LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
R3H domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I3Y4_LEIIN
TriTrypDb:
LINF_280032400
Length:
640

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 74

Expansion

Sequence features

A4I3Y4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Y4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0005488 binding 1 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 247 251 PF00656 0.735
CLV_C14_Caspase3-7 72 76 PF00656 0.678
CLV_MEL_PAP_1 173 179 PF00089 0.521
CLV_NRD_NRD_1 218 220 PF00675 0.494
CLV_NRD_NRD_1 381 383 PF00675 0.696
CLV_NRD_NRD_1 398 400 PF00675 0.522
CLV_NRD_NRD_1 491 493 PF00675 0.633
CLV_NRD_NRD_1 630 632 PF00675 0.633
CLV_PCSK_FUR_1 216 220 PF00082 0.608
CLV_PCSK_FUR_1 396 400 PF00082 0.685
CLV_PCSK_KEX2_1 218 220 PF00082 0.487
CLV_PCSK_KEX2_1 379 381 PF00082 0.693
CLV_PCSK_KEX2_1 396 398 PF00082 0.676
CLV_PCSK_KEX2_1 491 493 PF00082 0.633
CLV_PCSK_KEX2_1 630 632 PF00082 0.622
CLV_PCSK_PC1ET2_1 379 381 PF00082 0.693
CLV_PCSK_SKI1_1 101 105 PF00082 0.326
CLV_PCSK_SKI1_1 154 158 PF00082 0.446
CLV_PCSK_SKI1_1 218 222 PF00082 0.575
CLV_PCSK_SKI1_1 225 229 PF00082 0.601
CLV_PCSK_SKI1_1 28 32 PF00082 0.747
CLV_PCSK_SKI1_1 524 528 PF00082 0.466
CLV_PCSK_SKI1_1 617 621 PF00082 0.529
CLV_PCSK_SKI1_1 8 12 PF00082 0.594
DEG_APCC_DBOX_1 100 108 PF00400 0.562
DEG_APCC_KENBOX_2 88 92 PF00400 0.555
DEG_Nend_UBRbox_2 1 3 PF02207 0.662
DEG_SPOP_SBC_1 270 274 PF00917 0.701
DEG_SPOP_SBC_1 285 289 PF00917 0.552
DEG_SPOP_SBC_1 293 297 PF00917 0.679
DOC_CKS1_1 52 57 PF01111 0.802
DOC_CYCLIN_RxL_1 521 530 PF00134 0.488
DOC_CYCLIN_RxL_1 97 108 PF00134 0.564
DOC_MAPK_DCC_7 593 602 PF00069 0.608
DOC_MAPK_gen_1 110 117 PF00069 0.451
DOC_MAPK_gen_1 153 159 PF00069 0.639
DOC_MAPK_gen_1 510 519 PF00069 0.460
DOC_MAPK_gen_1 94 104 PF00069 0.367
DOC_MAPK_HePTP_8 507 519 PF00069 0.518
DOC_MAPK_MEF2A_6 510 519 PF00069 0.529
DOC_MAPK_MEF2A_6 563 572 PF00069 0.449
DOC_MAPK_MEF2A_6 593 602 PF00069 0.592
DOC_MAPK_MEF2A_6 97 106 PF00069 0.586
DOC_PP1_RVXF_1 152 159 PF00149 0.634
DOC_PP1_RVXF_1 174 180 PF00149 0.584
DOC_PP2B_LxvP_1 115 118 PF13499 0.482
DOC_PP4_FxxP_1 159 162 PF00568 0.584
DOC_USP7_MATH_1 14 18 PF00917 0.535
DOC_USP7_MATH_1 270 274 PF00917 0.735
DOC_USP7_MATH_1 285 289 PF00917 0.618
DOC_USP7_MATH_1 293 297 PF00917 0.720
DOC_USP7_MATH_1 3 7 PF00917 0.517
DOC_USP7_MATH_1 41 45 PF00917 0.767
DOC_USP7_MATH_1 437 441 PF00917 0.572
DOC_USP7_MATH_1 497 501 PF00917 0.687
DOC_USP7_MATH_1 53 57 PF00917 0.790
DOC_USP7_MATH_1 621 625 PF00917 0.522
DOC_USP7_MATH_1 632 636 PF00917 0.572
DOC_USP7_UBL2_3 28 32 PF12436 0.681
DOC_WW_Pin1_4 272 277 PF00397 0.738
DOC_WW_Pin1_4 286 291 PF00397 0.616
DOC_WW_Pin1_4 341 346 PF00397 0.560
DOC_WW_Pin1_4 51 56 PF00397 0.747
DOC_WW_Pin1_4 634 639 PF00397 0.645
LIG_14-3-3_CanoR_1 176 180 PF00244 0.614
LIG_14-3-3_CanoR_1 187 197 PF00244 0.602
LIG_14-3-3_CanoR_1 225 232 PF00244 0.617
LIG_14-3-3_CanoR_1 4 8 PF00244 0.664
LIG_14-3-3_CanoR_1 545 550 PF00244 0.661
LIG_14-3-3_CanoR_1 593 598 PF00244 0.582
LIG_deltaCOP1_diTrp_1 456 463 PF00928 0.453
LIG_eIF4E_1 232 238 PF01652 0.515
LIG_FHA_1 273 279 PF00498 0.710
LIG_FHA_1 296 302 PF00498 0.730
LIG_FHA_1 466 472 PF00498 0.625
LIG_FHA_1 578 584 PF00498 0.509
LIG_FHA_1 620 626 PF00498 0.575
LIG_FHA_2 231 237 PF00498 0.573
LIG_FHA_2 34 40 PF00498 0.784
LIG_FHA_2 437 443 PF00498 0.482
LIG_FHA_2 516 522 PF00498 0.434
LIG_FHA_2 528 534 PF00498 0.426
LIG_FHA_2 70 76 PF00498 0.758
LIG_LIR_Gen_1 529 539 PF02991 0.438
LIG_LIR_Nem_3 325 331 PF02991 0.542
LIG_LIR_Nem_3 480 484 PF02991 0.423
LIG_LIR_Nem_3 502 508 PF02991 0.465
LIG_LIR_Nem_3 529 534 PF02991 0.370
LIG_Pex14_1 459 463 PF04695 0.429
LIG_Pex14_2 477 481 PF04695 0.438
LIG_PTB_Apo_2 525 532 PF02174 0.509
LIG_Rb_LxCxE_1 358 373 PF01857 0.631
LIG_RPA_C_Fungi 302 314 PF08784 0.710
LIG_SH2_CRK 99 103 PF00017 0.410
LIG_SH2_PTP2 506 509 PF00017 0.483
LIG_SH2_SRC 328 331 PF00017 0.456
LIG_SH2_STAP1 113 117 PF00017 0.440
LIG_SH2_STAT3 232 235 PF00017 0.596
LIG_SH2_STAT5 188 191 PF00017 0.660
LIG_SH2_STAT5 232 235 PF00017 0.577
LIG_SH2_STAT5 353 356 PF00017 0.452
LIG_SH2_STAT5 506 509 PF00017 0.417
LIG_SH3_2 598 603 PF14604 0.415
LIG_SH3_3 287 293 PF00018 0.664
LIG_SH3_3 52 58 PF00018 0.793
LIG_SH3_3 595 601 PF00018 0.594
LIG_TRAF2_1 233 236 PF00917 0.540
LIG_TRAF2_1 403 406 PF00917 0.699
LIG_TRAF2_1 429 432 PF00917 0.783
LIG_TRAF2_1 624 627 PF00917 0.566
LIG_TYR_ITIM 326 331 PF00017 0.535
LIG_UBA3_1 103 112 PF00899 0.428
MOD_CK1_1 138 144 PF00069 0.324
MOD_CK1_1 295 301 PF00069 0.669
MOD_CK1_1 308 314 PF00069 0.654
MOD_CK1_1 40 46 PF00069 0.807
MOD_CK1_1 425 431 PF00069 0.756
MOD_CK1_1 465 471 PF00069 0.549
MOD_CK2_1 108 114 PF00069 0.342
MOD_CK2_1 175 181 PF00069 0.567
MOD_CK2_1 230 236 PF00069 0.514
MOD_CK2_1 383 389 PF00069 0.717
MOD_CK2_1 425 431 PF00069 0.758
MOD_CK2_1 621 627 PF00069 0.550
MOD_Cter_Amidation 394 397 PF01082 0.807
MOD_GlcNHglycan 12 15 PF01048 0.603
MOD_GlcNHglycan 190 193 PF01048 0.635
MOD_GlcNHglycan 259 262 PF01048 0.679
MOD_GlcNHglycan 38 42 PF01048 0.749
MOD_GlcNHglycan 386 389 PF01048 0.732
MOD_GlcNHglycan 393 396 PF01048 0.772
MOD_GlcNHglycan 420 423 PF01048 0.706
MOD_GlcNHglycan 428 431 PF01048 0.797
MOD_GlcNHglycan 451 455 PF01048 0.513
MOD_GlcNHglycan 535 538 PF01048 0.705
MOD_GlcNHglycan 547 550 PF01048 0.699
MOD_GSK3_1 10 17 PF00069 0.651
MOD_GSK3_1 135 142 PF00069 0.383
MOD_GSK3_1 175 182 PF00069 0.587
MOD_GSK3_1 265 272 PF00069 0.680
MOD_GSK3_1 292 299 PF00069 0.699
MOD_GSK3_1 33 40 PF00069 0.718
MOD_GSK3_1 418 425 PF00069 0.767
MOD_GSK3_1 446 453 PF00069 0.570
MOD_GSK3_1 47 54 PF00069 0.707
MOD_GSK3_1 513 520 PF00069 0.531
MOD_GSK3_1 573 580 PF00069 0.522
MOD_GSK3_1 632 639 PF00069 0.630
MOD_GSK3_1 77 84 PF00069 0.656
MOD_N-GLC_1 118 123 PF02516 0.424
MOD_N-GLC_1 135 140 PF02516 0.227
MOD_N-GLC_1 527 532 PF02516 0.332
MOD_N-GLC_1 573 578 PF02516 0.498
MOD_NEK2_1 230 235 PF00069 0.639
MOD_NEK2_1 294 299 PF00069 0.732
MOD_NEK2_1 305 310 PF00069 0.671
MOD_NEK2_1 37 42 PF00069 0.798
MOD_NEK2_1 515 520 PF00069 0.518
MOD_NEK2_1 527 532 PF00069 0.513
MOD_NEK2_2 14 19 PF00069 0.598
MOD_NEK2_2 3 8 PF00069 0.664
MOD_NEK2_2 573 578 PF00069 0.498
MOD_PIKK_1 230 236 PF00454 0.525
MOD_PIKK_1 619 625 PF00454 0.518
MOD_PK_1 593 599 PF00069 0.593
MOD_PKA_1 218 224 PF00069 0.610
MOD_PKA_2 14 20 PF00069 0.567
MOD_PKA_2 175 181 PF00069 0.615
MOD_PKA_2 218 224 PF00069 0.516
MOD_PKA_2 3 9 PF00069 0.665
MOD_PKA_2 348 354 PF00069 0.585
MOD_PKA_2 358 364 PF00069 0.536
MOD_PKA_2 383 389 PF00069 0.571
MOD_PKA_2 418 424 PF00069 0.777
MOD_PKA_2 425 431 PF00069 0.687
MOD_PKA_2 465 471 PF00069 0.547
MOD_PKA_2 544 550 PF00069 0.661
MOD_PKB_1 216 224 PF00069 0.611
MOD_PKB_1 382 390 PF00069 0.698
MOD_PKB_1 424 432 PF00069 0.673
MOD_Plk_1 118 124 PF00069 0.441
MOD_Plk_1 513 519 PF00069 0.553
MOD_Plk_1 527 533 PF00069 0.459
MOD_Plk_1 573 579 PF00069 0.502
MOD_Plk_1 81 87 PF00069 0.590
MOD_Plk_2-3 175 181 PF00069 0.582
MOD_Plk_2-3 201 207 PF00069 0.622
MOD_Plk_2-3 71 77 PF00069 0.678
MOD_Plk_4 26 32 PF00069 0.597
MOD_Plk_4 322 328 PF00069 0.563
MOD_Plk_4 358 364 PF00069 0.444
MOD_Plk_4 527 533 PF00069 0.392
MOD_Plk_4 573 579 PF00069 0.502
MOD_ProDKin_1 272 278 PF00069 0.740
MOD_ProDKin_1 286 292 PF00069 0.612
MOD_ProDKin_1 341 347 PF00069 0.563
MOD_ProDKin_1 51 57 PF00069 0.745
MOD_ProDKin_1 634 640 PF00069 0.659
MOD_SUMO_for_1 244 247 PF00179 0.693
MOD_SUMO_for_1 370 373 PF00179 0.672
MOD_SUMO_rev_2 175 184 PF00179 0.615
TRG_DiLeu_BaLyEn_6 98 103 PF01217 0.447
TRG_ENDOCYTIC_2 328 331 PF00928 0.433
TRG_ENDOCYTIC_2 506 509 PF00928 0.444
TRG_ENDOCYTIC_2 99 102 PF00928 0.408
TRG_ER_diArg_1 18 21 PF00400 0.543
TRG_ER_diArg_1 217 219 PF00400 0.500
TRG_ER_diArg_1 338 341 PF00400 0.484
TRG_ER_diArg_1 380 382 PF00400 0.813
TRG_ER_diArg_1 396 399 PF00400 0.539
TRG_ER_diArg_1 490 492 PF00400 0.636
TRG_ER_diArg_1 610 613 PF00400 0.559
TRG_ER_diArg_1 629 631 PF00400 0.591
TRG_NES_CRM1_1 360 373 PF08389 0.587
TRG_Pf-PMV_PEXEL_1 35 39 PF00026 0.795
TRG_Pf-PMV_PEXEL_1 524 529 PF00026 0.508
TRG_Pf-PMV_PEXEL_1 8 12 PF00026 0.576

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I070 Leptomonas seymouri 61% 100%
A0A1X0NQY1 Trypanosomatidae 33% 100%
A0A3Q8IE01 Leishmania donovani 99% 100%
A0A3R7KGE8 Trypanosoma rangeli 32% 100%
A4HGV4 Leishmania braziliensis 79% 100%
D0A955 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9B074 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q811 Leishmania major 94% 100%
V5BGS0 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS