Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3Y0_LEIIN

TriTrypDb:

LINF_280032000

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I3Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.829
CLV_NRD_NRD_1	272	274	PF00675	0.564
CLV_NRD_NRD_1	45	47	PF00675	0.785
CLV_NRD_NRD_1	73	75	PF00675	0.642
CLV_PCSK_KEX2_1	272	274	PF00082	0.563
CLV_PCSK_KEX2_1	45	47	PF00082	0.785
CLV_PCSK_KEX2_1	73	75	PF00082	0.642
CLV_PCSK_SKI1_1	278	282	PF00082	0.509
DOC_CYCLIN_RxL_1	166	176	PF00134	0.463
DOC_MAPK_gen_1	73	79	PF00069	0.437
DOC_USP7_MATH_1	160	164	PF00917	0.475
DOC_USP7_MATH_1	215	219	PF00917	0.571
DOC_USP7_MATH_1	263	267	PF00917	0.452
DOC_USP7_MATH_1	37	41	PF00917	0.498
DOC_WW_Pin1_4	119	124	PF00397	0.619
DOC_WW_Pin1_4	150	155	PF00397	0.580
LIG_14-3-3_CanoR_1	119	123	PF00244	0.541
LIG_14-3-3_CanoR_1	3	9	PF00244	0.757
LIG_14-3-3_CanoR_1	38	42	PF00244	0.472
LIG_14-3-3_CanoR_1	73	79	PF00244	0.437
LIG_BIR_III_4	279	283	PF00653	0.657
LIG_FHA_1	101	107	PF00498	0.648
LIG_FHA_1	128	134	PF00498	0.576
LIG_FHA_1	26	32	PF00498	0.367
LIG_FHA_2	223	229	PF00498	0.488
LIG_FHA_2	295	301	PF00498	0.758
LIG_FHA_2	37	43	PF00498	0.569
LIG_Integrin_isoDGR_2	43	45	PF01839	0.777
LIG_LIR_Nem_3	248	252	PF02991	0.406
LIG_PDZ_Class_2	296	301	PF00595	0.805
LIG_Pex14_2	243	247	PF04695	0.324
LIG_SH3_3	28	34	PF00018	0.452
LIG_SH3_3	283	289	PF00018	0.766
LIG_SH3_3	48	54	PF00018	0.491
LIG_SH3_3	76	82	PF00018	0.551
LIG_SUMO_SIM_par_1	254	260	PF11976	0.444
LIG_TRAF2_1	88	91	PF00917	0.556
LIG_WRC_WIRS_1	240	245	PF05994	0.515
LIG_WW_1	82	85	PF00397	0.476
MOD_CK1_1	217	223	PF00069	0.644
MOD_CK2_1	222	228	PF00069	0.590
MOD_CK2_1	36	42	PF00069	0.568
MOD_CK2_1	95	101	PF00069	0.598
MOD_Cter_Amidation	43	46	PF01082	0.780
MOD_Cter_Amidation	71	74	PF01082	0.642
MOD_DYRK1A_RPxSP_1	119	123	PF00069	0.563
MOD_GlcNHglycan	11	14	PF01048	0.473
MOD_GlcNHglycan	217	220	PF01048	0.791
MOD_GlcNHglycan	236	239	PF01048	0.563
MOD_GlcNHglycan	265	268	PF01048	0.567
MOD_GlcNHglycan	28	31	PF01048	0.293
MOD_GlcNHglycan	66	69	PF01048	0.755
MOD_GlcNHglycan	95	98	PF01048	0.684
MOD_GSK3_1	165	172	PF00069	0.551
MOD_GSK3_1	214	221	PF00069	0.557
MOD_GSK3_1	241	248	PF00069	0.477
MOD_GSK3_1	33	40	PF00069	0.513
MOD_GSK3_1	93	100	PF00069	0.555
MOD_NEK2_1	25	30	PF00069	0.530
MOD_NEK2_1	294	299	PF00069	0.810
MOD_PIKK_1	95	101	PF00454	0.621
MOD_PKA_2	118	124	PF00069	0.539
MOD_PKA_2	2	8	PF00069	0.721
MOD_PKA_2	274	280	PF00069	0.689
MOD_PKA_2	294	300	PF00069	0.812
MOD_PKA_2	37	43	PF00069	0.472
MOD_PKA_2	72	78	PF00069	0.494
MOD_Plk_1	100	106	PF00069	0.604
MOD_Plk_4	169	175	PF00069	0.528
MOD_ProDKin_1	119	125	PF00069	0.620
MOD_ProDKin_1	150	156	PF00069	0.579
MOD_SUMO_for_1	83	86	PF00179	0.510
TRG_ER_diArg_1	272	275	PF00400	0.765
TRG_ER_diArg_1	45	47	PF00400	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1W1	Leishmania donovani	99%	100%
A4HGV0	Leishmania braziliensis	55%	100%
E9B070	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q815	Leishmania major	82%	100%