LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Cactus-binding C-terminus of cactin protein - putative
Species:
Leishmania infantum
UniProt:
A4I3W4_LEIIN
TriTrypDb:
LINF_280030200
Length:
691

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005635 nuclear envelope 4 1
GO:0005681 spliceosomal complex 3 1
GO:0005737 cytoplasm 2 1
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4I3W4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3W4

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 1
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 1
GO:0000398 mRNA splicing, via spliceosome 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008380 RNA splicing 7 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045292 mRNA cis splicing, via spliceosome 9 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 172 176 PF00656 0.697
CLV_NRD_NRD_1 11 13 PF00675 0.690
CLV_NRD_NRD_1 656 658 PF00675 0.261
CLV_NRD_NRD_1 664 666 PF00675 0.255
CLV_PCSK_KEX2_1 618 620 PF00082 0.272
CLV_PCSK_KEX2_1 664 666 PF00082 0.348
CLV_PCSK_KEX2_1 9 11 PF00082 0.625
CLV_PCSK_PC1ET2_1 618 620 PF00082 0.272
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.607
CLV_PCSK_PC7_1 5 11 PF00082 0.725
CLV_PCSK_SKI1_1 149 153 PF00082 0.386
CLV_PCSK_SKI1_1 264 268 PF00082 0.558
CLV_PCSK_SKI1_1 622 626 PF00082 0.348
CLV_PCSK_SKI1_1 63 67 PF00082 0.505
CLV_PCSK_SKI1_1 679 683 PF00082 0.258
DEG_APCC_DBOX_1 263 271 PF00400 0.559
DEG_Nend_UBRbox_2 1 3 PF02207 0.639
DEG_SPOP_SBC_1 52 56 PF00917 0.586
DEG_SPOP_SBC_1 98 102 PF00917 0.490
DOC_CYCLIN_yClb5_NLxxxL_5 457 466 PF00134 0.586
DOC_CYCLIN_yCln2_LP_2 609 615 PF00134 0.458
DOC_MAPK_gen_1 261 270 PF00069 0.510
DOC_MAPK_gen_1 63 73 PF00069 0.474
DOC_MAPK_gen_1 664 672 PF00069 0.548
DOC_MAPK_MEF2A_6 261 270 PF00069 0.558
DOC_MAPK_MEF2A_6 63 72 PF00069 0.477
DOC_MAPK_MEF2A_6 664 672 PF00069 0.548
DOC_PP1_RVXF_1 667 673 PF00149 0.490
DOC_PP1_RVXF_1 677 683 PF00149 0.425
DOC_PP2B_LxvP_1 484 487 PF13499 0.664
DOC_PP4_FxxP_1 256 259 PF00568 0.565
DOC_USP7_MATH_1 381 385 PF00917 0.670
DOC_USP7_MATH_1 52 56 PF00917 0.554
DOC_USP7_MATH_2 296 302 PF00917 0.649
DOC_USP7_UBL2_3 312 316 PF12436 0.628
DOC_WW_Pin1_4 212 217 PF00397 0.640
DOC_WW_Pin1_4 292 297 PF00397 0.748
DOC_WW_Pin1_4 384 389 PF00397 0.713
DOC_WW_Pin1_4 397 402 PF00397 0.575
DOC_WW_Pin1_4 448 453 PF00397 0.500
DOC_WW_Pin1_4 541 546 PF00397 0.698
DOC_WW_Pin1_4 627 632 PF00397 0.543
LIG_14-3-3_CanoR_1 27 34 PF00244 0.509
LIG_14-3-3_CanoR_1 408 414 PF00244 0.615
LIG_14-3-3_CanoR_1 440 445 PF00244 0.355
LIG_14-3-3_CanoR_1 669 673 PF00244 0.458
LIG_deltaCOP1_diTrp_1 234 242 PF00928 0.473
LIG_deltaCOP1_diTrp_1 602 610 PF00928 0.548
LIG_eIF4E_1 262 268 PF01652 0.552
LIG_eIF4E_1 362 368 PF01652 0.635
LIG_eIF4E_1 675 681 PF01652 0.543
LIG_FHA_1 98 104 PF00498 0.432
LIG_FHA_2 11 17 PF00498 0.578
LIG_FHA_2 129 135 PF00498 0.527
LIG_FHA_2 136 142 PF00498 0.520
LIG_FHA_2 160 166 PF00498 0.610
LIG_FHA_2 196 202 PF00498 0.599
LIG_FHA_2 293 299 PF00498 0.678
LIG_FHA_2 339 345 PF00498 0.751
LIG_FHA_2 389 395 PF00498 0.603
LIG_FHA_2 449 455 PF00498 0.580
LIG_FHA_2 513 519 PF00498 0.509
LIG_FHA_2 587 593 PF00498 0.458
LIG_FHA_2 615 621 PF00498 0.460
LIG_Integrin_RGD_1 163 165 PF01839 0.629
LIG_LIR_Apic_2 2 6 PF02991 0.726
LIG_LIR_Gen_1 191 201 PF02991 0.726
LIG_LIR_Gen_1 234 243 PF02991 0.426
LIG_LIR_Gen_1 502 509 PF02991 0.547
LIG_LIR_Gen_1 606 615 PF02991 0.458
LIG_LIR_Gen_1 636 645 PF02991 0.458
LIG_LIR_Nem_3 191 197 PF02991 0.738
LIG_LIR_Nem_3 234 239 PF02991 0.424
LIG_LIR_Nem_3 422 428 PF02991 0.406
LIG_LIR_Nem_3 502 508 PF02991 0.550
LIG_LIR_Nem_3 582 586 PF02991 0.468
LIG_LIR_Nem_3 601 607 PF02991 0.458
LIG_LIR_Nem_3 608 614 PF02991 0.458
LIG_LIR_Nem_3 636 641 PF02991 0.458
LIG_LIR_Nem_3 671 675 PF02991 0.557
LIG_LYPXL_S_1 610 614 PF13949 0.258
LIG_LYPXL_yS_3 611 614 PF13949 0.458
LIG_NRBOX 21 27 PF00104 0.523
LIG_NRBOX 265 271 PF00104 0.433
LIG_NRP_CendR_1 690 691 PF00754 0.258
LIG_PTB_Apo_2 683 690 PF02174 0.458
LIG_PTB_Phospho_1 683 689 PF10480 0.458
LIG_REV1ctd_RIR_1 679 687 PF16727 0.458
LIG_RPA_C_Fungi 426 438 PF08784 0.511
LIG_SH2_CRK 425 429 PF00017 0.392
LIG_SH2_CRK 638 642 PF00017 0.302
LIG_SH2_NCK_1 171 175 PF00017 0.631
LIG_SH2_NCK_1 649 653 PF00017 0.302
LIG_SH2_SRC 171 174 PF00017 0.657
LIG_SH2_SRC 182 185 PF00017 0.574
LIG_SH2_SRC 649 652 PF00017 0.302
LIG_SH2_STAP1 262 266 PF00017 0.423
LIG_SH2_STAP1 505 509 PF00017 0.539
LIG_SH2_STAP1 605 609 PF00017 0.302
LIG_SH2_STAP1 649 653 PF00017 0.302
LIG_SH2_STAT5 498 501 PF00017 0.498
LIG_SH2_STAT5 531 534 PF00017 0.591
LIG_SH2_STAT5 638 641 PF00017 0.302
LIG_SH2_STAT5 79 82 PF00017 0.356
LIG_SH3_3 103 109 PF00018 0.360
LIG_SH3_3 352 358 PF00018 0.728
LIG_SH3_3 375 381 PF00018 0.653
LIG_SH3_3 484 490 PF00018 0.712
LIG_SH3_3 532 538 PF00018 0.663
LIG_SH3_3 628 634 PF00018 0.372
LIG_SH3_3 642 648 PF00018 0.224
LIG_SUMO_SIM_anti_2 265 271 PF11976 0.558
LIG_SUMO_SIM_anti_2 69 74 PF11976 0.449
LIG_SUMO_SIM_par_1 370 375 PF11976 0.611
LIG_TRAF2_1 13 16 PF00917 0.626
LIG_TRAF2_1 198 201 PF00917 0.752
LIG_TRAF2_1 467 470 PF00917 0.427
LIG_TYR_ITIM 609 614 PF00017 0.302
LIG_WRC_WIRS_1 441 446 PF05994 0.356
LIG_WW_1 259 262 PF00397 0.574
LIG_WW_3 258 262 PF00397 0.566
LIG_WW_3 597 601 PF00397 0.302
MOD_CK1_1 195 201 PF00069 0.676
MOD_CK1_1 247 253 PF00069 0.419
MOD_CK1_1 301 307 PF00069 0.762
MOD_CK1_1 384 390 PF00069 0.820
MOD_CK1_1 400 406 PF00069 0.636
MOD_CK1_1 448 454 PF00069 0.566
MOD_CK1_1 48 54 PF00069 0.639
MOD_CK1_1 546 552 PF00069 0.741
MOD_CK2_1 10 16 PF00069 0.617
MOD_CK2_1 135 141 PF00069 0.514
MOD_CK2_1 195 201 PF00069 0.787
MOD_CK2_1 292 298 PF00069 0.691
MOD_CK2_1 338 344 PF00069 0.741
MOD_CK2_1 448 454 PF00069 0.560
MOD_CK2_1 512 518 PF00069 0.509
MOD_CK2_1 98 104 PF00069 0.496
MOD_Cter_Amidation 7 10 PF01082 0.787
MOD_DYRK1A_RPxSP_1 212 216 PF00069 0.708
MOD_GlcNHglycan 178 181 PF01048 0.673
MOD_GlcNHglycan 212 215 PF01048 0.775
MOD_GlcNHglycan 249 252 PF01048 0.424
MOD_GlcNHglycan 304 307 PF01048 0.641
MOD_GlcNHglycan 350 354 PF01048 0.709
MOD_GlcNHglycan 364 367 PF01048 0.610
MOD_GlcNHglycan 402 405 PF01048 0.594
MOD_GlcNHglycan 409 412 PF01048 0.448
MOD_GlcNHglycan 447 450 PF01048 0.491
MOD_GlcNHglycan 480 483 PF01048 0.694
MOD_GlcNHglycan 55 58 PF01048 0.612
MOD_GlcNHglycan 558 561 PF01048 0.718
MOD_GlcNHglycan 6 9 PF01048 0.740
MOD_GSK3_1 110 117 PF00069 0.546
MOD_GSK3_1 298 305 PF00069 0.696
MOD_GSK3_1 379 386 PF00069 0.765
MOD_GSK3_1 396 403 PF00069 0.658
MOD_GSK3_1 48 55 PF00069 0.649
MOD_GSK3_1 539 546 PF00069 0.748
MOD_GSK3_1 586 593 PF00069 0.380
MOD_N-GLC_1 546 551 PF02516 0.747
MOD_N-GLC_1 586 591 PF02516 0.302
MOD_NEK2_1 122 127 PF00069 0.402
MOD_NEK2_1 225 230 PF00069 0.394
MOD_NEK2_1 242 247 PF00069 0.419
MOD_NEK2_1 26 31 PF00069 0.400
MOD_NEK2_1 302 307 PF00069 0.670
MOD_NEK2_1 372 377 PF00069 0.597
MOD_NEK2_1 53 58 PF00069 0.609
MOD_NEK2_1 581 586 PF00069 0.427
MOD_NEK2_1 614 619 PF00069 0.302
MOD_NEK2_1 641 646 PF00069 0.302
MOD_NEK2_1 682 687 PF00069 0.362
MOD_NEK2_1 80 85 PF00069 0.442
MOD_NEK2_2 605 610 PF00069 0.302
MOD_PIKK_1 45 51 PF00454 0.626
MOD_PIKK_1 581 587 PF00454 0.302
MOD_PKA_1 10 16 PF00069 0.663
MOD_PKA_2 195 201 PF00069 0.676
MOD_PKA_2 26 32 PF00069 0.391
MOD_PKA_2 4 10 PF00069 0.745
MOD_PKA_2 407 413 PF00069 0.639
MOD_PKA_2 445 451 PF00069 0.517
MOD_PKA_2 668 674 PF00069 0.302
MOD_PKA_2 682 688 PF00069 0.302
MOD_PKB_1 438 446 PF00069 0.363
MOD_Plk_1 453 459 PF00069 0.547
MOD_Plk_1 586 592 PF00069 0.302
MOD_Plk_1 605 611 PF00069 0.302
MOD_Plk_2-3 338 344 PF00069 0.688
MOD_Plk_4 122 128 PF00069 0.413
MOD_Plk_4 225 231 PF00069 0.383
MOD_ProDKin_1 212 218 PF00069 0.630
MOD_ProDKin_1 292 298 PF00069 0.750
MOD_ProDKin_1 384 390 PF00069 0.711
MOD_ProDKin_1 397 403 PF00069 0.572
MOD_ProDKin_1 448 454 PF00069 0.505
MOD_ProDKin_1 541 547 PF00069 0.701
MOD_ProDKin_1 627 633 PF00069 0.420
MOD_SUMO_for_1 311 314 PF00179 0.647
MOD_SUMO_for_1 319 322 PF00179 0.634
TRG_DiLeu_BaEn_1 263 268 PF01217 0.554
TRG_DiLeu_BaEn_2 140 146 PF01217 0.498
TRG_ENDOCYTIC_2 194 197 PF00928 0.748
TRG_ENDOCYTIC_2 425 428 PF00928 0.389
TRG_ENDOCYTIC_2 429 432 PF00928 0.382
TRG_ENDOCYTIC_2 505 508 PF00928 0.544
TRG_ENDOCYTIC_2 611 614 PF00928 0.302
TRG_ENDOCYTIC_2 638 641 PF00928 0.302
TRG_ENDOCYTIC_2 649 652 PF00928 0.302
TRG_ENDOCYTIC_2 678 681 PF00928 0.302
TRG_ER_diArg_1 10 12 PF00400 0.722
TRG_ER_diArg_1 36 39 PF00400 0.431
TRG_ER_diArg_1 654 657 PF00400 0.427
TRG_ER_diArg_1 689 691 PF00400 0.302
TRG_NLS_MonoCore_2 8 13 PF00514 0.707
TRG_NLS_MonoExtC_3 656 662 PF00514 0.427
TRG_NLS_MonoExtC_3 8 14 PF00514 0.621
TRG_NLS_MonoExtN_4 6 13 PF00514 0.704
TRG_NLS_MonoExtN_4 655 661 PF00514 0.427
TRG_Pf-PMV_PEXEL_1 105 110 PF00026 0.477
TRG_Pf-PMV_PEXEL_1 460 464 PF00026 0.591

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1P4 Leptomonas seymouri 62% 100%
A0A1X0NRC2 Trypanosomatidae 37% 100%
A0A3S7X1V8 Leishmania donovani 100% 100%
A0A422N9D9 Trypanosoma rangeli 39% 100%
A4HGT7 Leishmania braziliensis 86% 100%
D0A932 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9B054 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q831 Leishmania major 95% 100%
V5APW4 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS