LeishMANIAdb
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Putative acyl-CoA dehydrogenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative acyl-CoA dehydrogenase
Gene product:
acyl-CoA dehydrogenase - putative
Species:
Leishmania infantum
UniProt:
A4I3Y3_LEIIN
TriTrypDb:
LINF_280032300
Length:
629

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, acyl-CoA dehydrogenase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I3Y3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Y3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0003995 acyl-CoA dehydrogenase activity 5 6
GO:0005488 binding 1 13
GO:0016491 oxidoreductase activity 2 13
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 13
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 6
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0043958 acryloyl-CoA reductase (NADH) activity 5 6
GO:0050660 flavin adenine dinucleotide binding 4 13
GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4 6
GO:0097159 organic cyclic compound binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 233 237 PF00656 0.414
CLV_C14_Caspase3-7 65 69 PF00656 0.520
CLV_C14_Caspase3-7 87 91 PF00656 0.444
CLV_NRD_NRD_1 3 5 PF00675 0.525
CLV_NRD_NRD_1 350 352 PF00675 0.385
CLV_NRD_NRD_1 482 484 PF00675 0.289
CLV_NRD_NRD_1 610 612 PF00675 0.276
CLV_PCSK_FUR_1 348 352 PF00082 0.431
CLV_PCSK_KEX2_1 3 5 PF00082 0.534
CLV_PCSK_KEX2_1 350 352 PF00082 0.431
CLV_PCSK_KEX2_1 495 497 PF00082 0.551
CLV_PCSK_KEX2_1 499 501 PF00082 0.535
CLV_PCSK_KEX2_1 610 612 PF00082 0.341
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.551
CLV_PCSK_PC1ET2_1 499 501 PF00082 0.535
CLV_PCSK_SKI1_1 22 26 PF00082 0.472
CLV_PCSK_SKI1_1 315 319 PF00082 0.294
CLV_PCSK_SKI1_1 390 394 PF00082 0.383
CLV_PCSK_SKI1_1 483 487 PF00082 0.402
CLV_PCSK_SKI1_1 530 534 PF00082 0.383
DEG_APCC_DBOX_1 389 397 PF00400 0.383
DEG_APCC_DBOX_1 534 542 PF00400 0.298
DEG_Nend_Nbox_1 1 3 PF02207 0.551
DOC_CKS1_1 101 106 PF01111 0.349
DOC_CKS1_1 421 426 PF01111 0.289
DOC_PP1_RVXF_1 29 36 PF00149 0.299
DOC_PP4_FxxP_1 259 262 PF00568 0.277
DOC_PP4_FxxP_1 421 424 PF00568 0.289
DOC_USP7_MATH_1 20 24 PF00917 0.591
DOC_USP7_MATH_1 209 213 PF00917 0.476
DOC_USP7_MATH_1 547 551 PF00917 0.339
DOC_USP7_MATH_1 55 59 PF00917 0.563
DOC_USP7_MATH_1 9 13 PF00917 0.626
DOC_USP7_UBL2_3 286 290 PF12436 0.305
DOC_USP7_UBL2_3 48 52 PF12436 0.526
DOC_USP7_UBL2_3 495 499 PF12436 0.559
DOC_WW_Pin1_4 100 105 PF00397 0.364
DOC_WW_Pin1_4 420 425 PF00397 0.289
LIG_14-3-3_CanoR_1 164 170 PF00244 0.298
LIG_14-3-3_CanoR_1 22 27 PF00244 0.388
LIG_14-3-3_CanoR_1 245 251 PF00244 0.460
LIG_14-3-3_CanoR_1 350 354 PF00244 0.383
LIG_14-3-3_CanoR_1 530 539 PF00244 0.331
LIG_BIR_III_4 583 587 PF00653 0.341
LIG_BRCT_BRCA1_1 135 139 PF00533 0.305
LIG_BRCT_BRCA1_1 550 554 PF00533 0.383
LIG_CaM_IQ_9 522 537 PF13499 0.289
LIG_FHA_1 16 22 PF00498 0.479
LIG_FHA_1 188 194 PF00498 0.349
LIG_FHA_1 233 239 PF00498 0.338
LIG_FHA_1 251 257 PF00498 0.190
LIG_FHA_1 292 298 PF00498 0.371
LIG_FHA_1 470 476 PF00498 0.293
LIG_FHA_1 510 516 PF00498 0.341
LIG_FHA_1 531 537 PF00498 0.383
LIG_FHA_1 598 604 PF00498 0.383
LIG_FHA_1 61 67 PF00498 0.452
LIG_FHA_2 138 144 PF00498 0.365
LIG_FHA_2 205 211 PF00498 0.289
LIG_FHA_2 465 471 PF00498 0.289
LIG_FHA_2 588 594 PF00498 0.370
LIG_LIR_Apic_2 257 262 PF02991 0.299
LIG_LIR_Apic_2 418 424 PF02991 0.289
LIG_LIR_Gen_1 109 116 PF02991 0.414
LIG_LIR_Gen_1 558 568 PF02991 0.305
LIG_LIR_Gen_1 596 606 PF02991 0.370
LIG_LIR_Nem_3 109 114 PF02991 0.257
LIG_LIR_Nem_3 153 158 PF02991 0.324
LIG_LIR_Nem_3 38 44 PF02991 0.328
LIG_LIR_Nem_3 45 50 PF02991 0.358
LIG_LIR_Nem_3 551 557 PF02991 0.316
LIG_LIR_Nem_3 558 563 PF02991 0.268
LIG_LIR_Nem_3 596 602 PF02991 0.387
LIG_LIR_Nem_3 81 86 PF02991 0.428
LIG_Rb_pABgroove_1 38 46 PF01858 0.431
LIG_SH2_CRK 111 115 PF00017 0.349
LIG_SH2_CRK 155 159 PF00017 0.424
LIG_SH2_CRK 422 426 PF00017 0.277
LIG_SH2_CRK 47 51 PF00017 0.429
LIG_SH2_CRK 560 564 PF00017 0.431
LIG_SH2_NCK_1 37 41 PF00017 0.443
LIG_SH2_NCK_1 422 426 PF00017 0.289
LIG_SH2_SRC 305 308 PF00017 0.337
LIG_SH2_SRC 37 40 PF00017 0.470
LIG_SH2_STAP1 37 41 PF00017 0.436
LIG_SH2_STAT3 128 131 PF00017 0.324
LIG_SH2_STAT3 518 521 PF00017 0.431
LIG_SH2_STAT5 178 181 PF00017 0.289
LIG_SH2_STAT5 305 308 PF00017 0.324
LIG_SH2_STAT5 422 425 PF00017 0.289
LIG_SH2_STAT5 450 453 PF00017 0.305
LIG_SH2_STAT5 557 560 PF00017 0.316
LIG_SH2_STAT5 597 600 PF00017 0.363
LIG_SH3_3 98 104 PF00018 0.415
LIG_TYR_ITIM 563 568 PF00017 0.277
LIG_UBA3_1 538 542 PF00899 0.341
LIG_WRC_WIRS_1 317 322 PF05994 0.289
MOD_CDK_SPxxK_3 420 427 PF00069 0.289
MOD_CK1_1 153 159 PF00069 0.434
MOD_CK1_1 168 174 PF00069 0.499
MOD_CK1_1 249 255 PF00069 0.305
MOD_CK1_1 60 66 PF00069 0.594
MOD_CK1_1 88 94 PF00069 0.479
MOD_CK2_1 137 143 PF00069 0.405
MOD_CK2_1 204 210 PF00069 0.286
MOD_CK2_1 464 470 PF00069 0.289
MOD_CK2_1 86 92 PF00069 0.410
MOD_Cter_Amidation 481 484 PF01082 0.305
MOD_Cter_Amidation 497 500 PF01082 0.380
MOD_GlcNHglycan 155 158 PF01048 0.426
MOD_GlcNHglycan 183 186 PF01048 0.311
MOD_GlcNHglycan 187 190 PF01048 0.353
MOD_GlcNHglycan 210 214 PF01048 0.467
MOD_GlcNHglycan 227 230 PF01048 0.303
MOD_GlcNHglycan 309 313 PF01048 0.462
MOD_GlcNHglycan 7 10 PF01048 0.579
MOD_GSK3_1 133 140 PF00069 0.350
MOD_GSK3_1 181 188 PF00069 0.296
MOD_GSK3_1 200 207 PF00069 0.187
MOD_GSK3_1 214 221 PF00069 0.319
MOD_GSK3_1 246 253 PF00069 0.318
MOD_GSK3_1 291 298 PF00069 0.305
MOD_GSK3_1 460 467 PF00069 0.365
MOD_GSK3_1 5 12 PF00069 0.585
MOD_GSK3_1 555 562 PF00069 0.462
