Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4I3Y7_LEIIN

TriTrypDb:

LINF_280032700

Length:

1003

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Y7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.551
CLV_C14_Caspase3-7	268	272	PF00656	0.663
CLV_NRD_NRD_1	126	128	PF00675	0.491
CLV_NRD_NRD_1	130	132	PF00675	0.480
CLV_NRD_NRD_1	489	491	PF00675	0.497
CLV_NRD_NRD_1	525	527	PF00675	0.396
CLV_NRD_NRD_1	558	560	PF00675	0.517
CLV_NRD_NRD_1	822	824	PF00675	0.413
CLV_NRD_NRD_1	876	878	PF00675	0.652
CLV_NRD_NRD_1	888	890	PF00675	0.716
CLV_NRD_NRD_1	912	914	PF00675	0.669
CLV_PCSK_FUR_1	886	890	PF00082	0.667
CLV_PCSK_KEX2_1	126	128	PF00082	0.491
CLV_PCSK_KEX2_1	130	132	PF00082	0.480
CLV_PCSK_KEX2_1	489	491	PF00082	0.497
CLV_PCSK_KEX2_1	525	527	PF00082	0.394
CLV_PCSK_KEX2_1	558	560	PF00082	0.517
CLV_PCSK_KEX2_1	822	824	PF00082	0.413
CLV_PCSK_KEX2_1	875	877	PF00082	0.645
CLV_PCSK_KEX2_1	886	888	PF00082	0.718
CLV_PCSK_KEX2_1	912	914	PF00082	0.669
CLV_PCSK_PC7_1	126	132	PF00082	0.478
CLV_PCSK_PC7_1	554	560	PF00082	0.573
CLV_PCSK_SKI1_1	152	156	PF00082	0.381
CLV_PCSK_SKI1_1	334	338	PF00082	0.473
CLV_PCSK_SKI1_1	484	488	PF00082	0.419
CLV_PCSK_SKI1_1	525	529	PF00082	0.336
CLV_PCSK_SKI1_1	561	565	PF00082	0.557
CLV_PCSK_SKI1_1	664	668	PF00082	0.366
CLV_PCSK_SKI1_1	682	686	PF00082	0.378
CLV_PCSK_SKI1_1	741	745	PF00082	0.526
CLV_PCSK_SKI1_1	75	79	PF00082	0.371
CLV_PCSK_SKI1_1	809	813	PF00082	0.582
CLV_PCSK_SKI1_1	823	827	PF00082	0.389
CLV_PCSK_SKI1_1	844	848	PF00082	0.375
DEG_APCC_DBOX_1	129	137	PF00400	0.423
DEG_SPOP_SBC_1	282	286	PF00917	0.668
DEG_SPOP_SBC_1	391	395	PF00917	0.556
DEG_SPOP_SBC_1	405	409	PF00917	0.640
DOC_ANK_TNKS_1	188	195	PF00023	0.552
DOC_ANK_TNKS_1	538	545	PF00023	0.461
DOC_ANK_TNKS_1	943	950	PF00023	0.562
DOC_CKS1_1	922	927	PF01111	0.703
DOC_CKS1_1	971	976	PF01111	0.627
DOC_CYCLIN_RxL_1	329	342	PF00134	0.478
DOC_CYCLIN_RxL_1	4	12	PF00134	0.515
DOC_CYCLIN_RxL_1	661	670	PF00134	0.380
DOC_CYCLIN_RxL_1	841	851	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.416
DOC_MAPK_gen_1	126	136	PF00069	0.453
DOC_MAPK_gen_1	475	485	PF00069	0.461
DOC_MAPK_gen_1	525	532	PF00069	0.371
DOC_MAPK_gen_1	72	80	PF00069	0.445
DOC_MAPK_gen_1	822	828	PF00069	0.421
DOC_MAPK_MEF2A_6	478	487	PF00069	0.460
DOC_MAPK_MEF2A_6	525	534	PF00069	0.348
DOC_MAPK_NFAT4_5	525	533	PF00069	0.321
DOC_PP1_RVXF_1	842	849	PF00149	0.375
DOC_PP2B_LxvP_1	161	164	PF13499	0.427
DOC_PP2B_LxvP_1	374	377	PF13499	0.600
DOC_PP4_FxxP_1	774	777	PF00568	0.440
DOC_USP7_MATH_1	119	123	PF00917	0.630
DOC_USP7_MATH_1	276	280	PF00917	0.723
DOC_USP7_MATH_1	282	286	PF00917	0.652
DOC_USP7_MATH_1	375	379	PF00917	0.594
DOC_USP7_MATH_1	391	395	PF00917	0.713
DOC_USP7_MATH_1	405	409	PF00917	0.693
DOC_USP7_MATH_1	585	589	PF00917	0.564
DOC_USP7_MATH_1	842	846	PF00917	0.593
DOC_USP7_MATH_1	894	898	PF00917	0.738
DOC_USP7_MATH_2	219	225	PF00917	0.595
DOC_WW_Pin1_4	111	116	PF00397	0.581
DOC_WW_Pin1_4	269	274	PF00397	0.705
DOC_WW_Pin1_4	366	371	PF00397	0.600
DOC_WW_Pin1_4	426	431	PF00397	0.661
DOC_WW_Pin1_4	448	453	PF00397	0.495
DOC_WW_Pin1_4	502	507	PF00397	0.655
DOC_WW_Pin1_4	618	623	PF00397	0.605
DOC_WW_Pin1_4	761	766	PF00397	0.670
DOC_WW_Pin1_4	784	789	PF00397	0.480
DOC_WW_Pin1_4	906	911	PF00397	0.684
DOC_WW_Pin1_4	914	919	PF00397	0.605
DOC_WW_Pin1_4	921	926	PF00397	0.555
DOC_WW_Pin1_4	970	975	PF00397	0.668
LIG_14-3-3_CanoR_1	174	181	PF00244	0.456
LIG_14-3-3_CanoR_1	334	339	PF00244	0.624
LIG_14-3-3_CanoR_1	668	676	PF00244	0.337
LIG_14-3-3_CanoR_1	682	690	PF00244	0.390
LIG_14-3-3_CanoR_1	892	901	PF00244	0.592
LIG_Actin_WH2_2	545	563	PF00022	0.481
LIG_APCC_ABBA_1	165	170	PF00400	0.525
LIG_APCC_ABBAyCdc20_2	844	850	PF00400	0.374
LIG_BIR_II_1	1	5	PF00653	0.486
LIG_BIR_III_2	449	453	PF00653	0.512
LIG_BIR_III_4	280	284	PF00653	0.713
LIG_BRCT_BRCA1_1	341	345	PF00533	0.445
LIG_BRCT_BRCA1_1	844	848	PF00533	0.389
LIG_CaM_NSCaTE_8	575	582	PF13499	0.471
LIG_EH1_1	641	649	PF00400	0.411
LIG_EH1_1	659	667	PF00400	0.285
LIG_eIF4E_1	661	667	PF01652	0.377
LIG_FHA_1	695	701	PF00498	0.393
LIG_FHA_1	752	758	PF00498	0.465
LIG_FHA_2	140	146	PF00498	0.396
LIG_FHA_2	234	240	PF00498	0.597
LIG_FHA_2	284	290	PF00498	0.656
LIG_FHA_2	378	384	PF00498	0.794
LIG_FHA_2	499	505	PF00498	0.612
LIG_FHA_2	569	575	PF00498	0.430
LIG_FHA_2	906	912	PF00498	0.681
LIG_FHA_2	922	928	PF00498	0.556
LIG_Integrin_RGD_1	608	610	PF01839	0.584
LIG_LIR_Apic_2	771	777	PF02991	0.457
LIG_LIR_Gen_1	48	57	PF02991	0.367
LIG_LIR_Gen_1	935	945	PF02991	0.579
LIG_LIR_Nem_3	48	53	PF02991	0.380
LIG_LIR_Nem_3	935	940	PF02991	0.621
LIG_LIR_Nem_3	992	998	PF02991	0.437
LIG_LYPXL_S_1	80	84	PF13949	0.376
LIG_LYPXL_yS_3	81	84	PF13949	0.368
LIG_PCNA_APIM_2	129	135	PF02747	0.401
LIG_PCNA_yPIPBox_3	741	753	PF02747	0.494
LIG_Pex14_2	704	708	PF04695	0.374
LIG_REV1ctd_RIR_1	640	650	PF16727	0.360
LIG_RPA_C_Fungi	485	497	PF08784	0.416
LIG_SH2_CRK	535	539	PF00017	0.365
LIG_SH2_CRK	88	92	PF00017	0.375
LIG_SH2_NCK_1	88	92	PF00017	0.421
LIG_SH2_PTP2	810	813	PF00017	0.389
LIG_SH2_STAT5	132	135	PF00017	0.430
LIG_SH2_STAT5	149	152	PF00017	0.375
LIG_SH2_STAT5	168	171	PF00017	0.459
LIG_SH2_STAT5	313	316	PF00017	0.634
LIG_SH2_STAT5	463	466	PF00017	0.388
LIG_SH2_STAT5	661	664	PF00017	0.406
LIG_SH2_STAT5	810	813	PF00017	0.444
LIG_SH2_STAT5	816	819	PF00017	0.400
LIG_SH3_2	115	120	PF14604	0.574
LIG_SH3_3	112	118	PF00018	0.560
LIG_SH3_3	161	167	PF00018	0.416
LIG_SH3_3	203	209	PF00018	0.634
LIG_SH3_3	304	310	PF00018	0.563
LIG_SH3_3	350	356	PF00018	0.527
LIG_SH3_3	364	370	PF00018	0.607
LIG_SH3_3	79	85	PF00018	0.389
LIG_SH3_3	913	919	PF00018	0.724
LIG_SH3_3	968	974	PF00018	0.783
LIG_SH3_5	309	313	PF00018	0.611
LIG_SUMO_SIM_anti_2	198	205	PF11976	0.641
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.563
LIG_SUMO_SIM_par_1	372	380	PF11976	0.572
LIG_TRAF2_1	121	124	PF00917	0.531
LIG_TRAF2_1	257	260	PF00917	0.580
LIG_TRAF2_1	46	49	PF00917	0.417
LIG_TRAF2_2	444	449	PF00917	0.550
LIG_WW_3	117	121	PF00397	0.578
LIG_WW_3	969	973	PF00397	0.634
MOD_CDC14_SPxK_1	909	912	PF00782	0.656
MOD_CDK_SPK_2	111	116	PF00069	0.577
MOD_CDK_SPK_2	784	789	PF00069	0.473
MOD_CDK_SPxK_1	906	912	PF00069	0.660
MOD_CDK_SPxxK_3	761	768	PF00069	0.560
MOD_CDK_SPxxK_3	784	791	PF00069	0.517
MOD_CDK_SPxxK_3	906	913	PF00069	0.662
MOD_CK1_1	285	291	PF00069	0.725
MOD_CK1_1	293	299	PF00069	0.749
MOD_CK1_1	300	306	PF00069	0.736
MOD_CK1_1	42	48	PF00069	0.488
MOD_CK1_1	500	506	PF00069	0.558
MOD_CK1_1	586	592	PF00069	0.518
MOD_CK1_1	917	923	PF00069	0.668
MOD_CK1_1	929	935	PF00069	0.574
MOD_CK1_1	997	1003	PF00069	0.452
MOD_CK2_1	118	124	PF00069	0.556
MOD_CK2_1	197	203	PF00069	0.566
MOD_CK2_1	233	239	PF00069	0.632
MOD_CK2_1	377	383	PF00069	0.738
MOD_CK2_1	392	398	PF00069	0.520
MOD_CK2_1	42	48	PF00069	0.425
MOD_CK2_1	498	504	PF00069	0.614
MOD_CK2_1	568	574	PF00069	0.433
MOD_CK2_1	866	872	PF00069	0.457
MOD_CK2_1	905	911	PF00069	0.681
MOD_Cter_Amidation	873	876	PF01082	0.614
MOD_GlcNHglycan	181	184	PF01048	0.492
MOD_GlcNHglycan	232	236	PF01048	0.666
MOD_GlcNHglycan	289	293	PF01048	0.680
MOD_GlcNHglycan	395	398	PF01048	0.649
MOD_GlcNHglycan	414	417	PF01048	0.652
MOD_GlcNHglycan	435	438	PF01048	0.486
MOD_GlcNHglycan	44	47	PF01048	0.535
MOD_GlcNHglycan	464	467	PF01048	0.379
MOD_GlcNHglycan	535	538	PF01048	0.352
MOD_GlcNHglycan	580	583	PF01048	0.483
MOD_GlcNHglycan	585	588	PF01048	0.563
MOD_GlcNHglycan	594	597	PF01048	0.700
MOD_GlcNHglycan	896	899	PF01048	0.658
MOD_GlcNHglycan	932	935	PF01048	0.653
MOD_GlcNHglycan	937	940	PF01048	0.532
MOD_GlcNHglycan	961	964	PF01048	0.760
MOD_GlcNHglycan	984	988	PF01048	0.570
MOD_GSK3_1	179	186	PF00069	0.504
MOD_GSK3_1	281	288	PF00069	0.670
MOD_GSK3_1	293	300	PF00069	0.768
MOD_GSK3_1	313	320	PF00069	0.695
MOD_GSK3_1	406	413	PF00069	0.561
MOD_GSK3_1	450	457	PF00069	0.447
MOD_GSK3_1	498	505	PF00069	0.655
MOD_GSK3_1	533	540	PF00069	0.439
MOD_GSK3_1	583	590	PF00069	0.576
MOD_GSK3_1	614	621	PF00069	0.644
MOD_GSK3_1	917	924	PF00069	0.657
MOD_GSK3_1	926	933	PF00069	0.589
MOD_GSK3_1	959	966	PF00069	0.683
MOD_GSK3_1	979	986	PF00069	0.732
MOD_N-GLC_1	296	301	PF02516	0.694
MOD_N-GLC_2	56	58	PF02516	0.348
MOD_NEK2_1	202	207	PF00069	0.601
MOD_NEK2_1	233	238	PF00069	0.605
MOD_NEK2_1	406	411	PF00069	0.643
MOD_NEK2_1	433	438	PF00069	0.492
MOD_NEK2_1	583	588	PF00069	0.612
MOD_NEK2_1	737	742	PF00069	0.537
MOD_NEK2_1	848	853	PF00069	0.471
MOD_NEK2_1	905	910	PF00069	0.581
MOD_NEK2_1	926	931	PF00069	0.566
MOD_NEK2_1	994	999	PF00069	0.427
MOD_NEK2_2	2	7	PF00069	0.520
MOD_NEK2_2	677	682	PF00069	0.491
MOD_PIKK_1	313	319	PF00454	0.605
MOD_PIKK_1	377	383	PF00454	0.669
MOD_PIKK_1	848	854	PF00454	0.446
MOD_PK_1	912	918	PF00069	0.670
MOD_PKA_1	888	894	PF00069	0.624
MOD_PKA_1	912	918	PF00069	0.670
MOD_PKA_2	119	125	PF00069	0.552
MOD_PKA_2	221	227	PF00069	0.579
MOD_PKA_2	300	306	PF00069	0.752
MOD_PKA_2	339	345	PF00069	0.453
MOD_PKA_2	667	673	PF00069	0.339
MOD_PKA_2	888	894	PF00069	0.669
MOD_PKA_2	912	918	PF00069	0.670
MOD_PKB_1	886	894	PF00069	0.642
MOD_Plk_1	197	203	PF00069	0.563
MOD_Plk_1	357	363	PF00069	0.729
MOD_Plk_1	694	700	PF00069	0.396
MOD_Plk_2-3	417	423	PF00069	0.605
MOD_Plk_4	197	203	PF00069	0.631
MOD_Plk_4	290	296	PF00069	0.778
MOD_Plk_4	334	340	PF00069	0.417
MOD_Plk_4	866	872	PF00069	0.478
MOD_Plk_4	997	1003	PF00069	0.467
MOD_ProDKin_1	111	117	PF00069	0.583
MOD_ProDKin_1	269	275	PF00069	0.706
MOD_ProDKin_1	366	372	PF00069	0.602
MOD_ProDKin_1	426	432	PF00069	0.648
MOD_ProDKin_1	448	454	PF00069	0.483
MOD_ProDKin_1	502	508	PF00069	0.654
MOD_ProDKin_1	618	624	PF00069	0.604
MOD_ProDKin_1	761	767	PF00069	0.660
MOD_ProDKin_1	784	790	PF00069	0.488
MOD_ProDKin_1	906	912	PF00069	0.685
MOD_ProDKin_1	914	920	PF00069	0.606
MOD_ProDKin_1	921	927	PF00069	0.554
MOD_ProDKin_1	970	976	PF00069	0.668
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.676
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.537
TRG_DiLeu_BaLyEn_6	661	666	PF01217	0.270
TRG_DiLeu_BaLyEn_6	862	867	PF01217	0.478
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.456
TRG_DiLeu_BaLyEn_6	975	980	PF01217	0.627
TRG_DiLeu_LyEn_5	428	433	PF01217	0.479
TRG_ENDOCYTIC_2	535	538	PF00928	0.352
TRG_ENDOCYTIC_2	81	84	PF00928	0.387
TRG_ENDOCYTIC_2	88	91	PF00928	0.385
TRG_ER_diArg_1	125	127	PF00400	0.520
TRG_ER_diArg_1	129	131	PF00400	0.470
TRG_ER_diArg_1	319	322	PF00400	0.571
TRG_ER_diArg_1	489	491	PF00400	0.548
TRG_ER_diArg_1	525	527	PF00400	0.394
TRG_ER_diArg_1	538	541	PF00400	0.434
TRG_ER_diArg_1	558	561	PF00400	0.521
TRG_ER_diArg_1	788	791	PF00400	0.514
TRG_ER_diArg_1	821	823	PF00400	0.408
TRG_ER_diArg_1	863	866	PF00400	0.443
TRG_ER_diArg_1	875	877	PF00400	0.647
TRG_ER_diArg_1	885	888	PF00400	0.707
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	729	733	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	988	992	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B1	Leptomonas seymouri	54%	100%
A0A3Q8IE47	Leishmania donovani	100%	100%
A4HGV7	Leishmania braziliensis	76%	100%
E9B077	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q808	Leishmania major	91%	100%