LeishMANIAdb
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Coatomer subunit gamma

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Coatomer subunit gamma
Gene product:
Coatomer subunit gamma
Species:
Leishmania infantum
UniProt:
A4I3Z5_LEIIN
TriTrypDb:
LINF_280033500
Length:
865

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, coatomer gamma subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 12
GO:0016020 membrane 2 12
GO:0030117 membrane coat 3 12
GO:0030120 vesicle coat 4 12
GO:0030126 COPI vesicle coat 5 12
GO:0031090 organelle membrane 3 12
GO:0032991 protein-containing complex 1 12
GO:0098588 bounding membrane of organelle 4 12
GO:0098796 membrane protein complex 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005783 endoplasmic reticulum 5 1
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 5 1
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I3Z5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Z5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0016192 vesicle-mediated transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 1
GO:0006891 intra-Golgi vesicle-mediated transport 6 1
GO:0009306 protein secretion 4 1
GO:0032940 secretion by cell 3 1
GO:0035592 establishment of protein localization to extracellular region 4 1
GO:0046903 secretion 4 1
GO:0048193 Golgi vesicle transport 5 1
GO:0071692 protein localization to extracellular region 5 1
GO:0140352 export from cell 2 1
Molecular functions
Term Name Level Count
GO:0005198 structural molecule activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 377 381 PF00656 0.386
CLV_C14_Caspase3-7 415 419 PF00656 0.347
CLV_C14_Caspase3-7 515 519 PF00656 0.317
CLV_C14_Caspase3-7 567 571 PF00656 0.494
CLV_C14_Caspase3-7 633 637 PF00656 0.393
CLV_C14_Caspase3-7 755 759 PF00656 0.329
CLV_NRD_NRD_1 174 176 PF00675 0.293
CLV_NRD_NRD_1 505 507 PF00675 0.239
CLV_NRD_NRD_1 85 87 PF00675 0.224
CLV_PCSK_KEX2_1 452 454 PF00082 0.285
CLV_PCSK_KEX2_1 505 507 PF00082 0.239
CLV_PCSK_KEX2_1 513 515 PF00082 0.239
CLV_PCSK_KEX2_1 85 87 PF00082 0.224
CLV_PCSK_PC1ET2_1 452 454 PF00082 0.358
CLV_PCSK_PC1ET2_1 513 515 PF00082 0.258
CLV_PCSK_SKI1_1 176 180 PF00082 0.382
CLV_PCSK_SKI1_1 251 255 PF00082 0.273
CLV_PCSK_SKI1_1 280 284 PF00082 0.235
CLV_PCSK_SKI1_1 356 360 PF00082 0.258
CLV_PCSK_SKI1_1 452 456 PF00082 0.239
CLV_PCSK_SKI1_1 46 50 PF00082 0.285
CLV_PCSK_SKI1_1 526 530 PF00082 0.239
CLV_PCSK_SKI1_1 532 536 PF00082 0.218
CLV_PCSK_SKI1_1 557 561 PF00082 0.444
CLV_PCSK_SKI1_1 608 612 PF00082 0.279
CLV_PCSK_SKI1_1 782 786 PF00082 0.187
CLV_PCSK_SKI1_1 841 845 PF00082 0.200
CLV_Separin_Metazoa 172 176 PF03568 0.342
CLV_Separin_Metazoa 183 187 PF03568 0.277
DEG_APCC_DBOX_1 607 615 PF00400 0.283
DEG_APCC_DBOX_1 855 863 PF00400 0.441
DEG_SCF_FBW7_1 282 287 PF00400 0.349
DOC_CKS1_1 750 755 PF01111 0.438
DOC_MAPK_gen_1 201 210 PF00069 0.225
DOC_MAPK_gen_1 221 230 PF00069 0.094
DOC_MAPK_gen_1 452 458 PF00069 0.261
DOC_MAPK_gen_1 505 511 PF00069 0.239
DOC_MAPK_MEF2A_6 190 198 PF00069 0.295
DOC_MAPK_MEF2A_6 221 230 PF00069 0.244
DOC_MAPK_MEF2A_6 280 288 PF00069 0.247
DOC_MAPK_MEF2A_6 841 848 PF00069 0.397
DOC_MAPK_NFAT4_5 841 849 PF00069 0.472
DOC_PP4_FxxP_1 750 753 PF00568 0.387
DOC_USP7_MATH_1 267 271 PF00917 0.376
DOC_USP7_MATH_1 341 345 PF00917 0.399
DOC_USP7_MATH_1 463 467 PF00917 0.358
DOC_USP7_MATH_1 623 627 PF00917 0.397
DOC_USP7_MATH_1 688 692 PF00917 0.506
DOC_USP7_MATH_1 777 781 PF00917 0.429
DOC_USP7_UBL2_3 388 392 PF12436 0.217
DOC_WD40_RPTOR_TOS_1 743 749 PF00400 0.489
DOC_WW_Pin1_4 280 285 PF00397 0.206
DOC_WW_Pin1_4 749 754 PF00397 0.395
DOC_WW_Pin1_4 93 98 PF00397 0.279
LIG_14-3-3_CanoR_1 175 185 PF00244 0.317
LIG_14-3-3_CanoR_1 207 211 PF00244 0.226
LIG_14-3-3_CanoR_1 221 227 PF00244 0.233
LIG_14-3-3_CanoR_1 275 284 PF00244 0.318
LIG_14-3-3_CanoR_1 310 316 PF00244 0.257
LIG_14-3-3_CanoR_1 335 341 PF00244 0.203
LIG_14-3-3_CanoR_1 46 55 PF00244 0.310
LIG_14-3-3_CanoR_1 514 523 PF00244 0.364
LIG_14-3-3_CanoR_1 625 629 PF00244 0.457
LIG_Actin_WH2_2 286 303 PF00022 0.239
LIG_Actin_WH2_2 333 349 PF00022 0.238
LIG_Actin_WH2_2 397 415 PF00022 0.367
LIG_Actin_WH2_2 490 507 PF00022 0.239
LIG_Actin_WH2_2 546 563 PF00022 0.408
LIG_Actin_WH2_2 800 817 PF00022 0.472
LIG_APCC_ABBA_1 795 800 PF00400 0.411
LIG_BIR_III_2 15 19 PF00653 0.436
LIG_BIR_III_4 593 597 PF00653 0.547
LIG_CSK_EPIYA_1 682 686 PF00017 0.454
LIG_CtBP_PxDLS_1 753 757 PF00389 0.387
LIG_EH1_1 655 663 PF00400 0.489
LIG_eIF4E_1 193 199 PF01652 0.239
LIG_eIF4E_1 858 864 PF01652 0.411
LIG_FHA_1 155 161 PF00498 0.367
LIG_FHA_1 242 248 PF00498 0.333
LIG_FHA_1 252 258 PF00498 0.341
LIG_FHA_1 281 287 PF00498 0.383
LIG_FHA_1 337 343 PF00498 0.235
LIG_FHA_1 449 455 PF00498 0.372
LIG_FHA_1 47 53 PF00498 0.224
LIG_FHA_1 625 631 PF00498 0.482
LIG_FHA_1 674 680 PF00498 0.397
LIG_FHA_1 773 779 PF00498 0.415
LIG_FHA_1 808 814 PF00498 0.528
LIG_FHA_1 824 830 PF00498 0.385
LIG_FHA_2 141 147 PF00498 0.239
LIG_FHA_2 167 173 PF00498 0.370
LIG_FHA_2 346 352 PF00498 0.224
LIG_FHA_2 375 381 PF00498 0.367
LIG_FHA_2 542 548 PF00498 0.539
LIG_FHA_2 565 571 PF00498 0.578
LIG_FHA_2 575 581 PF00498 0.618
LIG_FHA_2 60 66 PF00498 0.240
LIG_FHA_2 631 637 PF00498 0.408
LIG_FHA_2 672 678 PF00498 0.489
LIG_FHA_2 750 756 PF00498 0.444
LIG_GBD_Chelix_1 226 234 PF00786 0.349
LIG_GBD_Chelix_1 285 293 PF00786 0.367
LIG_IRF3_LxIS_1 417 424 PF10401 0.367
LIG_LIR_Apic_2 682 688 PF02991 0.425
LIG_LIR_Apic_2 748 753 PF02991 0.386
LIG_LIR_Gen_1 134 145 PF02991 0.282
LIG_LIR_Gen_1 391 401 PF02991 0.306
LIG_LIR_Gen_1 444 455 PF02991 0.339
LIG_LIR_Gen_1 79 89 PF02991 0.275
LIG_LIR_Nem_3 248 253 PF02991 0.258
LIG_LIR_Nem_3 391 396 PF02991 0.355
LIG_LIR_Nem_3 444 450 PF02991 0.263
LIG_LIR_Nem_3 696 702 PF02991 0.390
LIG_LIR_Nem_3 79 84 PF02991 0.391
LIG_LIR_Nem_3 793 798 PF02991 0.407
LIG_LYPXL_yS_3 193 196 PF13949 0.349
LIG_PCNA_yPIPBox_3 413 421 PF02747 0.367
LIG_PCNA_yPIPBox_3 655 668 PF02747 0.441
LIG_PTB_Apo_2 383 390 PF02174 0.283
LIG_PTB_Apo_2 661 668 PF02174 0.489
LIG_SH2_CRK 250 254 PF00017 0.258
LIG_SH2_CRK 530 534 PF00017 0.239
LIG_SH2_CRK 685 689 PF00017 0.451
LIG_SH2_CRK 699 703 PF00017 0.344
LIG_SH2_CRK 81 85 PF00017 0.396
LIG_SH2_NCK_1 476 480 PF00017 0.239
LIG_SH2_PTP2 701 704 PF00017 0.473
LIG_SH2_SRC 306 309 PF00017 0.393
LIG_SH2_SRC 545 548 PF00017 0.278
LIG_SH2_SRC 685 688 PF00017 0.411
LIG_SH2_SRC 706 709 PF00017 0.505
LIG_SH2_SRC 798 801 PF00017 0.379
LIG_SH2_STAP1 393 397 PF00017 0.317
LIG_SH2_STAP1 530 534 PF00017 0.239
LIG_SH2_STAT5 292 295 PF00017 0.224
LIG_SH2_STAT5 306 309 PF00017 0.224
LIG_SH2_STAT5 474 477 PF00017 0.333
LIG_SH2_STAT5 53 56 PF00017 0.224
LIG_SH2_STAT5 530 533 PF00017 0.239
LIG_SH2_STAT5 545 548 PF00017 0.478
LIG_SH2_STAT5 639 642 PF00017 0.387
LIG_SH2_STAT5 701 704 PF00017 0.438
LIG_SH2_STAT5 798 801 PF00017 0.397
LIG_SH2_STAT5 858 861 PF00017 0.411
LIG_SH2_STAT5 89 92 PF00017 0.239
LIG_SH3_2 171 176 PF14604 0.367
LIG_SH3_3 168 174 PF00018 0.367
LIG_SUMO_SIM_anti_2 507 513 PF11976 0.258
LIG_SUMO_SIM_anti_2 826 831 PF11976 0.411
LIG_SUMO_SIM_par_1 338 344 PF11976 0.239
LIG_SUMO_SIM_par_1 418 424 PF11976 0.250
LIG_SUMO_SIM_par_1 626 634 PF11976 0.518
LIG_SUMO_SIM_par_1 669 674 PF11976 0.439
LIG_SUMO_SIM_par_1 752 758 PF11976 0.433
LIG_TRAF2_1 27 30 PF00917 0.436
LIG_TRAF2_1 765 768 PF00917 0.441
LIG_TYR_ITIM 528 533 PF00017 0.239
LIG_TYR_ITSM 695 702 PF00017 0.429
LIG_UBA3_1 109 116 PF00899 0.258
LIG_UBA3_1 420 425 PF00899 0.288
LIG_UBA3_1 661 668 PF00899 0.441
LIG_UBA3_1 69 75 PF00899 0.258
MOD_CK1_1 119 125 PF00069 0.322
MOD_CK1_1 154 160 PF00069 0.257
MOD_CK1_1 270 276 PF00069 0.270
MOD_CK1_1 362 368 PF00069 0.317
MOD_CK1_1 426 432 PF00069 0.272
MOD_CK1_1 448 454 PF00069 0.367
MOD_CK1_1 500 506 PF00069 0.294
MOD_CK1_1 578 584 PF00069 0.668
MOD_CK2_1 140 146 PF00069 0.259
MOD_CK2_1 166 172 PF00069 0.370
MOD_CK2_1 242 248 PF00069 0.409
MOD_CK2_1 275 281 PF00069 0.239
MOD_CK2_1 345 351 PF00069 0.224
MOD_CK2_1 388 394 PF00069 0.317
MOD_CK2_1 426 432 PF00069 0.328
MOD_CK2_1 541 547 PF00069 0.529
MOD_CK2_1 59 65 PF00069 0.229
MOD_CK2_1 671 677 PF00069 0.452
MOD_CK2_1 724 730 PF00069 0.379
MOD_GlcNHglycan 122 125 PF01048 0.275
MOD_GlcNHglycan 25 28 PF01048 0.402
MOD_GlcNHglycan 362 365 PF01048 0.284
MOD_GlcNHglycan 409 412 PF01048 0.371
MOD_GlcNHglycan 567 570 PF01048 0.548
MOD_GlcNHglycan 577 580 PF01048 0.687
MOD_GlcNHglycan 593 597 PF01048 0.423
MOD_GlcNHglycan 712 715 PF01048 0.187
MOD_GlcNHglycan 816 819 PF01048 0.224
MOD_GlcNHglycan 851 854 PF01048 0.221
MOD_GSK3_1 116 123 PF00069 0.317
MOD_GSK3_1 132 139 PF00069 0.238
MOD_GSK3_1 147 154 PF00069 0.280
MOD_GSK3_1 280 287 PF00069 0.349
MOD_GSK3_1 336 343 PF00069 0.246
MOD_GSK3_1 345 352 PF00069 0.232
MOD_GSK3_1 356 363 PF00069 0.304
MOD_GSK3_1 388 395 PF00069 0.264
MOD_GSK3_1 402 409 PF00069 0.214
MOD_GSK3_1 423 430 PF00069 0.341
MOD_GSK3_1 500 507 PF00069 0.262
MOD_GSK3_1 537 544 PF00069 0.435
MOD_GSK3_1 574 581 PF00069 0.604
MOD_GSK3_1 745 752 PF00069 0.197
MOD_GSK3_1 99 106 PF00069 0.317
MOD_N-GLC_1 275 280 PF02516 0.217
MOD_N-GLC_1 769 774 PF02516 0.235
MOD_N-GLC_1 782 787 PF02516 0.141
MOD_NEK2_1 103 108 PF00069 0.224
MOD_NEK2_1 132 137 PF00069 0.258
MOD_NEK2_1 140 145 PF00069 0.094
MOD_NEK2_1 166 171 PF00069 0.347
MOD_NEK2_1 252 257 PF00069 0.274
MOD_NEK2_1 291 296 PF00069 0.263
MOD_NEK2_1 340 345 PF00069 0.228
MOD_NEK2_1 374 379 PF00069 0.374
MOD_NEK2_1 412 417 PF00069 0.306
MOD_NEK2_1 421 426 PF00069 0.317
MOD_NEK2_1 504 509 PF00069 0.256
MOD_NEK2_1 512 517 PF00069 0.252
MOD_NEK2_1 541 546 PF00069 0.524
MOD_NEK2_1 573 578 PF00069 0.710
MOD_NEK2_1 592 597 PF00069 0.542
MOD_NEK2_1 70 75 PF00069 0.317
MOD_NEK2_1 76 81 PF00069 0.322
MOD_NEK2_1 814 819 PF00069 0.367
MOD_NEK2_2 688 693 PF00069 0.527
MOD_NEK2_2 777 782 PF00069 0.431
MOD_PIKK_1 176 182 PF00454 0.257
MOD_PIKK_1 292 298 PF00454 0.313
MOD_PIKK_1 356 362 PF00454 0.283
MOD_PIKK_1 445 451 PF00454 0.317
MOD_PIKK_1 46 52 PF00454 0.258
MOD_PIKK_1 694 700 PF00454 0.489
MOD_PK_1 151 157 PF00069 0.367
MOD_PKA_1 565 571 PF00069 0.642
MOD_PKA_2 206 212 PF00069 0.246
MOD_PKA_2 222 228 PF00069 0.252
MOD_PKA_2 309 315 PF00069 0.291
MOD_PKA_2 504 510 PF00069 0.224
MOD_PKA_2 59 65 PF00069 0.359
MOD_PKA_2 624 630 PF00069 0.411
MOD_Plk_1 132 138 PF00069 0.239
MOD_Plk_1 140 146 PF00069 0.094
MOD_Plk_1 350 356 PF00069 0.224
MOD_Plk_1 445 451 PF00069 0.317
MOD_Plk_1 537 543 PF00069 0.452
MOD_Plk_1 823 829 PF00069 0.461
MOD_Plk_1 99 105 PF00069 0.317
MOD_Plk_2-3 206 212 PF00069 0.367
MOD_Plk_4 132 138 PF00069 0.227
MOD_Plk_4 151 157 PF00069 0.328
MOD_Plk_4 252 258 PF00069 0.267
MOD_Plk_4 284 290 PF00069 0.342
MOD_Plk_4 341 347 PF00069 0.231
MOD_Plk_4 362 368 PF00069 0.322
MOD_Plk_4 374 380 PF00069 0.357
MOD_Plk_4 392 398 PF00069 0.280
MOD_Plk_4 412 418 PF00069 0.289
MOD_Plk_4 537 543 PF00069 0.413
MOD_Plk_4 639 645 PF00069 0.390
MOD_Plk_4 99 105 PF00069 0.242
MOD_ProDKin_1 280 286 PF00069 0.206
MOD_ProDKin_1 749 755 PF00069 0.395
MOD_ProDKin_1 93 99 PF00069 0.279
MOD_SUMO_rev_2 755 765 PF00179 0.417
TRG_DiLeu_BaEn_1 823 828 PF01217 0.489
TRG_DiLeu_BaEn_2 247 253 PF01217 0.251
TRG_DiLeu_BaEn_4 12 18 PF01217 0.539
TRG_DiLeu_BaLyEn_6 209 214 PF01217 0.258
TRG_ENDOCYTIC_2 129 132 PF00928 0.317
TRG_ENDOCYTIC_2 137 140 PF00928 0.094
TRG_ENDOCYTIC_2 193 196 PF00928 0.231
TRG_ENDOCYTIC_2 250 253 PF00928 0.261
TRG_ENDOCYTIC_2 393 396 PF00928 0.224
TRG_ENDOCYTIC_2 530 533 PF00928 0.224
TRG_ENDOCYTIC_2 699 702 PF00928 0.390
TRG_ENDOCYTIC_2 81 84 PF00928 0.312
TRG_ENDOCYTIC_2 89 92 PF00928 0.242
TRG_ER_diArg_1 504 506 PF00400 0.239
TRG_ER_diArg_1 84 86 PF00400 0.226
TRG_NES_CRM1_1 50 65 PF08389 0.367
TRG_NES_CRM1_1 789 800 PF08389 0.399
TRG_Pf-PMV_PEXEL_1 142 146 PF00026 0.224
TRG_Pf-PMV_PEXEL_1 212 216 PF00026 0.240
TRG_Pf-PMV_PEXEL_1 356 360 PF00026 0.250
TRG_Pf-PMV_PEXEL_1 402 406 PF00026 0.283
TRG_Pf-PMV_PEXEL_1 615 619 PF00026 0.191
TRG_Pf-PMV_PEXEL_1 782 786 PF00026 0.269

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1Q5 Leptomonas seymouri 81% 100%
A0A0S4IV67 Bodo saltans 49% 100%
A0A1X0NR86 Trypanosomatidae 57% 96%
A0A3Q8IEU8 Leishmania donovani 99% 100%
A0A3R7MHH9 Trypanosoma rangeli 56% 100%
A2VE21 Bos taurus 33% 99%
A4HGW5 Leishmania braziliensis 88% 99%
D0A965 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 99%
D4ABY2 Rattus norvegicus 34% 100%
E9B085 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P32074 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 93%
P53620 Bos taurus 34% 99%
P87140 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 96%
Q0WW26 Arabidopsis thaliana 36% 98%
Q22498 Caenorhabditis elegans 33% 99%
Q29AE5 Drosophila pseudoobscura pseudoobscura 34% 99%
Q4AEF8 Rattus norvegicus 34% 99%
Q4Q800 Leishmania major 97% 100%
Q54HL0 Dictyostelium discoideum 34% 96%
Q66JI9 Xenopus tropicalis 33% 99%
Q6DKD7 Xenopus laevis 33% 99%
Q6Z382 Oryza sativa subsp. japonica 35% 97%
Q7PVF6 Anopheles gambiae 32% 100%
Q8I0G5 Drosophila melanogaster 34% 98%
Q9I8E6 Takifugu rubripes 33% 99%
Q9PUE4 Danio rerio 32% 99%
Q9QXK3 Mus musculus 34% 99%
Q9QZE5 Mus musculus 34% 99%
Q9UBF2 Homo sapiens 33% 99%
Q9Y678 Homo sapiens 35% 99%
V5DCV8 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS