400 0.575
TRG_ER_diArg_1 238 241 PF00400 0.239
TRG_ER_diArg_1 26 28 PF00400 0.574
TRG_ER_diArg_1 420 422 PF00400 0.654
TRG_ER_diArg_1 461 463 PF00400 0.618
TRG_ER_diArg_1 548 550 PF00400 0.713
TRG_ER_diArg_1 577 580 PF00400 0.648
TRG_ER_diArg_1 642 644 PF00400 0.627
TRG_ER_diArg_1 806 808 PF00400 0.708
TRG_ER_diArg_1 841 844 PF00400 0.748
TRG_NES_CRM1_1 274 288 PF08389 0.449
TRG_NLS_Bipartite_1 748 762 PF00514 0.652
TRG_NLS_MonoCore_2 639 644 PF00514 0.755
TRG_NLS_MonoExtC_3 639 644 PF00514 0.585
TRG_NLS_MonoExtC_3 884 889 PF00514 0.642
TRG_NLS_MonoExtN_4 640 645 PF00514 0.653
TRG_NLS_MonoExtN_4 757 762 PF00514 0.755
TRG_NLS_MonoExtN_4 882 889 PF00514 0.635
TRG_Pf-PMV_PEXEL_1 328 332 PF00026 0.605
TRG_Pf-PMV_PEXEL_1 4 8 PF00026 0.438
TRG_Pf-PMV_PEXEL_1 454 458 PF00026 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIP1 Leptomonas seymouri 55% 100%
A0A3Q8IDC7 Leishmania donovani 99% 100%
A4HGW7 Leishmania braziliensis 69% 100%
E9B087 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q7Z8 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS