ADP-ribosylglycohydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylglycohydrolase - putative

Species:

Leishmania infantum

UniProt:

A4I3Z3_LEIIN

TriTrypDb:

LINF_280033300

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Z3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.449
CLV_C14_Caspase3-7	332	336	PF00656	0.466
CLV_PCSK_SKI1_1	369	373	PF00082	0.316
CLV_PCSK_SKI1_1	93	97	PF00082	0.502
CLV_Separin_Metazoa	136	140	PF03568	0.447
DEG_APCC_DBOX_1	298	306	PF00400	0.609
DEG_SPOP_SBC_1	111	115	PF00917	0.565
DOC_CKS1_1	185	190	PF01111	0.436
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.337
DOC_MAPK_MEF2A_6	30	38	PF00069	0.375
DOC_MAPK_MEF2A_6	398	407	PF00069	0.496
DOC_USP7_MATH_1	102	106	PF00917	0.696
DOC_USP7_MATH_1	111	115	PF00917	0.614
DOC_USP7_MATH_1	140	144	PF00917	0.410
DOC_USP7_MATH_1	192	196	PF00917	0.428
DOC_USP7_MATH_1	198	202	PF00917	0.335
DOC_USP7_MATH_1	292	296	PF00917	0.651
DOC_USP7_MATH_1	328	332	PF00917	0.462
DOC_USP7_MATH_2	387	393	PF00917	0.567
DOC_WW_Pin1_4	184	189	PF00397	0.389
DOC_WW_Pin1_4	210	215	PF00397	0.500
DOC_WW_Pin1_4	228	233	PF00397	0.494
DOC_WW_Pin1_4	70	75	PF00397	0.580
DOC_WW_Pin1_4	97	102	PF00397	0.583
LIG_14-3-3_CanoR_1	108	116	PF00244	0.630
LIG_14-3-3_CanoR_1	139	148	PF00244	0.389
LIG_14-3-3_CanoR_1	156	164	PF00244	0.442
LIG_14-3-3_CanoR_1	301	306	PF00244	0.468
LIG_14-3-3_CanoR_1	312	317	PF00244	0.604
LIG_14-3-3_CanoR_1	330	339	PF00244	0.436
LIG_AP2alpha_2	204	206	PF02296	0.464
LIG_BIR_III_4	221	225	PF00653	0.576
LIG_eIF4E_1	152	158	PF01652	0.497
LIG_FHA_1	128	134	PF00498	0.348
LIG_FHA_1	185	191	PF00498	0.403
LIG_FHA_1	205	211	PF00498	0.432
LIG_FHA_1	245	251	PF00498	0.421
LIG_FHA_1	274	280	PF00498	0.363
LIG_FHA_1	400	406	PF00498	0.356
LIG_FHA_2	292	298	PF00498	0.632
LIG_FHA_2	330	336	PF00498	0.493
LIG_LIR_Apic_2	201	205	PF02991	0.440
LIG_LIR_Apic_2	411	415	PF02991	0.407
LIG_LIR_Gen_1	204	214	PF02991	0.372
LIG_LIR_Gen_1	245	255	PF02991	0.336
LIG_LIR_Nem_3	118	124	PF02991	0.491
LIG_LIR_Nem_3	128	134	PF02991	0.295
LIG_LIR_Nem_3	20	24	PF02991	0.395
LIG_LIR_Nem_3	204	209	PF02991	0.353
LIG_LIR_Nem_3	245	251	PF02991	0.336
LIG_LIR_Nem_3	322	327	PF02991	0.547
LIG_SH2_CRK	121	125	PF00017	0.459
LIG_SH2_GRB2like	17	20	PF00017	0.372
LIG_SH2_SRC	17	20	PF00017	0.372
LIG_SH2_SRC	202	205	PF00017	0.474
LIG_SH2_STAP1	193	197	PF00017	0.488
LIG_SH2_STAP1	246	250	PF00017	0.331
LIG_SH2_STAT5	134	137	PF00017	0.402
LIG_SH2_STAT5	152	155	PF00017	0.371
LIG_SH2_STAT5	202	205	PF00017	0.498
LIG_SH2_STAT5	246	249	PF00017	0.313
LIG_SH2_STAT5	59	62	PF00017	0.553
LIG_SH3_2	286	291	PF14604	0.411
LIG_SH3_3	283	289	PF00018	0.501
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.300
LIG_TRAF2_2	216	221	PF00917	0.532
LIG_WW_3	90	94	PF00397	0.529
MOD_CK1_1	110	116	PF00069	0.663
MOD_CK1_1	315	321	PF00069	0.622
MOD_CK1_1	331	337	PF00069	0.400
MOD_CK2_1	112	118	PF00069	0.509
MOD_CK2_1	228	234	PF00069	0.614
MOD_CK2_1	291	297	PF00069	0.606
MOD_CK2_1	335	341	PF00069	0.540
MOD_GlcNHglycan	109	112	PF01048	0.650
MOD_GlcNHglycan	142	145	PF01048	0.430
MOD_GlcNHglycan	159	162	PF01048	0.390
MOD_GlcNHglycan	293	297	PF01048	0.645
MOD_GlcNHglycan	318	321	PF01048	0.654
MOD_GlcNHglycan	391	394	PF01048	0.360
MOD_GSK3_1	102	109	PF00069	0.677
MOD_GSK3_1	112	119	PF00069	0.650
MOD_GSK3_1	173	180	PF00069	0.439
MOD_GSK3_1	204	211	PF00069	0.478
MOD_GSK3_1	308	315	PF00069	0.651
MOD_GSK3_1	331	338	PF00069	0.468
MOD_N-GLC_2	62	64	PF02516	0.339
MOD_NEK2_1	1	6	PF00069	0.587
MOD_NEK2_1	116	121	PF00069	0.646
MOD_NEK2_1	125	130	PF00069	0.479
MOD_NEK2_1	157	162	PF00069	0.411
MOD_NEK2_1	177	182	PF00069	0.420
MOD_NEK2_1	316	321	PF00069	0.579
MOD_NEK2_2	17	22	PF00069	0.371
MOD_PKA_2	107	113	PF00069	0.611
MOD_PKA_2	311	317	PF00069	0.556
MOD_PKA_2	329	335	PF00069	0.519
MOD_PKB_1	299	307	PF00069	0.441
MOD_Plk_1	117	123	PF00069	0.459
MOD_Plk_1	244	250	PF00069	0.449
MOD_Plk_1	80	86	PF00069	0.448
MOD_Plk_2-3	335	341	PF00069	0.427
MOD_Plk_4	112	118	PF00069	0.700
MOD_Plk_4	173	179	PF00069	0.328
MOD_Plk_4	180	186	PF00069	0.416
MOD_Plk_4	22	28	PF00069	0.502
MOD_ProDKin_1	184	190	PF00069	0.391
MOD_ProDKin_1	210	216	PF00069	0.515
MOD_ProDKin_1	228	234	PF00069	0.491
MOD_ProDKin_1	70	76	PF00069	0.568
MOD_ProDKin_1	97	103	PF00069	0.587
MOD_SUMO_rev_2	392	400	PF00179	0.512
TRG_DiLeu_BaEn_1	173	178	PF01217	0.330
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.423
TRG_ENDOCYTIC_2	121	124	PF00928	0.445
TRG_ENDOCYTIC_2	134	137	PF00928	0.370
TRG_ER_diArg_1	298	301	PF00400	0.715
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW3	Leptomonas seymouri	59%	97%
A0A0S4IN38	Bodo saltans	32%	100%
A0A1X0NQK8	Trypanosomatidae	43%	100%
A0A3Q8IF26	Leishmania donovani	100%	100%
A0A3R7KDQ9	Trypanosoma rangeli	45%	100%
A4HGW3	Leishmania braziliensis	82%	99%
D0A963	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B083	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q802	Leishmania major	92%	100%
V5BC55	Trypanosoma cruzi	45%	100%