Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3W5_LEIIN

TriTrypDb:

LINF_280030400

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.541
CLV_NRD_NRD_1	256	258	PF00675	0.683
CLV_NRD_NRD_1	262	264	PF00675	0.730
CLV_NRD_NRD_1	38	40	PF00675	0.526
CLV_NRD_NRD_1	67	69	PF00675	0.643
CLV_PCSK_KEX2_1	132	134	PF00082	0.579
CLV_PCSK_KEX2_1	256	258	PF00082	0.683
CLV_PCSK_KEX2_1	262	264	PF00082	0.479
CLV_PCSK_KEX2_1	67	69	PF00082	0.643
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.681
CLV_PCSK_PC7_1	252	258	PF00082	0.676
CLV_PCSK_SKI1_1	133	137	PF00082	0.574
CLV_PCSK_SKI1_1	153	157	PF00082	0.529
CLV_PCSK_SKI1_1	96	100	PF00082	0.520
DEG_APCC_DBOX_1	27	35	PF00400	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.663
DEG_SPOP_SBC_1	221	225	PF00917	0.672
DOC_MAPK_DCC_7	3	11	PF00069	0.661
DOC_MAPK_gen_1	86	95	PF00069	0.584
DOC_MAPK_MEF2A_6	3	11	PF00069	0.628
DOC_PP1_RVXF_1	78	84	PF00149	0.713
DOC_PP4_FxxP_1	4	7	PF00568	0.624
DOC_SPAK_OSR1_1	3	7	PF12202	0.673
DOC_USP7_MATH_1	233	237	PF00917	0.726
DOC_USP7_MATH_1	242	246	PF00917	0.670
DOC_USP7_MATH_1	264	268	PF00917	0.721
DOC_USP7_MATH_1	281	285	PF00917	0.736
DOC_USP7_UBL2_3	132	136	PF12436	0.659
DOC_USP7_UBL2_3	37	41	PF12436	0.544
DOC_WW_Pin1_4	180	185	PF00397	0.702
DOC_WW_Pin1_4	22	27	PF00397	0.527
LIG_14-3-3_CanoR_1	113	117	PF00244	0.617
LIG_14-3-3_CanoR_1	256	260	PF00244	0.756
LIG_14-3-3_CanoR_1	263	272	PF00244	0.625
LIG_14-3-3_CanoR_1	3	7	PF00244	0.590
LIG_14-3-3_CanoR_1	88	93	PF00244	0.590
LIG_APCC_ABBAyCdc20_2	172	178	PF00400	0.663
LIG_CSL_BTD_1	181	184	PF09270	0.703
LIG_FHA_1	120	126	PF00498	0.584
LIG_FHA_1	141	147	PF00498	0.480
LIG_FHA_1	256	262	PF00498	0.757
LIG_FHA_1	30	36	PF00498	0.535
LIG_FHA_1	68	74	PF00498	0.518
LIG_Integrin_RGD_1	192	194	PF01839	0.715
LIG_LIR_Apic_2	178	184	PF02991	0.706
LIG_LIR_Gen_1	103	111	PF02991	0.588
LIG_LIR_Nem_3	48	53	PF02991	0.642
LIG_Pex14_1	150	154	PF04695	0.485
LIG_Pex14_2	131	135	PF04695	0.594
LIG_SH2_PTP2	154	157	PF00017	0.479
LIG_SH2_STAP1	176	180	PF00017	0.594
LIG_SH2_STAT5	111	114	PF00017	0.753
LIG_SH2_STAT5	154	157	PF00017	0.479
LIG_SH2_STAT5	45	48	PF00017	0.571
LIG_SH2_STAT5	72	75	PF00017	0.577
LIG_SH3_3	258	264	PF00018	0.661
LIG_SUMO_SIM_par_1	32	38	PF11976	0.551
LIG_TRAF2_1	139	142	PF00917	0.550
LIG_TYR_ITIM	152	157	PF00017	0.481
LIG_UBA3_1	156	162	PF00899	0.533
LIG_UBA3_1	33	41	PF00899	0.537
MOD_CDK_SPxK_1	22	28	PF00069	0.527
MOD_CK1_1	119	125	PF00069	0.561
MOD_CK1_1	185	191	PF00069	0.635
MOD_CK1_1	223	229	PF00069	0.613
MOD_CK1_1	273	279	PF00069	0.714
MOD_GlcNHglycan	225	228	PF01048	0.642
MOD_GlcNHglycan	230	233	PF01048	0.645
MOD_GlcNHglycan	237	240	PF01048	0.647
MOD_GlcNHglycan	249	252	PF01048	0.716
MOD_GSK3_1	100	107	PF00069	0.493
MOD_GSK3_1	112	119	PF00069	0.534
MOD_GSK3_1	221	228	PF00069	0.723
MOD_GSK3_1	266	273	PF00069	0.688
MOD_GSK3_1	84	91	PF00069	0.587
MOD_N-GLC_1	109	114	PF02516	0.631
MOD_N-GLC_1	88	93	PF02516	0.540
MOD_NEK2_1	100	105	PF00069	0.546
MOD_NEK2_1	120	125	PF00069	0.435
MOD_NEK2_1	2	7	PF00069	0.645
MOD_NEK2_1	220	225	PF00069	0.673
MOD_NEK2_1	255	260	PF00069	0.699
MOD_NEK2_1	29	34	PF00069	0.544
MOD_PIKK_1	100	106	PF00454	0.567
MOD_PKA_1	161	167	PF00069	0.566
MOD_PKA_1	67	73	PF00069	0.613
MOD_PKA_2	112	118	PF00069	0.613
MOD_PKA_2	2	8	PF00069	0.626
MOD_PKA_2	255	261	PF00069	0.722
MOD_PKA_2	67	73	PF00069	0.613
MOD_PKB_1	86	94	PF00069	0.552
MOD_Plk_1	109	115	PF00069	0.652
MOD_Plk_1	116	122	PF00069	0.559
MOD_Plk_1	140	146	PF00069	0.577
MOD_Plk_1	29	35	PF00069	0.550
MOD_Plk_1	88	94	PF00069	0.535
MOD_Plk_4	161	167	PF00069	0.580
MOD_Plk_4	29	35	PF00069	0.537
MOD_Plk_4	88	94	PF00069	0.653
MOD_ProDKin_1	180	186	PF00069	0.704
MOD_ProDKin_1	22	28	PF00069	0.527
MOD_SUMO_for_1	139	142	PF00179	0.616
MOD_SUMO_rev_2	267	272	PF00179	0.652
TRG_DiLeu_BaEn_1	30	35	PF01217	0.575
TRG_ENDOCYTIC_2	105	108	PF00928	0.705
TRG_ENDOCYTIC_2	111	114	PF00928	0.673
TRG_ENDOCYTIC_2	154	157	PF00928	0.479
TRG_ER_diArg_1	255	257	PF00400	0.682
TRG_ER_diArg_1	261	263	PF00400	0.472
TRG_ER_diArg_1	66	68	PF00400	0.656
TRG_NLS_MonoExtC_3	39	44	PF00514	0.541
TRG_NLS_MonoExtN_4	37	44	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ2	Leptomonas seymouri	55%	100%
A0A0S4IRF0	Bodo saltans	44%	100%
A0A1X0NQP5	Trypanosomatidae	46%	100%
A0A3Q8IB55	Leishmania donovani	100%	100%
A4HGT8	Leishmania braziliensis	80%	100%
D0A933	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B055	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q830	Leishmania major	97%	100%
V5D5Q3	Trypanosoma cruzi	49%	90%