Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3W1_LEIIN

TriTrypDb:

LINF_280029800

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3W1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.547
CLV_C14_Caspase3-7	80	84	PF00656	0.506
CLV_NRD_NRD_1	163	165	PF00675	0.596
CLV_NRD_NRD_1	167	169	PF00675	0.596
CLV_NRD_NRD_1	235	237	PF00675	0.701
CLV_NRD_NRD_1	334	336	PF00675	0.667
CLV_NRD_NRD_1	445	447	PF00675	0.437
CLV_NRD_NRD_1	47	49	PF00675	0.563
CLV_NRD_NRD_1	61	63	PF00675	0.531
CLV_NRD_NRD_1	9	11	PF00675	0.441
CLV_PCSK_FUR_1	233	237	PF00082	0.601
CLV_PCSK_KEX2_1	162	164	PF00082	0.600
CLV_PCSK_KEX2_1	167	169	PF00082	0.594
CLV_PCSK_KEX2_1	235	237	PF00082	0.657
CLV_PCSK_KEX2_1	333	335	PF00082	0.684
CLV_PCSK_KEX2_1	445	447	PF00082	0.437
CLV_PCSK_KEX2_1	47	49	PF00082	0.534
CLV_PCSK_KEX2_1	61	63	PF00082	0.433
CLV_PCSK_KEX2_1	8	10	PF00082	0.441
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.546
CLV_PCSK_PC7_1	163	169	PF00082	0.570
CLV_PCSK_PC7_1	330	336	PF00082	0.624
CLV_PCSK_SKI1_1	475	479	PF00082	0.615
DEG_APCC_DBOX_1	474	482	PF00400	0.510
DEG_SPOP_SBC_1	251	255	PF00917	0.610
DEG_SPOP_SBC_1	311	315	PF00917	0.558
DOC_ANK_TNKS_1	393	400	PF00023	0.596
DOC_CKS1_1	245	250	PF01111	0.527
DOC_PP2B_LxvP_1	390	393	PF13499	0.640
DOC_USP7_MATH_1	120	124	PF00917	0.619
DOC_USP7_MATH_1	144	148	PF00917	0.691
DOC_USP7_MATH_1	2	6	PF00917	0.521
DOC_USP7_MATH_1	251	255	PF00917	0.687
DOC_USP7_MATH_1	312	316	PF00917	0.668
DOC_USP7_MATH_1	370	374	PF00917	0.818
DOC_WW_Pin1_4	116	121	PF00397	0.551
DOC_WW_Pin1_4	134	139	PF00397	0.554
DOC_WW_Pin1_4	157	162	PF00397	0.589
DOC_WW_Pin1_4	177	182	PF00397	0.434
DOC_WW_Pin1_4	183	188	PF00397	0.515
DOC_WW_Pin1_4	227	232	PF00397	0.683
DOC_WW_Pin1_4	244	249	PF00397	0.511
DOC_WW_Pin1_4	257	262	PF00397	0.644
DOC_WW_Pin1_4	273	278	PF00397	0.525
DOC_WW_Pin1_4	281	286	PF00397	0.620
DOC_WW_Pin1_4	287	292	PF00397	0.650
DOC_WW_Pin1_4	321	326	PF00397	0.679
DOC_WW_Pin1_4	335	340	PF00397	0.549
DOC_WW_Pin1_4	345	350	PF00397	0.553
LIG_14-3-3_CanoR_1	131	135	PF00244	0.698
LIG_14-3-3_CanoR_1	145	149	PF00244	0.507
LIG_14-3-3_CanoR_1	183	187	PF00244	0.551
LIG_14-3-3_CanoR_1	236	246	PF00244	0.584
LIG_14-3-3_CanoR_1	410	419	PF00244	0.467
LIG_14-3-3_CanoR_1	61	65	PF00244	0.513
LIG_14-3-3_CanoR_1	77	82	PF00244	0.606
LIG_Actin_WH2_2	32	49	PF00022	0.465
LIG_Actin_WH2_2	71	88	PF00022	0.457
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BRCT_BRCA1_1	343	347	PF00533	0.811
LIG_DLG_GKlike_1	77	85	PF00625	0.504
LIG_EH1_1	189	197	PF00400	0.565
LIG_FHA_1	187	193	PF00498	0.534
LIG_FHA_2	349	355	PF00498	0.602
LIG_LIR_Gen_1	147	155	PF02991	0.523
LIG_LIR_Gen_1	41	51	PF02991	0.590
LIG_LIR_Gen_1	489	499	PF02991	0.470
LIG_LIR_Nem_3	266	270	PF02991	0.605
LIG_LIR_Nem_3	41	46	PF02991	0.583
LIG_LIR_Nem_3	489	495	PF02991	0.405
LIG_SH2_CRK	211	215	PF00017	0.699
LIG_SH2_STAP1	492	496	PF00017	0.569
LIG_SH2_STAT5	148	151	PF00017	0.523
LIG_SH2_STAT5	204	207	PF00017	0.550
LIG_SH2_STAT5	487	490	PF00017	0.410
LIG_SH3_1	243	249	PF00018	0.626
LIG_SH3_2	389	394	PF14604	0.624
LIG_SH3_3	114	120	PF00018	0.630
LIG_SH3_3	169	175	PF00018	0.566
LIG_SH3_3	242	248	PF00018	0.653
LIG_SH3_3	336	342	PF00018	0.682
LIG_SH3_3	363	369	PF00018	0.694
LIG_SH3_3	385	391	PF00018	0.679
LIG_SH3_CIN85_PxpxPR_1	389	394	PF14604	0.602
LIG_SUMO_SIM_anti_2	493	501	PF11976	0.433
LIG_TRAF2_1	56	59	PF00917	0.524
LIG_TYR_ITIM	209	214	PF00017	0.622
LIG_UBA3_1	447	454	PF00899	0.413
LIG_WW_3	260	264	PF00397	0.599
LIG_WW_3	391	395	PF00397	0.600
MOD_CDC14_SPxK_1	160	163	PF00782	0.588
MOD_CDC14_SPxK_1	180	183	PF00782	0.435
MOD_CDC14_SPxK_1	230	233	PF00782	0.620
MOD_CDC14_SPxK_1	338	341	PF00782	0.600
MOD_CDK_SPK_2	116	121	PF00069	0.540
MOD_CDK_SPK_2	157	162	PF00069	0.525
MOD_CDK_SPK_2	345	350	PF00069	0.644
MOD_CDK_SPxK_1	157	163	PF00069	0.584
MOD_CDK_SPxK_1	177	183	PF00069	0.435
MOD_CDK_SPxK_1	227	233	PF00069	0.626
MOD_CDK_SPxK_1	257	263	PF00069	0.604
MOD_CDK_SPxK_1	335	341	PF00069	0.603
MOD_CDK_SPxxK_3	157	164	PF00069	0.567
MOD_CDK_SPxxK_3	321	328	PF00069	0.641
MOD_CDK_SPxxK_3	345	352	PF00069	0.581
MOD_CK1_1	129	135	PF00069	0.604
MOD_CK1_1	186	192	PF00069	0.559
MOD_CK1_1	255	261	PF00069	0.612
MOD_CK1_1	280	286	PF00069	0.628
MOD_CK1_1	299	305	PF00069	0.619
MOD_CK1_1	321	327	PF00069	0.642
MOD_CK1_1	348	354	PF00069	0.580
MOD_CK1_1	373	379	PF00069	0.684
MOD_CK2_1	116	122	PF00069	0.660
MOD_CK2_1	348	354	PF00069	0.679
MOD_CK2_1	53	59	PF00069	0.671
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.551
MOD_GlcNHglycan	172	175	PF01048	0.635
MOD_GlcNHglycan	257	260	PF01048	0.600
MOD_GlcNHglycan	285	288	PF01048	0.635
MOD_GlcNHglycan	306	309	PF01048	0.632
MOD_GlcNHglycan	314	317	PF01048	0.582
MOD_GlcNHglycan	325	328	PF01048	0.522
MOD_GlcNHglycan	362	365	PF01048	0.651
MOD_GSK3_1	116	123	PF00069	0.621
MOD_GSK3_1	126	133	PF00069	0.732
MOD_GSK3_1	134	141	PF00069	0.598
MOD_GSK3_1	182	189	PF00069	0.576
MOD_GSK3_1	251	258	PF00069	0.666
MOD_GSK3_1	273	280	PF00069	0.607
MOD_GSK3_1	281	288	PF00069	0.627
MOD_GSK3_1	290	297	PF00069	0.589
MOD_GSK3_1	298	305	PF00069	0.733
MOD_GSK3_1	319	326	PF00069	0.650
MOD_GSK3_1	341	348	PF00069	0.662
MOD_GSK3_1	370	377	PF00069	0.677
MOD_GSK3_1	434	441	PF00069	0.455
MOD_GSK3_1	73	80	PF00069	0.465
MOD_N-GLC_1	405	410	PF02516	0.483
MOD_NEK2_1	279	284	PF00069	0.627
MOD_NEK2_1	32	37	PF00069	0.572
MOD_NEK2_1	405	410	PF00069	0.487
MOD_PIKK_1	357	363	PF00454	0.659
MOD_PIKK_1	438	444	PF00454	0.437
MOD_PKA_2	130	136	PF00069	0.635
MOD_PKA_2	144	150	PF00069	0.534
MOD_PKA_2	182	188	PF00069	0.544
MOD_PKA_2	2	8	PF00069	0.514
MOD_PKA_2	22	28	PF00069	0.468
MOD_PKA_2	60	66	PF00069	0.553
MOD_PKB_1	355	363	PF00069	0.568
MOD_PKB_1	75	83	PF00069	0.498
MOD_Plk_1	32	38	PF00069	0.531
MOD_ProDKin_1	116	122	PF00069	0.550
MOD_ProDKin_1	134	140	PF00069	0.548
MOD_ProDKin_1	157	163	PF00069	0.592
MOD_ProDKin_1	177	183	PF00069	0.435
MOD_ProDKin_1	227	233	PF00069	0.685
MOD_ProDKin_1	244	250	PF00069	0.513
MOD_ProDKin_1	257	263	PF00069	0.645
MOD_ProDKin_1	273	279	PF00069	0.527
MOD_ProDKin_1	281	287	PF00069	0.619
MOD_ProDKin_1	321	327	PF00069	0.678
MOD_ProDKin_1	335	341	PF00069	0.548
MOD_ProDKin_1	345	351	PF00069	0.554
MOD_SUMO_rev_2	450	456	PF00179	0.466
TRG_DiLeu_BaEn_4	41	47	PF01217	0.514
TRG_ENDOCYTIC_2	148	151	PF00928	0.523
TRG_ENDOCYTIC_2	211	214	PF00928	0.655
TRG_ENDOCYTIC_2	267	270	PF00928	0.615
TRG_ENDOCYTIC_2	492	495	PF00928	0.455
TRG_ER_diArg_1	163	165	PF00400	0.570
TRG_ER_diArg_1	166	168	PF00400	0.579
TRG_ER_diArg_1	205	208	PF00400	0.554
TRG_ER_diArg_1	232	235	PF00400	0.657
TRG_ER_diArg_1	333	335	PF00400	0.680
TRG_ER_diArg_1	340	343	PF00400	0.591
TRG_ER_diArg_1	349	352	PF00400	0.539
TRG_ER_diArg_1	444	446	PF00400	0.443
TRG_ER_diArg_1	46	48	PF00400	0.544
TRG_ER_diArg_1	472	475	PF00400	0.520
TRG_ER_diArg_1	74	77	PF00400	0.443
TRG_ER_diArg_1	8	10	PF00400	0.482
TRG_NLS_MonoExtC_3	161	166	PF00514	0.539
TRG_NLS_MonoExtN_4	159	166	PF00514	0.536
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	445	450	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAD1	Leptomonas seymouri	42%	89%
A0A3S7X1S1	Leishmania donovani	99%	78%
A4HGT4	Leishmania braziliensis	74%	100%
E9B051	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q834	Leishmania major	90%	100%