Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3X5_LEIIN

TriTrypDb:

LINF_280031500

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	1
GO:0032045	guanyl-nucleotide exchange factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A4I3X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3X5

Function

Biological processes
Term	Name	Level	Count
GO:0002183	cytoplasmic translational initiation	4	1
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0009058	biosynthetic process	2	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003743	translation initiation factor activity	4	1
GO:0003824	catalytic activity	1	7
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016779	nucleotidyltransferase activity	4	7
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0045182	translation regulator activity	1	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0008879	glucose-1-phosphate thymidylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.652
CLV_C14_Caspase3-7	269	273	PF00656	0.479
CLV_C14_Caspase3-7	362	366	PF00656	0.316
CLV_C14_Caspase3-7	450	454	PF00656	0.481
CLV_C14_Caspase3-7	589	593	PF00656	0.541
CLV_NRD_NRD_1	228	230	PF00675	0.593
CLV_NRD_NRD_1	353	355	PF00675	0.383
CLV_NRD_NRD_1	390	392	PF00675	0.495
CLV_PCSK_KEX2_1	230	232	PF00082	0.677
CLV_PCSK_KEX2_1	353	355	PF00082	0.383
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.677
CLV_PCSK_PC7_1	226	232	PF00082	0.607
CLV_PCSK_SKI1_1	110	114	PF00082	0.446
CLV_PCSK_SKI1_1	190	194	PF00082	0.338
CLV_PCSK_SKI1_1	33	37	PF00082	0.314
CLV_PCSK_SKI1_1	373	377	PF00082	0.452
CLV_PCSK_SKI1_1	392	396	PF00082	0.409
CLV_PCSK_SKI1_1	524	528	PF00082	0.564
CLV_PCSK_SKI1_1	57	61	PF00082	0.362
DEG_APCC_DBOX_1	372	380	PF00400	0.448
DEG_APCC_DBOX_1	523	531	PF00400	0.574
DEG_SCF_FBW7_2	48	53	PF00400	0.374
DEG_SPOP_SBC_1	285	289	PF00917	0.576
DOC_CKS1_1	413	418	PF01111	0.474
DOC_MAPK_gen_1	108	115	PF00069	0.423
DOC_MAPK_gen_1	353	359	PF00069	0.392
DOC_MAPK_gen_1	391	397	PF00069	0.494
DOC_MAPK_gen_1	419	426	PF00069	0.510
DOC_MAPK_MEF2A_6	341	348	PF00069	0.456
DOC_MAPK_MEF2A_6	419	426	PF00069	0.510
DOC_PP1_RVXF_1	39	46	PF00149	0.449
DOC_PP4_FxxP_1	413	416	PF00568	0.398
DOC_PP4_FxxP_1	446	449	PF00568	0.403
DOC_PP4_FxxP_1	525	528	PF00568	0.608
DOC_USP7_MATH_1	160	164	PF00917	0.655
DOC_USP7_MATH_1	273	277	PF00917	0.547
DOC_USP7_MATH_1	281	285	PF00917	0.661
DOC_USP7_MATH_1	286	290	PF00917	0.696
DOC_USP7_MATH_1	383	387	PF00917	0.403
DOC_USP7_MATH_1	491	495	PF00917	0.591
DOC_USP7_MATH_1	526	530	PF00917	0.740
DOC_USP7_MATH_1	555	559	PF00917	0.612
DOC_USP7_MATH_1	563	567	PF00917	0.513
DOC_USP7_MATH_1	633	637	PF00917	0.354
DOC_USP7_MATH_1	644	648	PF00917	0.271
DOC_USP7_UBL2_3	104	108	PF12436	0.402
DOC_WW_Pin1_4	142	147	PF00397	0.733
DOC_WW_Pin1_4	295	300	PF00397	0.496
DOC_WW_Pin1_4	310	315	PF00397	0.703
DOC_WW_Pin1_4	412	417	PF00397	0.480
DOC_WW_Pin1_4	46	51	PF00397	0.431
LIG_14-3-3_CanoR_1	182	189	PF00244	0.510
LIG_14-3-3_CanoR_1	212	218	PF00244	0.492
LIG_14-3-3_CanoR_1	345	349	PF00244	0.426
LIG_14-3-3_CanoR_1	617	624	PF00244	0.434
LIG_Actin_WH2_2	100	116	PF00022	0.489
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	74	78	PF00533	0.561
LIG_Clathr_ClatBox_1	201	205	PF01394	0.487
LIG_EVH1_2	596	600	PF00568	0.521
LIG_FHA_1	197	203	PF00498	0.385
LIG_FHA_1	219	225	PF00498	0.491
LIG_FHA_1	258	264	PF00498	0.589
LIG_FHA_1	269	275	PF00498	0.472
LIG_FHA_1	450	456	PF00498	0.451
LIG_FHA_1	47	53	PF00498	0.384
LIG_FHA_1	517	523	PF00498	0.749
LIG_FHA_1	600	606	PF00498	0.411
LIG_FHA_1	617	623	PF00498	0.302
LIG_FHA_1	640	646	PF00498	0.398
LIG_FHA_2	118	124	PF00498	0.509
LIG_FHA_2	26	32	PF00498	0.416
LIG_FHA_2	413	419	PF00498	0.477
LIG_FHA_2	458	464	PF00498	0.311
LIG_FHA_2	572	578	PF00498	0.627
LIG_FHA_2	96	102	PF00498	0.343
LIG_LIR_Apic_2	410	416	PF02991	0.428
LIG_LIR_Gen_1	211	222	PF02991	0.434
LIG_LIR_Gen_1	65	74	PF02991	0.395
LIG_LIR_Gen_1	82	92	PF02991	0.308
LIG_LIR_Nem_3	211	217	PF02991	0.452
LIG_LIR_Nem_3	479	484	PF02991	0.338
LIG_LIR_Nem_3	53	59	PF02991	0.361
LIG_LIR_Nem_3	65	70	PF02991	0.325
LIG_LIR_Nem_3	75	81	PF02991	0.388
LIG_LIR_Nem_3	82	88	PF02991	0.265
LIG_MAD2	651	659	PF02301	0.380
LIG_MYND_1	528	532	PF01753	0.605
LIG_Pex14_1	374	378	PF04695	0.363
LIG_Pex14_2	56	60	PF04695	0.452
LIG_SH2_CRK	214	218	PF00017	0.378
LIG_SH2_CRK	225	229	PF00017	0.390
LIG_SH2_CRK	481	485	PF00017	0.475
LIG_SH2_CRK	67	71	PF00017	0.354
LIG_SH2_GRB2like	334	337	PF00017	0.429
LIG_SH2_PTP2	85	88	PF00017	0.455
LIG_SH2_SRC	334	337	PF00017	0.467
LIG_SH2_STAP1	214	218	PF00017	0.447
LIG_SH2_STAP1	259	263	PF00017	0.393
LIG_SH2_STAT5	106	109	PF00017	0.337
LIG_SH2_STAT5	259	262	PF00017	0.435
LIG_SH2_STAT5	334	337	PF00017	0.441
LIG_SH2_STAT5	369	372	PF00017	0.286
LIG_SH2_STAT5	73	76	PF00017	0.354
LIG_SH2_STAT5	85	88	PF00017	0.325
LIG_SH3_3	566	572	PF00018	0.519
LIG_SH3_3	591	597	PF00018	0.547
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.483
LIG_SUMO_SIM_par_1	198	205	PF11976	0.438
LIG_SUMO_SIM_par_1	570	577	PF11976	0.617
LIG_TRAF2_1	267	270	PF00917	0.339
LIG_TRFH_1	85	89	PF08558	0.336
LIG_TYR_ITAM	211	228	PF00017	0.410
LIG_WRC_WIRS_1	206	211	PF05994	0.453
LIG_WRC_WIRS_1	587	592	PF05994	0.458
MOD_CDK_SPxxK_3	412	419	PF00069	0.478
MOD_CK1_1	134	140	PF00069	0.552
MOD_CK1_1	147	153	PF00069	0.551
MOD_CK1_1	196	202	PF00069	0.311
MOD_CK1_1	2	8	PF00069	0.532
MOD_CK1_1	216	222	PF00069	0.345
MOD_CK1_1	251	257	PF00069	0.712
MOD_CK1_1	284	290	PF00069	0.575
MOD_CK1_1	386	392	PF00069	0.380
MOD_CK1_1	401	407	PF00069	0.301
MOD_CK1_1	436	442	PF00069	0.495
MOD_CK2_1	117	123	PF00069	0.503
MOD_CK2_1	147	153	PF00069	0.638
MOD_CK2_1	205	211	PF00069	0.519
MOD_CK2_1	25	31	PF00069	0.501
MOD_CK2_1	310	316	PF00069	0.725
MOD_CK2_1	412	418	PF00069	0.466
MOD_CK2_1	444	450	PF00069	0.594
MOD_CK2_1	457	463	PF00069	0.291
MOD_CK2_1	571	577	PF00069	0.618
MOD_CK2_1	667	673	PF00069	0.648
MOD_GlcNHglycan	133	136	PF01048	0.746
MOD_GlcNHglycan	139	143	PF01048	0.693
MOD_GlcNHglycan	160	163	PF01048	0.802
MOD_GlcNHglycan	184	187	PF01048	0.599
MOD_GlcNHglycan	250	253	PF01048	0.707
MOD_GlcNHglycan	283	286	PF01048	0.676
MOD_GlcNHglycan	295	298	PF01048	0.729
MOD_GlcNHglycan	305	308	PF01048	0.610
MOD_GlcNHglycan	381	384	PF01048	0.420
MOD_GlcNHglycan	434	438	PF01048	0.608
MOD_GlcNHglycan	489	492	PF01048	0.475
MOD_GlcNHglycan	503	506	PF01048	0.528
MOD_GlcNHglycan	519	522	PF01048	0.613
MOD_GlcNHglycan	551	554	PF01048	0.574
MOD_GlcNHglycan	557	560	PF01048	0.428
MOD_GlcNHglycan	646	649	PF01048	0.335
MOD_GSK3_1	134	141	PF00069	0.714
MOD_GSK3_1	166	173	PF00069	0.729
MOD_GSK3_1	251	258	PF00069	0.622
MOD_GSK3_1	280	287	PF00069	0.660
MOD_GSK3_1	293	300	PF00069	0.743
MOD_GSK3_1	379	386	PF00069	0.372
MOD_GSK3_1	398	405	PF00069	0.412
MOD_GSK3_1	487	494	PF00069	0.533
MOD_GSK3_1	586	593	PF00069	0.433
MOD_GSK3_1	635	642	PF00069	0.386
MOD_N-GLC_1	131	136	PF02516	0.518
MOD_N-GLC_1	665	670	PF02516	0.640
MOD_NEK2_1	303	308	PF00069	0.677
MOD_NEK2_1	398	403	PF00069	0.355
MOD_NEK2_1	590	595	PF00069	0.416
MOD_PIKK_1	297	303	PF00454	0.714
MOD_PIKK_1	398	404	PF00454	0.356
MOD_PIKK_1	491	497	PF00454	0.591
MOD_PK_1	144	150	PF00069	0.583
MOD_PKA_2	344	350	PF00069	0.469
MOD_PKA_2	616	622	PF00069	0.343
MOD_Plk_1	131	137	PF00069	0.588
MOD_Plk_1	255	261	PF00069	0.590
MOD_Plk_1	355	361	PF00069	0.423
MOD_Plk_1	386	392	PF00069	0.504
MOD_Plk_2-3	117	123	PF00069	0.503
MOD_Plk_2-3	205	211	PF00069	0.492
MOD_Plk_4	144	150	PF00069	0.599
MOD_Plk_4	196	202	PF00069	0.311
MOD_Plk_4	205	211	PF00069	0.347
MOD_Plk_4	31	37	PF00069	0.450
MOD_Plk_4	457	463	PF00069	0.321
MOD_Plk_4	526	532	PF00069	0.762
MOD_Plk_4	563	569	PF00069	0.474
MOD_Plk_4	586	592	PF00069	0.427
MOD_Plk_4	618	624	PF00069	0.361
MOD_Plk_4	635	641	PF00069	0.433
MOD_Plk_4	652	658	PF00069	0.487
MOD_Plk_4	667	673	PF00069	0.513
MOD_ProDKin_1	142	148	PF00069	0.734
MOD_ProDKin_1	295	301	PF00069	0.497
MOD_ProDKin_1	310	316	PF00069	0.704
MOD_ProDKin_1	412	418	PF00069	0.481
MOD_ProDKin_1	46	52	PF00069	0.439
MOD_SUMO_for_1	178	181	PF00179	0.655
MOD_SUMO_rev_2	337	342	PF00179	0.393
TRG_DiLeu_BaEn_4	269	275	PF01217	0.444
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.400
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.431
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.691
TRG_ENDOCYTIC_2	214	217	PF00928	0.361
TRG_ENDOCYTIC_2	225	228	PF00928	0.371
TRG_ENDOCYTIC_2	481	484	PF00928	0.365
TRG_ENDOCYTIC_2	67	70	PF00928	0.349
TRG_ENDOCYTIC_2	85	88	PF00928	0.325
TRG_ER_diArg_1	228	231	PF00400	0.617
TRG_ER_diArg_1	353	355	PF00400	0.391
TRG_NLS_MonoExtN_4	226	233	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH8	Leptomonas seymouri	66%	100%
A0A0S4IV50	Bodo saltans	34%	100%
A0A1X0NS55	Trypanosomatidae	38%	100%
A0A3R7REE6	Trypanosoma rangeli	34%	100%
A0A3S7X1Y8	Leishmania donovani	100%	100%
A4HGU7	Leishmania braziliensis	83%	100%
D0A943	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B065	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q820	Leishmania major	95%	100%
V5BC43	Trypanosoma cruzi	36%	100%