DUF2451 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3Y1_LEIIN

TriTrypDb:

LINF_280032100

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Y1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.604
CLV_C14_Caspase3-7	280	284	PF00656	0.620
CLV_C14_Caspase3-7	397	401	PF00656	0.614
CLV_C14_Caspase3-7	64	68	PF00656	0.647
CLV_NRD_NRD_1	200	202	PF00675	0.488
CLV_NRD_NRD_1	213	215	PF00675	0.556
CLV_NRD_NRD_1	491	493	PF00675	0.388
CLV_NRD_NRD_1	52	54	PF00675	0.594
CLV_NRD_NRD_1	75	77	PF00675	0.668
CLV_PCSK_FUR_1	213	217	PF00082	0.553
CLV_PCSK_KEX2_1	200	202	PF00082	0.488
CLV_PCSK_KEX2_1	213	215	PF00082	0.538
CLV_PCSK_KEX2_1	277	279	PF00082	0.581
CLV_PCSK_KEX2_1	491	493	PF00082	0.388
CLV_PCSK_KEX2_1	52	54	PF00082	0.594
CLV_PCSK_KEX2_1	75	77	PF00082	0.668
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.573
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.581
CLV_PCSK_SKI1_1	160	164	PF00082	0.587
CLV_PCSK_SKI1_1	466	470	PF00082	0.399
CLV_PCSK_SKI1_1	55	59	PF00082	0.537
CLV_PCSK_SKI1_1	75	79	PF00082	0.502
DEG_Nend_UBRbox_2	1	3	PF02207	0.580
DEG_SPOP_SBC_1	175	179	PF00917	0.595
DEG_SPOP_SBC_1	262	266	PF00917	0.652
DEG_SPOP_SBC_1	374	378	PF00917	0.654
DOC_CYCLIN_RxL_1	460	473	PF00134	0.397
DOC_MAPK_gen_1	310	319	PF00069	0.563
DOC_MAPK_gen_1	502	510	PF00069	0.475
DOC_MAPK_gen_1	52	59	PF00069	0.552
DOC_PP2B_PxIxI_1	451	457	PF00149	0.454
DOC_USP7_MATH_1	119	123	PF00917	0.655
DOC_USP7_MATH_1	147	151	PF00917	0.560
DOC_USP7_MATH_1	174	178	PF00917	0.628
DOC_USP7_MATH_1	187	191	PF00917	0.584
DOC_USP7_MATH_1	23	27	PF00917	0.603
DOC_USP7_MATH_1	243	247	PF00917	0.723
DOC_USP7_MATH_1	248	252	PF00917	0.809
DOC_USP7_MATH_1	254	258	PF00917	0.710
DOC_USP7_MATH_1	262	266	PF00917	0.611
DOC_WW_Pin1_4	228	233	PF00397	0.641
DOC_WW_Pin1_4	255	260	PF00397	0.709
DOC_WW_Pin1_4	41	46	PF00397	0.623
DOC_WW_Pin1_4	475	480	PF00397	0.506
DOC_WW_Pin1_4	503	508	PF00397	0.478
LIG_14-3-3_CanoR_1	75	80	PF00244	0.666
LIG_APCC_ABBA_1	57	62	PF00400	0.551
LIG_BIR_III_2	346	350	PF00653	0.671
LIG_BIR_III_4	125	129	PF00653	0.561
LIG_BRCT_BRCA1_1	147	151	PF00533	0.591
LIG_deltaCOP1_diTrp_1	411	418	PF00928	0.585
LIG_FHA_1	119	125	PF00498	0.621
LIG_FHA_1	376	382	PF00498	0.569
LIG_FHA_1	471	477	PF00498	0.524
LIG_FHA_1	52	58	PF00498	0.555
LIG_FHA_2	240	246	PF00498	0.592
LIG_FHA_2	30	36	PF00498	0.671
LIG_FHA_2	316	322	PF00498	0.495
LIG_FXI_DFP_1	415	419	PF00024	0.647
LIG_Integrin_isoDGR_2	302	304	PF01839	0.522
LIG_LIR_Gen_1	414	422	PF02991	0.578
LIG_LIR_Nem_3	294	299	PF02991	0.597
LIG_LIR_Nem_3	411	415	PF02991	0.589
LIG_PDZ_Class_1	512	517	PF00595	0.559
LIG_SH2_CRK	497	501	PF00017	0.420
LIG_SH2_STAP1	315	319	PF00017	0.558
LIG_SH3_3	159	165	PF00018	0.590
LIG_SH3_3	256	262	PF00018	0.699
LIG_SH3_3	267	273	PF00018	0.616
LIG_SH3_3	30	36	PF00018	0.636
LIG_SH3_3	39	45	PF00018	0.696
LIG_SH3_3	473	479	PF00018	0.513
LIG_SUMO_SIM_par_1	433	439	PF11976	0.399
LIG_SUMO_SIM_par_1	505	511	PF11976	0.557
LIG_TRAF2_1	134	137	PF00917	0.567
LIG_TRAF2_1	3	6	PF00917	0.545
LIG_WW_3	49	53	PF00397	0.666
MOD_CDK_SPK_2	228	233	PF00069	0.652
MOD_CK1_1	150	156	PF00069	0.619
MOD_CK1_1	263	269	PF00069	0.844
MOD_CK1_1	27	33	PF00069	0.712
MOD_CK2_1	11	17	PF00069	0.643
MOD_CK2_1	131	137	PF00069	0.573
MOD_CK2_1	239	245	PF00069	0.625
MOD_CK2_1	261	267	PF00069	0.686
MOD_CK2_1	315	321	PF00069	0.488
MOD_CK2_1	475	481	PF00069	0.506
MOD_Cter_Amidation	73	76	PF01082	0.679
MOD_GlcNHglycan	140	143	PF01048	0.578
MOD_GlcNHglycan	189	192	PF01048	0.523
MOD_GlcNHglycan	222	225	PF01048	0.624
MOD_GlcNHglycan	245	248	PF01048	0.681
MOD_GlcNHglycan	250	253	PF01048	0.675
MOD_GlcNHglycan	27	30	PF01048	0.691
MOD_GlcNHglycan	37	40	PF01048	0.662
MOD_GlcNHglycan	385	388	PF01048	0.710
MOD_GlcNHglycan	96	99	PF01048	0.536
MOD_GSK3_1	114	121	PF00069	0.641
MOD_GSK3_1	220	227	PF00069	0.696
MOD_GSK3_1	23	30	PF00069	0.681
MOD_GSK3_1	239	246	PF00069	0.559
MOD_NEK2_2	176	181	PF00069	0.618
MOD_PIKK_1	75	81	PF00454	0.655
MOD_PKA_1	75	81	PF00069	0.655
MOD_PKA_2	51	57	PF00069	0.601
MOD_PKA_2	75	81	PF00069	0.655
MOD_PKB_1	158	166	PF00069	0.587
MOD_Plk_1	109	115	PF00069	0.523
MOD_Plk_1	315	321	PF00069	0.568
MOD_Plk_2-3	333	339	PF00069	0.588
MOD_Plk_4	119	125	PF00069	0.660
MOD_Plk_4	147	153	PF00069	0.515
MOD_Plk_4	29	35	PF00069	0.567
MOD_Plk_4	496	502	PF00069	0.504
MOD_ProDKin_1	228	234	PF00069	0.643
MOD_ProDKin_1	255	261	PF00069	0.709
MOD_ProDKin_1	41	47	PF00069	0.621
MOD_ProDKin_1	475	481	PF00069	0.506
MOD_ProDKin_1	503	509	PF00069	0.476
TRG_DiLeu_BaEn_1	194	199	PF01217	0.478
TRG_DiLeu_BaEn_2	456	462	PF01217	0.402
TRG_DiLeu_BaEn_4	424	430	PF01217	0.593
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.536
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.383
TRG_ENDOCYTIC_2	497	500	PF00928	0.419
TRG_ER_diArg_1	157	160	PF00400	0.628
TRG_ER_diArg_1	199	201	PF00400	0.483
TRG_ER_diArg_1	213	216	PF00400	0.546
TRG_ER_diArg_1	309	312	PF00400	0.582
TRG_ER_diArg_1	490	492	PF00400	0.391
TRG_ER_diArg_1	501	504	PF00400	0.461
TRG_ER_diArg_1	51	53	PF00400	0.667
TRG_NLS_Bipartite_1	200	218	PF00514	0.499
TRG_NLS_MonoExtC_3	213	218	PF00514	0.558
TRG_NLS_MonoExtN_4	213	218	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA28	Leptomonas seymouri	43%	100%
A0A3S5H7K0	Leishmania donovani	99%	100%
A4HGV1	Leishmania braziliensis	64%	98%
E9B071	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q814	Leishmania major	85%	99%