MOD_GSK3_1 587 594 PF00069 0.383
MOD_N-GLC_1 99 104 PF02516 0.445
MOD_NEK2_1 144 149 PF00069 0.282
MOD_NEK2_1 299 304 PF00069 0.345
MOD_NEK2_1 460 465 PF00069 0.418
MOD_NEK2_1 509 514 PF00069 0.328
MOD_NEK2_1 555 560 PF00069 0.305
MOD_NEK2_1 587 592 PF00069 0.364
MOD_NEK2_1 71 76 PF00069 0.396
MOD_NEK2_2 150 155 PF00069 0.437
MOD_NEK2_2 295 300 PF00069 0.276
MOD_NEK2_2 78 83 PF00069 0.412
MOD_PIKK_1 200 206 PF00454 0.341
MOD_PKA_1 499 505 PF00069 0.409
MOD_PKA_2 218 224 PF00069 0.365
MOD_PKA_2 349 355 PF00069 0.289
MOD_PKA_2 460 466 PF00069 0.370
MOD_PKA_2 499 505 PF00069 0.467
MOD_Plk_1 200 206 PF00069 0.341
MOD_Plk_2-3 268 274 PF00069 0.462
MOD_Plk_4 254 260 PF00069 0.387
MOD_Plk_4 464 470 PF00069 0.289
MOD_Plk_4 57 63 PF00069 0.546
MOD_Plk_4 78 84 PF00069 0.365
MOD_ProDKin_1 100 106 PF00069 0.363
MOD_ProDKin_1 420 426 PF00069 0.289
MOD_SUMO_rev_2 210 217 PF00179 0.287
MOD_SUMO_rev_2 279 287 PF00179 0.412
TRG_DiLeu_BaEn_4 72 78 PF01217 0.371
TRG_DiLeu_BaLyEn_6 395 400 PF01217 0.319
TRG_DiLeu_BaLyEn_6 437 442 PF01217 0.341
TRG_ENDOCYTIC_2 111 114 PF00928 0.305
TRG_ENDOCYTIC_2 155 158 PF00928 0.289
TRG_ENDOCYTIC_2 37 40 PF00928 0.360
TRG_ENDOCYTIC_2 422 425 PF00928 0.277
TRG_ENDOCYTIC_2 47 50 PF00928 0.323
TRG_ENDOCYTIC_2 560 563 PF00928 0.277
TRG_ENDOCYTIC_2 565 568 PF00928 0.277
TRG_ER_diArg_1 2 4 PF00400 0.533
TRG_ER_diArg_1 28 31 PF00400 0.349
TRG_ER_diArg_1 610 612 PF00400 0.276
TRG_Pf-PMV_PEXEL_1 22 27 PF00026 0.502
TRG_Pf-PMV_PEXEL_1 390 395 PF00026 0.322

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3D6 Leptomonas seymouri 76% 99%
A0A0S4IUT5 Bodo saltans 63% 87%
A0A0S4JQE6 Bodo saltans 53% 97%
A0A1X0NQM6 Trypanosomatidae 65% 100%
A0A1X0P5J1 Trypanosomatidae 25% 100%
A0A3Q8IIB9 Leishmania donovani 100% 100%
A0A3S5H5T1 Leishmania donovani 27% 100%
A0A422NKY7 Trypanosoma rangeli 61% 100%
A4H4Q0 Leishmania braziliensis 28% 100%
A4H4Q2 Leishmania braziliensis 27% 100%
A4HGV3 Leishmania braziliensis 89% 100%
A4HMU0 Leishmania braziliensis 25% 100%
A4HSY0 Leishmania infantum 26% 100%
D0A954 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AKW6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B073 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O32176 Bacillus subtilis (strain 168) 25% 100%
O53666 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 31% 100%
P15650 Rattus norvegicus 26% 100%
Q0AVA8 Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) 28% 100%
Q0AVM4 Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) 32% 100%
Q3L887 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 31% 100%
Q4Q812 Leishmania major 97% 100%
Q4QIY9 Leishmania major 27% 100%
Q5LLW7 Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) 38% 100%
V5DCV2 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS